{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:05:21Z","timestamp":1785823521150,"version":"3.56.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673440"],"award-info":[{"award-number":["81673440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473585"],"award-info":[{"award-number":["81473585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.00187","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T04:21:11Z","timestamp":1520223671000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Exploring the Mechanism of Dangguiliuhuang Decoction Against Hepatic Fibrosis by Network Pharmacology and Experimental Validation"],"prefix":"10.3389","volume":"9","author":[{"given":"Hui","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongdan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis.","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00445","article-title":"Immune and metabolic regulation mechanism of Dangguiliuhuang decoction against insulin resistance and hepatic steatosis.","volume":"8","author":"Cao","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015939","article-title":"TCM Database@Taiwan: the world\u2019s largest traditional Chinese medicine database for drug screening in silico.","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"B4","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ejphar.2017.06.027","article-title":"Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-kappa B and MAPK signaling pathways.","volume":"811","author":"Chen","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jnutbio.2016.03.011","article-title":"Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by upregulating PPAR-\u03b3 associated mechanisms.","volume":"33","author":"Chuang","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2003-4-9-r60","article-title":"DAVID: database for annotation, visualization, and integrated discovery.","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.jhep.2011.09.024","article-title":"Clinical evidence for the regression of liver fibrosis.","volume":"56","author":"Ellis","year":"2012","journal-title":"J. Hepatol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020191","article-title":"Silymarin\/Silybin and chronic liver disease: a marriage of many years.","volume":"22","author":"Federico","year":"2017","journal-title":"Molecules"},{"key":"B9","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1159\/000374098","article-title":"Hepatic fibrosis: emerging therapies.","volume":"33","author":"Friedman","year":"2015","journal-title":"Dig. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online mendelian inheritance in man (OMIM), a knowledgebase of human genes and genetic disorders.","volume":"33","author":"Hamosh","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"11392","DOI":"10.1074\/jbc.M310284200","article-title":"Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells.","volume":"279","author":"Hazra","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies.","volume":"46","author":"Hemmann","year":"2007","journal-title":"J. Hepatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis.","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.2042-7158.2012.01570.x","article-title":"Inhibitory effect of Astragalus membranaceus root on matrix metalloproteinase-1 collagenase expression and procollagen destruction in ultraviolet B-irradiated human dermal fibroblasts by suppressing nuclear factor kappa-B activity.","volume":"65","author":"Hong","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.jep.2013.12.011","article-title":"Metabonomics study on the hepatoprotective effect of polysaccharides from different preparations of Angelica sinensis.","volume":"151","author":"Hua","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/hep.24190","article-title":"Suppression of innate immunity (Natural Killer Cell\/Interferon-gamma) in the advanced stages of liver fibrosis in mice.","volume":"53","author":"Jeong","year":"2011","journal-title":"Hepatology"},{"key":"B17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes.","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3181\/0707-MR-190","article-title":"Mechanisms of fibrogenesis.","volume":"233","author":"Kisseleva","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.imbio.2017.10.046","article-title":"An in vitro inflammation model to study the Nrf2 and NF-\u03baB crosstalk in presence of ferulic acid as modulator.","volume":"223","author":"Lampiasi","year":"2017","journal-title":"Immunobiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biochi.2015.10.006","article-title":"6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-\u03baB in human monocytic cells.","volume":"119","author":"Le","year":"2015","journal-title":"Biochimie"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112497","article-title":"Quercetin mitigates inflammatory responses induced by vascular endothelial growth factor in mouse retinal photoreceptor cells through suppression of nuclear factor Kappa B.","volume":"18","author":"Lee","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/jdi.12516","article-title":"Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe-\/- mice with hyperhomocysteinemia.","volume":"7","author":"Li","year":"2016","journal-title":"J. Diabetes Investig."},{"key":"B23","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/labinvest.2008.20","article-title":"Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.","volume":"88","author":"Lin","year":"2008","journal-title":"Lab. Invest."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/srep13982","article-title":"Interaction of dendritic cells and T lymphocytes for the therapeutic effect of Dangguiliuhuang decoction to autoimmune diabetes.","volume":"5","author":"Liu","year":"2015","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1478-3231.2005.01192.x","article-title":"Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis.","volume":"26","author":"Liu","year":"2006","journal-title":"Liver Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1146\/annurev.pharmtox.45.120403.095906","article-title":"Hepatic fibrosis: molecular mechanisms and drug targets.","volume":"45","author":"Lotersztajn","year":"2005","journal-title":"Annu. Rev. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-kappa B in the liver-linking injury, fibrosis and hepatocellular carcinoma.","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepat."},{"key":"B28","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.biopha.2017.01.107","article-title":"Sorafenib: a potential therapeutic drug for hepatic fibrosis and its outcomes.","volume":"88","author":"Ma","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B29","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.biopha.2017.07.101","article-title":"Berberine ameliorates methotrexate-induced liver injury by activating Nrf2\/HO-1 pathway and PPAR\u03b3, and suppressing oxidative stress and apoptosis in rats.","volume":"94","author":"Mahmoud","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B30","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1007\/s11418-016-0988-y","article-title":"Catalpol reduces the production of inflammatory mediators via PPAR-\u03b3 activation in human intestinal Caco-2 cells.","volume":"70","author":"Park","year":"2016","journal-title":"J. Nat. Med."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"key":"B32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/nar\/gkg050","article-title":"Human gene-centric databases at the Weizmann institute of science: GeneCards, UDB, CroW 21 and HORDE.","volume":"31","author":"Safran","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways.","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s11418-017-1129-y","article-title":"Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-\u03baB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids.","volume":"72","author":"Shimizu","year":"2018","journal-title":"J. Nat. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"G631","DOI":"10.1152\/ajpgi.00185.2007","article-title":"Selective inactivation of NF-kappa B in the liver using NF-kappa B decoy suppresses CCl4-induced liver injury and fibrosis.","volume":"293","author":"Son","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ejphar.2010.01.002","article-title":"Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats.","volume":"631","author":"Sun","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/S0140-6736(08)61354-9","article-title":"Traditional Chinese medicine.","volume":"372","author":"Tang","year":"2008","journal-title":"Lancet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2012.09.051","article-title":"Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease.","volume":"145","author":"Tao","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8762345","article-title":"Berberine inhibition of fibrogenesis in a rat model of liver fibrosis and in hepatic stellate cells.","volume":"2016","author":"Wang","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071036","article-title":"Demethyleneberberine protects against hepatic fibrosis in mice by modulating NF-\u03baB signaling.","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ejphar.2016.03.037","article-title":"Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.","volume":"780","author":"Wu","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bcp.2014.10.016","article-title":"Ferulic acid suppresses activation of hepatic stellate cells through ERK1\/2 and Smad signaling pathways in vitro.","volume":"93","author":"Xu","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"6964","DOI":"10.3390\/ijms13066964","article-title":"A novel chemometric method for the prediction of human oral bioavailability.","volume":"13","author":"Xu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"B44","first-page":"91","article-title":"Experimental advance of applying emodin for prevention and treatment of liver diseases.","volume":"28","author":"Xu","year":"2008","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/srep09463","article-title":"Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation.","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/srep04154","article-title":"A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma.","volume":"4","author":"Zhang","year":"2014","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00187\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T23:32:03Z","timestamp":1603927923000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00187\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":46,"alternative-id":["10.3389\/fphar.2018.00187"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.00187","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]},"article-number":"187"}}