{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:20:49Z","timestamp":1792628449884,"version":"4.5.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.00511","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:51:58Z","timestamp":1526345518000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation"],"prefix":"10.3389","volume":"9","author":[{"given":"Ya-wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-qin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-ming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-juan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.bbr.2015.05.029","article-title":"The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: involvement of glucocorticoid receptor and C\/EBP-beta.","volume":"291","author":"Adzic","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2011.00138","article-title":"Phylogeny and ontogeny of the habenular structure.","volume":"5","author":"Aizawa","year":"2011","journal-title":"Front. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ejphar.2010.06.028","article-title":"Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats.","volume":"643","author":"Alboni","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.168","article-title":"A requirement of serotonergic p38alpha mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors.","volume":"5","author":"Baganz","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00051","article-title":"Habenula circuit development: past, present, and future.","volume":"6","author":"Beretta","year":"2012","journal-title":"Front. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1183\/09031936.00.16594700","article-title":"Effect of the p38 kinase inhibitor, SB 203580, on sephadex induced airway inflammation in the rat.","volume":"16","author":"Birrell","year":"2000","journal-title":"Eur. Respir. J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.biopsych.2016.06.003","article-title":"Translating the Habenula\u2014From Rodents to Humans.","volume":"81","author":"Boulos","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbr.2008.10.036","article-title":"The effect of chronic fluoxetine on social isolation-induced changes on sucrose consumption, immobility behavior, and on serotonin and dopamine function in hippocampus and ventral striatum.","volume":"198","author":"Brenes","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s12264-014-1486-4","article-title":"New hypothesis and treatment targets of depression: an integrated view of key findings.","volume":"31","author":"Cai","year":"2015","journal-title":"Neurosci. Bull."},{"key":"B10","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1177\/1933719117725828","article-title":"p38 mitogen-activated protein kinase is involved in the pathogenesis of endometriosis by modulating inflammation, but not cell survival.","volume":"25","author":"Cakmak","year":"2017","journal-title":"Reprod. Sci."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004185.pub2","article-title":"Fluoxetine versus other types of pharmacotherapy for depression.","author":"Cipriani","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.neurobiolaging.2014.11.016","article-title":"BDNF prevents amyloid-dependent impairment of LTP in the entorhinal cortex by attenuating p38 MAPK phosphorylation.","volume":"36","author":"Criscuolo","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B13","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling.","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jpsychires.2009.05.010","article-title":"Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression.","volume":"43","author":"Dhabhar","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1038\/nm.2219","article-title":"A negative regulator of MAP kinase causes depressive behavior.","volume":"16","author":"Duric","year":"2010","journal-title":"Nat. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.neubiorev.2017.02.010","article-title":"The habenula in psychiatric disorders: more than three decades of translational investigation.","volume":"83","author":"Fakhoury","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.bbi.2011.02.015","article-title":"Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue.","volume":"25","author":"Felger","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4847","DOI":"10.1007\/s12035-016-0032-y","article-title":"The neurobiology of depression: an integrated overview from biological theories to clinical evidence.","volume":"54","author":"Ferrari","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.08.019","article-title":"). Information processing in the vertebrate habenula.","author":"Fore","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neuroscience.2013.06.066","article-title":"Windows of vulnerability: maternal separation, age, and fluoxetine on adolescent depressive-like behavior in rats.","author":"Freund","year":"2013","journal-title":"Neuroscience"},{"key":"B21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.neuropharm.2011.07.020","article-title":"Selective modulation of the PKCvarepsilon\/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline.","volume":"62","author":"Galeotti","year":"2012","journal-title":"Neuropharmacology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/PMC.S11375","article-title":"Revisiting the monoamine hypothesis of depression: a new perspective.","volume":"6","author":"Goldberg","year":"2014","journal-title":"Perspect. Med. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/pchj.87","article-title":"Comparison of stress-induced and LPS-induced depressive-like behaviors and the alterations of central proinflammatory cytokines mRNA in rats.","volume":"4","author":"Guan","year":"2015","journal-title":"Psych. J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2014.10.002","article-title":"Integrating the monoamine, neurotrophin and cytokine hypotheses of depression \u2014 A central role for the serotonin transporter?","volume":"147","author":"Haase","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1038\/sj.bjp.0704022","article-title":"Role of p38 MAP kinase in LPS-induced airway inflammation in the rat.","volume":"132","author":"Haddad","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neulet.2011.05.032","article-title":"Effects of chronic administration of tryptophan with or without concomitant fluoxetine in depression-related and anxiety-like behaviors on adult rat.","volume":"499","author":"Hansen","year":"2011","journal-title":"Neurosci. Lett."},{"key":"B27","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.eurpsy.2008.03.013","article-title":"Depression, comorbidities and the TNF-\u03b1 system.","volume":"23","author":"Himmerich","year":"2008","journal-title":"Eur. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"11366","DOI":"10.1523\/JNEUROSCI.1861-14.2014","article-title":"Role of the dorsal medial habenula in the regulation of voluntary activity, motor function, hedonic state, and primary reinforcement.","volume":"34","author":"Hsu","year":"2014","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.5498\/wjp.v6.i3.283","article-title":"Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?","volume":"6","author":"Jeon","year":"2016","journal-title":"World J. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases.","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B31","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.pnpbp.2015.06.008","article-title":"The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression.","volume":"64","author":"Kim","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B32","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/mp.2016.81","article-title":"Disrupted habenula function in major depression.","volume":"22","author":"Lawson","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/372739a0","article-title":"A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.","volume":"372","author":"Lee","year":"1994","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nature09742","article-title":"Synaptic potentiation onto habenula neurons in the learned helplessness model of depression.","volume":"470","author":"Li","year":"2011","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.expneurol.2016.08.010","article-title":"Why depression and pain often coexist and mutually reinforce: role of the lateral habenula.","author":"Li","year":"2016","journal-title":"Exp. Neurol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s13555-015-0072-7","article-title":"p38 MAP kinase inhibition reduces propionibacterium acnes-induced inflammation in Vitro.","volume":"5","author":"Li","year":"2015","journal-title":"Dermatol. Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.neuropharm.2011.04.033","article-title":"Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells.","volume":"61","author":"Liu","year":"2011","journal-title":"Neuropharmacology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1684\/ecn.2015.0362","article-title":"TNF\u03b1 mediates stress-induced depression by upregulating indoleamine 2,3-dioxygenase in a mouse model of unpredictable chronic mild stress.","volume":"26","author":"Liu","year":"2015","journal-title":"Eur. Cytokine Netw."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2016.00028","article-title":"Mitogen-Activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology.","volume":"3","author":"Lloberas","year":"2016","journal-title":"Front. Mol. Biosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.brainresbull.2014.11.006","article-title":"Lateral habenula as a link between dopaminergic and serotonergic systems contributes to depressive symptoms in Parkinson\u2019s disease.","volume":"110","author":"Luo","year":"2015","journal-title":"Brain Res. Bull."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/nature05860","article-title":"Lateral habenula as a source of negative reward signals in dopamine neurons.","volume":"447","author":"Matsumoto","year":"2007","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jpsychires.2008.02.004","article-title":"IL-10 modulates depressive-like behavior.","volume":"43","author":"Mesquita","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/da.22084","article-title":"Cytokine targets in the brain: impact on neurotransmitters and neurocircuits.","volume":"30","author":"Miller","year":"2013","journal-title":"Depress. Anxiety"},{"key":"B44","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/978-0-585-37970-8_7","article-title":"Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression.","volume":"461","author":"Miller","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.2298\/abs150130065m","article-title":"Effects of female gonadal hormones and LPS on depressive-like behavior in rats.","volume":"67","author":"Mitic","year":"2015","journal-title":"Arch. Biol. Sci."},{"key":"B46","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/clinchem\/40.2.288","article-title":"Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.","volume":"40","author":"Owens","year":"1994","journal-title":"Clin. Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bbi.2006.08.009","article-title":"Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression.","volume":"21","author":"Pace","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.bbr.2013.03.031","article-title":"The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats.","volume":"247","author":"Pan","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","article-title":"Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment.","volume":"49","author":"Pariante","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"B50","author":"Paxinos","year":"2004","journal-title":"The Rat Brain in Stereotaxic Coordinates - The New Coronal Set."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1389200219666180305143501","article-title":"Current therapeutic approaches for targeting inflammation in depression and cardiovascular disease.","volume":"19","author":"Pedro","year":"2018","journal-title":"Curr. Drug Metab."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/S0140-6736(13)60989-7","article-title":"Bipolar disorder diagnosis: challenges and future directions.","volume":"381","author":"Phillips","year":"2013","journal-title":"Lancet"},{"key":"B53","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.bbr.2008.11.051","article-title":"A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior.","volume":"199","author":"Qi","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1017\/S0033291709990821","article-title":"Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia.","volume":"40","author":"Ranft","year":"2010","journal-title":"Psychol. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jpsychires.2014.04.010","article-title":"MAPK signaling correlates with the antidepressant effects of ketamine.","volume":"55","author":"Reus","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.bbi.2014.06.016","article-title":"Early molecular and behavioral response to lipopolysaccharide in the WAG\/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT\/mTOR pathways and neuroinflammatory cytokine release.","volume":"42","author":"Russo","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00067","article-title":"Redundancy in the World of MAP Kinases: all for One.","volume":"4","author":"Saba-El-Leil","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.96","article-title":"Elevation of p11 in lateral habenula mediates depression-like behavior.","author":"Seo","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.pnpbp.2018.01.003","article-title":"Targeting cytokines in reduction of depressive symptoms: a comprehensive review.","volume":"83","author":"Shariq","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0166-2236(96)81863-7","article-title":"Mast cells in the brain: evidence and functional significance.","volume":"19","author":"Silver","year":"1996","journal-title":"Trends Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.3109\/02699052.2016.1163618","article-title":"Bifunctional role of pro-inflammatory cytokines after traumatic brain injury.","volume":"30","author":"Sordillo","year":"2016","journal-title":"Brain Inj."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0006-8993(02)03363-2","article-title":"Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS.","volume":"958","author":"Sugama","year":"2002","journal-title":"Brain Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.physbeh.2016.04.034","article-title":"Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.","volume":"161","author":"Tang","year":"2016","journal-title":"Physiol. Behav."},{"key":"B64","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.bbi.2017.05.013","article-title":"Exogenous FGF2 reverses depressive-like behaviors and restores the suppressed FGF2-ERK1\/2 signaling and the impaired hippocampal neurogenesis induced by neuroinflammation.","volume":"66","author":"Tang","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis, neuroendocrine factors and stress.","volume":"53","author":"Tsigos","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/sj.mp.4001339","article-title":"Interleukin 1alpha (IL-1alpha) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function.","volume":"9","author":"Wang","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"B67","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.bbr.2010.07.034","article-title":"Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression.","volume":"216","author":"Winter","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3724\/SP.J.1206.2013.00477","article-title":"Anti-inflammatory cytokines and depression.","volume":"41","author":"Xu","year":"2014","journal-title":"Prog. Biochem. Biophys."},{"key":"B69","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.bbr.2007.10.022","article-title":"Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus.","volume":"188","author":"Yang","year":"2008","journal-title":"Behav. Brain Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"721","DOI":"10.2174\/1570159X14666160119094646","article-title":"Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets.","volume":"14","author":"Zhang","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/HJH.0b013e3283358b6e","article-title":"Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling.","volume":"28","author":"Zhang","year":"2010","journal-title":"J. Hypertens."},{"key":"B72","first-page":"266","article-title":"p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1 beta and footshock in conscious rats.","volume":"25","author":"Zheng","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1038\/npp.2010.116","article-title":"Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters.","volume":"35","author":"Zhu","year":"2010","journal-title":"Neuropsychopharmacology"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00511\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T19:09:26Z","timestamp":1604257766000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2018.00511\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":73,"alternative-id":["10.3389\/fphar.2018.00511"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.00511","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"article-number":"511"}}