{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:09:38Z","timestamp":1783649378646,"version":"3.55.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["C2016063"],"award-info":[{"award-number":["C2016063"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M591311"],"award-info":[{"award-number":["2016M591311"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31602100"],"award-info":[{"award-number":["31602100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.00619","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:22:48Z","timestamp":1528849368000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Antibacterial Activity and Mechanism of Action of Aspidinol Against Multi-Drug-Resistant Methicillin-Resistant Staphylococcus aureus"],"prefix":"10.3389","volume":"9","author":[{"given":"Xin","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenye","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1128\/AAC.02697-15","article-title":"Role of the stringent stress response in the antibiotic resistance phenotype of methicillin-resistant Staphylococcus aureus.","volume":"60","author":"Aedo","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"B2","doi-asserted-by":"publisher","first-page":"21972","DOI":"10.1074\/jbc.M302109200","article-title":"Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.","volume":"278","author":"Colca","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/adt.2015.673","article-title":"Opportunities and challenges for natural products as novel antituberculosis agents.","volume":"14","author":"Farah","year":"2016","journal-title":"Assay Drug Dev. Technol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00403-015-1603-x","article-title":"Investigation of antibacterial activity of aspidin BB against Propionibacterium acnes.","volume":"308","author":"Gao","year":"2016","journal-title":"Arch. Dermatol. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"4647","DOI":"10.1128\/JB.00257-09","article-title":"The oligopeptide transport system is essential for the development of natural competence in Streptococcus thermophilus strain LMD-9.","volume":"191","author":"Gardan","year":"2009","journal-title":"J. Bacteriol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.tim.2008.11.005","article-title":"Staphylococcus aureus: new evidence for intracellular persistence.","volume":"17","author":"Garzoni","year":"2009","journal-title":"Trends Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1093\/jac\/dkq313","article-title":"Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis.","volume":"65","author":"Guzman","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"B8","doi-asserted-by":"publisher","first-page":"414","DOI":"10.5114\/aoms.2011.23404","article-title":"Co-blockade of mecR1\/blaR1 signal pathway to restore antibiotic susceptibility in clinical isolates of methicillin-resistant Staphylococcus aureus.","volume":"7","author":"Hou","year":"2011","journal-title":"Arch. Med. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/molecules19010507","article-title":"Characterization of a new sesquiterpene and antifungal activities of chemical constituents from Dryopteris fragrans (L.) Schott.","volume":"19","author":"Huang","year":"2014","journal-title":"Molecules"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1021\/jm800379d","article-title":"Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit.","volume":"51","author":"Ippolito","year":"2008","journal-title":"J. Med. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1128\/IAI.71.5.2656-2664.2003","article-title":"MtsABC is important for manganese and iron transport, oxidative stress resistance, and virulence of Streptococcus pyogenes.","volume":"71","author":"Janulczyk","year":"2003","journal-title":"Infect. Immun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature16057","article-title":"Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.","volume":"527","author":"Lehar","year":"2015","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1128\/AAC.00123-08","article-title":"Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.","volume":"52","author":"Lemaire","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01622-15","article-title":"Methamphetamine alters the antimicrobial efficacy of phagocytic cells during methicillin-resistant Staphylococcus aureus skin infection.","volume":"6","author":"Mihu","year":"2015","journal-title":"MBio"},{"key":"B15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10858-016-0042-0","article-title":"Highly efficient residue-selective labeling with isotope-labeled Ile, Leu, and Val using a new auxotrophic E. coli strain.","volume":"65","author":"Miyanoiri","year":"2016","journal-title":"J. Biomol. NMR"},{"key":"B16","article-title":"Aspidin Phenolic Compounds and Their Use in the Orparation of Anti-drug Resistant. CN Patent No. 102464578 A.","author":"Mu","year":"2012"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4800","DOI":"10.1128\/AAC.48.12.4800-4807.2004","article-title":"Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureus.","volume":"48","author":"Nishi","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"B18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/10286020.2015.1121853","article-title":"Two new glycosides from Dryopteris fragrans with anti-inflammatory activities.","volume":"18","author":"Peng","year":"2016","journal-title":"J. Asian Nat. Prod. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1128\/JB.00205-06","article-title":"Albomycin uptake via a ferric hydroxamate transport system of Streptococcus pneumoniae R6.","volume":"188","author":"Pramanik","year":"2006","journal-title":"J. Bacteriol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-3-642-28951-4_4","article-title":"Current and future challenges in the development of antimicrobial agents.","volume":"211","author":"Rennie","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1093\/cid\/cit614","article-title":"Methicillin-resistant Staphylococcus aureus therapy: past, present, and future.","author":"Rodvold","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"S378","DOI":"10.1086\/533594","article-title":"Pneumonia caused by methicillin-resistant Staphylococcus aureus.","volume":"46","author":"Rubinstein","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"4394","DOI":"10.1128\/JB.182.16.4394-4400.2000","article-title":"Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus.","volume":"182","author":"Sebulsky","year":"2000","journal-title":"J. Bacteriol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1574-6968.2009.01530.x","article-title":"Targeting Brucella melitensis with polymeric nanoparticles containing streptomycin and doxycycline.","volume":"294","author":"Seleem","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-177","article-title":"Natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE): a systematic review.","volume":"14","author":"Shenoy","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1128\/JB.188.6.2048-2055.2006","article-title":"Requirement of Staphylococcus aureus ATP-binding cassette-ATPase FhuC for iron-restricted growth and evidence that it functions with more than one iron transporter.","volume":"188","author":"Speziali","year":"2006","journal-title":"J. Bacteriol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1055\/s-0034-1377747","article-title":"Antibiotics for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA).","volume":"68","author":"Stahlmann","year":"2014","journal-title":"Pneumologie"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1021\/bi501463k","article-title":"Investigation of signal transduction routes within the sensor\/transducer protein BlaR1 of Staphylococcus aureus.","volume":"54","author":"Staude","year":"2015","journal-title":"Biochemistry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"6184","DOI":"10.1021\/bi900552c","article-title":"Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes.","volume":"48","author":"Sun","year":"2009","journal-title":"Biochemistry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.febslet.2008.03.020","article-title":"Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion.","volume":"582","author":"Sun","year":"2008","journal-title":"FEBS Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.pop.2013.06.002","article-title":"Methicillin-resistant Staphylococcus aureus infections.","volume":"40","author":"Taylor","year":"2013","journal-title":"Prim. Care"},{"key":"B32","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/jac\/dkp241","article-title":"Methicillin-resistant Staphylococcus aureus strain USA300: origin and epidemiology.","volume":"64","author":"Tenover","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133877","article-title":"Repurposing clinical molecule ebselen to combat drug resistant pathogens.","volume":"10","author":"Thangamani","year":"2015","journal-title":"PLoS One"},{"key":"B34","doi-asserted-by":"publisher","first-page":"10630","DOI":"10.1073\/pnas.0601971103","article-title":"Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium.","volume":"103","author":"Thumanu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3109\/13880209.2014.942867","article-title":"Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.","volume":"53","author":"Vandal","year":"2015","journal-title":"Pharm. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jiac.2016.02.012","article-title":"Empirical therapy in methicillin-resistant Staphylococcus aureus infections: an up-to-date approach.","volume":"22","author":"VanEperen","year":"2016","journal-title":"J. Infect. Chemother."},{"key":"B37","year":"2017","journal-title":"Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"47278","DOI":"10.1074\/jbc.M407054200","article-title":"Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus.","volume":"279","author":"Wilke","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"13339","DOI":"10.1073\/pnas.0804276105","article-title":"The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.","volume":"105","author":"Wilson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5198","DOI":"10.1128\/IAI.69.8.5198-5202.2001","article-title":"Identification and analysis of Staphylococcus aureus components expressed by a model system of growth in serum.","volume":"69","author":"Wiltshire","year":"2001","journal-title":"Infect. Immun."},{"key":"B41","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1586\/17476348.2014.940323","article-title":"Methicillin-resistant Staphylococcus aureus pneumonia in adults.","volume":"8","author":"Woods","year":"2014","journal-title":"Expert Rev. Respir. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cbi.2012.06.007","article-title":"Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway.","volume":"199","author":"Zhang","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.3390\/molecules19033345","article-title":"Compounds from Dryopteris fragrans (L.) Schott with cytotoxic activity.","volume":"19","author":"Zhao","year":"2014","journal-title":"Molecules"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00119-16","article-title":"Transcriptomic analysis of the activity of a novel polymyxin against Staphylococcus aureus.","volume":"1","author":"Zhao","year":"2016","journal-title":"mSphere"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010180","article-title":"A new human cancer cell proliferation inhibition sesquiterpene, dryofraterpene a, from medicinal plant Dryopteris fragrans (L.) Schott.","volume":"22","author":"Zhong","year":"2017","journal-title":"Molecules"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-309","article-title":"A solute-binding protein for iron transport in Streptococcus iniae.","volume":"10","author":"Zou","year":"2010","journal-title":"BMC Microbiol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.00619\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:22:58Z","timestamp":1528849378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.00619\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":46,"alternative-id":["10.3389\/fphar.2018.00619"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.00619","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"article-number":"619"}}