{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:05:23Z","timestamp":1791939923868,"version":"4.3.4"},"reference-count":89,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00462","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T23:44:20Z","timestamp":1500421460000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":57,"title":["S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms"],"prefix":"10.3389","volume":"8","author":[{"given":"Indira","family":"Mendez-David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Guilloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Tritschler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Mocaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain M.","family":"Gardier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Bretin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis J.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.biopsych.2007.09.019","article-title":"Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy.","volume":"63","author":"Adachi","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.1144400","article-title":"High-speed imaging reveals neurophysiological links to behavior in an animal model of depression.","volume":"317","author":"Airan","year":"2007","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00213-013-3153-2","article-title":"Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR.","volume":"230","author":"Akinfiresoye","year":"2013","journal-title":"Psychopharmacology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.bcp.2005.12.022","article-title":"A role for AMPA receptors in mood disorders.","volume":"71","author":"Alt","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.brainres.2015.01.001","article-title":"Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action.","volume":"1601","author":"Andreasen","year":"2015","journal-title":"Brain Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.neulet.2013.04.045","article-title":"Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests.","volume":"546","author":"Andreasen","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0028-3908(03)00104-7","article-title":"Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus.","volume":"44","author":"Bai","year":"2003","journal-title":"Neuropharmacology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1038\/sj.npp.1301312","article-title":"Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.","volume":"32","author":"Beneyto","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.biopsych.2006.08.048","article-title":"Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects.","volume":"61","author":"Bhagwagar","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s00213-004-2065-6","article-title":"Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data.","volume":"179","author":"Black","year":"2005","journal-title":"Psychopharmacology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.nbd.2016.07.010","article-title":"Brain-derived neurotrophic factor in mood disorders and antidepressant treatments.","author":"Castren","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1523\/JNEUROSCI.4372-06.2007","article-title":"The prefrontal cortex as a key target of the maladaptive response to stress.","volume":"27","author":"Cerqueira","year":"2007","journal-title":"J. Neurosci."},{"key":"B14","article-title":"\u201cElectrophysiological characterization of S 47445 a novel positive allosteric modulator of AMPA type glutamate receptors,\u201d in","author":"Danober","year":"2016","journal-title":"Proceedings of the 2016 Neuroscience Meeting Planner"},{"key":"B15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.neulet.2016.01.055","article-title":"Chronic 5-HT receptor agonist treatment restores learning and memory deficits in a neuroendocrine mouse model of anxiety\/depression.","volume":"616","author":"Darcet","year":"2016","journal-title":"Neurosci. Lett."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00136","article-title":"Learning and memory impairments in a neuroendocrine mouse model of anxiety\/depression.","volume":"8","author":"Darcet","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression.","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"B18","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1016\/S0013-7006(16)30015-X","article-title":"Pharmacological properties of vortioxetine and its pre-clinical consequences.","author":"David","year":"2016","journal-title":"Encephale"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6503162","article-title":"Coping with the forced swim stressor: towards understanding an adaptive mechanism.","volume":"2016","author":"de Kloet","year":"2016","journal-title":"Neural Plast."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000369974","article-title":"Molecular and genetic characterization of depression: overlap with other psychiatric disorders and aging.","volume":"1","author":"Ding","year":"2015","journal-title":"Mol. Neuropsychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.physbeh.2004.01.013","article-title":"Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice.","volume":"81","author":"Ducottet","year":"2004","journal-title":"Physiol. Behav."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1017\/S1461145709991076","article-title":"Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.","volume":"13","author":"Farley","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012769","article-title":"Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice.","volume":"5","author":"Fuss","year":"2010","journal-title":"PLoS ONE"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.06.009","article-title":"The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice.","author":"Giralt","year":"2017","journal-title":"Neuropharmacology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/npp.2008.123","article-title":"A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2\/3 and BDNF.","volume":"34","author":"Gourley","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.neuropharm.2011.02.009","article-title":"Characterization of 5-HT(1A\/1B)-\/- mice: an animal model sensitive to anxiolytic treatments.","volume":"61","author":"Guilloux","year":"","journal-title":"Neuropharmacology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.neuropharm.2013.05.014","article-title":"Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice.","volume":"73","author":"Guilloux","year":"2013","journal-title":"Neuropharmacology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jneumeth.2011.01.019","article-title":"Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex.","volume":"197","author":"Guilloux","year":"","journal-title":"J. Neurosci. Methods"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.biopsych.2007.03.017","article-title":"Increased levels of glutamate in brains from patients with mood disorders.","volume":"62","author":"Hashimoto","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1038\/npp.2015.85","article-title":"Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors.","volume":"40","author":"Hill","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1177\/2040622315579059","article-title":"Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.","volume":"6","author":"Iadarola","year":"2015","journal-title":"Ther. Adv. Chronic Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.neuropharm.2009.01.015","article-title":"BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices.","volume":"56","author":"Jourdi","year":"2009","journal-title":"Neuropharmacology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0014-2999(02)01338-9","article-title":"Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model.","volume":"440","author":"Knapp","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression.","volume":"224","author":"Koike","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1523\/JNEUROSCI.20-01-00008.2000","article-title":"Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.","volume":"20","author":"Lauterborn","year":"2000","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1523\/JNEUROSCI.3157-15.2016","article-title":"Chronic ampakine treatments stimulate dendritic growth and promote learning in middle-aged rats.","volume":"36","author":"Lauterborn","year":"2016","journal-title":"J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1124\/jpet.103.053694","article-title":"Chronic elevation of brain-derived neurotrophic factor by ampakines.","volume":"307","author":"Lauterborn","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.neuroscience.2014.05.050","article-title":"NREM sleep hypersomnia and reduced sleep\/wake continuity in a neuroendocrine mouse model of anxiety\/depression based on chronic corticosterone administration.","volume":"274","author":"Le Dantec","year":"2014","journal-title":"Neuroscience"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0028-3908(01)00006-5","article-title":"Regulation of BDNF expression in primary neuron culture by LY392098 a novel AMPA receptor potentiator.","volume":"40","author":"Legutko","year":"2001","journal-title":"Neuropharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","article-title":"Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure.","volume":"69","author":"Li","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/S0028-3908(00)00194-5","article-title":"Antidepressant-like actions of an AMPA receptor potentiator (LY392098).","volume":"40","author":"Li","year":"2001","journal-title":"Neuropharmacology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1023\/A:1023648923447","article-title":"Enhancement of antidepressant potency by a potentiator of AMPA receptors.","volume":"23","author":"Li","year":"2003","journal-title":"Cell Mol. Neurobiol."},{"key":"B43","article-title":"\u201cIn vivo pharmacological profile of S 47445 a novel positive allosteric modulator of ampa-type glutamate receptors,\u201d in","author":"Louis","year":"2015","journal-title":"Proceedings of the 12th International Conference on Alzheimer\u2019s & Parkinson\u2019s Diseases (ADPD)"},{"key":"B44","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.neubiorev.2011.05.014","article-title":"Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of (1)H-MRS findings.","volume":"36","author":"Luykx","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.coph.2005.09.005","article-title":"Glutamate-based therapeutic approaches: ampakines.","volume":"6","author":"Lynch","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.tins.2006.07.007","article-title":"Ampakines and the threefold path to cognitive enhancement.","volume":"29","author":"Lynch","year":"2006","journal-title":"Trends Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0028-3908(02)00066-7","article-title":"An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study.","volume":"43","author":"Mackowiak","year":"2002","journal-title":"Neuropharmacology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/S0006-3223(03)00700-5","article-title":"Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis.","volume":"54","author":"Madsen","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B50","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.","volume":"20","author":"Malberg","year":"2000","journal-title":"J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1037\/pha0000112","article-title":"Chronic corticosterone administration effects on behavioral emotionality in female c57bl6 mice.","volume":"25","author":"Mekiri","year":"2017","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/npp.2013.332","article-title":"Rapid anxiolytic effects of a 5-HT(4) receptor agonist are mediated by a neurogenesis-independent mechanism.","volume":"39","author":"Mendez-David","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00124","article-title":"A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: beta-arrestin 1 protein levels in depression and treatment.","volume":"4","author":"Mendez-David","year":"2013","journal-title":"Front. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.conb.2014.08.012","article-title":"The current state of the neurogenic theory of depression and anxiety.","volume":"30","author":"Miller","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"10827","DOI":"10.1073\/pnas.0402141101","article-title":"Essential role of brain-derived neurotrophic factor in adult hippocampal function.","volume":"101","author":"Monteggia","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B56","first-page":"571","article-title":"Recent advances in positive allosteric modulators of the AMPA receptor.","volume":"9","author":"Morrow","year":"2006","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1176\/appi.ajp.2013.13030392","article-title":"Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.","volume":"170","author":"Murrough","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1177\/0269881112458728","article-title":"Examination of Org 26576 an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial.","volume":"26","author":"Nations","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders.","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B60","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","article-title":"Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments.","volume":"15","author":"Nibuya","year":"1995","journal-title":"J. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00702-013-1130-x","article-title":"Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder.","volume":"121","author":"Niciu","year":"2014","journal-title":"J. Neural Transm."},{"key":"B62","doi-asserted-by":"publisher","first-page":"181","DOI":"10.2174\/1568007043337508","article-title":"AMPA receptor potentiators for the treatment of CNS disorders.","volume":"3","author":"O\u2019Neill","year":"2004","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"B63","first-page":"185","article-title":"AMPA receptor potentiators as cognitive enhancers.","volume":"10","author":"O\u2019Neill","year":"2007","journal-title":"IDrugs"},{"key":"B64","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity.","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1517\/13543776.2013.770840","article-title":"AMPA receptor positive allosteric modulators: a patent review.","volume":"23","author":"Pirotte","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"B66","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments.","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.brainresbull.2011.03.002","article-title":"Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression.","volume":"85","author":"Quan","year":"2011","journal-title":"Brain Res. Bull."},{"key":"B68","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1017\/S1461145711000356","article-title":"Beneficial behavioural and neurogenic effects of agomelatine in a model of depression\/anxiety.","volume":"15","author":"Rainer","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1152\/jn.00336.2006","article-title":"Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor.","volume":"96","author":"Rex","year":"2006","journal-title":"J. Neurophysiol."},{"key":"B70","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1523\/JNEUROSCI.23-01-00349.2003","article-title":"Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.","volume":"23","author":"Saarelainen","year":"2003","journal-title":"J. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-61779-313-4_7","article-title":"\u201cNovelty-Suppressed Feeding in the Mouse,\u201d in","author":"Samuels","year":"2011","journal-title":"Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests"},{"key":"B73","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1001\/archpsyc.61.7.705","article-title":"Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.","volume":"61","author":"Sanacora","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"B74","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"B75","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1097\/WNR.0b013e3283293e59","article-title":"Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response.","volume":"20","author":"Schloesser","year":"2009","journal-title":"Neuroreport"},{"key":"B76","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/35066584","article-title":"Neurogenesis in the adult is involved in the formation of trace memories.","volume":"410","author":"Shors","year":"2001","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice.","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00213-009-1598-0","article-title":"Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus.","volume":"206","author":"Su","year":"2009","journal-title":"Psychopharmacology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.neuroscience.2008.04.073","article-title":"What is the mammalian dentate gyrus good for?","volume":"154","author":"Treves","year":"2008","journal-title":"Neuroscience"},{"key":"B80","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.biopsych.2013.09.024","article-title":"Dysfunctional glutamatergic and gamma-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression.","volume":"76","author":"Veeraiah","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1523\/JNEUROSCI.3632-07.2008","article-title":"Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells.","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1476-5381.2010.00726.x","article-title":"Challenges for and current status of research into positive modulators of AMPA receptors.","volume":"160","author":"Ward","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ynstr.2016.08.002","article-title":"The chronic mild stress (CMS) model of depression: history, evaluation and usage.","volume":"6","author":"Willner","year":"2017","journal-title":"Neurobiol. Stress"},{"key":"B84","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00213-008-1325-2","article-title":"Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-213-benzoxadiazole (CX691), in the rat.","volume":"202","author":"Woolley","year":"2009","journal-title":"Psychopharmacology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neulet.2012.05.046","article-title":"Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT1A and 5-HT1B receptors disruption in mice.","volume":"521","author":"Xia","year":"2012","journal-title":"Neurosci. Lett"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.112","article-title":"A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques.","volume":"4","author":"Yamanaka","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"B87","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites.","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"B89","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.eurpsy.2013.10.005","article-title":"Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex.","volume":"29","author":"Zhou","year":"2014","journal-title":"Eur. Psychiatry"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00462\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T17:17:31Z","timestamp":1569863851000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00462\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,19]]},"references-count":89,"alternative-id":["10.3389\/fphar.2017.00462"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00462","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,19]]},"article-number":"462"}}