{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:03:02Z","timestamp":1789819382728,"version":"4.0.1"},"reference-count":104,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100005597","name":"Cerebral Palsy International Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD070996"],"award-info":[{"award-number":["R01 HD070996"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD074593"],"award-info":[{"award-number":["R01HD074593"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K08 HD073315-01"],"award-info":[{"award-number":["K08 HD073315-01"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL119664"],"award-info":[{"award-number":["R01 HL119664"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R21 EB018426"],"award-info":[{"award-number":["R21 EB018426"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2016.00196","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T23:10:45Z","timestamp":1468365045000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Blood Biomarkers for Evaluation of Perinatal Encephalopathy"],"prefix":"10.3389","volume":"7","author":[{"given":"Ernest M.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Burd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen D.","family":"Everett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances J.","family":"Northington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"B1","volume-title":"Neonatal Encephalopathy and Neurologic Outcome, 2nd Edn","author":"American College of Obstetricians Gynecologists","year":"2014"},{"key":"B2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1067\/mcp.2001.113989","article-title":"Biomarkers and surrogate endpoints. Perferred definitions and conceptual framework","volume":"69","author":"Atkinson","year":"2001","journal-title":"Clin. Pharmacol. Therapeut."},{"key":"B3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.bbi.2015.10.002","article-title":"Assessing blood granulocyte colony-stimulating factor as a potential biomarker of acute traumatic brain injury in mice and humans","volume":"52","author":"Banks","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12974-015-0434-1","article-title":"Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit","volume":"12","author":"Banks","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1111\/j.1471-4159.1988.tb01153.x","article-title":"Expression and localization of myelin basic protein in oligodendrocytes and transfected fibroblasts","volume":"51","author":"Barbarese","year":"1988","journal-title":"J. Neurochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1089\/neu.2007.0316","article-title":"Serum biomarker concentrations and outcome after pediatric traumatic brain injury","volume":"24","author":"Berger","year":"2007","journal-title":"J. Neurotrauma"},{"key":"B7","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/01.shk.0000209534.61058.35","article-title":"Serum S-100B concentration provides additional information fot the indication of computed tomography in patients after minor head injury: a prospective multicenter study","volume":"25","author":"Biberthaler","year":"2006","journal-title":"Shock"},{"key":"B8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00381-013-2314-2","article-title":"The use of handheld near-infrared device (infrascanner)for detecting intracranial haemorrhages in children with minor head injury","volume":"30","author":"Bressan","year":"2014","journal-title":"Childs. Nerv. Syst."},{"key":"B9","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jpeds.2013.10.067","article-title":"Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy","volume":"164","author":"Chalak","year":"2014","journal-title":"J. Pediatr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1080\/0268869021000030285","article-title":"Discordant temporal patterns of S100beta and cleaved tau protein elevation after head injury: a pilot study","volume":"16","author":"Chatfield","year":"2002","journal-title":"Br. J. Neurosurg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s12975-015-0429-3","article-title":"Effects of focal cerebral ischemia on exosomal versus serum miR126","volume":"6","author":"Chen","year":"2015","journal-title":"Transl. Stroke Res."},{"key":"B12","first-page":"32","article-title":"Expression and significance of serum miRNA-21 control HIE-1a in newborn with asphyxia","volume":"23","author":"Chen","year":"2012","journal-title":"Chin. J. Child Health Care"},{"key":"B13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuroscience.2014.04.018","article-title":"Developmental study of the distribution of hypoxia-induced factor-1 alpha and microtubule-associated protein 2 in children's brainstem: comparison between controls and cases with signs of perinatal hypoxia","volume":"271","author":"Covenas","year":"2014","journal-title":"Neuroscience"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1203\/00006450-199707000-00001","article-title":"Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn","volume":"42","author":"Dammann","year":"1997","journal-title":"Pediatr. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1089\/neu.2013.3040","article-title":"Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein","volume":"31","author":"Diaz-Arrastia","year":"2014","journal-title":"J. Neurotrauma"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e108034","DOI":"10.1371\/journal.pone.0108034","article-title":"Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury","volume":"9","author":"Dohi","year":"2014","journal-title":"PLoS ONE"},{"key":"B17","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.cca.2015.09.013","article-title":"Changes in plasma thrombospondin-1 concentrations following acute intracerebral hemorrhage","volume":"450","author":"Dong","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"273","key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00273","article-title":"UCH-L1 and GFAP serum levels in neonates with hypoxic-ischemic encephalopathy: a single center pilot study","volume":"5","author":"Douglas-Escobar","year":"2014","journal-title":"Front. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/S0140-6736(01)06723-X","article-title":"Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions","volume":"358","author":"Duggan","year":"2001","journal-title":"Lancet"},{"key":"B20","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1160\/TH12-08-0613","article-title":"Circulating miRNAs: messengers on the move in cardiovascular disease","volume":"108","author":"Egea","year":"2012","journal-title":"Thromb. Haemost."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1089\/neu.2012.2606","article-title":"S100B protein may detect brain death development after severe traumatic brain injury","volume":"30","author":"Egea-Guerrero","year":"2013","journal-title":"J. Neurotrauma"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.ajog.2011.06.025","article-title":"Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling","volume":"251","author":"Ennen","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1177\/1545968315586465","article-title":"Brain-derived neurotrophic factor (BDNF) in traumatic brain injury-related mortality: interrelationships between genetics and acute systemic and central nervous system BDNF profiles","volume":"30","author":"Failla","year":"2016","journal-title":"Neurorehabil. Neural Repair"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1007\/s00134-010-1913-6","article-title":"Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats","volume":"36","author":"Fathali","year":"2010","journal-title":"Intensive Care Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.tins.2005.06.008","article-title":"IL-18: A key player in neuroinflammation and neurodegeneration?","volume":"28","author":"Felderhoff-Mueser","year":"2005","journal-title":"Trends Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/jnr.490410404","article-title":"Glial fibrillary acidic protein mRNA isotypes: expression in vitro and in vivo","volume":"41","author":"Galea","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0115194","DOI":"10.1371\/journal.pone.0115194","article-title":"Neurological abnormalities in full-term asphyxiated newborns and salivary S100B testing: the \u201ccooperative multitask against brain injury of neonates\u201d (CoMBINe) international study","volume":"10","author":"Gazzolo","year":"2015","journal-title":"PLoS ONE"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.3109\/02699052.2012.694567","article-title":"Multiple indicators model of long-term mortality in traumatic brain injury","volume":"26","author":"Gradisek","year":"2012","journal-title":"Brain Inj."},{"issue":"61","key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00061","article-title":"Integration of proteomics, bioinformatics, and systems biology in traumatic brain injury biomarker discovery","volume":"4","author":"Guingab-Cagmat","year":"2013","journal-title":"Front. Neurol."},{"key":"B30","first-page":"105","article-title":"Dynamic study of serum interleukin 18 levels in neonatal hypoxic ischemic encephalopathy","volume":"35","author":"Guo","year":"2014","journal-title":"J. Hebei Med. Univ."},{"key":"B31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1089\/neu.2000.17.113","article-title":"Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography","volume":"17","author":"Herrmann","year":"2000","journal-title":"J. Neurotrauma"},{"key":"B32","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1385\/NMM:2:2:131","article-title":"Tau and axonopathy in neurodegenerative disorders","volume":"2","author":"Higuchi","year":"2002","journal-title":"Neuromolecular Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.3923\/pjbs.2009.1498.1504","article-title":"Cord blood brain derived neurotrophic factor: diagnostic and prognostic marker in fullterm newborns with perinatal asphyxia","volume":"12","author":"Imam","year":"2009","journal-title":"Pak. J. Biol. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1097\/00006123-199909000-00010","article-title":"Traumatic brain damage in minor head injury: relation of serum S-100 protein measurements to magnetic resonance imaging and neurobehavioral outcome","volume":"45","author":"Ingebrigtsen","year":"1999","journal-title":"Neurosurgery"},{"key":"B35","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/978-94-017-7215-0_9","article-title":"Neuron-specific enolase as a biomarker: biochemical and clinical aspects","volume":"867","author":"Isgro","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12974-015-0397-2","article-title":"New means to assess neonatal inflammatory brain injury","volume":"12","author":"Jin","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1002\/prca.200800011","article-title":"Neuroproteomics and systems biology-based discovery of protein biomarkers for traumatic brain injury and clinical validation","volume":"2","author":"Kobeissy","year":"2008","journal-title":"Proteomics Clin. Appl."},{"key":"B38","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1089\/neu.2015.3949","article-title":"Circulating brain-derived neurotrophic factor has diagnostic and prognostic value in traumatic brain injury","volume":"33","author":"Korley","year":"2016","journal-title":"J. Neurotrauma"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e1000389","DOI":"10.1371\/journal.pmed.1000389","article-title":"Setting research priorities to reduce almost one million deaths from birth asphyxia by 2015","volume":"8","author":"Lawn","year":"2011","journal-title":"PLoS Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/pr.2013.206","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"Lee","year":"2013","journal-title":"Pediatr. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3340\/jkns.2015.58.2.93","article-title":"A role of serum-based neuronal and glial markers as potential predictors for distinguishing severity and related outcomes in traumatic brain injury","volume":"58","author":"Lee","year":"2015","journal-title":"J. Korean Neurosurg. Soc."},{"key":"B42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1469-8749.1993.tb11688.x","article-title":"Preterm birth and cerebral palsy: is tumor necrosis factor the missing link?","volume":"35","author":"Leviton","year":"1993","journal-title":"Dev. Med. Child Neurol."},{"key":"B43","first-page":"134","article-title":"The expression of VEGF and VEGF mRNA in hypoxic-ischemic brain injury","volume":"12","author":"Liang","year":"2005","journal-title":"Chin. Pediatr. Emerg. Med."},{"key":"B44","first-page":"842","article-title":"Changes and clinical significance of serum levels of MMP-9 and MMP-2 in newborns with hypoxic-ischemic encephalopathy","volume":"27","author":"Liu","year":"2009","journal-title":"J. Clin. Pediatr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/tropej\/fmp098","article-title":"Increased umbilical cord plasma interleukin-1 beta levels was correlated with adverse outcomes of neonatal hypoxic-ischemic encephalopathy","volume":"56","author":"Liu","year":"2010","journal-title":"J. Trop. Pediatr."},{"key":"B46","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"Loscher","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"B47","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.cca.2015.08.021","article-title":"Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid","volume":"450","author":"Lv","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"B48","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/PCC.0b013e3182720642","article-title":"Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study","volume":"14","author":"Massaro","year":"2013","journal-title":"Pediatr. Crit. Care Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/dmcn.12726","article-title":"Early predictors of outcome in infants treated with hypothermia for hypoxic-ischaemic encephalopathy","volume":"57","author":"Merchant","year":"2015","journal-title":"Dev. Med. Child Neurol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3109\/02699052.2012.700083","article-title":"Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury","volume":"26","author":"Mondello","year":"2012c","journal-title":"Brain Inj."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1089\/neu.2011.2092","article-title":"Glial neuronal ratio: a novel index for differentiating injury type in patients with severe traumatic brain injury","volume":"29","author":"Mondello","year":"2012a","journal-title":"J. Neurotrauma"},{"key":"B52","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1227\/NEU.0b013e318236a809","article-title":"Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury","volume":"70","author":"Mondello","year":"2012b","journal-title":"Neurosurgery"},{"key":"B53","doi-asserted-by":"publisher","first-page":"R156","DOI":"10.1186\/cc10286","article-title":"Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study","volume":"15","author":"Mondello","year":"2011","journal-title":"Crit. Care"},{"key":"B54","doi-asserted-by":"crossref","DOI":"10.1201\/b18126-25","article-title":"CNS trauma biomarkers and surrogate endpoints pipeline from bench to bedside: a translational perspective","volume-title":"Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects","author":"Mouhieddine","year":"2015"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/sj.jcbfm.9600423","article-title":"Activin is a neuronal survival factor that is rapidly increased after transient cerebral ischemia and hypoxia in mice","volume":"27","author":"Mukerji","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B56","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1203\/00006450-200104000-00011","article-title":"Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia","volume":"49","author":"Nagdyman","year":"2001","journal-title":"Pediatr. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1203\/01.PDR.0000056802.22454.AB","article-title":"Neonatal cytokines and cerebral palsy in very preterm infants","volume":"53","author":"Nelson","year":"2003","journal-title":"Pediatr. Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/HTR.0b013e3181e52c2a","article-title":"Diffusion tensor imaging of mild traumatic brain injury","volume":"25","author":"Niogi","year":"2010","journal-title":"J. Head Trauma Rehabil."},{"key":"B59","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.pediatrneurol.2008.07.004","article-title":"Tau and s-100B proteins as biochemical markers of bilirubin-induced neurotoxicity in term neonates","volume":"39","author":"Okumus","year":"2008","journal-title":"Pediatr. Neurol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1111\/j.1471-4159.2007.05086.x","article-title":"Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry","volume":"104","author":"Ottens","year":"2008","journal-title":"J. Neurochem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1517\/17530059.2.8.937","article-title":"Use of biomarkers for diagnosis and management of traumatic brain injury patients","volume":"2","author":"Papa","year":"2008","journal-title":"Expert Opin. Med. Diagn."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1089\/neu.2012.2596","article-title":"More than cell dust: microparticles isolated from cerebrospinal fluid of brain injured patients are messengers carrying mRNAs, miRNAs, and proteins","volume":"30","author":"Patz","year":"2013","journal-title":"J. Neurotrauma"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1364\/OE.20.004159","article-title":"Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals","volume":"20","author":"Petrov","year":"2012a","journal-title":"Opt. Express"},{"key":"B64","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1364\/BOE.3.000125","article-title":"Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood","volume":"3","author":"Petrov","year":"2012b","journal-title":"Biomed. Opt. Express"},{"key":"B65","doi-asserted-by":"publisher","first-page":"F257","DOI":"10.1136\/adc.2003.047985","article-title":"Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study","volume":"90","author":"Pierrat","year":"2005","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"B66","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1089\/neu.2006.003789","article-title":"Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury","volume":"24","author":"Pineda","year":"2007","journal-title":"J. Neurotrauma"},{"key":"B67","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00431-008-0711-4","article-title":"Umbilical artery blood S100beta protein: a tool for the early identification of neonatal hypoxic-ischemic encephalopathy","volume":"168","author":"Qian","year":"2009","journal-title":"Eur. J. Pediatr."},{"key":"B68","first-page":"312","article-title":"Clinical values of superoxide dismutase and malondialdehyde detection in cord blood of newborns with fetal distress","volume":"40","author":"Qin","year":"2005","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"B69","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s007010050180","article-title":"Correlation of computed tomography findings and serum brain damage markers following severe head injury","volume":"140","author":"Raabe","year":"1998","journal-title":"Acta Neurochir. (Wien)."},{"key":"B70","doi-asserted-by":"publisher","first-page":"15482","DOI":"10.1523\/JNEUROSCI.3258-14.2014","article-title":"Emerging roles of extracellular vesicles in the nervous system","volume":"34","author":"Rajendran","year":"2014","journal-title":"J. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1089\/neu.2010.1481","article-title":"Human traumatic brain injury alters plasma microRNA levels","volume":"27","author":"Redell","year":"2010","journal-title":"J. Neurotrauma"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1083\/jcb.102.6.2088","article-title":"Brain spectrin(240\/235) and brain spectrin(240\/235E): two distinct spectrin subtypes with different locations within mammalian neural cells","volume":"102","author":"Riederer","year":"1986","journal-title":"J. Cell Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1089\/neu.2004.21.1443","article-title":"A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels","volume":"21","author":"Ringger","year":"2004","journal-title":"J. Neurotrauma"},{"key":"B74","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1651-2227.2011.02480.x","article-title":"Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia","volume":"101","author":"Roka","year":"2012","journal-title":"Acta Paediatr."},{"key":"B75","doi-asserted-by":"publisher","first-page":"14143","DOI":"10.1038\/srep14143","article-title":"MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy\u2013comparison with human epileptic samples","volume":"5","author":"Roncon","year":"2015","journal-title":"Sci. Rep."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1097\/00006123-200112000-00054","article-title":"High serum S100B levels for trauma patients without head injuries","volume":"49","author":"Rothoerl","year":"2001","journal-title":"Neurosurgery"},{"key":"B77","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1089\/neu.2008.0586","article-title":"Classification of traumatic brain injury for targeted therapies","volume":"25","author":"Saatman","year":"2008","journal-title":"J. Neurotrauma"},{"key":"B78","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.neulet.2015.09.025","article-title":"Shedding of soluble platelet-derived growth factor receptor-beta from human brain pericytes","volume":"607","author":"Sagare","year":"2015","journal-title":"Neurosci. Lett."},{"key":"B79","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/NEN.0000000000000056","article-title":"Correlation between clinical and histologic findings in the human neonatal hippocampus after perinatal asphyxia","volume":"73","author":"Schiering","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF03256432","article-title":"A literature review of the feasibility of glial fibrillary acidic protein as a biomarker for stroke and traumatic brain injury","volume":"16","author":"Schiff","year":"2012","journal-title":"Mol. Diagn. Ther."},{"key":"B81","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.jocn.2004.07.019","article-title":"The increase of neuron-specific enolase in cerebrospinal fluid and plasma as a marker of neuronal damage in patients with acute brain infarction","volume":"12","author":"Selakovic","year":"2005","journal-title":"J. Clin. Neurosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neuint.2007.05.007","article-title":"The functions of UCH-L1 and its relation to neurodegenerative diseases","volume":"51","author":"Setsuie","year":"2007","journal-title":"Neurochem. Int."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.3892\/etm.2014.1869","article-title":"Clinical significance of interleukin-6, tumor necrosis factor-alpha and high-sensitivity C-reactive protein in neonates with hypoxic-ischemic encephalopathy","volume":"8","author":"Shang","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/BF01406367","article-title":"Increased serum creatine kinase BB and neuron specific enolase following head injury indicates brain damage","volume":"115","author":"Skogseid","year":"1992","journal-title":"Acta Neurochir. (Wien)."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1038\/jcbfm.2009.182","article-title":"High serum levels of growth factors are associated with good outcome in intracerebral hemorrhage","volume":"29","author":"Sobrino","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B86","doi-asserted-by":"publisher","first-page":"27.e1","DOI":"10.1016\/j.ajog.2013.02.049","article-title":"Glial fibrillary acidic protein as a biomarker for periventricular white matter injury","volume":"209","author":"Stewart","year":"2013","journal-title":"Am. J. Obstet Gynecol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1089\/neu.2012.2553","article-title":"S100B is an important outcome predictor in traumatic brain injury","volume":"30","author":"Thelin","year":"2013","journal-title":"J. Neurotrauma"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"key":"B89","first-page":"92","article-title":"Determination and clinical significance of serum hs-CRF, TNF-a, MMP-9 in neonatal hypoxic ischemic encephalopathy","volume":"19","author":"Tian","year":"2012","journal-title":"China Mod. Med."},{"issue":"223","key":"B90","doi-asserted-by":"publisher","DOI":"10.11138\/fneur\/2014.29.4.223","article-title":"Neurophotonics: non-invasive optical techniques for monitoring brain functions","volume":"29","author":"Torricelli","year":"2014","journal-title":"Funct. Neurol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1741-7015-11-50","article-title":"Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update","volume":"11","author":"Unden","year":"2013","journal-title":"BMC Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1212\/01.WNL.0000120550.00643.DC","article-title":"Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury","volume":"62","author":"Vos","year":"2004","journal-title":"Neurology"},{"key":"B93","first-page":"442","article-title":"Clinical significance of serum interleukin 10 levels in neonatal hypoxic ischemic encephalopathy","volume":"18","author":"Wang","year":"2003","journal-title":"J. Appl. Clin. Pediatr."},{"key":"B94","first-page":"237","article-title":"MicroRNAs in ischemia-reperfusion injury","volume":"2","author":"Weiss","year":"2012","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"B95","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1089\/neu.2015.4149","article-title":"Ability of serum glial fibrillary acidic protein, ubiquitin C-terminal hydrolase-L1, and S100B to differentiate normal and abnormal head computed tomography findings in patients with suspected mild or moderate traumatic brain injury","volume":"33","author":"Welch","year":"2016","journal-title":"J. Neurotrauma"},{"key":"B96","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/WCO.0000000000000265","article-title":"Traumatic brain injury: recent advances in plasticity and regeneration","volume":"28","author":"Werner","year":"2015","journal-title":"Curr. Opin. Neurol."},{"key":"B97","first-page":"180","article-title":"Relationship between serum inflammatory factors and neonatal brain injury","volume":"27","author":"Wu","year":"2012","journal-title":"Chin. J. Neonatol."},{"key":"B98","first-page":"138","article-title":"Serum granulocyte colony-stimulating factor levels in gliomas","volume":"16","author":"Yildiz","year":"2011","journal-title":"J. BUON."},{"key":"B99","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/cns.12127","article-title":"Biomarkers for the clinical differential diagnosis in traumatic brain injury\u2013a systematic review","volume":"19","author":"Yokobori","year":"2013","journal-title":"CNS Neurosci. Ther."},{"key":"B100","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0002-9378(97)70432-0","article-title":"Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy","volume":"177","author":"Yoon","year":"1997","journal-title":"Am. J. Obstet Gynecol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1365-3083.2012.02710.x","article-title":"Serial examination of serum IL-8, IL-10 and IL-1Ra levels is significant in neonatal seizures induced by hypoxic-ischaemic encephalopathy","volume":"76","author":"Youn","year":"2012","journal-title":"Scand. J. Immunol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3109\/1354750X.2012.668712","article-title":"Endogenous granulocyte colony-stimulating factor: a biomarker in acute ischemic stroke","volume":"17","author":"Yu","year":"2012","journal-title":"Biomarkers"},{"key":"B103","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0006-8993(02)02920-7","article-title":"C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome","volume":"947","author":"Zemlan","year":"2002","journal-title":"Brain Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/0361-9230(95)00040-2","article-title":"The S100 protein family: history, function, and expression","volume":"37","author":"Zimmer","year":"1995","journal-title":"Brain Res. Bull."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T14:18:34Z","timestamp":1498313914000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphar.2016.00196\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,13]]},"references-count":104,"URL":"https:\/\/doi.org\/10.3389\/fphar.2016.00196","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,13]]}}}