{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:34:01Z","timestamp":1776854041710,"version":"3.51.2"},"reference-count":36,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30500093"],"award-info":[{"award-number":["30500093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81274162"],"award-info":[{"award-number":["81274162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360292"],"award-info":[{"award-number":["81360292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81120108015"],"award-info":[{"award-number":["81120108015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00246","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T13:33:15Z","timestamp":1493991195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Hydrostatin-SN1, a Sea Snake-Derived Bioactive Peptide, Reduces Inflammation in a Mouse Model of Acute Lung Injury"],"prefix":"10.3389","volume":"8","author":[{"given":"Guosheng","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S195","DOI":"10.1097\/01.CCM.0000057843.47705.E8","article-title":"Neutrophils and acute lung injury.","author":"Abraham","year":"2003","journal-title":"Crit. Care Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"F421","DOI":"10.1152\/ajprenal.00559.2010","article-title":"Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury.","volume":"302","author":"Altmann","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/path.1491","article-title":"Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome.","volume":"202","author":"Bhatia","year":"2004","journal-title":"J. Pathol."},{"key":"B4","first-page":"BR141","article-title":"Ghrelin attenuates lipopolysaccharide-induced acute lung injury through NO pathway.","volume":"14","author":"Chen","year":"2008","journal-title":"Med. Sci. Monit."},{"key":"B5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1600-079X.2010.00829.x","article-title":"Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-kappaB and STAT1 activity.","volume":"50","author":"Choi","year":"2011","journal-title":"J. Pineal Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S1359-6101(03)00059-5","article-title":"Cytokine-mediated inflammation in acute lung injury.","volume":"14","author":"Goodman","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1165\/ajrcmb.15.5.8918372","article-title":"Intra-alveolar macrophage-inflammatory peptide 2 induces rapid neutrophil localization in the lung.","volume":"15","author":"Gupta","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0782-3","article-title":"Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury.","volume":"19","author":"Hirano","year":"2015","journal-title":"Crit. Care"},{"key":"B9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10753-013-9734-8","article-title":"Cepharanthine, an alkaloid from Stephania cephalantha Hayata, inhibits the inflammatory response in the RAW264.7 cell and mouse models.","volume":"37","author":"Huang","year":"2014","journal-title":"Inflammation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1164\/ajrccm\/144.2.268","article-title":"Tumor necrosis factor levels in serum and bronchoalveolar lavage fluid of patients with the adult respiratory distress syndrome.","volume":"144","author":"Hyers","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/00024382-200210000-00008","article-title":"Kinetics of mitogen-activated protein kinase family in lipopolysaccharide-stimulated mouse Kupffer cells and their role in cytokine production.","volume":"18","author":"Jiang","year":"2002","journal-title":"Shock"},{"key":"B12","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1164\/ajrccm.163.3.2003065","article-title":"Fas\/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.","author":"Kitamura","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01902148.2016.1267823","article-title":"Low concentration of oleic acid exacerbates LPS-induced cell death and inflammation in human alveolar epithelial cells.","volume":"43","author":"Kucukgul","year":"2017","journal-title":"Exp. Lung Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3109\/01902149109063278","article-title":"Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung.","volume":"17","author":"Kunkel","year":"1991","journal-title":"Exp. Lung Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1146\/annurev.pa.35.040195.003255","article-title":"Macrophages and inflammatory mediators in tissue injury.","volume":"35","author":"Laskin","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-125","article-title":"Role of TNFalpha in pulmonary pathophysiology.","volume":"7","author":"Mukhopadhyay","year":"2006","journal-title":"Respir. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1164\/rccm.200511-1737OC","article-title":"Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury.","volume":"173","author":"Nonas","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1055\/s-0030-1253452","article-title":"New developments in lung endothelial heterogeneity: Von Willebrand factor, P-selectin, and the Weibel-Palade body.","volume":"36","author":"Ochoa","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1164\/ajrccm.164.10.2104013","article-title":"Cytokine balance in the lungs of patients with acute respiratory distress syndrome.","author":"Park","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1164\/rccm.200309-1258OC","article-title":"Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.","volume":"169","author":"Peng","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-014-0159-1","article-title":"17beta-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K\/Akt\/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro.","volume":"15","author":"Qi","year":"2014","journal-title":"Respir. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.intimp.2012.08.002","article-title":"The therapeutic efficacy of Ulinastatin for rats with smoking inhalation injury.","volume":"14","author":"Qiu","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"B23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1189\/jlb.69.1.3","article-title":"MAP kinase activation in macrophages.","volume":"69","author":"Rao","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.bcp.2009.03.012","article-title":"Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury.","volume":"77","author":"Schuh","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jss.2015.05.019","article-title":"The effects of porcine pulmonary surfactant on smoke inhalation injury.","volume":"198","author":"Sun","year":"2015","journal-title":"J. Surg. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1164\/ajrccm\/145.5.1016","article-title":"High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.","volume":"145","author":"Suter","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-33","article-title":"Macrophage CD74 contributes to MIF-induced pulmonary inflammation.","volume":"10","author":"Takahashi","year":"2009","journal-title":"Respir. Res."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111940","article-title":"Hydrostatin-TL1, an anti-inflammatory active peptide from the venom gland of Hydrophis cyanocinctus in the South China Sea.","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome.","volume":"342","author":"Ware","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"L743","DOI":"10.1152\/ajplung.00181.2001","article-title":"Effect of surfactant on pulmonary expression of type IIA PLA(2) in an animal model of acute lung injury.","volume":"282","author":"Wu","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1600-079X.2012.01002.x","article-title":"Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.","volume":"53","author":"Xia","year":"2012","journal-title":"J. Pineal Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/labinvest.2016.31","article-title":"ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells.","volume":"96","author":"Xie","year":"2016","journal-title":"Lab. Invest."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113107","article-title":"The protective effect of Esculentoside A on experimental acute liver injury in mice.","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS ONE"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0472-y","article-title":"Pulmonary endothelial activation caused by extracellular histones contributes to neutrophil activation in acute respiratory distress syndrome.","volume":"17","author":"Zhang","year":"2016","journal-title":"Respir. Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/srep25672","article-title":"Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis.","volume":"6","author":"Zheng","year":"2016","journal-title":"Sci. Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.jss.2013.05.018","article-title":"Protective effect of esculentoside A on lipopolysaccharide-induced acute lung injury in mice.","volume":"185","author":"Zhong","year":"2013","journal-title":"J. Surg. Res."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00246\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T12:31:55Z","timestamp":1692793915000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00246\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,5]]},"references-count":36,"alternative-id":["10.3389\/fphar.2017.00246"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00246","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,5]]},"article-number":"246"}}