{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:32:32Z","timestamp":1787610752491,"version":"build-2736575974"},"reference-count":24,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BI893\/5-2"],"award-info":[{"award-number":["BI893\/5-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR1710\/5-1"],"award-info":[{"award-number":["KR1710\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZZ9603"],"award-info":[{"award-number":["01ZZ9603"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZZ0103"],"award-info":[{"award-number":["01ZZ0103"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZZ0403"],"award-info":[{"award-number":["01ZZ0403"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["03Z1CN22"],"award-info":[{"award-number":["03Z1CN22"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00807","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T04:15:11Z","timestamp":1511496911000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1"],"prefix":"10.3389","volume":"8","author":[{"given":"Jessica","family":"M\u00fchlhaus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Dinter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Jyrch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Teumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon F.","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Homuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"K\u00fchnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Wiegand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Gr\u00fcters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Raile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Kleinau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Krude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Biebermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8966","DOI":"10.1073\/pnas.151105198","article-title":"Trace amines: Identification of a family of mammalian G protein-coupled receptors.","volume":"98","author":"Borowsky","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1126\/science.1150577","article-title":"High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.","volume":"318","author":"Cherezov","year":"2007","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps3001s73","article-title":"Site-specific protein labeling with SNAP-tags.","volume":"73","author":"Cole","year":"2013","journal-title":"Curr. Protoc. Protein Sci."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117774","article-title":"Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.","volume":"10","author":"Dinter","year":"2015","journal-title":"PLOS ONE"},{"key":"B5","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/ncpendmet0966","article-title":"Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity.","volume":"4","author":"Farooqi","year":"2008","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13690","article-title":"Monogenic diabetes mellitus due to defects in insulin secretion.","volume":"142","author":"Henzen","year":"2012","journal-title":"Swiss Med. Wkly"},{"key":"B7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s00787-010-0096-6","article-title":"From monogenic to polygenic obesity: recent advances.","volume":"19","author":"Hinney","year":"2010","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00441-009-0859-x","article-title":"Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL\/6J mice.","volume":"338","author":"Ito","year":"2009","journal-title":"Cell Tissue Res."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.02.020","article-title":"Possible role of rare variants in trace amine associated receptor 1 in schizophrenia.","author":"John","year":"2017","journal-title":"Schizophr. Res."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027073","article-title":"Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.","volume":"6","author":"Kleinau","year":"2011","journal-title":"PLOS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s001120170107","article-title":"Percentiles of body mass index in children and adolescents evaluated from different regional German studies.","volume":"149","author":"Kromeyer-Hauschild","year":"2001","journal-title":"Monatsschr. Kinderheilkd."},{"key":"B12","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tips.2005.03.007","article-title":"A renaissance in trace amines inspired by a novel GPCR family.","volume":"26","author":"Lindemann","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"20638","DOI":"10.3390\/ijms151120638","article-title":"Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile.","volume":"15","author":"Muhlhaus","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.molmet.2015.09.015","article-title":"Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.","volume":"5","author":"Raab","year":"2016","journal-title":"Mol. Metab."},{"key":"B15","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1172\/JCI32994","article-title":"Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.","volume":"117","author":"Regard","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B16","doi-asserted-by":"publisher","first-page":"8485","DOI":"10.1073\/pnas.1103029108","article-title":"TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaaminergic and hypoglutamatergic activity.","volume":"108","author":"Revel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/mp.2012.57","article-title":"A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.","volume":"18","author":"Revel","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nm1051","article-title":"3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone.","volume":"10","author":"Scanlan","year":"2004","journal-title":"Nat. Med."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152581","article-title":"Genetic polymorphisms affect mouse and human trace amine-associated receptor 1 function.","volume":"11","author":"Shi","year":"2016","journal-title":"PLOS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"E1001","DOI":"10.1210\/jc.2011","article-title":"The coexistence of a novel inactivating mutant thyrotropin receptor allele with two thyroid peroxidase mutations: a genotype-phenotype correlation.","volume":"96","author":"Sriphrapradang","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation.","volume":"526","year":"2015","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.cell.2015.03.008","article-title":"The hunger genes: pathways to obesity.","volume":"161","author":"van der Klaauw","year":"2015","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1093\/ije\/dyp394","article-title":"Cohort profile: the study of health in Pomerania.","volume":"40","author":"Volzke","year":"2011","journal-title":"Int. J. Epidemiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1124\/jpet.106.112532","article-title":"Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1.","volume":"320","author":"Wainscott","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00807\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T04:15:17Z","timestamp":1511496917000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00807\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":24,"alternative-id":["10.3389\/fphar.2017.00807"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00807","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]},"article-number":"807"}}