{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:12:41Z","timestamp":1788199961561,"version":"build-2803163510"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2017.00986","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T04:36:35Z","timestamp":1515558995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Adenine Nucleotides Attenuate Murine T Cell Activation Induced by Concanavalin A or T Cell Receptor Stimulation"],"prefix":"10.3389","volume":"8","author":[{"given":"Yuria","family":"Shinohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutoshi","family":"Tsukimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0100-879X2008005000037","article-title":"Purinergic signalling: past, present and future.","volume":"42","author":"Burnstock","year":"2009","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s11302-014-9427-2","article-title":"Purinergic signalling and immune cells.","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic Signal."},{"key":"B3","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4049\/jimmunol.157.4.1371","article-title":"Murine T lymphocytes modulate activity of an ATP-activated P2Z-type purinoceptor during differentiation.","volume":"157","author":"Chused","year":"1996","journal-title":"J. Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S0736-5748(00)00084-8","article-title":"Involvement of astrocytes in purine-mediated reparative processes in the brain.","volume":"19","author":"Ciccarelli","year":"2001","journal-title":"Int. J. Dev. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/sj.cdd.4400341","article-title":"Cytolytic P2X purinoceptors.","volume":"5","author":"Di Virgilio","year":"1998","journal-title":"Cell Death Differ."},{"key":"B6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response.","volume":"20","author":"Dong","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.immuni.2005.08.013","article-title":"The role of erk1 and erk2 in multiple stages of T cell development.","volume":"23","author":"Fischer","year":"2005","journal-title":"Immunity"},{"key":"B8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ni1295","article-title":"Lymphocyte calcium signaling from membrane to nucleus.","volume":"7","author":"Gallo","year":"2006","journal-title":"Nat. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/83134","article-title":"Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.","volume":"2","author":"Gong","year":"2001","journal-title":"Nat. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"28827","DOI":"10.1074\/jbc.R400012200","article-title":"T cell receptor signaling: beyond complex complexes.","volume":"279","author":"Huang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1093\/emboj\/cdf321","article-title":"The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements.","volume":"21","author":"Kim","year":"2002","journal-title":"EMBO J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1126\/science.8266076","article-title":"Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.","volume":"262","author":"Kondo","year":"1993","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.4049\/jimmunol.174.2.1073","article-title":"A2A Adenosine receptor induction inhibits IFN-\u03b3 production in murine CD4+ T cells.","volume":"174","author":"Lappas","year":"2005","journal-title":"J. Immunol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-10","article-title":"Lectin of concanavalin A as an anti-hepatoma therapeutic agent.","volume":"16","author":"Lei","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S1359-6101(97)00021-X","article-title":"Signaling from the IL-2 receptor to the nucleus.","volume":"8","author":"Lin","year":"1997","journal-title":"Cytokine Growth Factor Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1172\/JCI110786","article-title":"2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets.","volume":"71","author":"Macfarlane","year":"1983","journal-title":"J. Clin. Invest."},{"key":"B17","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/nri1435","article-title":"Tolerance, not immunity, crucially depends on IL-2.","volume":"4","author":"Malek","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1126\/science.181845","article-title":"Selective in vitro growth of T lymphocytes from normal human bone marrows.","volume":"193","author":"Morgan","year":"1976","journal-title":"Science"},{"key":"B20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/369333a0","article-title":"Cytoplasmic domains of the interleukin-2 receptor \u03b2 and \u03b3 chains mediate the signal for T-cell proliferation.","volume":"369","author":"Nelson","year":"1994","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1600-065X.2009.00819.x","article-title":"Calcium signaling in the development and function of T-lineage cells.","volume":"231","author":"Oh-hora","year":"2009","journal-title":"Immunol. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1046\/j.1440-1711.2000.00900.x","article-title":"Do T cells care about the mitogen-activated protein kinase signalling pathways?","volume":"78","author":"Rincon","year":"","journal-title":"Immunol. Cell Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/S0891-5849(00)00219-7","article-title":"The JNK and P38 MAP kinase signaling pathways in T cell\u2013mediated immune responses.","volume":"28","author":"Rincon","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1006\/abbi.2001.2616","article-title":"A retrospective of recombinant P2Y receptor subtypes and their pharmacology.","volume":"397","author":"Sak","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"B25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1006\/cyto.2002.1948","article-title":"Cytokine expression in three mouse models of experimental hepatitis.","volume":"19","author":"Sass","year":"2002","journal-title":"Cytokine"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1160583","article-title":"Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels.","volume":"1","author":"Schenk","year":"2008","journal-title":"Sci. Signal."},{"key":"B27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A.","volume":"90","author":"Tiegs","year":"1992","journal-title":"J. Clin. Invest."},{"key":"B28","doi-asserted-by":"publisher","first-page":"17406","DOI":"10.1074\/jbc.M110.112417","article-title":"Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation.","volume":"285","author":"Tokunaga","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.4049\/jimmunol.1103800","article-title":"Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.","volume":"189","author":"Trabanelli","year":"2012","journal-title":"J. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.4049\/jimmunol.177.5.2842","article-title":"P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways.","volume":"177","author":"Tsukimoto","year":"2006","journal-title":"J. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.bbrc.2009.05.011","article-title":"Blockade of murine T cell activation by antagonists of P2Y6 and P2X7 receptors.","volume":"384","author":"Tsukimoto","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yexcr.2016.05.017","article-title":"Inhibitory effect of extracellular purine nucleotide and nucleoside concentrations on T cell proliferation.","volume":"349","author":"Weiler","year":"2016","journal-title":"Exp. Cell Res."},{"key":"B33","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4049\/jimmunol.156.3.1020","article-title":"MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells.","volume":"156","author":"Whitehurst","year":"1996","journal-title":"J. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1182\/blood-2010-04-277707","article-title":"Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.","volume":"116","author":"Woehrle","year":"2010","journal-title":"Blood"},{"key":"B35","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/01.shk.0000245014.96419.3a","article-title":"Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine.","volume":"27","author":"Yip","year":"2007","journal-title":"Shock"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1096\/fj.08-126458","article-title":"Autocrine regulation of T-cell activation by ATP release and P2X7 receptors.","volume":"23","author":"Yip","year":"2009","journal-title":"FASEB J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1124\/jpet.301.2.705","article-title":"P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse.","volume":"301","author":"Zhang","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B38","first-page":"20","article-title":"MAP kinases in immune responses.","volume":"2","author":"Zhang","year":"2005","journal-title":"Cell. Mol. Immunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00986\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T14:42:21Z","timestamp":1693406541000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2017.00986\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":38,"alternative-id":["10.3389\/fphar.2017.00986"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2017.00986","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]},"article-number":"986"}}