{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:31:10Z","timestamp":1777030270005,"version":"3.51.4"},"reference-count":23,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00011","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T12:59:33Z","timestamp":1485262773000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the Pharmacokinetic Profile of Remifentanil in Mid-Trimester Gestations Undergoing Fetal Intervention Procedures"],"prefix":"10.3389","volume":"8","author":[{"given":"Judith A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopali V.","family":"Donepudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro S.","family":"Argoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita L.","family":"Giezentanner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranu","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Boring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Moise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0009-8981(81)90382-X","article-title":"Plasma \u03b11-acid glycoprotein levels in pregnancy","volume":"112","author":"Chu","year":"1981","journal-title":"Clin. Chim. Acta"},{"key":"B2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.bbi.2006.08.006","article-title":"Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy","volume":"21","author":"Coussons-Read","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0010-468X(79)90025-4","article-title":"A program package for simulation and parameter estimation in pharmacokinetic systems","volume":"9","author":"D'argenio","year":"1979","journal-title":"Comput. Progr. Biomed."},{"key":"B4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.siny.2009.10.002","article-title":"Fetal surgery is a clinical reality","volume":"15","author":"Deprest","year":"2010","journal-title":"Semin. Fetal. Neonatal. Med."},{"key":"B5","first-page":"619","article-title":"Initial clinical experience with remifentanil, a new opioid metabolized by esterases","volume":"81","author":"Dershwitz","year":"1995","journal-title":"Anesth. Analg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1471-0528.1981.tb00929.x","article-title":"Serial changes in renal haemodynamics during normal human pregnancy","volume":"88","author":"Dunlop","year":"1981","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2165\/00003088-199529020-00003","article-title":"Remifentanil pharmacokinetics and pharmacodynamics. A preliminary appraisal","volume":"29","author":"Egan","year":"1995","journal-title":"Clin. Pharmacokinet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1399-6576.2007.01566.x","article-title":"Remifentanil and the brain","volume":"52","author":"Fodale","year":"2008","journal-title":"Acta Anaesthesiol. Scand."},{"key":"B9","volume":"Vol. 2015","author":"Guidance for Industry: Bioanalytical Method Assay Validation","year":"2001","journal-title":"Guidance for Industry: Bioanalytical Method Assay Validation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1399-6576.2012.02723.x","article-title":"Maternal and foetal effects of remifentanil for general anaesthesia in parturients undergoing caesarean section: a systematic review and meta-analysis","volume":"57","author":"Heesen","year":"2013","journal-title":"Acta Anaesthesiol. Scand."},{"key":"B11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1471-0528.1963.tb04922.x","article-title":"Increase in plasma volume during normal pregnancy","volume":"70","author":"Hytten","year":"1963","journal-title":"J. Obstet. Gynaecol. Br. Emp."},{"key":"B12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/ANA.0b013e3182368d70","article-title":"Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats","volume":"24","author":"Jeong","year":"2012","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1097\/00000542-199806000-00008","article-title":"Intravenous remifentanil: placental transfer, maternal and neonatal effects","volume":"88","author":"Kan","year":"1998","journal-title":"Anesthesiology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1213\/ane.0b013e318167ad77","article-title":"An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function","volume":"106","author":"Loepke","year":"2008","journal-title":"Anesth. Analg."},{"key":"B15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/00000542-199701000-00004","article-title":"Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development","volume":"86","author":"Minto","year":"1997","journal-title":"Anesthesiology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/00000542-200601000-00004","article-title":"Maternal and neonatal effects of remifentanil at induction of general anesthesia for cesarean delivery: a randomized, double-blind, controlled trial","volume":"104","author":"Ngan Kee","year":"2006","journal-title":"Anesthesiology"},{"key":"B17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/B978-0-12-386007-1.00002-7","article-title":"Physiological changes during pregnancy","volume-title":"Clincial Pharmacology During Pregnancy","author":"Pacheco","year":"2013"},{"key":"B18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ijoa.2012.01.005","article-title":"Maternal anesthesia and fetal neurodevelopment","volume":"21","author":"Palanisamy","year":"2012","journal-title":"Int. J. Obstet. Anesth."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.2165\/00023210-200519120-00010","article-title":"Spotlight on remifentanil for general anaesthesia","volume":"19","author":"Scott","year":"2005","journal-title":"CNS Drugs"},{"key":"B20","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1213\/01.ane.0000156566.62182.ab","article-title":"Remifentanil for fetal immobilization and maternal sedation during fetoscopic surgery: a randomized, double-blind comparison with diazepam","volume":"101","author":"Van de Velde","year":"2005","journal-title":"Anesth. Analg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/ALN.0b013e318204e043","article-title":"Remifentanil degradation in umbilical cord blood of preterm infants","volume":"114","author":"Welzing","year":"2011","journal-title":"Anesthesiology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1097\/00000542-199311000-00005","article-title":"Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery","volume":"79","author":"Westmoreland","year":"1993","journal-title":"Anesthesiology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/clpt.1981.73","article-title":"Changes in plasma drug binding and \u03b11-acid glycoprotein in mother and newborn infant","volume":"29","author":"Wood","year":"1981","journal-title":"Clin. Pharmacol. Ther."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00011\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T08:56:46Z","timestamp":1498381006000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00011\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":23,"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00011","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]}}}