{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:47:45Z","timestamp":1793533665892,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010377","name":"National Institute for Health and Care Excellence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.01370","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T09:12:32Z","timestamp":1543482752000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Cost-Utility Analysis of Venous Thromboembolism Prophylaxis Strategies for People Undergoing Elective Total Hip and Total Knee Replacement Surgeries in the English National Health Service"],"prefix":"10.3389","volume":"9","author":[{"given":"Dalia M.","family":"Dawoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wonderling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Glen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedina","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier L.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley J.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Stansby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Rossiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagjot Kaur","family":"Chahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sharpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"800","DOI":"10.7326\/0003-4819-158-11-201306040-00004","article-title":"Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial","volume":"158","author":"Anderson","year":"2013","journal-title":"Ann. Intern. Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1179\/acb.2004.050","article-title":"Cost consequence analysis of fondaparinux versus enoxaparin in the prevention of venous thromboembolism after major orthopaedic surgery in Belgium","volume":"59","author":"Annemans","year":"2004","journal-title":"Acta Clin. Belg"},{"key":"B3","volume-title":"Implementation of Thromboprophylaxis in Hospitals. E-learning for Healthcare","author":"Arya","year":"2010"},{"key":"B4","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1160\/TH15-08-0670","article-title":"European Union-28: an annualised cost-of-illness model for venous thromboembolism","volume":"115","author":"Barco","year":"2016","journal-title":"Thromb. Haemost"},{"key":"B5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1586\/14737167.6.2.171","article-title":"Cost-effectiveness of extended venous thromboembolism prophylaxis with fondaparinux in hip surgery patients","volume":"6","author":"Bischof","year":"2006","journal-title":"Exp. Rev. Pharmacoeconom. Outcomes Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2165\/00129784-200505020-00006","article-title":"Fondaparinux sodium compared with enoxaparin sodium: a cost-effectiveness analysis","volume":"5","author":"Bjorvatn","year":"2005","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"B7","volume-title":"National Joint Registry 14th Annual Report","year":"2017"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/S0149-2918(02)80091-1","article-title":"Results of an economic model to assess the cost-effectiveness of enoxaparin, a low-molecular-weight heparin, versus warfarin for the prophylaxis of deep vein thrombosis and associated long-term complications in total hip replacement surgery in the United States","volume":"24","author":"Botteman","year":"2002","journal-title":"Clin. Ther"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4321\/S1886-36552011000100001","article-title":"Evaluating the impact of new anticoagulants in the hospital setting","volume":"9","author":"Braidy","year":"2011","journal-title":"Pharm Pract."},{"key":"B10","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s40273-017-0486-4","article-title":"Economic evaluations of new oral anticoagulants for the prevention of venous thromboembolism after total hip or knee replacement: a systematic review","volume":"35","author":"Brockbank","year":"2017","journal-title":"Pharmacoeconomics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11739-009-0324-6","article-title":"Extended prophylaxis of venous thromboembolism with fondaparinux in patients undergoing major orthopaedic surgery in Italy: a cost-effectiveness analysis","volume":"5","author":"Capri","year":"2010","journal-title":"Intern Emerg. Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1046\/j.1524-4733.2003.00204.x","article-title":"Economic burden of long-term complications of deep vein thrombosis after total hip replacement surgery in the United States","volume":"6","author":"Caprini","year":"2003","journal-title":"Value Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.surg.2014.10.005","article-title":"Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation: a population-based longitudinal study","volume":"157","author":"Cohoon","year":"2015","journal-title":"Surgery"},{"key":"B14","volume-title":"Unit Costs of Health and Social Care 2016","author":"Curtis","year":"2016"},{"key":"B15","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1046\/j.1538-7836.2003.00236.x","article-title":"Investment in prolonged thromboprophylaxis with dalteparin improves clinical outcomes after hip replacement","volume":"1","author":"Dahl","year":"2003","journal-title":"J. Thromb. Haemost"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1111\/j.1538-7836.2010.03965.x","article-title":"A critical appraisal of bleeding events reported in venous thromboembolism prevention trials of patients undergoing hip and knee arthroplasty","volume":"8","author":"Dahl","year":"2010","journal-title":"J. Thromb. Haemost"},{"key":"B17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1046\/j.1524-4733.2000.36005.x","article-title":"Economic evaluation of enoxaparin as postdischarge prophylaxis for deep vein thrombosis (DVT) in elective hip surgery","volume":"3","author":"Davies","year":"2000","journal-title":"Value Health"},{"key":"B18","first-page":"2015","volume-title":"NHS Reference Costs","year":"2015"},{"key":"B19","volume-title":"NHS Reference Costs 2015\u201316","year":"2016"},{"key":"B20","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1160\/TH10-01-0071","article-title":"Cost-effectiveness of rivaroxaban versus enoxaparin for the prevention of postsurgical venous thromboembolism in Canada","volume":"104","author":"Diamantopoulos","year":"2010","journal-title":"Thromb. Haemost"},{"key":"B21","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2165\/00129784-200404050-00005","article-title":"Pharmacoeconomic analysis of fondaparinux versus enoxaparin for the prevention of thromboembolic events in orthopedic surgery patients","volume":"4","author":"Dranitsaris","year":"2004","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"B22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/BF03256594","article-title":"Extended dalteparin prophylaxis for venous thromboembolic events: cost-utility analysis in patients undergoing major orthopedic surgery","volume":"9","author":"Dranitsaris","year":"2009","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1601792","DOI":"10.1183\/13993003.01792-2016","article-title":"Incidence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: a contemporary view of the published literature","volume":"49","author":"Ende-Verhaar","year":"2017","journal-title":"Eur. Respir. J"},{"key":"B24","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s40273-014-0175-5","article-title":"Pharmacoeconomic evaluation of dabigatran, rivaroxaban and apixaban versus enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement in Spain","volume":"32","author":"Gomez-Outes","year":"2014","journal-title":"Pharmacoeconomics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1046\/j.1538-7836.2003.00396.x","article-title":"The cost-effectiveness of fondaparinux compared with enoxaparin as prophylaxis against thromboembolism following major orthopedic surgery","volume":"1","author":"Gordois","year":"2003","journal-title":"J. Thromb. Haemost"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e227S","DOI":"10.1378\/chest.11-2297","article-title":"Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines","volume":"141","author":"Gould","year":"2012","journal-title":"Chest"},{"key":"B27","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00402-004-0720-3","article-title":"Prolonged enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. A cost-utility analysis","volume":"124","author":"Haentjens","year":"2004","journal-title":"Arch. Orthop. Trauma Surg"},{"key":"B28","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1017\/S0266462313000251","article-title":"New anticoagulants as thromboprophylaxis after total hip or knee replacement","volume":"29","author":"Hamidi","year":"2013","journal-title":"Int. J. Technol. Assess. Health Care"},{"key":"B29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/MLR.0000000000000631","article-title":"Healthy life-years lost and excess bed-days due to 6 patient safety incidents: empirical evidence from english hospitals","volume":"55","author":"Hauck","year":"2017","journal-title":"Med Care"},{"key":"B30","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1055\/s-0037-1616243","article-title":"The epidemiology of venous thromboembolism in the community","volume":"86","author":"Heit","year":"2001","journal-title":"Thromb. Haemost"},{"key":"B31","unstructured":"HuntB. J.\n          Blood Clots are More Common (and deadly) Than You May Think2016"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jval.2013.02.010","article-title":"Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement","volume":"16","author":"Husereau","year":"2013","journal-title":"Value Health"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1111\/jth.12698","article-title":"Thrombosis: a major contributor to the global disease burden","volume":"12","year":"2014","journal-title":"J. Thromb. Haemost"},{"key":"B34","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1302\/0301-620X.94B7.29129","article-title":"The effect of aspirin and low-molecular-weight heparin on venous thromboembolism after knee replacement: a non-randomised comparison using national joint registry data","volume":"94","author":"Jameson","year":"2012","journal-title":"J. Bone Joint Surg. Br"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1302\/0301-620X.93B11.27622","article-title":"The effect of aspirin and low-molecular-weight heparin on venous thromboembolism after hip replacement: A non-randomised comparison from information in the National Joint Registry","volume":"93","author":"Jameson","year":"2011","journal-title":"J. Bone Joint Surg. Ser. B"},{"key":"B36","volume-title":"British National Formulary (BNF) July 2016 Update","year":"2016"},{"key":"B37","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s11239-015-1312-5","article-title":"Guidance for the prevention and treatment of the post-thrombotic syndrome","volume":"41","author":"Kahn","year":"2016","journal-title":"J. Thromb. Thrombolysis"},{"key":"B38","doi-asserted-by":"publisher","first-page":"521","DOI":"10.2165\/11535210-000000000-00000","article-title":"Cost effectiveness of venous thromboembolism pharmacological prophylaxis in total hip and knee replacement: a systematic review","volume":"28","author":"Kapoor","year":"2010","journal-title":"Pharmacoeconomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s10198-003-0175-4","article-title":"Cost-effectiveness of fondaparinux vs. enoxaparin as venous thromboembolism prophylaxis in Sweden","volume":"4","author":"Lundkvist","year":"2003","journal-title":"Eur. J. Health Econom"},{"key":"B40","doi-asserted-by":"publisher","first-page":"829","DOI":"10.2165\/11313800-000000000-00000","article-title":"A cost-effectiveness model comparing rivaroxaban and dabigatran etexilate with enoxaparin sodium as thromboprophylaxis after total hip and total knee replacement in the Irish healthcare setting","volume":"27","author":"McCullagh","year":"2009","journal-title":"Pharmacoeconomics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"941","DOI":"10.2165\/11591510-000000000-00000","article-title":"Value-of-information analysis to reduce decision uncertainty associated with the choice of thromboprophylaxis after total hip replacement in the Irish healthcare setting","volume":"30","author":"McCullagh","year":"2012","journal-title":"Pharmacoeconomics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3111\/13696998.2012.684116","article-title":"Cost-effectiveness of rivaroxaban in the prevention of venous thromboembolism: a Canadian analysis using the Ontario Ministry of Health perspective","volume":"15","author":"McDonald","year":"2012","journal-title":"J. Med. Econ"},{"key":"B43","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3810\/pgm.2012.01.2516","article-title":"Anticoagulation prophylaxis in orthopedic surgery: an efficiency frontier approach","volume":"124","author":"Migliaccio-Walle","year":"2012","journal-title":"Postgrad. Med"},{"key":"B44","volume-title":"Venous Thromoembolism: Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital","year":"2010"},{"key":"B45","first-page":"144","volume-title":"Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing","year":""},{"key":"B46","first-page":"147","volume-title":"Lower Limb Peripheral Arterial Disease: Diagnosis and Management","year":""},{"key":"B47","volume-title":"Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Inpatients Undergoing Surgery.","year":"2007"},{"key":"B48","volume-title":"Developing NICE Guidelines: The Manual","year":"2014"},{"key":"B49","first-page":"354","volume-title":"Edoxaban for Treating and for Preventing Deep Vein Thrombosis and Pulmonary Embolism","year":"2015"},{"key":"B50","first-page":"89","volume-title":"Venous Thromboembolism in Over 16s: Reducing the Risk of Hospital-Acquired Deep Vein Thrombosis or Pulmonary Embolism","year":"2018"},{"key":"B51","first-page":"157","volume-title":"Dabigatran Etexilate for the Prevention of Venous Thromboembolism After Hip or Knee Replacement Surgery in Adults","year":"2008"},{"key":"B52","first-page":"170","volume-title":"Rivaroxaban for the Prevention of Venous Thromboembolism","year":"2009"},{"key":"B53","first-page":"245","volume-title":"Apixaban for the Prevention of Venous Thromboembolism After Total Hip or Knee Replacement in Adults","year":"2012"},{"key":"B54","volume-title":"NHS Electronic Drug Tariff June 2016","year":""},{"key":"B55","volume-title":"NHS Supply Chain Catalogue 2015\u20132016.","year":""},{"key":"B56","volume-title":"Finalised Patient Reported Outcome Measures (PROMs) in England","year":"2016"},{"key":"B57","volume-title":"Purchasing Power Parities","year":"2012"},{"key":"B58","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3111\/13696998.2012.691144","article-title":"Economic evaluation of dabigatran etexilate for the primary prevention of venous tromboembolic events following major orthopedic surgery in the Netherlands","volume":"15","author":"Postma","year":"2012","journal-title":"J. Med. Econ"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1111\/j.1538-7836.2007.02571.x","article-title":"Association between asymptomatic deep vein thrombosis detected by venography and symptomatic venous thromboembolism in patients undergoing elective hip or knee surgery","volume":"5","author":"Quinlan","year":"2007","journal-title":"J. Thromb. Haemost"},{"key":"B60","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1023\/B:PHAR.0000026804.25975.be","article-title":"An economic evaluation of the costs and benefits of heparin rationalisation in a hospital pharmacy","volume":"26","author":"Reeves","year":"2004","journal-title":"Pharm. World Sci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3810\/pgm.2013.07.2686","article-title":"A Canadian study of the cost-effectiveness of apixaban compared with enoxaparin for post-surgical venous thromboembolism prevention","volume":"125","author":"Revankar","year":"2013","journal-title":"Postgrad. Med"},{"key":"B62","volume-title":"Apixaban for the Prevention of Venous Thromboembolism in People Undergoing Elective Knee and Hip Replacement Surgery: A Single Technology Appraisal","author":"Riemsma","year":"2011"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1378\/chest.13-0267","article-title":"Comprehensive VTE prevention program incorporating mandatory risk assessment reduces the incidence of hospital-associated thrombosis","volume":"144","author":"Roberts","year":"2013","journal-title":"Chest"},{"key":"B64","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1586\/erp.11.65","article-title":"Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden","volume":"11","author":"Ryttberg","year":"2011","journal-title":"Exp. Rev. Pharmacoeconom. Outcomes Res"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta21090","article-title":"Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis","volume":"21","author":"Sterne","year":"2016","journal-title":"Health Technol. Assess"},{"key":"B66","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3310\/hta13suppl3\/07","article-title":"Rivaroxaban for the prevention of venous thromboembolism: a single technology appraisal","volume":"13","author":"Stevenson","year":"2009","journal-title":"Health Technol. Assess"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta19980","article-title":"Graduated compression stockings for the prevention of deep-vein thrombosis in postoperative surgical patients: a systematic review and economic model with a value of information analysis","volume":"19","author":"Wade","year":"2015","journal-title":"Health Technol. Assess"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e91755","DOI":"10.1371\/journal.pone.0091755","article-title":"Surgical site infections and other postoperative complications following prophylactic anticoagulation in total joint arthroplasty","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS ONE"},{"key":"B69","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1302\/0301-620X.89B6.18844","article-title":"Insufficient duration of venous thromboembolism prophylaxis after total hip or knee replacement when compared with the time course of thromboembolic events: findings from the Global Orthopaedic Registry","volume":"89","author":"Warwick","year":"2007","journal-title":"J. Bone Joint Surg. Br"},{"key":"B70","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1177\/0268355514537487","article-title":"Litigation claims relating to venous thromboembolism in the NHS","volume":"30","author":"White","year":"2015","journal-title":"Phlebology"},{"key":"B71","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1160\/TH04-09-0570","article-title":"Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome. A systematic review and meta-analysis","volume":"93","author":"Wille-J\u00f8rgensen","year":"2005","journal-title":"Thromb. Haemost"},{"key":"B72","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.clinthera.2009.01.001","article-title":"Economic evaluation of dabigatran etexilate for the prevention of venous thromboembolism after total knee and hip replacement surgery","volume":"31","author":"Wolowacz","year":"2009","journal-title":"Clin Ther"},{"key":"B73","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1160\/TH09-08-0579","article-title":"Economic evaluation of dabigatran etexilate for the prevention of venous thromboembolism in patients aged over 75 years or with moderate renal impairment undergoing total knee or hip replacement","volume":"103","author":"Wolowacz","year":"2010","journal-title":"Thromb Haemost"},{"key":"B74","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/1472-6963-12-192","article-title":"A multi-perspective cost-effectiveness analysis comparing rivaroxaban with enoxaparin sodium for thromboprophylaxis after total hip and knee replacement in the German healthcare setting","volume":"12","author":"Zindel","year":"2012","journal-title":"BMC Health Serv. Res"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.01370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T13:06:56Z","timestamp":1543928816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.01370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":74,"alternative-id":["10.3389\/fphar.2018.01370"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.01370","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"article-number":"1370"}}