{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:06:58Z","timestamp":1781154418062,"version":"3.54.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2017FE467-160"],"award-info":[{"award-number":["2017FE467-160"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2017FE467-024"],"award-info":[{"award-number":["2017FE467-024"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2015FB006"],"award-info":[{"award-number":["2015FB006"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2015FB003"],"award-info":[{"award-number":["2015FB003"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.01126","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T04:48:16Z","timestamp":1538455696000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Antidepressant Effects of Rosemary Extracts Associate With Anti-inflammatory Effect and Rebalance of Gut Microbiota"],"prefix":"10.3389","volume":"9","author":[{"given":"Ying","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jnr.24107","article-title":"Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats.","volume":"96","author":"Aalling","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"B2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.18433\/J3PW38","article-title":"Antidepressant, anxiolytic and antinociceptive activities of constituents from rosmarinus officinalis.","volume":"18","author":"Abdelhalim","year":"2015","journal-title":"J. Pharm. Pharm. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ntt.2018.04.002","article-title":"Glyphosate based- herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice.","volume":"67","author":"Aitbali","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/ajmg.b.32567","article-title":"Microbiome, inflammation, epigenetic alterations, and mental diseases.","volume":"174","author":"Alam","year":"2017","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","article-title":"Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation.","volume":"25","author":"Bailey","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/612798","article-title":"NF-kappaB mediated regulation of adult hippocampal neurogenesis: relevance to mood disorders and antidepressant activity.","volume":"2014","author":"Bortolotto","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pnpbp.2012.05.018","article-title":"Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex.","volume":"39","author":"Chiba","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1039\/c7fo01928a","article-title":"Water soluble compounds of rosmarinus officinalis L. improve the oxidative and inflammatory states of rats with adjuvant-induced arthritis.","volume":"9","author":"de Almeida Goncalves","year":"2018","journal-title":"Food Funct."},{"key":"B9","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression.","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neulet.2012.06.075","article-title":"Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region.","volume":"524","author":"Guo","year":"2012","journal-title":"Neurosci. Lett."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/1028415x.2018.1465713","article-title":"High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome.","author":"Hassan","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1017\/s0033291712000128","article-title":"Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis.","volume":"42","author":"Hiles","year":"2012","journal-title":"Psychol. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s12264-016-0037-6","article-title":"The current situation on major depressive disorder in china: research on mechanisms and clinical practice.","volume":"32","author":"Hou","year":"2016","journal-title":"Neurosci. Bull."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2015.04.004","article-title":"Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.","volume":"288","author":"Huang","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder.","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0896-9","article-title":"Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type.","volume":"15","author":"Justo","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.lfs.2018.01.013","article-title":"Targeting BDNF modulation by plant glycosides as a novel therapeutic strategy in the treatment of depression.","volume":"196","author":"Khan","year":"2018","journal-title":"Life Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.psyneuen.2018.02.006","article-title":"Changes in pro-inflammatory cytokine levels and late-life depression: a two year population based longitudinal study.","volume":"90","author":"Kim","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.jpsychires.2013.03.015","article-title":"Mortality associated with depression as compared with other severe mental disorders: a 20-year follow-up study of the GAZEL cohort.","volume":"47","author":"Lemogne","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.neuroscience.2015.09.033","article-title":"Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress.","volume":"310","author":"Liang","year":"2015","journal-title":"Neuroscience"},{"key":"B21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ijdevneu.2013.12.008","article-title":"Spreading depression features and Iba1 immunoreactivity in the cerebral cortex of developing rats submitted to treadmill exercise after treatment with monosodium glutamate.","volume":"33","author":"Lima","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jad.2016.09.012","article-title":"Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness.","volume":"208","author":"Macedo","year":"2017","journal-title":"J. Affect. Disord."},{"key":"B23","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bbr.2017.01.035","article-title":"Up-regulation of SIRT6 in the hippocampus induced rats with depression-like behavior via the block Akt\/GSK3beta signaling pathway.","volume":"323","author":"Mao","year":"2017","journal-title":"Behav. Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2174\/1745017901713010213","article-title":"Relationship between brain-derived neurotrofic factor (bdnf) and sleep on depression: a critical review.","volume":"13","author":"Monteiro","year":"2017","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"B25","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/mp.2009.91","article-title":"Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury.","volume":"15","author":"Norman","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jphotobiol.2014.04.007","article-title":"Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers.","volume":"136","author":"Perez-Sanchez","year":"2014","journal-title":"J. Photochem. Photobiol. B"},{"key":"B27","doi-asserted-by":"publisher","first-page":"688","DOI":"10.2174\/1389200219666171227204144","article-title":"We are not alone in our body: insights into the involvement of microbiota in the etiopathogenesis and pharmacology of mental illness.","volume":"19","author":"Pisanu","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"B28","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.phrs.2018.01.014","article-title":"Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK\/NF-kappaB signaling pathways in LPS-activated BV-2 microglia.","volume":"133","author":"Qin","year":"2018","journal-title":"Pharmacol. Res."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094687","article-title":"A rosemary extract rich in carnosic acid selectively modulates caecum microbiota and inhibits beta-glucosidase activity, altering fiber and short chain fatty acids fecal excretion in lean and obese female rats.","volume":"9","author":"Romo-Vaquero","year":"2014","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122046","article-title":"Comparative study of green sub- and supercritical processes to obtain carnosic acid and carnosol-enriched rosemary extracts with in vitro anti-proliferative activity on colon cancer cells.","volume":"17","author":"Sanchez-Camargo","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1038\/npp.2011.151","article-title":"Functional biomarkers of depression: diagnosis, treatment, and pathophysiology.","volume":"36","author":"Schmidt","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/mp.2010.52","article-title":"Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression.","volume":"16","author":"Shelton","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ebiom.2017.09.013","article-title":"Effect of Lactobacillus rhamnosus hn001 in pregnancy on postpartum symptoms of depression and anxiety: a randomised double-blind placebo-controlled trial.","volume":"24","author":"Slykerman","year":"2017","journal-title":"EBioMedicine"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1248\/bpb.b17-00131","article-title":"Ketamine alleviates depressive-like behaviors via down-regulating inflammatory cytokines induced by chronic restraint stress in mice.","volume":"40","author":"Tan","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1676808","article-title":"Antidepressant mechanism research of acupuncture: insights from a genome-wide transcriptome analysis of frontal cortex in rats with chronic restraint stress.","volume":"2017","author":"Wang","year":"2017","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1515\/revneuro-2017-0072","article-title":"Gut microbiome and depression: what we know and what we need to know.","volume":"29","author":"Winter","year":"2018","journal-title":"Rev. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.bbr.2016.12.045","article-title":"Effects of the chronic restraint stress induced depression on reward-related learning in rats.","volume":"321","author":"Xu","year":"2017","journal-title":"Behav. Brain Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.brainres.2017.12.004","article-title":"Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice.","volume":"1680","author":"Yamawaki","year":"2018","journal-title":"Brain Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.neuroscience.2014.06.016","article-title":"Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-kappaB, p38-MAPK and ERK1\/2 activation in lipopolysaccharide-induced BV-2 microglia cells.","volume":"275","author":"Yang","year":"2014","journal-title":"Neuroscience"},{"key":"B40","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s11130-010-0166-4","article-title":"Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines.","volume":"65","author":"Yesil-Celiktas","year":"2010","journal-title":"Plant Foods Hum. Nutr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1093\/ijnp\/pyy008","article-title":"Association of BDNF Val66Met polymorphism and brain BDNF levels with major depression and suicide.","volume":"21","author":"Youssef","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.3892\/mmr.2017.6851","article-title":"Resveratrol reversed chronic restraint stress-induced impaired cognitive function in rats.","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.05.064","article-title":"Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression.","author":"Zhao","year":"2017","journal-title":"Behav. Brain Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host\u2019s metabolism.","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00464","article-title":"Attenuation of TNF-alpha-induced inflammatory injury in endothelial cells by ginsenoside Rb1 via inhibiting NF-kappaB, JNK and p38 signaling pathways.","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Pharmacol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.01126\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T12:51:30Z","timestamp":1539175890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.01126\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":45,"alternative-id":["10.3389\/fphar.2018.01126"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.01126","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"article-number":"1126"}}