{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:33:48Z","timestamp":1782430428439,"version":"3.54.5"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.00489","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T05:03:36Z","timestamp":1526360616000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Combination Therapy Strategies Against Multiple-Resistant Streptococcus Suis"],"prefix":"10.3389","volume":"9","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s10096-016-2616-x","article-title":"Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance","volume":"35","author":"Bojarska","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e005066","DOI":"10.1099\/jmmcr.0.005066","article-title":"Streptococcus suis serotype 2 strains isolated in Argentina (South America) are different from those recovered in North America and present a higher risk for humans","volume":"3","author":"Callejo","year":"2016","journal-title":"JMM Case Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ijantimicag.2009.01.007","article-title":"Resistance to tetracycline, erythromycin and clindamycin in Streptococcus suis serotype 2 in Hong Kong","volume":"34","author":"Chu","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B4","volume-title":"Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacterial Isolated from Animals; Approved Standard-Fourth Edition and Supplement, VET01A4E and VET01S2E","year":"2013"},{"key":"B5","first-page":"775","article-title":"Resumption of cell division in filaments induced in E. coli by beta-lactam antibiotics possessing affinity for PBP-3","volume":"10","author":"Costa","year":"1984","journal-title":"Drugs Exp. Clin. Res."},{"key":"B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/516284","article-title":"Pharmacokinetic-pharmacodynamic parameters: rationale for antibacterial dosing of mice and men","volume":"26","author":"Craig","year":"1998","journal-title":"Clin Infect Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ijid.2017.09.011","article-title":"Streptococcus suis meningitis can require a prolonged treatment course","volume":"65","author":"Dejace","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"556","DOI":"10.14202\/vetworld.2017.556-561","article-title":"Prevalence of multiple drug resistant Streptococcus suis in and around Guwahati, India","volume":"10","author":"Devi","year":"2017","journal-title":"Vet. World"},{"key":"B9","first-page":"677","article-title":"Streptococcus suis bacteraemia","volume":"100","author":"Dickie","year":"1987","journal-title":"N. Z. Med. J."},{"key":"B10","first-page":"106","article-title":"Genetic diversity of Streptococcus suis serotype 2 isolated from pigs in Brazil","volume":"80","author":"Doto","year":"2016","journal-title":"Can. J. Vet. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"683","DOI":"10.26444\/aaem\/79813","article-title":"Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part I \u2013 Epidemiology","volume":"24","author":"Dutkiewicz","year":"2017","journal-title":"Ann. Agric. Environ. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.vetmic.2009.06.024","article-title":"Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United States","volume":"139","author":"Fittipaldi","year":"2009","journal-title":"Vet. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.3201\/eid2312.171005","article-title":"Human case of Streptococcus suis disease, Ontario, Canada","volume":"23","author":"Gomez-Torres","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1017\/S1466252307001247","article-title":"Streptococcus suis infections in humans: the Chinese experience and the situation in North America","volume":"8","author":"Gottschalk","year":"2007","journal-title":"Anim. Heal. Res. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1038\/emi.2014.45","article-title":"Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing","volume":"3","author":"Goyette-Desjardins","year":"2014","journal-title":"Emerg. Microbes Infect."},{"key":"B16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.medmal.2017.10.001","article-title":"Understanding the virulence of Streptococcus suis: a veterinary, medical, and economic challenge","volume":"48","author":"Haas","year":"2017","journal-title":"Med. Mal. Infect."},{"key":"B17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.vetmic.2017.06.002","article-title":"Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014","volume":"207","author":"Hernandez-Garcia","year":"2017","journal-title":"Vet. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2334-11-6","article-title":"The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008","volume":"11","author":"Hoa","year":"2011","journal-title":"BMC Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e6072","DOI":"10.1371\/journal.pone.0006072","article-title":"Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis","volume":"4","author":"Holden","year":"2009","journal-title":"PLoS ONE"},{"key":"B20","first-page":"150","article-title":"[Studies on human streptococcal infectious syndrome caused by infected pigs]","volume":"34","author":"Hu","year":"2000","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1002\/jsfa.6841","article-title":"Genetic diversity of Streptococcus suis isolated from three pig farms of China obtained by acquiring antibiotic resistance genes","volume":"95","author":"Huang","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"B22","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.clineuro.2004.10.006","article-title":"Bacterial meningitis in Hong Kong: 10-years' experience","volume":"107","author":"Hui","year":"2005","journal-title":"Clin Neurol Neurosurg"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3201\/eid2007.131594","article-title":"Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans","volume":"20","author":"Huong","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"B24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.5694\/j.1326-5377.2008.tb02100.x","article-title":"Two cases of Streptococcus suis endocarditis in Australian piggery workers","volume":"189","author":"Kennedy","year":"2008","journal-title":"Med. J. Aust."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1128\/AAC.01324-10","article-title":"Dose range evaluation of Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, in combination with amphotericin B-desoxycholate for treatment of murine systemic candidiasis","volume":"55","author":"Louie","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S1473-3099(07)70001-4","article-title":"Streptococcus suis: an emerging zoonotic pathogen","volume":"7","author":"Lun","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1086\/527385","article-title":"Streptococcus suis meningitis in adults in Vietnam","volume":"46","author":"Mai","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"B28","volume-title":"Resistance Breakpoints for Antimicrobials Used in Animals","year":"2014"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5636","DOI":"10.1128\/AAC.02630-14","article-title":"Genetic environment of the lnu(B) gene in a Streptococcus agalactiae clinical isolate","volume":"58","author":"Montilla","year":"2014","journal-title":"Antimicrob. Agents Chemother"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e17604","DOI":"10.1371\/journal.pone.0017604","article-title":"Risk factors of Streptococcus suis infection in Vietnam. a case-control study","volume":"6","author":"Nghia","year":"2011","journal-title":"PLoS ONE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fmicb.2011.00235","article-title":"Streptococcus suis, an emerging drug-resistant animal and human pathogen","volume":"2","author":"Palmieri","year":"2011","journal-title":"Front. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1699-0463.1968.tb03456.x","article-title":"Group R streptococci pathogenic for man. Two cases of meningitis and one fatal case of sepsis","volume":"74","author":"Perch","year":"1968","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"B33","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1186\/s12879-016-2006-0","article-title":"Human meningitis due to Streptococcus suis in Lom\u00e9, Togo: a case report","volume":"16","author":"Prince-David","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12879-017-2294-z","article-title":"Case report: two human Streptococcus suis infections in Borneo, Sabah, Malaysia","volume":"17","author":"Rajahram","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.femsle.2005.02.034","article-title":"Update on acquired tetracycline resistance genes","volume":"245","author":"Roberts","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.1002\/1873-3468.12364","article-title":"Initial steps of the pathogenesis of the infection caused by Streptococcus suis: fighting against nonspecific defenses","volume":"590","author":"Segura","year":"2016","journal-title":"FEBS Lett."},{"key":"B37","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.tim.2017.02.005","article-title":"Critical streptococcus suis virulence factors: are they all really critical?","volume":"25","author":"Segura","year":"2017","journal-title":"Trends Microbiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/82_2016_506","article-title":"Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis","volume":"398","author":"Seitz","year":"2016","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1017\/S0022215100089040","article-title":"Permanent perceptive deafness due to Streptococcus suis type II infection","volume":"94","author":"Shneerson","year":"1980","journal-title":"J. Laryngol. Otol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.idcr.2016.09.011","article-title":"Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: the first report and literature review","volume":"6","author":"Taniyama","year":"2016","journal-title":"IDCases"},{"key":"B41","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1017\/S1466252313000029","article-title":"Antimicrobial resistance and prudent drug use for Streptococcus suis","volume":"14","author":"Varela","year":"2013","journal-title":"Anim. Health Res. Rev."},{"key":"B42","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1128\/AAC.00713-13","article-title":"First report of the multiresistance gene cfr in Streptococcus suis","volume":"57","author":"Wang","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B43","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fvets.2016.00075","article-title":"Pharmacokinetic\/pharmacodynamic profiles of tiamulin in an experimental intratracheal infection model of mycoplasma gallisepticum","volume":"3","author":"Xiao","year":"2016","journal-title":"Front. Vet. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"914","DOI":"10.3201\/eid1206.051194","article-title":"Human Streptococcus suis outbreak, Sichuan, China","volume":"12","author":"Yu","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"284303","DOI":"10.1155\/2015\/284303","article-title":"Antimicrobial resistance profile and genotypic characteristics of Streptococcus suis capsular type 2 isolated from clinical carrier sows and diseased pigs in China","volume":"2015","author":"Zhang","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"B46","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.tvjl.2014.05.010","article-title":"Integration of pharmacokinetic and pharmacodynamic indices of valnemulin in broiler chickens after a single intravenous and intramuscular administration","volume":"201","author":"Zhao","year":"2014","journal-title":"Vet. J."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00489\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T01:39:24Z","timestamp":1571362764000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00489\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":46,"alternative-id":["10.3389\/fphar.2018.00489"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.00489","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"article-number":"489"}}