{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:49:17Z","timestamp":1765486157675,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00826","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T04:41:12Z","timestamp":1511239272000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["The Clinical Pharmacokinetics and Pharmacodynamics of Warfarin When Combined with Compound Danshen: A Case Study for Combined Treatment of Coronary Heart Diseases with Atrial Fibrillation"],"prefix":"10.3389","volume":"8","author":[{"given":"Chunxiao","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuhua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00280-015-2934-1","article-title":"A phase I clinical trial of the effect of belinostat on the pharmacokinetics and pharmacodynamics of warfarin.","volume":"77","author":"Agarwal","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2147\/CIA.S37818","article-title":"Oral anticoagulation to reduce risk of stroke in patients with atrial fibrillation: current and future therapies.","volume":"8","author":"Alpesh","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"B3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s40291-016-0247-7","article-title":"Quantitative assessment of CYP2C9 genetic polymorphisms effect on the oral clearance of S-Warfarin in healthy subjects.","volume":"21","author":"Chanan","year":"2016","journal-title":"Mol. Diagn. Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.jep.2011.08.035","article-title":"The effect of compound Danshen dripping pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats.","volume":"137","author":"Chu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/jcph.813","article-title":"CYP2C9 genotype-dependent warfarin pharmacokinetics: impact of CYP2C9 genotype on R- and S-warfarin and their oxidative metabolites.","volume":"57","author":"Darcy","year":"2017","journal-title":"J. Clin. Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10928-009-9138-4","article-title":"Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin.","volume":"37","author":"Eunice","year":"2010","journal-title":"J. Pharmacokinet. Pharcodyn."},{"key":"B7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/sj.clpt.6100084","article-title":"A PK-PD model for predicting impact of age, CYP2C9 and VKORC1 genotype on individualization of Warfarin therapy.","volume":"81","author":"Hamberg","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1161\/CIRCRESAHA.114.303211","article-title":"The clinical profile and pathophysiology of atrial fibrillation relationships among clinical features, epidemiology, and mechanisms.","volume":"114","author":"Jason","year":"2014","journal-title":"Circ. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1177\/0091270006292124","article-title":"Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach.","volume":"46","author":"Jiang","year":"2006","journal-title":"J. Clin. Pharmacol."},{"key":"B10","first-page":"105","article-title":"Enantioselective determinination of R-warfarin\/S-warfarin in human plasma using liquid chromatography-tandem mass spectrometry and its application in a drug-drug interaction study.","volume":"47","author":"Jin","year":"2012","journal-title":"Acta Pharm. Sin."},{"key":"B11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1365-2125.2012.04335.x","article-title":"The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype.","volume":"75","author":"John","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/FPC.0b013e3283317ab5","article-title":"Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study, accepted.","volume":"19","author":"Jorgensen","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.4062\/biomolther.2013.011","article-title":"Self-nanoemulsifying drug delivery system of lutein: physicochemical properties and effect bioavailability of warfarin.","volume":"21","author":"Juno","year":"2013","journal-title":"Biomol. Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1124\/dmd.108.020396","article-title":"Differential genotype dependent inhibition of Cyp2c9 in humans.","volume":"36","author":"Kumar","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"B15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/FJC.0000000000000254","article-title":"Improvements in CYP2C9 genotyping accuracy are needed: a report of the first proficiency testing for warfarin-related CYP2C9 and VKORC1 genotyping in China.","volume":"66","author":"Lin","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B16","first-page":"1280","article-title":"Population pharmacokinetic\/pharmacodynamic modeling of warfarin by nonlinear mixed effects model.","volume":"50","author":"Lin","year":"2015","journal-title":"Acta Pharm. Sin."},{"key":"B17","doi-asserted-by":"publisher","first-page":"454","DOI":"10.5414\/CP201996","article-title":"Warfarin compared with aspirin for older Chinese patients with stable coronary heart diseases and atrial fibrillation complications.","volume":"52","author":"Liu","year":"2014","journal-title":"Int. J. Clin. Pharm. Ther."},{"key":"B18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/00007691-200302000-00005","article-title":"A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens.","volume":"25","author":"Maria","year":"2003","journal-title":"Ther. Drug Monit."},{"key":"B19","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1177\/0148607109337257","article-title":"Warfarin bioavailability with feeding tubes and enteral formula.","volume":"34","author":"Mark","year":"2010","journal-title":"JPEN J. Parenter Enteral Nutr."},{"key":"B20","doi-asserted-by":"publisher","first-page":"S125","DOI":"10.1016\/j.copbio.2011.05.408","article-title":"The effect of polymorphisms in CYP2C9, CYP4F2, EPHX1 and VKORC1 on warfarin dose in Turkish patients.","volume":"22","author":"\u00d6zer","year":"2011","journal-title":"Curr. Opin. Biotechnol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"6471","DOI":"10.1128\/AAC.01321-15","article-title":"Population pharmacokinetics of fosfomycin in critically Ill patients.","volume":"59","author":"Parker","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S1570-0232(04)00512-4","article-title":"Study of the determination and pharmacokinetics of compound Danshen dripping pills in human serum by column switching liquid chromatography electrospray ion trap mass spectrometry.","volume":"809","author":"Pei","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1093\/jac\/dkx140","article-title":"Population pharmacokinetics and dosing considerations for the use of daptomycin in adult patients with haematological malignancies.","volume":"72","author":"Pier","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2015.07.071","article-title":"Microsomal epoxide hydrolase 1 (EPHX1): gene, structure, function, and role in human disease.","volume":"571","author":"Radka","year":"2015","journal-title":"Gene"},{"key":"B25","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1365-2125.2011.04051.x","article-title":"The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.","volume":"73","author":"Steven","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/718305","article-title":"Metabonomic strategy to the evaluation of Chinese medicine compound Danshen dripping pills interfering myocardial ischemia in rats.","volume":"2013","author":"Xin","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1007\/s00228-016-2098-x","article-title":"Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese.","volume":"72","author":"Zeng","year":"2016","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/jssc.200600287","article-title":"Determination of the main bioactive metabolites of Radix Salvia miltiorrhizae in compound Danshen dripping pills and the tissue distribution of Danshensu in rabbit by SPE-HPLC-MSn.","volume":"30","author":"Zheng","year":"2007","journal-title":"J. Sep. Sci."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00826\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T04:41:13Z","timestamp":1511239273000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00826\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,21]]},"references-count":28,"alternative-id":["10.3389\/fphar.2017.00826"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00826","relation":{},"ISSN":["1663-9812"],"issn-type":[{"type":"electronic","value":"1663-9812"}],"subject":[],"published":{"date-parts":[[2017,11,21]]},"article-number":"826"}}