{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:11:45Z","timestamp":1789776705268,"version":"4.0.1"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1064247"],"award-info":[{"award-number":["GNT1064247"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001215","name":"La Trobe University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00748","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T04:33:35Z","timestamp":1508819615000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":81,"title":["The Human Amnion Epithelial Cell Secretome Decreases Hepatic Fibrosis in Mice with Chronic Liver Fibrosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Majid","family":"Alhomrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Zavou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Leaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Kuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed I.","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Greening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/ctr.12179","article-title":"Short-term evaluation of autologous transplantation of bone marrow\u2013derived mesenchymal stem cells in patients with cirrhosis: Egyptian study.","volume":"27","author":"Amin","year":"2013","journal-title":"Clin. Transplant."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1053\/j.gastro.2016.12.003","article-title":"Milk fat globule-EGF factor 8, secreted by mesenchymal stem cells, protects against liver fibrosis in mice.","volume":"152","author":"An","year":"2017","journal-title":"Gastroenterology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1172\/JCI40053","article-title":"Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.","volume":"119","author":"Atabai","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1073\/pnas.1310501111","article-title":"Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion.","volume":"111","author":"Atay","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00359","article-title":"Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy.","volume":"3","author":"Baglio","year":"2012","journal-title":"Front. Physiol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/srep18272","article-title":"The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis.","volume":"5","author":"Bansal","year":"2015","journal-title":"Sci. Rep."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/srep39520","article-title":"Chronic hepatitis C infection\u2013induced liver fibrogenesis is associated with M2 macrophage activation.","volume":"6","author":"Bility","year":"2016","journal-title":"Sci. Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/35073073","article-title":"Rap1 signalling: adhering to new models.","volume":"2","author":"Bos","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrrheum.2014.19","article-title":"Emerging role of extracellular vesicles in inflammatory diseases.","volume":"10","author":"Buzas","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/sj.leu.2402824","article-title":"Involvement of PI3K\/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"B11","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.lfs.2009.08.003","article-title":"Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis.","volume":"85","author":"Chang","year":"2009","journal-title":"Life Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1111\/j.1478-3231.2010.02364.x","article-title":"Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.","volume":"31","author":"Cho","year":"2011","journal-title":"Liver Int."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1002\/hep.27376","article-title":"Liver sinusoidal endothelial cells in hepatic fibrosis.","volume":"61","author":"DeLeve","year":"2015","journal-title":"Hepatology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities.","volume":"12","author":"El Andaloussi","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2005.09.002","article-title":"Cu\u2013Zn super oxide dismutase as a potential antifibrotic drug for hepatitis C related fibrosis.","volume":"60","author":"Emerit","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3886","DOI":"10.1021\/acsnano.5b08015","article-title":"Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine.","volume":"10","author":"Fais","year":"2016","journal-title":"ACS Nano"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1089\/scd.2011.0560","article-title":"Secreted factors of human liver-derived mesenchymal stem cells promote liver regeneration early after partial hepatectomy.","volume":"21","author":"Fouraschen","year":"2012","journal-title":"Stem Cells Dev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.bpg.2006.07.007","article-title":"Indications of liver transplantation in patients with complications of cirrhosis.","volume":"21","author":"Francoz","year":"2007","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1158\/0008-5472.CAN-12-3918","article-title":"Synergistic induction of adaptive antitumor immunity by codelivery of antigen with alpha-galactosylceramide on exosomes.","volume":"73","author":"Gehrmann","year":"2013","journal-title":"Cancer Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"13718","DOI":"10.18632\/oncotarget.3764","article-title":"YBX1\/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment.","volume":"6","author":"Gopal","year":"2015","journal-title":"Oncotarget"},{"key":"B23","doi-asserted-by":"publisher","first-page":"6319","DOI":"10.1021\/acs.analchem.5b01166","article-title":"SuperQuant: a data processing approach to increase quantitative proteome coverage.","volume":"87","author":"Gorshkov","year":"2015","journal-title":"Anal. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.semcdb.2015.02.008","article-title":"Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression.","volume":"40","author":"Greening","year":"","journal-title":"Semin. Cell Dev. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.semcdb.2015.02.009","article-title":"Exosomes and their roles in immune regulation and cancer.","volume":"40","author":"Greening","year":"","journal-title":"Semin. Cell Dev. Biol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/srep32643","article-title":"Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.","volume":"6","author":"Greening","year":"","journal-title":"Sci. Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.115.134890","article-title":"Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial-embryo interactions.","volume":"94","author":"Greening","year":"","journal-title":"Biol. Reprod."},{"key":"B28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/14789450.2017.1260450","article-title":"Proteomic insights into extracellular vesicle biology - defining exosomes and shed microvesicles.","volume":"14","author":"Greening","year":"2017","journal-title":"Expert Rev. Proteomics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-pharmtox-010814-124630","article-title":"Therapeutic applications of extracellular vesicles: clinical promise and open questions.","volume":"55","author":"Gyorgy","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.jcyt.2014.01.005","article-title":"Soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells.","volume":"16","author":"Hodge","year":"2014","journal-title":"Cytotherapy"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0792-1","article-title":"Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively.","volume":"14","author":"Huang","year":"2016","journal-title":"J. Transl. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1002\/hep.26135","article-title":"Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis.","volume":"57","author":"Huang","year":"2013","journal-title":"Hepatology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"B34","doi-asserted-by":"publisher","first-page":"816","DOI":"10.5966\/sctm.2015-0191","article-title":"Hypoxic conditioned medium from human adipose-derived stem cells promotes mouse liver regeneration through JAK\/STAT3 Signaling.","volume":"5","author":"Lee","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12072-014-9599-4","article-title":"A novel cell-free strategy for promoting mouse liver regeneration: utilization of a conditioned medium from adipose-derived stem cells.","volume":"9","author":"Lee","year":"2015","journal-title":"Hepatol. Int."},{"key":"B36","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story.","volume":"64","author":"Lee","year":"2015","journal-title":"Gut"},{"key":"B37","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1089\/scd.2012.0395","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.","volume":"22","author":"Li","year":"2012","journal-title":"Stem Cells Dev."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-6-19","article-title":"Experimental liver fibrosis research: update on animal models, legal issues and translational aspects.","volume":"6","author":"Liedtke","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"B39","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1681\/ASN.2011030310","article-title":"Mannose receptor 2 attenuates renal fibrosis.","volume":"23","author":"L\u00f3pez-Guisa","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.7150\/ijbs.7.1273","article-title":"Th2-associated alternative Kupffer cell activation promotes liver fibrosis without inducing local inflammation.","volume":"7","author":"L\u00f3pez-Navarrete","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the international society for extracellular vesicles.","volume":"3","author":"L\u00f6tvall","year":"2014","journal-title":"J. Extracell. Vesicles"},{"key":"B42","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.immuni.2010.01.013","article-title":"Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.","volume":"32","author":"Luber","year":"2010","journal-title":"Immunity"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1016\/j.bbapap.2013.01.032","article-title":"Stem cells: insights into the secretome.","volume":"1834","author":"Makridakis","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038631","article-title":"Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis.","volume":"7","author":"Manuelpillai","year":"2012","journal-title":"PLOS ONE"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3727\/096368910X504496","article-title":"Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl4-treated mice.","volume":"19","author":"Manuelpillai","year":"2010","journal-title":"Cell Transplant."},{"key":"B46","doi-asserted-by":"publisher","first-page":"F202","DOI":"10.1152\/ajprenal.00468.2007","article-title":"HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy.","volume":"295","author":"Mao","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment.","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"B48","doi-asserted-by":"crossref","DOI":"10.1615\/ForumImmunDisTher.2016015877","article-title":"Exosomes, ectosomes and the two together. physiology and pathology","author":"Meldolesi","year":"2015","journal-title":"Forum on Immunopathological Diseases and Therapeutics"},{"key":"B49","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.ccell.2014.09.005","article-title":"Cancer exosomes perform cell-independent MicroRNA biogenesis and promote tumorigenesis.","volume":"26","author":"Melo","year":"2014","journal-title":"Cancer Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1582-4934.2006.tb00406.x","article-title":"Prospects for exosomes in immunotherapy of cancer.","volume":"10","author":"Mignot","year":"2006","journal-title":"J. Cell Mol. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1111\/liv.12228","article-title":"Randomized placebo - controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis.","volume":"33","author":"Mohamadnejad","year":"2013","journal-title":"Liver Int."},{"key":"B52","doi-asserted-by":"publisher","first-page":"909","DOI":"10.3727\/096368910X543385","article-title":"Human amnion epithelial cells prevent bleomycin-induced lung injury and preserve lung function.","volume":"20","author":"Murphy","year":"2011","journal-title":"Cell Transplant."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1E.6.1","DOI":"10.1002\/9780470151808.sc01e06s13","article-title":"Amnion epithelial cell isolation and characterization for clinical use.","volume":"13","author":"Murphy","year":"2010","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nrurol.2014.301","article-title":"The emerging role of extracellular vesicles as biomarkers for urogenital cancers.","volume":"11","author":"Nawaz","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1586\/14789450.2016.1165613","article-title":"Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery.","volume":"13","author":"Nawaz","year":"2016","journal-title":"Exp. Rev. Proteom."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058502","article-title":"Endometrial exosomes\/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation.","volume":"8","author":"Ng","year":"2013","journal-title":"PLOS ONE"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/hep.26429","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice.","volume":"58","author":"Pradere","year":"2013","journal-title":"Hepatology"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026136","article-title":"Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications.","volume":"6","author":"Pratama","year":"2011","journal-title":"PLOS ONE"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00021","article-title":"Extracellular vesicles - biomarkers and effectors of the cellular interactome in cancer.","volume":"4","author":"Rak","year":"2013","journal-title":"Front. Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B61","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1006\/cimm.2000.1687","article-title":"Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts.","volume":"204","author":"Song","year":"2000","journal-title":"Cell Immunol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1186\/scrt465","article-title":"Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models.","volume":"5","author":"Tan","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"B63","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.ymeth.2012.01.002","article-title":"Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes.","volume":"56","author":"Tauro","year":"","journal-title":"Methods"},{"key":"B64","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1074\/mcp.M112.021303","article-title":"Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids.","volume":"12","author":"Tauro","year":"","journal-title":"Mol. Cell. Proteom."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1002\/stem.459","article-title":"Concise review: hitting the right spot with mesenchymal stromal cells.","volume":"28","author":"Tolar","year":"2010","journal-title":"Stem Cells"},{"key":"B66","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.molmed.2014.03.002","article-title":"Extracellular vesicles: emerging targets for cancer therapy.","volume":"20","author":"Vader","year":"2014","journal-title":"Trends Mol. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt signaling pathway in macrophage activation and M1\/M2 polarization.","volume":"198","author":"Vergadi","year":"2017","journal-title":"J. Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1158\/0008-5472.CAN-09-3276","article-title":"Dendritic cell-derived exosomes for cancer immunotherapy: what\u2019s next?","volume":"70","author":"Viaud","year":"2010","journal-title":"Cancer Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1016\/j.ajog.2011.03.054","article-title":"Human amnion epithelial cells as a treatment for inflammation-induced fetal lung injury in sheep.","volume":"205","author":"Vosdoganes","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.jcyt.2013.03.004","article-title":"Human amnion epithelial cells modulate hyperoxia-induced neonatal lung injury in mice.","volume":"15","author":"Vosdoganes","year":"2013","journal-title":"Cytotherapy"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1089\/ten.2006.0313","article-title":"Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue.","volume":"13","author":"Wolbank","year":"2007","journal-title":"Tissue Eng."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease.","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1172\/JCI81129","article-title":"Extracellular vesicle isolation and characterization: toward clinical application.","volume":"126","author":"Xu","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B74","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1681\/ASN.2009050552","article-title":"HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition.","volume":"21","author":"Zhou","year":"2010","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00748\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T09:09:11Z","timestamp":1525770551000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00748\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,24]]},"references-count":74,"alternative-id":["10.3389\/fphar.2017.00748"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00748","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,24]]},"article-number":"748"}}