{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:34:00Z","timestamp":1791686040330,"version":"4.3.4"},"reference-count":148,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL116571"],"award-info":[{"award-number":["R01HL116571"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00664","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T02:30:59Z","timestamp":1506393059000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["Recent Development of Hydrogen Sulfide Releasing\/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders"],"prefix":"10.3389","volume":"8","author":[{"given":"Chun-tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob J.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1677\/JOE-07-0184","article-title":"Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway.","volume":"195","author":"Ali","year":"2007","journal-title":"J. Endocrinol."},{"key":"B2","doi-asserted-by":"crossref","first-page":"716S","DOI":"10.1093\/jn\/136.3.716S","article-title":"Clarifying the real bioactive constituents of garlic.","author":"Amagase","year":"2006","journal-title":"J. Nutr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.niox.2014.12.013","article-title":"Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress.","volume":"46","author":"Barr","year":"2015","journal-title":"Nitric Oxide"},{"key":"B4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3109\/10408448409029321","article-title":"A critical review of the literature on hydrogen sulfide toxicity.","volume":"13","author":"Beauchamp","year":"1984","journal-title":"Crit. Rev. Toxicol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1016\/j.ejca.2011.03.003","article-title":"Diabetes mellitus and risk of pancreatic cancer: a meta-analysis of cohort studies.","volume":"47","author":"Ben","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic.","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079167","article-title":"Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance.","volume":"8","author":"Bhattacharyya","year":"2013","journal-title":"PLOS ONE"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation-like state in mice.","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1582-4934.2003.tb00198.x","article-title":"Tetrathiomolybdate anticopper therapy for Wilson\u2019s disease inhibits angiogenesis, fibrosis and inflammation.","volume":"7","author":"Brewer","year":"2003","journal-title":"J. Cell. Mol. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1039\/b901614g","article-title":"Zinc and tetrathiomolybdate for the treatment of Wilson\u2019s disease and the potential efficacy of anticopper therapy in a wide variety of diseases.","volume":"1","author":"Brewer","year":"2009","journal-title":"Metallomics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1042\/cbi20090368","article-title":"Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21.","volume":"34","author":"Cai","year":"2010","journal-title":"Cell Biol. Int."},{"key":"B12","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis.","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.bcp.2011.12.018","article-title":"Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect.","volume":"83","author":"Chattopadhyay","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1021\/acs.orglett.6b03336","article-title":"Esterase activated carbonyl sulfide\/hydrogen sulfide (H2S) donors.","volume":"19","author":"Chauhan","year":"2017","journal-title":"Org. Lett."},{"key":"B15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bcp.2016.08.016","article-title":"GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia.","volume":"118","author":"Chen","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"11601","DOI":"10.1074\/jbc.M808026200","article-title":"H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.","volume":"284","author":"Chiku","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3857\/roj.2015.33.4.328","article-title":"Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor.","volume":"33","author":"Cho","year":"2015","journal-title":"Radiat. Oncol. J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects.","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"H2693","DOI":"10.1152\/ajpheart.00853.2007","article-title":"S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway.","volume":"293","author":"Chuah","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"84338","DOI":"10.18632\/oncotarget.12609","article-title":"H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair.","volume":"7","author":"Ciocci","year":"2016","journal-title":"Oncotarget"},{"key":"B21","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/nrc2663","article-title":"Apoptosis and cancer: the genesis of a research field.","volume":"9","author":"Cotter","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"B22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.phrs.2016.10.019","article-title":"ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo.","volume":"114","author":"De Cicco","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ab.2011.10.016","article-title":"Passive loss of hydrogen sulfide in biological experiments.","volume":"421","author":"DeLeon","year":"2012","journal-title":"Anal. Biochem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrd4275","article-title":"Targeting inflammation in the treatment of type 2 diabetes: time to start.","volume":"13","author":"Donath","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"B25","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00125-016-3873-z","article-title":"Multiple benefits of targeting inflammation in the treatment of type 2 diabetes.","volume":"59","author":"Donath","year":"2016","journal-title":"Diabetologia"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002310","article-title":"Ammonium tetrathiomolybdate following ischemia\/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models.","volume":"14","author":"Dyson","year":"2017","journal-title":"PLOS Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function.","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1517\/13543784.2015.974804","article-title":"Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease.","volume":"24","author":"Esser","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.actbio.2015.09.010","article-title":"Biological thiols-triggered hydrogen sulfide releasing microfibers for tissue engineering applications.","volume":"27","author":"Feng","year":"2015","journal-title":"Acta Biomater."},{"key":"B30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bbrc.2009.01.059","article-title":"Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator.","volume":"380","author":"Feng","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.tcb.2013.07.006","article-title":"Evading apoptosis in cancer.","volume":"23","author":"Fernald","year":"2013","journal-title":"Trends Cell Biol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.133","article-title":"NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain.","volume":"3","author":"Fonseca","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"B33","doi-asserted-by":"publisher","first-page":"5089","DOI":"10.1021\/ma501044b","article-title":"Functionalization of methacrylate polymers with thiooximes: a robust postpolymerization modification reaction and a method for the preparation of H2S-releasing polymers.","volume":"47","author":"Foster","year":"2014","journal-title":"Macromolecules"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1021\/acs.molpharmaceut.6b01117","article-title":"H2S-releasing polymer micelles for studying selective cell toxicity.","volume":"14","author":"Foster","year":"2017","journal-title":"Mol. Pharm."},{"key":"B35","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.semcancer.2014.05.002","article-title":"Targeting apoptosis for anticancer therapy.","volume":"31","author":"Fulda","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1126\/science.349.6244.128","article-title":"BIOMEDICINE. Targeting copper to treat breast cancer.","volume":"349","author":"Garber","year":"2015","journal-title":"Science"},{"key":"B37","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbi.2010.09.001","article-title":"S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-kappaB pathway in rats.","volume":"25","author":"Gong","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1021\/bc500150s","article-title":"Design and synthesis of polymeric hydrogen sulfide donors.","volume":"25","author":"Hasegawa","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1089\/ars.2014.5933","article-title":"The therapeutic potential of cystathionine beta-synthetase\/hydrogen sulfide inhibition in cancer.","volume":"22","author":"Hellmich","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"B40","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1681\/ASN.2013030291","article-title":"Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor.","volume":"25","author":"Holwerda","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"462","DOI":"10.4103\/0970-9185.142799","article-title":"Sodium nitroprusside in 2014: a clinical concepts review.","volume":"30","author":"Hottinger","year":"2014","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/cbf.2920","article-title":"Endogenous CSE\/H2S system mediates TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.","volume":"31","author":"Huang","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.3892\/or.2017.5513","article-title":"Role of the cystathionine beta-synthase\/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system.","volume":"37","author":"Jia","year":"2017","journal-title":"Oncol. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s10654-011-9617-y","article-title":"Diabetes mellitus and incidence and mortality of colorectal cancer: a systematic review and meta-analysis of cohort studies.","volume":"26","author":"Jiang","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.bbagen.2015.08.003","article-title":"H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells.","volume":"1850","author":"Ju","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B46","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues.","volume":"15","author":"Kabil","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"B47","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.febslet.2008.12.026","article-title":"Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose.","volume":"583","author":"Kaneko","year":"2009","journal-title":"FEBS Lett."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.2337\/db05-1082","article-title":"L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter.","volume":"55","author":"Kaneko","year":"2006","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"6336","DOI":"10.1021\/jacs.6b01373","article-title":"pH-Controlled hydrogen sulfide release for myocardial ischemia-reperfusion injury.","volume":"138","author":"Kang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"B50","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1021\/acs.jafc.6b04948","article-title":"Preparation of S-allylcysteine-enriched black garlic juice and its antidiabetic effects in streptozotocin-induced insulin-deficient mice.","volume":"65","author":"Kim","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1080\/10715760600719540","article-title":"S-Allyl-L-cysteine attenuates cerebral ischemic injury by scavenging peroxynitrite and inhibiting the activity of extracellular signal-regulated kinase.","volume":"40","author":"Kim","year":"2006","journal-title":"Free Radic. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.bcp.2015.09.014","article-title":"NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid has enhanced chemo-preventive properties compared to aspirin, is gastrointestinal safe with all the classic therapeutic indications.","volume":"98","author":"Kodela","year":"","journal-title":"Biochem. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4873","DOI":"10.2147\/DDDT.S91116","article-title":"Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-kappaB signaling.","volume":"9","author":"Kodela","year":"","journal-title":"Drug Des. Devel. Ther."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"H2S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase.","volume":"127","author":"Kondo","year":"2013","journal-title":"Circulation"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021077","article-title":"The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.","volume":"6","author":"Lee","year":"2011","journal-title":"PLOS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"17907","DOI":"10.1073\/pnas.0709010104","article-title":"A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide.","volume":"104","author":"Lefer","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.canlet.2010.11.015","article-title":"Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.","volume":"301","author":"Li","year":"2011","journal-title":"Cancer Lett."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse.","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1021\/acs.orglett.5b01962","article-title":"Diallyl trisulfide is a fast H2S donor, but diallyl disulfide is a slow one: the reaction pathways and intermediates of glutathione with polysulfides.","volume":"17","author":"Liang","year":"2015","journal-title":"Org. Lett."},{"key":"B61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/156652406775574613","article-title":"Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes.","volume":"6","author":"Lipson","year":"2006","journal-title":"Curr. Mol. Med."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046301","article-title":"H2S-releasing aspirin protects against aspirin-induced gastric injury via reducing oxidative stress.","volume":"7","author":"Liu","year":"2012","journal-title":"PLOS ONE"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.3892\/ijo.2014.2305","article-title":"GYY4137, a hydrogen sulfide (H2S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway.","volume":"44","author":"Lu","year":"2014","journal-title":"Int. J. Oncol."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00232.","article-title":"Cadmium disrupts the balance between hydrogen peroxide and superoxide radical by regulating endogenous hydrogen sulfide in the root tip of Brassica rapa.","volume":"8","author":"Lv","year":"2017","journal-title":"Front. Plant Sci."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020525","article-title":"H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S?","volume":"6","author":"Ma","year":"2011","journal-title":"PLOS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/odi.12223","article-title":"Hydrogen sulfide accelerates cell cycle progression in oral squamous cell carcinoma cell lines.","volume":"21","author":"Ma","year":"2015","journal-title":"Oral Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nrc2602","article-title":"Cell cycle, CDKs and cancer: a changing paradigm.","volume":"9","author":"Malumbres","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"B68","doi-asserted-by":"publisher","first-page":"39848","DOI":"10.1074\/jbc.M111.270884","article-title":"Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)\/serine\/threonine protein kinase (AKT)\/protein kinase Czeta\/lambda (PKCzeta\/lambda) in 3T3l1 adipocytes.","volume":"286","author":"Manna","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"42324","DOI":"10.1074\/jbc.M112.407833","article-title":"Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes.","volume":"287","author":"Manna","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1042\/BJ20110841","article-title":"Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide.","volume":"439","author":"Mikami","year":"2011","journal-title":"Biochem. J."},{"key":"B71","doi-asserted-by":"publisher","first-page":"E1178","DOI":"10.1152\/ajpendo.00313.2002","article-title":"ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue.","volume":"283","author":"Miki","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B72","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.yexcr.2013.10.023","article-title":"Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: role of PHLDA1 as an apoptosis suppressor.","volume":"320","author":"Murata","year":"2014","journal-title":"Exp. Cell Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.niox.2014.11.007","article-title":"Protective effect of hydrogen sulfide on pancreatic beta-cells.","volume":"46","author":"Okamoto","year":"2015","journal-title":"Nitric Oxide"},{"key":"B74","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbrc.2013.11.023","article-title":"Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.","volume":"442","author":"Okamoto","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B75","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.tox.2006.04.039","article-title":"Preventive effect of S-allylcysteine on lipid peroxides and antioxidants in normal and isoproterenol-induced cardiotoxicity in rats: a histopathological study.","volume":"224","author":"Padmanabhan","year":"2006","journal-title":"Toxicology"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-13-155","article-title":"Involvement of CSE\/ H2S in high glucose induced aberrant secretion of adipokines in 3T3-L1 adipocytes.","volume":"13","author":"Pan","year":"2014","journal-title":"Lipids Health Dis."},{"key":"B77","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/pcmr.12312","article-title":"Role of the cystathionine gamma lyase\/hydrogen sulfide pathway in human melanoma progression.","volume":"28","author":"Panza","year":"2015","journal-title":"Pigment Cell Melanoma Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease.","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/1755-5922.12128","article-title":"A novel hydrogen sulfide prodrug, SG1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patients.","volume":"33","author":"Polhemus","year":"2015","journal-title":"Cardiovasc. Ther."},{"key":"B80","doi-asserted-by":"publisher","first-page":"13477","DOI":"10.1021\/jacs.6b07204","article-title":"Therapeutic delivery of H2S via COS: small molecule and polymeric donors with benign byproducts.","volume":"138","author":"Powell","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1055\/s-2002-34863","article-title":"Chemistry of tetrathiomolybdate: applications in organic synthesis","volume":"2002","author":"Prabhu","year":"2002","journal-title":"Synlett"},{"key":"B82","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.3748\/wjg.v11.i26.3990","article-title":"Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis.","volume":"11","author":"Rose","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/hep.23267","article-title":"Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.","volume":"51","author":"Saito","year":"2010","journal-title":"Hepatology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"9408","DOI":"10.1200\/jco.2005.01.5594","article-title":"Targeting the cell cycle: a new approach to cancer therapy.","volume":"23","author":"Schwartz","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"B85","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1749-6632.1963.tb16647.x","article-title":"The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-acetyl-L-cysteine.","volume":"106","author":"Sheffner","year":"1963","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"4967","DOI":"10.1039\/C7SC00873B","article-title":"\u201cOn demand\u201d redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor.","volume":"8","author":"Shukla","year":"2017","journal-title":"Chem. Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","article-title":"Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions.","volume":"284","author":"Singh","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1021\/acschembio.7b00279","article-title":"Inhibition of mitochondrial bioenergetics by esterase-triggered COS\/H2S donors.","volume":"12","author":"Steiger","year":"","journal-title":"ACS Chem. Biol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"7256","DOI":"10.1021\/jacs.6b03780","article-title":"Self-immolative thiocarbamates provide access to triggered H2S donors and analyte replacement fluorescent probes.","volume":"138","author":"Steiger","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7119","article-title":"Emerging roles of carbonyl sulfide in chemical biology: sulfide transporter or gasotransmitter?","author":"Steiger","year":"","journal-title":"Antioxid. Redox Signal."},{"key":"B91","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential.","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"B92","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1089\/ars.2011.4451","article-title":"Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications.","volume":"17","author":"Szabo","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"B93","doi-asserted-by":"publisher","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer.","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.4161\/cc.26064","article-title":"Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation.","volume":"12","author":"Szabo","year":"2013","journal-title":"Cell Cycle"},{"key":"B95","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00125-012-2806-8","article-title":"Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells.","volume":"56","author":"Tang","year":"2013","journal-title":"Diabetologia"},{"key":"B96","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1440-1681.2007.04799.x","article-title":"Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells.","volume":"35","author":"Tang","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1111\/j.1476-5381.2010.01119.x","article-title":"Hydrogen sulphide protects mouse pancreatic beta-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress.","volume":"162","author":"Taniguchi","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1254\/jphs.11R01CP","article-title":"Significance of hydrogen sulfide production in the pancreatic beta-cell.","volume":"116","author":"Taniguchi","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1089\/ars.2012.4565","article-title":"VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells.","volume":"19","author":"Tao","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B100","first-page":"79","article-title":"Failure of glibenclamide to stimulate glucose uptake by adipose tissue in vitro West.","volume":"3","author":"Tayo","year":"1976","journal-title":"Afr. J. Pharmacol. Drug Res."},{"key":"B101","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/j.1365-2125.2010.03636.x","article-title":"Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide.","volume":"69","author":"Toombs","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119511","article-title":"Hydrogen sulfide promotes adipogenesis in 3T3L1 cells.","volume":"10","author":"Tsai","year":"2015","journal-title":"PLOS ONE"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7607","article-title":"Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies.","volume":"350","author":"Tsilidis","year":"2015","journal-title":"BMJ"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7046","article-title":"Hydrogen sulfide and glucose homeostasis: a tale of sweet and the stink.","author":"Untereiner","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"B105","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1089\/ars.2015.6369","article-title":"Decreased gluconeogenesis in the absence of cystathionine gamma-lyase and the underlying mechanisms.","volume":"24","author":"Untereiner","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"B106","doi-asserted-by":"publisher","first-page":"4677","DOI":"10.1016\/j.bmcl.2015.08.023","article-title":"Synthesis and anti-cancer potential of the positional isomers of NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybrid.","volume":"25","author":"Vannini","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1186\/cc10079","article-title":"Of mice and men (and sheep, swine etc.): the intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S).","volume":"15","author":"Wagner","year":"2011","journal-title":"Crit. Care"},{"key":"B108","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1089\/ars.2014.5901","article-title":"Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics.","volume":"22","author":"Wallace","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"B109","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1053\/j.gastro.2009.04.012","article-title":"Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.","volume":"137","author":"Wallace","year":"2009","journal-title":"Gastroenterology"},{"key":"B110","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter.","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"B111","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1023\/A:1018538424373","article-title":"Synthesis and characterization of molybdenum disulphide formed from ammonium tetrathiomolybdate.","volume":"32","author":"Wang","year":"1997","journal-title":"J. Mater. Sci."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163289","article-title":"S-propargyl-cysteine, a novel hydrogen sulfide donor, inhibits inflammatory hepcidin and relieves anemia of inflammation by inhibiting IL-6\/STAT3 pathway.","volume":"11","author":"Wang","year":"2016","journal-title":"PLOS ONE"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1089\/ars.2009.2945","article-title":"The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia.","volume":"12","author":"Wang","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"B114","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/FJC.0b013e3181ac8e12","article-title":"S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia\/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway.","volume":"54","author":"Wang","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"B116","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s11010-011-1194-6","article-title":"Hydrogen sulfide protects H9c2 cells against doxorubicin-induced cardiotoxicity through inhibition of endoplasmic reticulum stress.","volume":"363","author":"Wang","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets.","volume":"17","author":"Weis","year":"2011","journal-title":"Nat. Med."},{"key":"B118","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3409\/fb60_3-4.243-247","article-title":"Vitamin D3 (cholecalciferol) boosts hydrogen sulfide tissue concentrations in heart and other mouse organs.","volume":"60","author":"Wilinski","year":"2012","journal-title":"Folia Biol."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.209","article-title":"Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity.","volume":"7","author":"Wu","year":"","journal-title":"Cell Death Dis."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b06466","article-title":"Novel H2S releasing nanofibrous coating for in vivo dermal wound regeneration.","author":"Wu","year":"","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"B121","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/labinvest.2008.109","article-title":"Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.","volume":"89","author":"Wu","year":"2009","journal-title":"Lab. Invest."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.bmcl.2016.02.005","article-title":"Ammonium tetrathiomolybdate as a water-soluble and slow-release hydrogen sulfide donor.","volume":"26","author":"Xu","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058079","article-title":"Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies.","volume":"8","author":"Xu","year":"2013","journal-title":"PLOS ONE"},{"key":"B124","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1089\/ars.2012.5024","article-title":"Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes.","volume":"19","author":"Xue","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B125","doi-asserted-by":"publisher","first-page":"20002","DOI":"10.1074\/jbc.M113.466177","article-title":"Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase.","volume":"288","author":"Yadav","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021971","article-title":"Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS\/NF-kappaB\/COX-2 pathway.","volume":"6","author":"Yang","year":"2011","journal-title":"PLOS ONE"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13166","article-title":"A novel pH-controlled hydrogen sulfide donor protects gastric mucosa from aspirin-induced injury.","author":"Yang","year":"","journal-title":"J. Cell. Mol. Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1159\/000458734","article-title":"Inhibition of methylglyoxal-induced AGEs\/RAGE expression contributes to dermal protection by N-acetyl-L-cysteine.","volume":"41","author":"Yang","year":"","journal-title":"Cell. Physiol. Biochem."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1159\/000366339","article-title":"A novel controllable hydrogen sulfide-releasing molecule protects human skin keratinocytes against methylglyoxal-induced injury and dysfunction.","volume":"34","author":"Yang","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B130","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"B131","doi-asserted-by":"publisher","first-page":"16567","DOI":"10.1074\/jbc.M700605200","article-title":"H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells.","volume":"282","author":"Yang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B132","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ejphar.2015.05.001","article-title":"The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: a novel mechanism mediated by the activation of Nrf2.","volume":"761","author":"Yang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1113\/jphysiol.2005.097642","article-title":"Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.","author":"Yang","year":"2005","journal-title":"J. Physiol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cellsig.2012.02.003","article-title":"Sp1 is involved in regulation of cystathionine gamma-lyase gene expression and biological function by PI3K\/Akt pathway in human hepatocellular carcinoma cell lines.","volume":"24","author":"Yin","year":"2012","journal-title":"Cell. Signal."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.bbrc.2005.06.021","article-title":"Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis.","volume":"333","author":"Yusuf","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B136","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1096\/fj.06-6270fje","article-title":"Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation.","volume":"20","author":"Zanardo","year":"2006","journal-title":"FASEB J."},{"key":"B137","doi-asserted-by":"publisher","first-page":"6530","DOI":"10.1073\/pnas.1304321110","article-title":"Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis.","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B138","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neuint.2015.12.005","article-title":"Calcitriol prevents peripheral RSC96 Schwann neural cells from high glucose & methylglyoxal-induced injury through restoration of CBS\/H2S expression.","volume":"92","author":"Zhang","year":"2016","journal-title":"Neurochem. Int."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/resp.12372","article-title":"Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma.","volume":"19","author":"Zhang","year":"2014","journal-title":"Respirology"},{"key":"B140","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4187\/respcare.03519","article-title":"Exhaled hydrogen sulfide predicts airway inflammation phenotype in COPD.","volume":"60","author":"Zhang","year":"2015","journal-title":"Respir. Care"},{"key":"B141","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1210\/en.2012-1658","article-title":"Hydrogen sulfide impairs glucose utilization and increases gluconeogenesis in hepatocytes.","volume":"154","author":"Zhang","year":"2013","journal-title":"Endocrinology"},{"key":"B142","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1021\/cb400090d","article-title":"Controllable hydrogen sulfide donors and the activity against myocardial ischemia-reperfusion injury.","volume":"8","author":"Zhao","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"11788","DOI":"10.1039\/c4cc00968a","article-title":"Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem. Commun."},{"key":"B144","doi-asserted-by":"publisher","first-page":"14638","DOI":"10.1002\/anie.201608052","article-title":"Hydrogen sulfide donors activated by reactive oxygen species.","volume":"55","author":"Zhao","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"B145","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.1021\/acs.jmedchem.5b01033","article-title":"Design, synthesis, and cardioprotective effects of N-mercapto-based hydrogen sulfide donors.","volume":"58","author":"Zhao","year":"2015","journal-title":"J. Med. Chem."},{"key":"B146","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.3892\/ijo.2015.2914","article-title":"Exogenous hydrogen sulfide exerts proliferation\/anti-apoptosis\/angiogenesis\/migration effects via amplifying the activation of NF-kappaB pathway in PLC\/PRF\/5 hepatoma cells.","volume":"46","author":"Zhen","year":"2015","journal-title":"Int. J. Oncol."},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1002\/med.21433","article-title":"Toward hydrogen sulfide based therapeutics: critical drug delivery and developability issues.","author":"Zheng","year":"2017","journal-title":"Med. Res. Rev."},{"key":"B148","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1002\/anie.201511244","article-title":"Esterase-sensitive prodrugs with tunable release rates and direct generation of hydrogen sulfide.","volume":"55","author":"Zheng","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00664\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T19:41:53Z","timestamp":1570131713000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00664\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,26]]},"references-count":148,"alternative-id":["10.3389\/fphar.2017.00664"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00664","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,26]]},"article-number":"664"}}