{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:28:29Z","timestamp":1762295309450,"version":"3.41.2"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.00499","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T04:26:23Z","timestamp":1526531183000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Proton Pump Inhibitors in IPF: A Call for Clinical Trials"],"prefix":"10.3389","volume":"9","author":[{"given":"Yohannes T.","family":"Ghebre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3109\/08923970009016425","article-title":"Omeprazole inhibits phagocytosis and acidification of phagolysosomes of normal human neutrophils in vitro.","volume":"22","author":"Agastya","year":"2000","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.bbrc.2006.04.170","article-title":"Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells.","volume":"345","author":"Becker","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"10993","DOI":"10.1074\/jbc.M210328200","article-title":"A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.","volume":"278","author":"Biswas","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.biopha.2017.11.028","article-title":"Esomeprazole ameliorates CCl4 induced liver fibrosis in rats via modulating oxidative stress, inflammatory, fibrogenic and apoptotic markers.","volume":"97","author":"Eltahir","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1093\/qjmed\/hcw115","article-title":"Proton pump inhibitors in IPF: beyond mere suppression of gastric acidity.","volume":"109","author":"Ghebre","year":"","journal-title":"QJM"},{"key":"B6","article-title":"Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: flip side of the story.","volume":"3","author":"Ghebre","year":"2016","journal-title":"Inflamm. Cell Signal."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1164\/rccm.201512-2316PP","article-title":"Idiopathic pulmonary fibrosis: novel concepts of proton pump inhibitors as antifibrotic drugs.","volume":"193","author":"Ghebre","year":"","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0614-x","article-title":"Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis.","volume":"13","author":"Ghebremariam","year":"2015","journal-title":"J. Transl. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1161\/CIRCULATIONAHA.113.003602","article-title":"Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.","volume":"128","author":"Ghebremariam","year":"2013","journal-title":"Circulation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s00011-006-6056-4","article-title":"Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors.","volume":"55","author":"Handa","year":"2006","journal-title":"Inflamm. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1001\/archsurg.2011.216","article-title":"Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation.","volume":"146","author":"Hoppo","year":"2011","journal-title":"Arch. Surg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1200\/JOP.2013.001351","article-title":"High cancer drug prices in the United States: reasons and proposed solutions.","volume":"10","author":"Kantarjian","year":"2014","journal-title":"J. Oncol. Pract."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1007\/s10620-009-0951-9","article-title":"Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications.","volume":"54","author":"Kedika","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.","volume":"370","author":"King","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1159\/000468546","article-title":"Antacid therapy and disease progression in patients with idiopathic pulmonary fibrosis who received pirfenidone.","volume":"93","author":"Kreuter","year":"2017","journal-title":"Respiration"},{"key":"B16","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S2213-2600(16)00067-9","article-title":"Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: a pooled analysis.","volume":"4","author":"Kreuter","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0014-5793(96)00155-X","article-title":"Antioxidant properties of omeprazole.","volume":"382","author":"Lapenna","year":"1996","journal-title":"FEBS Lett."},{"key":"B18","doi-asserted-by":"publisher","first-page":"444","DOI":"10.5056\/jnm15192","article-title":"Protective effect of proton pump inhibitor for survival in patients with gastroesophageal reflux disease and idiopathic pulmonary fibrosis.","volume":"22","author":"Lee","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"key":"B19","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S2213-2600(13)70105-X","article-title":"Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials.","volume":"1","author":"Lee","year":"2013","journal-title":"Lancet Respir. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1164\/rccm.201101-0138OC","article-title":"Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis.","volume":"184","author":"Lee","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtcvs.2005.10.014","article-title":"Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation.","volume":"131","author":"Linden","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1365-2710.2008.00907.x","article-title":"A succinct review of the general and immunological pharmacologic effects of proton pump inhibitors.","volume":"33","author":"Namazi","year":"2008","journal-title":"J. Clin. Pharm. Ther."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00016","article-title":"Therapeutic efficacy of esomeprazole in cotton smoke-induced lung injury model.","volume":"8","author":"Nelson","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1183\/09031936.00099910","article-title":"Prevalence of hiatal hernia by blinded multidetector CT in patients with idiopathic pulmonary fibrosis.","volume":"39","author":"Noth","year":"2012","journal-title":"Eur. Respir. J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1023\/A:1026604203237","article-title":"Lansoprazole decreases peripheral blood monocytes and intercellular adhesion molecule-1-positive mononuclear cells.","volume":"44","author":"Ohara","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00210-008-0314-7","article-title":"Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin.","volume":"378","author":"Pastoris","year":"2008","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.gassur.2005.06.027","article-title":"Idiopathic pulmonary fibrosis: how often is it really idiopathic?","volume":"9","author":"Patti","year":"2005","journal-title":"J. Gastrointest. Surg."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2015.OA4502","article-title":"Effect of anti-acid medication on reduction in FVC decline with nintedanib.","author":"Raghu","year":"","journal-title":"Paper Presented at the European Respiratory Society Annual Meeting"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","article-title":"An official ATS\/ERS\/JRS\/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline.","volume":"192","author":"Raghu","year":"","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1183\/09031936.06.00037005","article-title":"High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis.","volume":"27","author":"Raghu","year":"","journal-title":"Eur. Respir. J."},{"key":"B31","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1378\/chest.129.3.794","article-title":"Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: a case series.","volume":"129","author":"Raghu","year":"","journal-title":"Chest"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1056\/NEJMoa1402584","article-title":"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis.","volume":"370","author":"Richeldi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.dld.2006.05.012","article-title":"Gastro-oesophageal reflux and interstitial lung disease.","volume":"38","author":"Salvioli","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ejphar.2004.12.042","article-title":"The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells.","volume":"509","author":"Sasaki","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.bcp.2006.01.009","article-title":"Hydroxyl radical scavenging reactivity of proton pump inhibitors.","volume":"71","author":"Simon","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/0891-5849(96)00180-3","article-title":"Omeprazole attenuates oxygen-derived free radical production from human neutrophils.","volume":"21","author":"Suzuki","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"S93","DOI":"10.1097\/00004836-199506002-00025","article-title":"Lansoprazole inhibits oxygen-derived free radical production from neutrophils activated by Helicobacter pylori.","author":"Suzuki","year":"1995","journal-title":"J. Clin. Gastroenterol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.jtcvs.2006.09.085","article-title":"Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation.","volume":"133","author":"Sweet","year":"2007","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B39","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1124\/jpet.109.152702","article-title":"Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1.","volume":"331","author":"Takagi","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1164\/ajrccm.158.6.9804105","article-title":"Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis.","volume":"158","author":"Tobin","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1136\/gut.33.5.617","article-title":"Effects of omeprazole on neutrophil chemotaxis, super oxide production, degranulation, and translocation of cytochrome b-245.","volume":"33","author":"Wandall","year":"1992","journal-title":"Gut"},{"key":"B42","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1164\/rccm.2111053","article-title":"Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography.","volume":"167","author":"Wells","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.cell.2017.01.034","article-title":"How much longer will we put up With $100,000 Cancer Drugs?","volume":"168","author":"Workman","year":"2017","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1183\/09031936.00125407","article-title":"Decreased expression of haem oxygenase-1 by alveolar macrophages in idiopathic pulmonary fibrosis.","volume":"31","author":"Ye","year":"2008","journal-title":"Eur. Respir. J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1046\/j.1365-2036.2000.014s1074.x","article-title":"A new mechanism for anti-inflammatory actions of proton pump inhibitors\u2013inhibitory effects on neutrophil-endothelial cell interactions.","author":"Yoshida","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1097\/00003246-200205000-00026","article-title":"Omeprazole treatment diminishes intra- and extracellular neutrophil reactive oxygen production and bactericidal activity.","volume":"30","author":"Zedtwitz-Liebenstein","year":"2002","journal-title":"Crit. Care Med."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00499\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T04:26:26Z","timestamp":1526531186000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00499\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":46,"alternative-id":["10.3389\/fphar.2018.00499"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.00499","relation":{},"ISSN":["1663-9812"],"issn-type":[{"type":"electronic","value":"1663-9812"}],"subject":[],"published":{"date-parts":[[2018,5,17]]},"article-number":"499"}}