{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:03:02Z","timestamp":1790744582599,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.00484","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T07:50:09Z","timestamp":1526975409000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Vasorelaxant and Hypotensive Effects of an Ethanolic Extract of Eulophia macrobulbon and Its Main Compound 1-(4\u2032-Hydroxybenzyl)-4,8-Dimethoxyphenanthrene-2,7-Diol"],"prefix":"10.3389","volume":"9","author":[{"given":"Sutthinee","family":"Wisutthathum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krongkarn","family":"Chootip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornkanok","family":"Ingkaninan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapapan","family":"Temkitthawon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perle","family":"Totoson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Demougeot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00299-015-1829-2","article-title":"Medicinal orchids in India and their conservation: a review.","volume":"7","author":"Behera","year":"2013","journal-title":"Floricult. Ornament. Biotechnol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1549-8719.2011.00109.x","article-title":"Smooth muscle Ca2+-activated and voltage-gated K+ channels modulate conducted dilation in rat isolated small mesenteric arteries.","volume":"18","author":"Beleznai","year":"2011","journal-title":"Microcirculation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/qjmed\/hci094","article-title":"The uses and misuses of orchids in medicine.","volume":"98","author":"Bulpitt","year":"2005","journal-title":"QJM"},{"key":"B4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0008-6363(02)00611-9","article-title":"NO contributes to EDHF-like responses in rat small arteries: a role for NO stores.","volume":"57","author":"Chauhan","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.sajb.2010.09.015","article-title":"The ethnobotany of South African medicinal orchids.","volume":"77","author":"Chinsamy","year":"2011","journal-title":"S. Afr. J. Bot."},{"key":"B6","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.sajb.2013.12.004","article-title":"Anti-inflammatory, antioxidant, anti-cholinesterase activity and mutagenicity of South African medicinal orchids.","volume":"91","author":"Chinsamy","year":"2014","journal-title":"S. Afr. J. Bot."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1016\/j.fct.2012.05.005","article-title":"Suppression of adhesion molecule expression by phenanthrene-containing extract of bulbils of Chinese Yam in vascular smooth muscle cells through inhibition of MAPK, Akt and NF-\u03baB.","volume":"50","author":"Choi","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1111\/j.1476-5381.2010.00780.x","article-title":"9,10-dihydro-2,5dimethoxyphenanthrene-1,7diol, from Eulophia ochreata, inhibits inflammatory signalling mediated by Toll-like receptors.","volume":"160","author":"Datla","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"B9","first-page":"106","article-title":"Total phenolics, flavonoids content and antioxidant activities of some Eulophia species.","volume":"5","author":"Dawande","year":"2017","journal-title":"J. Med. Plants"},{"key":"B10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1006\/jmcc.1998.0840","article-title":"The alternative: EDHF.","volume":"31","author":"F\u00e9l\u00e9tou","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1124\/pr.110.002907","article-title":"cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.","volume":"62","author":"Francis","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"6276","DOI":"10.1021\/jf0508044","article-title":"Phytotoxic activity of bibenzyl derivatives from the orchid Epidendrum rigidum.","volume":"53","author":"Hern\u00e1ndez-Romero","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ejphar.2008.08.013","article-title":"Litebamine, a phenanthrene alkaloid from the wood of Litsea cubeba, inhibits rat smooth muscle cell adhesion and migration on collagen.","volume":"596","author":"Huang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/01.HYP.35.1.173","article-title":"Ion channels and vascular tone.","volume":"35","author":"Jackson","year":"2000","journal-title":"Hypertension"},{"key":"B15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/ptr.4685","article-title":"Bacopa monnieri increases cerebral blood flow in rat independent of blood pressure.","volume":"27","author":"Kamkaew","year":"2013","journal-title":"Phytother. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0922-4106(91)90056-N","article-title":"Characterisation of cyclic nucleotide phosphodiesterases from rat mesenteric artery.","volume":"208","author":"Komas","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"B17","first-page":"7","article-title":"Recent advances in traditional plant drugs and orchids.","volume":"24","author":"Kong","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.phytochem.2007.12.005","article-title":"Natural phenanthrenes and their biological activity.","volume":"69","author":"Kov\u00e1cs","year":"2008","journal-title":"Phytochemistry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1159\/000457802","article-title":"A phenanthrene derivative, 5,7-dimethoxy-1,4-phenanthrenequinone, inhibits cell adhesion molecule expression and migration in vascular endothelial and smooth muscle cells.","volume":"99","author":"Lo","year":"2017","journal-title":"Pharmacology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.pharmthera.2005.07.003","article-title":"Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.","volume":"109","author":"Lugnier","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-987398","article-title":"Dendrobium huoshanense C.Z. Tang et S.J. Cheng: micropropagation and anticataract acitivity.","volume":"73","author":"Luo","year":"2007","journal-title":"Planta Med."},{"key":"B22","first-page":"705","article-title":"Phytochemical survey of orchids in the Tirunelveli hills of South India.","volume":"2008","author":"Maridass","year":"2008","journal-title":"Ethnobotanical Leaflets"},{"key":"B23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nrd4228","article-title":"Advances in targeting cyclic nucleotide phosphodiesterases.","volume":"13","author":"Maurice","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"B24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00018-011-0815-2","article-title":"Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle.","volume":"69","author":"Morgado","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"198","DOI":"10.5455\/jice.20160324054420","article-title":"Amarkand: a comprehensive review on its ethnopharmacology, nutritional aspects, and taxonomy.","volume":"5","author":"Narkhede","year":"2016","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1161\/01.CIR.57.1.144","article-title":"Hemodynamic effects of intravenous sodium nitroprusside in the conscious dog.","volume":"57","author":"Pagani","year":"1978","journal-title":"Circulation"},{"key":"B27","doi-asserted-by":"publisher","first-page":"448","DOI":"10.5897\/AJPS2013.1031","article-title":"Medicinal orchids and their uses: tissue culture a potential alternative for conservation.","volume":"7","author":"Pant","year":"2013","journal-title":"Afr. J. Plant Sci."},{"key":"B28","first-page":"297","article-title":"Ethnobotanical potential of Eulophia species for their possible biological activity.","volume":"21","author":"Patil","year":"2013","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1021\/np300508v","article-title":"Ex vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa.","volume":"75","author":"Rend\u00f3n-Vallejo","year":"2012","journal-title":"J. Nat. Prod."},{"key":"B30","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1161\/01.RES.0000087541.15600.2B","article-title":"Cyclic GMP phosphodiesterases and regulation of smooth muscle function.","volume":"93","author":"Rybalkin","year":"2003","journal-title":"Circ. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/sj.bjp.0703831","article-title":"Evidence for expression and function of phosphodiesterase type 5 (PDE-V) in rat resistance arteries.","volume":"132","author":"Sampson","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone.","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.phymed.2016.11.018","article-title":"Eulophia macrobulbon - an orchid with significant anti-inflammatory and antioxidant effect and anticancerogenic potential exerted by its root extract.","volume":"24","author":"Schuster","year":"2017","journal-title":"Phytomedicine"},{"key":"B34","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/j.1472-8206.2011.01025.x","article-title":"New insights into the mechanisms of the vasorelaxant effects of apocynin in rat thoracic aorta.","volume":"27","author":"Senejoux","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/BF03022053","article-title":"Etomidate attenuates phenylephrine-induced contraction in isolated rat aorta.","volume":"52","author":"Shin","year":"2005","journal-title":"Can. J. Anaesth."},{"key":"B36","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jep.2009.12.031","article-title":"Cytotoxic activity of 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol from Eulophia nuda against human cancer cells.","volume":"128","author":"Shriram","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"B37","first-page":"11627","article-title":"Medicinal properties and uses of orchids: a concise review.","volume":"52","author":"Singh","year":"2012","journal-title":"Elixir Appl. Bot."},{"key":"B38","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0014-5793(93)80542-3","article-title":"Verapamil and diltiazem inhibit receptor-operated calcium channels and intracellular calcium oscillations in rat hepatocytes.","volume":"318","author":"Striggow","year":"1993","journal-title":"FEBS Lett."},{"key":"B39","first-page":"300","article-title":"Aphrodisiac activity of Vanda tessellates (Roxb.) Hook. ex Don extract in male mice.","volume":"32","author":"Suresh Kumar","year":"2000","journal-title":"Ind. J. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3329\/bjp.v8i3.14880","article-title":"Evaluation of hypolipidemic, antidiabetic and antioxidant activity of Eulophia herbacea tubers.","volume":"8","author":"Tatiya","year":"2013","journal-title":"Bangladesh J. Pharmacol."},{"key":"B41","first-page":"79","article-title":"Phenanthrenes from Eulophia macrobulbon as Novel Phosphodiesterase-5 Inhibitors.","volume":"12","author":"Temkitthawon","year":"2017","journal-title":"Nat. Prod. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jep.2009.10.036","article-title":"Vasorelaxant effects of extracts of the stem bark of Terminalia superba Engler & Diels (Combretaceae).","volume":"127","author":"Tom","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1016\/S0031-9422(00)98006-3","article-title":"Benzylated phenanthrenes from Eulophi nuda.","volume":"28","author":"Tuchinda","year":"1989","journal-title":"Phytochemistry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1152\/advan.00025.2003","article-title":"Smooth muscle contraction and relaxation.","volume":"27","author":"Webb","year":"2003","journal-title":"Adv. Physiol. Educ."},{"key":"B45","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1440-1681.1993.tb01717.x","article-title":"Different responses to acetylcholine in the presence of nitric oxide inhibitor in rat aortae and mesenteric arteries.","volume":"20","author":"Wu","year":"1993","journal-title":"Clin. Exp. Pharmacol. Physiol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.00484\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T07:50:15Z","timestamp":1526975415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.00484\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,22]]},"references-count":45,"alternative-id":["10.3389\/fphar.2018.00484"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.00484","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,22]]},"article-number":"484"}}