{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:49:02Z","timestamp":1790696942617,"version":"4.1.0"},"reference-count":95,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370154"],"award-info":[{"award-number":["81370154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81622004"],"award-info":[{"award-number":["81622004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670395"],"award-info":[{"award-number":["81670395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00608","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T04:16:50Z","timestamp":1504671410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":161,"title":["H2S-Induced Sulfhydration: Biological Function and Detection Methodology"],"prefix":"10.3389","volume":"8","author":[{"given":"Da","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoshu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005478","article-title":"The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide.","volume":"7","author":"Altaany","year":"2014","journal-title":"Sci. Signal."},{"key":"B2","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1152\/ajpregu.90524.2008","article-title":"Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis.","volume":"3","author":"Andruski","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"55117","DOI":"10.1074\/jbc.M404524200","article-title":"Involvement of poly(ADP-ribose) polymerase-1 and XRCC1\/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.","volume":"279","author":"Audebert","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.niox.2014.04.008","article-title":"AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], a mitochondrially targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.","volume":"41","author":"Bartosz","year":"2014","journal-title":"Nitric Oxide"},{"key":"B5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ccr.2016.07.002","article-title":"The metal face of protein tyrosine phosphatase 1B.","volume":"32","author":"Bellomo","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1021\/cr60311a003","article-title":"Thermochemistry and kinetics of sulfur-containing molecules and radicals.","volume":"78","author":"Benson","year":"1978","journal-title":"Chem. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1096\/fj.04-3023fje","article-title":"Role of hydrogen sulfide in acute pancreatitis and associated lung injury.","volume":"6","author":"Bhatia","year":"2005","journal-title":"FASEB J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.bbalip.2016.03.001","article-title":"Cystathionine \u03b3 lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor \u03b3 activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes.","volume":"1861","author":"Cai","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1172\/JCI73780","article-title":"S-nitrosoglutathione reductase-dependent PPAR\u03b3 denitrosylation participates in MSC-derived adipogenesis and osteogenesis.","volume":"125","author":"Cao","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B11","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.cyto.2010.12.006","article-title":"Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung.","volume":"3","author":"Chen","year":"2011","journal-title":"Cytokine"},{"key":"B12","doi-asserted-by":"publisher","first-page":"35265","DOI":"10.1074\/jbc.M805287200","article-title":"Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation.","volume":"283","author":"Chen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"H2316","DOI":"10.1152\/ajpheart.00331.2004","article-title":"Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats.","volume":"287","author":"Cheng","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1126\/science.1093891","article-title":"S-Nitrosylation of parkin regulates ubiquitination and compromises parkin\u2019s protective function.","volume":"304","author":"Chung","year":"2004","journal-title":"Science"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/cdd.2009.137","article-title":"Novel roles for GAPDH in cell death and carcinogenesis.","volume":"12","author":"Colell","year":"2009","journal-title":"Cell Death Differ."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500968","article-title":"A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems.","volume":"2","author":"D\u00f3ka","year":"2016","journal-title":"Sci. Adv."},{"key":"B17","doi-asserted-by":"publisher","first-page":"9741","DOI":"10.1074\/jbc.M113.517995","article-title":"Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor \u03baB (NF-\u03baB) pathway.","volume":"289","author":"Du","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1111\/j.1476-5381.2010.00640.x","article-title":"Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat.","volume":"7","author":"Ekundi-Valentim","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/sj.bjp.0707193","article-title":"Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.","volume":"8","author":"Fiorucci","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1007\/s00018-014-1662-8","article-title":"Tyrosine nitration as mediator of cell death.","volume":"71","author":"Franco","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160521","article-title":"Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis.","volume":"11","author":"Gaddam","year":"2016","journal-title":"PLOS ONE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1124\/mol.112.081596","article-title":"Hydrogen sulfide as an allosteric modulator of ATP-sensitive potassium channels in colonic inflammation.","volume":"83","author":"Gade","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.phrs.2014.06.014","article-title":"Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism.","volume":"87","author":"Gambari","year":"2014","journal-title":"Pharmacol. Res."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10067","article-title":"Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.","volume":"4","author":"Gao","year":"2015","journal-title":"Elife"},{"key":"B25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ejphar.2014.01.009","article-title":"Hydrogen sulfide protected gastric epithelial cell from ischemia\/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-\u03baB dependent anti-inflammation pathway.","volume":"725","author":"Guo","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1089\/ars.2010.3821","article-title":"Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice.","volume":"15","author":"Han","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"B27","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/ncb1268","article-title":"S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.","volume":"7","author":"Hara","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1089\/ars.2012.4944","article-title":"The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.","volume":"19","author":"Hourihan","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2807490","article-title":"Hydrogen sulfide inhibits High-salt diet-induced renal oxidative stress and kidney injury in Dahl rats.","volume":"2016","author":"Huang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/35055104","article-title":"Protein S-nitrosylation: a physiological signal for neuronal nitric oxide.","volume":"3","author":"Jaffrey","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.freeradbiomed.2015.09.007","article-title":"Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is inactivated by S-sulfuration in vitro.","volume":"89","author":"Jarosz","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/ars.2009.2894","article-title":"Molecular mechanism for H2S-induced activation of KATP channels.","volume":"12","author":"Jiang","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"B34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis.","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.bbagen.2015.08.003","article-title":"H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells.","volume":"1850","author":"Ju","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B36","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S biogenesis, decay and signaling.","volume":"20","author":"Kabil","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"B37","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1152\/ajpgi.00281.2014","article-title":"Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.","volume":"308","author":"Kang","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1089\/ars.2014.6082","article-title":"Signaling molecules: hydrogen sulfide and polysulfide.","volume":"22","author":"Kimura","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002329","article-title":"H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.","volume":"203","author":"Krishnan","year":"2011","journal-title":"Sci. Signal."},{"key":"B40","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1089\/ars.2014.6186","article-title":"Hydrogen sulfide maintains mitochondrial DNA replication via demethylation of TFAM.","volume":"23","author":"Li","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089856","article-title":"Hydrogen sulfide inhibits formaldehyde-induced endoplasmic reticulum stress in PC12 cells by upregulation of SIRT-1.","volume":"9","author":"Li","year":"2014","journal-title":"PLOS ONE"},{"key":"B42","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1111\/cns.12585","article-title":"Hydrogen sulfide promotes surface insertion of hippocampal AMPA receptor GluR1 subunit via phosphorylating at Serine-831\/Serine-845 sites through a sulfhydration-dependent mechanism.","volume":"22","author":"Li","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.stem.2014.03.005","article-title":"Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca2+ channel sulfhydration.","volume":"15","author":"Liu","year":"2014","journal-title":"Cell Stem Cell"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/srep29808","article-title":"Quantitative persulfide site identification (qPerS-SID) reveals protein targets of H2S releasing donors in Mammalian cells.","volume":"6","author":"Longen","year":"2016","journal-title":"Sci. Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ymeth.2013.05.020","article-title":"S-sulfhydration\/desulfhydration and S-nitrosylation\/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO.","volume":"62","author":"Lu","year":"2013","journal-title":"Methods"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002125","article-title":"Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia.","volume":"4","author":"Marutani","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004160","article-title":"Hydrogen sulfide regulates kr\u00fcppel-like factor 5 transcription activity via specificity protein 1 S-sulfhydration at Cys664 to prevent myocardial hypertrophy.","volume":"9","author":"Meng","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"B48","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.phrs.2016.08.023","article-title":"S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics.","volume":"113","author":"M\u00f3dis","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration.","volume":"96","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels.","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1089\/ars.2012.4973","article-title":"Kinetics and mechanisms of thiol-disulfide exchange covering direct substitution and thiol oxidation-mediated pathways.","volume":"18","author":"Nagy","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B52","doi-asserted-by":"publisher","first-page":"H1437","DOI":"10.1152\/ajpheart.00465.2016","article-title":"Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels.","volume":"311","author":"Naik","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/j.1440-1681.2011.05599.x","article-title":"GAPDH: a common enzyme with uncommon functions.","volume":"8","author":"Nicholls","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bbrc.2014.11.066","article-title":"Endogenous S-sulfhydration of PTEN helps protect against modification by nitric oxide.","volume":"456","author":"Ohno","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1021\/cb4001052","article-title":"Persulfide reactivity in the detection of protein s-sulfhydration.","volume":"8","author":"Pan","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/bs.mie.2014.11.033","article-title":"Use of the \u201ctag-switch\u201d method for the detection of protein S-sulfhydration.","volume":"555","author":"Park","year":"2015","journal-title":"Methods Enzymol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H2S signalling through protein sulfhydration and beyond.","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1096\/fj.15-278648","article-title":"Cystathionine \u03b2-synthase regulates endothelial function via protein S-sulfhydration.","volume":"30","author":"Saha","year":"2016","journal-title":"FASEB J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0014-5793(98)00123-9","article-title":"Involvement of protein-tyrosine phosphorylation and dephosphorylation in sperm-induced Xenopus egg activation.","volume":"424","author":"Sato","year":"1998","journal-title":"FEBS Lett."},{"key":"B60","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions.","volume":"45","author":"Sen","year":"2012","journal-title":"Mol. Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1007\/s00595-014-1064-4","article-title":"Hydrogen sulfide augments survival signals in warm ischemia and reperfusion of the mouse liver.","volume":"45","author":"Shimada","year":"2015","journal-title":"Surg. Today"},{"key":"B62","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/nm738","article-title":"Kr\u00fcppel-like zinc-finger transcription factor KLF5\/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.","volume":"8","author":"Shindo","year":"2002","journal-title":"Nat. Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1902\/jop.2015.150240","article-title":"Physiologic levels of endogenous hydrogen sulfide maintain the proliferation and differentiation capacity of periodontal ligament stem cells.","volume":"86","author":"Su","year":"2015","journal-title":"J. Periodontol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/cvr\/cvw037","article-title":"Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation.","volume":"110","author":"Sun","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"31888","DOI":"10.18632\/oncotarget.16649","article-title":"Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide.","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"key":"B66","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/ja.2016.99","article-title":"Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.","volume":"70","author":"Uesugi","year":"2017","journal-title":"J. Antibiot."},{"key":"B67","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.niox.2016.06.005","article-title":"Stimulatory effect of CSE-generated H2S on hepatic mitochondrial biogenesis and the underlying mechanisms.","volume":"58","author":"Untereiner","year":"","journal-title":"Nitric Oxide"},{"key":"B68","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bcp.2017.03.025","article-title":"H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells.","volume":"136","author":"Untereiner","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1089\/ars.2015.6369","article-title":"Decreased gluconeogenesis in the absence of cystathionine gamma-lyase and the underlying mechanisms.","volume":"24","author":"Untereiner","year":"","journal-title":"Antioxid. Redox Signal."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2623","article-title":"Sulfhydration mediates neuroprotective actions of parkin.","volume":"4","author":"Vandiver","year":"2013","journal-title":"Nat. Commun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1089\/ars.2011.4351","article-title":"Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury.","volume":"17","author":"Wallace","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"B72","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1053\/j.gastro.2009.04.012","article-title":"Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.","volume":"137","author":"Wallace","year":"2009","journal-title":"Gastroenterology"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6875","article-title":"Age-dependent allergic asthma development and cystathionine gamma-lyase deficiency.","author":"Wang","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"B74","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/ATVBAHA.108.179333","article-title":"Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.","volume":"29","author":"Wang","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neuroscience.2012.12.057","article-title":"L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS\/H2S pathway.","volume":"237","author":"Wang","year":"2013","journal-title":"Neuroscience"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/srep44769","article-title":"Protection against oxidative stress mediated by the Nrf2\/Keap1 axis is impaired in primary biliary cholangitis.","volume":"7","author":"Wasik","year":"2017","journal-title":"Sci. Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.1039\/c5sc04818d","article-title":"Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.","volume":"7","author":"Wedmann","year":"2016","journal-title":"Chem. Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/aps.2013.197","article-title":"Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway.","volume":"35","author":"Wei","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"B79","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1586\/ecp.10.134","article-title":"Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising.","volume":"4","author":"Whiteman","year":"2011","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation.","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B81","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1152\/ajpcell.00281.2011","article-title":"Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress.","volume":"303","author":"Xie","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1089\/ars.2013.5604","article-title":"Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide.","volume":"21","author":"Xie","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"B83","doi-asserted-by":"publisher","first-page":"13143","DOI":"10.1074\/jbc.M117.778654","article-title":"Hydrogen sulfide modulates eukaryotic translation initiation factor 2\u03b1 (eIF2\u03b1) phosphorylation status in the integrated stress response pathway.","volume":"292","author":"Yadav","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B85","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.lfs.2015.11.025","article-title":"Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway.","volume":"144","author":"Ying","year":"2016","journal-title":"Life Sci."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004971","article-title":"Endogenous hydrogen sulfide enhances carotid sinus baroreceptor sensitivity by activating the transient receptor potential cation channel subfamily v member 1 (TRPV1) channel.","volume":"6","author":"Yu","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1096\/fj.06-6270fje","article-title":"Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation.","volume":"12","author":"Zanardo","year":"2006","journal-title":"FASEB J."},{"key":"B88","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/anie.201305876","article-title":"Detection of protein S-sulfhydration by a tag-switch technique.","volume":"53","author":"Zhang","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.jdiacomp.2017.06.011","article-title":"Hydrogen sulfide improves diabetic wound healing in ob\/ob mice via attenuating inflammation.","volume":"31","author":"Zhao","year":"2017","journal-title":"J. Diabetes Complications"},{"key":"B90","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/embr.201338213","article-title":"S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair.","volume":"15","author":"Zhao","year":"","journal-title":"EMBO Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"20824","DOI":"10.1074\/jbc.M114.559518","article-title":"Hydrogen sulfide represses androgen receptor transactivation by targeting at the second zinc finger module.","volume":"289","author":"Zhao","year":"","journal-title":"J. Biol. Chem."},{"key":"B92","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener.","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6826","article-title":"Cystathionine \u03b3-lyase-hydrogen sulfide induces runt-related transcription factor 2 sulfhydration, thereby increasing osteoblast activity to promote bone fracture healing.","author":"Zheng","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"B94","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.freeradbiomed.2017.01.026","article-title":"Hydrogen sulfide reduces RAGE toxicity through inhibition of its dimer formation.","volume":"104","author":"Zhou","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1152\/ajpheart.01229.2009","article-title":"Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of BK channels.","volume":"299","author":"Zuidema","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00608\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T04:16:53Z","timestamp":1504671413000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00608\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":95,"alternative-id":["10.3389\/fphar.2017.00608"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00608","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]},"article-number":"608"}}