{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:20:02Z","timestamp":1789842002615,"version":"4.0.1"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.00121","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T04:49:52Z","timestamp":1519102192000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression"],"prefix":"10.3389","volume":"9","author":[{"given":"Kyle J.","family":"Brymer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin Y.","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa E.","family":"Kalynchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector J.","family":"Caruncho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.29","article-title":"Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression.","volume":"7","author":"Alves","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1017\/S0033291715001488","article-title":"Depression and the risk of autoimmune disease: a nationally representative, prospective longitudinal study.","volume":"45","author":"Andersson","year":"2015","journal-title":"Psychol. Med."},{"key":"B3","first-page":"460","article-title":"The effects of doxepin on stress-induced learning, memory impairments, and TNF-\u03b1 level in the rat hippocampus.","volume":"10","author":"Azadbakht","year":"2015","journal-title":"Res. Pharm. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.ceb.2011.09.002","article-title":"Cell atrophy and loss in depression: reversal by antidepressant treatment.","volume":"23","author":"Banasr","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1523\/JNEUROSCI.4447-07.2008","article-title":"NMDA receptor plasticity in the perirhinal and prefrontal cortices is crucial for the acquisition of long-term object-in-place associative memory.","volume":"28","author":"Barker","year":"2008","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/cercor\/bht245","article-title":"Object-in-place associative recognition memory depends on glutamate receptor neurotransmission within two defined hippocampal-cortical circuits: a critical role for AMPA and NMDA receptors in the hippocampus, perirhinal, and prefrontal cortices.","volume":"25","author":"Barker","year":"2015","journal-title":"Cereb. Cortex"},{"key":"B7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.physbeh.2013.06.010","article-title":"Effects of long-term etanercept treatment on anxiety- and depression-like neurobehaviors in rats.","volume":"119","author":"Bayramgurler","year":"2013","journal-title":"Physiol. Behav."},{"key":"B8","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.neuron.2005.07.007","article-title":"Modulation of synaptic plasticity and memory by reelin involves differential splicing of the lipoprotein receptor Apoer2.","volume":"47","author":"Beffert","year":"2005","journal-title":"Neuron"},{"key":"B9","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/mp.2008.119","article-title":"The mood- improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling.","volume":"14","author":"Bessa","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jbiotec.2010.01.011","article-title":"Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein.","volume":"146","author":"Boado","year":"2010","journal-title":"J. Biotechnol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.biopsych.2012.04.024","article-title":"Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression.","volume":"72","author":"Boldrini","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","first-page":"558","DOI":"10.2174\/1570159X13666150630171433","article-title":"The involvement of TNF-\u03b1 in cognitive dysfunction associated with major depressive disorder: an opportunity for domain specific treatments.","volume":"13","author":"Bortolato","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"4282","DOI":"10.1093\/cercor\/bhw216","article-title":"Reelin regulates the maturation of dendritic spines, synaptogenesis and glial ensheathment of newborn granule cells.","volume":"26","author":"Bosch","year":"","journal-title":"Cereb. Cortex"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00138","article-title":"Reelin exerts structural, biochemical and transcriptional regulation over presynaptic and postsynaptic elements in the adult hippocampus.","volume":"10","author":"Bosch","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.yebeh.2015.04.046","article-title":"Aberrant hippocampal neurogenesis after limbic kindling: relationship to BDNF and hippocampal-dependent memory.","volume":"47","author":"Botterill","year":"2015","journal-title":"Epilepsy Behav."},{"key":"B16","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.yhbeh.2010.07.012","article-title":"Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam.","volume":"58","author":"Brummelte","year":"","journal-title":"Horm. Behav."},{"key":"B17","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.neuroscience.2010.04.023","article-title":"Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats.","volume":"168","author":"Brummelte","year":"","journal-title":"Neuroscience"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s00213-016-4218-9","article-title":"Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness.","volume":"233","author":"Calcia","year":"2016","journal-title":"Psychopharmacology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1176\/appi.ajp.161.4.598","article-title":"Lower hippocampal volume in patients suffering from depression: a meta-analysis.","volume":"161","author":"Campbell","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00048","article-title":"Reelin-related disturbances in depression: implications for translational studies.","volume":"10","author":"Caruncho","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1073\/pnas.0810764106","article-title":"The N- terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons.","volume":"106","author":"Chameau","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1089\/ars.2012.4569","article-title":"Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress.","volume":"18","author":"Colianna","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbi.2014.09.014","article-title":"Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation.","volume":"44","author":"Czerniawski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain.","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B25","first-page":"12","article-title":"Reelin-mediated signaling during normal and pathological forms of aging.","volume":"1","author":"Doehner","year":"2010","journal-title":"Aging Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression.","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.neubiorev.2005.03.023","article-title":"Cytokines as mediators of depression: what can we learn from animal studies?","volume":"29","author":"Dunn","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173015","article-title":"A bidirectional relationship between depression and the autoimmune disorders \u2013 new perspectives from the national child development study.","volume":"12","author":"Euesden","year":"2017","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.bbi.2010.09.020","article-title":"Dopaminergic neuronal injury in the adult brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicity.","volume":"25","author":"Fan","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/sj.mp.4000783","article-title":"Reduction in reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression.","volume":"5","author":"Fatemi","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.pnpbp.2015.02.001","article-title":"Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation.","volume":"60","author":"Fenton","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B32","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbr.2004.05.013","article-title":"Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats.","volume":"156","author":"Gregus","year":"2005","journal-title":"Behav. Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1038\/npp.2011.220","article-title":"Depression, antidepressants, and neurogenesis: a critical reappraisal.","volume":"36","author":"Hanson","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00078","article-title":"Object location and object recognition memory impairments, motivation deficits and depression in a model of gulf war illness.","volume":"8","author":"Hattiangady","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1111\/ejn.12893","article-title":"Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome.","volume":"41","author":"Hethorn","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1038\/npp.2015.85","article-title":"Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors.","volume":"40","author":"Hill","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.nlm.2014.01.018","article-title":"Chronic stress disrupts fear extinction and enhances amygdala and hippocampal fos expression in an animal model of post-traumatic stress disorder.","volume":"112","author":"Hoffman","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuroscience.2011.11.011","article-title":"Altered object-in-place recognition memory, prepulse inhibition, and locomotor activity in the offspring of rats exposed to a viral mimetic during pregnancy.","volume":"201","author":"Howland","year":"2012","journal-title":"Neuroscience"},{"key":"B39","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.nlm.2009.10.006","article-title":"Effects of acute stress and GluN2B-containing NMDA receptor antagonism on object and object-place recognition memory.","volume":"93","author":"Howland","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"B40","doi-asserted-by":"crossref","first-page":"R807","DOI":"10.1186\/ar1743","article-title":"The differential contribution of tumor necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation.","volume":"7","author":"Inglis","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.bbr.2005.11.019","article-title":"Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor.","volume":"168","author":"Johnson","year":"2006","journal-title":"Behav. Brain Res."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12703","article-title":"The effects of group and single housing and automated animal monitoring on urinary corticosterone levels in male C57BL\/6 mice.","volume":"4","author":"Kamakura","year":"2016","journal-title":"Physiol. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/mp.2016.167","article-title":"Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions.","volume":"23","author":"Kappelmann","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1001\/archgenpsychiatry.2010.136","article-title":"Dependent stressful life events and prior depressive episodes in the prediction of major depression: the problem of causal interference in psychiatric epidemiology.","volume":"67","author":"Kendler","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/hep.21003","article-title":"TNF-\u03b1 secreting monocytes are recruited into the brain of cholestatic mice.","volume":"43","author":"Kerfoot","year":"2006","journal-title":"Hepatology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1016\/j.bbi.2012.05.017","article-title":"Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors.","volume":"30","author":"Kesler","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.bbi.2016.08.001","article-title":"Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice.","volume":"58","author":"Klaus","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.jpsychires.2013.01.007","article-title":"Antidepressant effects of TNF-\u03b1 blockade in an animal model of depression.","volume":"47","author":"Krugel","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"B49","first-page":"16","article-title":"Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB\/c and C57BL\/6 mice.","volume":"47","author":"Laber","year":"2008","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1023\/A:1021171129766","article-title":"Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission.","volume":"33","author":"Lapiz","year":"2003","journal-title":"Neurosci. Behav. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.pbb.2003.11.011","article-title":"Long-term social isolation and medial prefrontal cortex: dopaminergic and cholinergic neurotransmission.","volume":"77","author":"Leng","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B52","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ynstr.2014.11.003","article-title":"Role of adult hippocampal neurogenesis in stress resilience.","volume":"1","author":"Levone","year":"2015","journal-title":"Neurobiol. Stress"},{"key":"B53","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neulet.2009.05.050","article-title":"Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus.","volume":"460","author":"Lussier","year":"2009","journal-title":"Neurosci. Lett."},{"key":"B54","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neuropharm.2013.04.012","article-title":"The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus.","volume":"71","author":"Lussier","year":"","journal-title":"Neuropharmacology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neuroscience.2012.11.037","article-title":"Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress.","volume":"231","author":"Lussier","year":"","journal-title":"Neuroscience"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.neuropharm.2010.09.007","article-title":"Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice.","volume":"60","author":"Lussier","year":"2011","journal-title":"Neuropharmacology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"617","DOI":"10.2217\/ijr.11.62","article-title":"Depression in patients with rheumatoid arthritis: description, causes, and mechanisms.","volume":"6","author":"Margaretten","year":"2011","journal-title":"Int. J. Clin. Rheumatol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.physbeh.2009.04.014","article-title":"Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced-swim test without altering nonspecific locomotor activity or muscle strength.","volume":"98","author":"Marks","year":"2009","journal-title":"Physiol. Behav."},{"key":"B59","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/mp.2013.56","article-title":"Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression.","volume":"18","author":"Mateus-Pinheiro","year":"","journal-title":"Mol. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.141","article-title":"Sustained remission from depressive-like behavior depends on hippocampal neurogenesis.","volume":"3","author":"Mateus-Pinheiro","year":"","journal-title":"Transl. Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-45","article-title":"TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease.","volume":"5","author":"McCoy","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"B62","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression.","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.120","article-title":"The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression.","volume":"7","author":"Morais","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2017.00101","article-title":"The evidence for altered BNDF expression in the brain of rats reared or housed in social isolation: a systematic review.","volume":"11","author":"Murinova","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"10339","DOI":"10.1523\/JNEUROSCI.1917-08.2008","article-title":"The reelin signaling pathway promotes dendritic spine development in hippocampal neurons.","volume":"28","author":"Niu","year":"2008","journal-title":"J. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1007\/s10620-015-4007-z","article-title":"Inflammatory bowel disease provoked by etanercept: report of 443 possible cases combined from an IBD referral center and the FDA.","volume":"61","author":"O\u2019Toole","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1073\/pnas.95.6.3221","article-title":"Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats.","volume":"95","author":"Pesold","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4636","DOI":"10.1523\/JNEUROSCI.5284-09.2010","article-title":"Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation.","volume":"30","author":"Pujadas","year":"2010","journal-title":"J. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4443","article-title":"Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer\u2019s disease.","volume":"5","author":"Pujadas","year":"2014","journal-title":"Nat. Commun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","article-title":"A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment resistant depression: the role of baseline inflammatory biomarkers.","volume":"70","author":"Raison","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/sj.mp.4001791","article-title":"Neural stem cell proliferation is decreased in schizophrenia, but not in depression.","volume":"11","author":"Reif","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.11.023","article-title":"Cytokines dysregulation in schizophrenia: a systematic review of psychoneuroimmune relationship.","author":"Rodrigues-Amorim","year":"2017","journal-title":"Schizophr. Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1017\/S1740925X09990184","article-title":"Reelin and apoE actions on signal transduction, synaptic function and memory formation.","volume":"4","author":"Rogers","year":"2008","journal-title":"Neuron Glia Biol."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/130429","article-title":"The coexpression of reelin and neuronal nitric oxide synthase in a subpopulation of dentate gyrus neurons is downregulated in heterozygous reeler mice.","volume":"2010","author":"Romay-Tallon","year":"2010","journal-title":"Neural Plast."},{"key":"B75","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.brainres.2014.10.050","article-title":"Differential effects of corticosterone on the colocalization of reelin and neuronal nitric oxide synthase in the adult hippocampus in wild type and heterozygous reeler mice.","volume":"1594","author":"Romay-Tallon","year":"2015","journal-title":"Brain Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1146\/annurev.ne.02.030179.002445","article-title":"The biology of affective disorders.","volume":"2","author":"Sachar","year":"1979","journal-title":"Annu. Rev. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bbr.2015.05.062","article-title":"TNF-\u03b1lpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression.","volume":"292","author":"Sahin","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1756-185X.2012.01740.x","article-title":"Severe pancytopenia following etanercept administration in rheumatoid arthritis.","volume":"15","author":"Santana","year":"2012","journal-title":"Int. J. Rheum. Dis."},{"key":"B79","first-page":"624","article-title":"The laboratory rat: relating its age with human\u2019s.","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1007\/s11064-017-2203-2","article-title":"Brief social isolation in the adolescent wistar-kyoto rat model of endogenous depression alters corticosterone and regional monoamine concentrations.","volume":"42","author":"Shetty","year":"","journal-title":"Neurochem. Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.bbr.2016.12.030","article-title":"Immediate and delayed anxiety-and depression-like profiles in the adolescent wistar-kyoto rat model of endogenous depression following postweaning social isolation.","volume":"320","author":"Shetty","year":"","journal-title":"Behav. Brain Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3109\/10253890903531582","article-title":"Stress-induced suppression of hippocampal neurogenesis in adult male rats is altered by prenatal ethanol exposure.","volume":"13","author":"Sliwowska","year":"2010","journal-title":"Stress"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1038\/nn.3572","article-title":"Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.","volume":"16","author":"Song","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1523\/JNEUROSCI.4486-04.2005","article-title":"Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha.","volume":"25","author":"Stellwagen","year":"2005","journal-title":"J. Neurosci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.pnpbp.2010.03.005","article-title":"Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: relevance to depression.","volume":"34","author":"Sterner","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B86","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1038\/npp.2011.153","article-title":"Overexpression of reelin prevents the manifestation of behavioural phenotypes related to schizophrenia and bipolar disorder.","volume":"36","author":"Teixeira","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.rmed.2009.01.002","article-title":"Pulmonary complications of tumor necrosis factor-targeted therapy.","volume":"103","author":"Thavaranjah","year":"2009","journal-title":"Respir. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbr.2013.07.038","article-title":"Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice.","volume":"253","author":"van Heesch","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s12640-016-9696-3","article-title":"Early-life social isolation-induced depressive-like behavior in rats results in microglial activation and neuronal histone methylation that are mitigated by minocycline.","volume":"31","author":"Wang","year":"2017","journal-title":"Neurotox. Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pbb.2013.09.014","article-title":"Intermittent swim stress causes Morris water maze performance deficits in a massed-learning trial procedure that are exacerbated by reboxetine.","volume":"113","author":"Warner","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B91","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.bbr.2003.10.015","article-title":"Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat.","volume":"152","author":"Weiss","year":"2004","journal-title":"Behav. Brain Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nm.2016.69","article-title":"Integrating neuroimmune stress systems in the neurobiology of depression.","volume":"17","author":"Wohleb","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0165-5728(00)00375-1","article-title":"Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior.","volume":"111","author":"Yamanda","year":"2000","journal-title":"J. Neuroimmunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00121\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T04:49:57Z","timestamp":1519102197000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00121\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":93,"alternative-id":["10.3389\/fphar.2018.00121"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.00121","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,20]]},"article-number":"121"}}