{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:35:41Z","timestamp":1781768141593,"version":"3.54.5"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.01504","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T16:47:55Z","timestamp":1546966075000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["The Role of S1P and the Related Signaling Pathway in the Development of Tissue Fibrosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Erjin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00645","article-title":"Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) attenuates myocardial fibrosis in post-heterotopic heart transplantation.","volume":"8","author":"Ahmed","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00210-007-0132-3","article-title":"Regulation and functional roles of sphingosine kinases.","volume":"374","author":"Alemany","year":"2007","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B3","article-title":"Correction to: heart disease and stroke statistics-2017 update: a report from the american heart association.","volume":"135","author":"Amp","year":"2017","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/srep24939","article-title":"Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer\u2019s disease.","volume":"6","author":"Aytan","year":"2016","journal-title":"Sci. Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.cellsig.2012.03.003","article-title":"A conserved TGF\u03b21\/HuR feedback circuit regulates the fibrogenic response in fibroblasts.","volume":"24","author":"Bai","year":"2012","journal-title":"Cell. Signal."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174424","article-title":"Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis.","volume":"12","author":"Bartels","year":"2017","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bbrc.2011.03.072","article-title":"Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts.","volume":"408","author":"Benamer","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1164\/rccm.201401-0121OC","article-title":"Commentary: the sphingosine kinase 1\/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.","volume":"190","author":"Bhavanam","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059630","article-title":"Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.","volume":"8","author":"Billich","year":"2013","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s005350050087","article-title":"Hepatic fibrosis as wound repair: a progress report.","volume":"33","author":"Bissell","year":"1998","journal-title":"J. Gastroenterol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nature14462","article-title":"HDL-bound sphingosine 1-phosphate restrains lymphopoiesis and neuroinflammation.","volume":"523","author":"Blaho","year":"2015","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4161\/isl.20102","article-title":"Roles of ceramide and sphingolipids in pancreatic \u03b2-cell function and dysfunction.","volume":"4","author":"Boslem","year":"2012","journal-title":"Islets"},{"key":"B14","author":"Brinkmann","year":"2010","journal-title":"Fingolimod (FTY720): Discovery and Development of an Oral Drug to Treat Multiple Sclerosis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"21453","DOI":"10.1074\/jbc.C200176200","article-title":"The immune modulator FTY720 targets sphingosine 1-phosphate receptors.","volume":"277","author":"Brinkmann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.bbamcr.2007.11.008","article-title":"Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures.","volume":"1783","author":"Brunati","year":"2008","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1002\/art.27463","article-title":"Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels.","volume":"62","author":"Bu","year":"2010","journal-title":"Arthritis Rheum."},{"key":"B18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.exer.2008.07.012","article-title":"Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization.","volume":"88","author":"Caballero","year":"2009","journal-title":"Exp. Eye Res."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1091\/mbc.E09-09-0812","article-title":"Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1\/S1P3 axis.","volume":"21","author":"Cencetti","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00109-016-1460-x","article-title":"HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis.","volume":"95","author":"Chang","year":"2017","journal-title":"J. Mol. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/jcb.24670","article-title":"Sphingosine 1-phosphate receptors negatively regulate collagen type I\/III expression in human bone marrow-derived mesenchymal stem cell.","volume":"115","author":"Chang","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"9613","DOI":"10.1073\/pnas.1103187108","article-title":"Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.","volume":"108","author":"Christoffersen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B22","first-page":"10S","article-title":"Epidemiology of heart failure.","author":"Corrao","year":"2014","journal-title":"G. Ital. Cardiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev-immunol-020711-075011","article-title":"Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.","volume":"30","author":"Cyster","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1016\/j.transproceed.2007.04.027","article-title":"FTY720 reduces extracellular matrix expansion associated with ischemia-reperfusion induced injury.","volume":"39","author":"Delbridge","year":"2007","journal-title":"Transplant. Proc."},{"key":"B25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.2174\/187152012800228643","article-title":"Sphingolipid modulation: a strategy for cancer therapy.","volume":"12","author":"Delgado","year":"2012","journal-title":"Anticancer Agents Med. Chem."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.87058","article-title":"HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver.","volume":"1","author":"Ding","year":"2016","journal-title":"JCI Insight"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-274936","article-title":"Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.","volume":"29","author":"Donoviel","year":"2015","journal-title":"FASEB J."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/eji.200737898","article-title":"TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells.","volume":"38","author":"Eskan","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.drudis.2008.04.002","article-title":"Relaxin family peptide receptors\u2013from orphans to therapeutic targets.","volume":"13","author":"Et","year":"2008","journal-title":"Drug Discov. Today"},{"key":"B30","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis.","volume":"59","author":"Fern\u00e1ndez","year":"2015","journal-title":"J. Pineal Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"The cellular basis of hepatic fibrosis \u2013 mechanisms and treatment strategies.","volume":"328","author":"Flier","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1210\/me.2014-1201","article-title":"Role of sphingosine kinase \/ S1P Axis in ECM remodeling of cardiac cells elicited by relaxin.","volume":"29","author":"Frati","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1172\/JCI60746","article-title":"The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.","volume":"122","author":"Fukuhara","year":"2012","journal-title":"J. Clin. Invest"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa2581","article-title":"HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.","volume":"8","author":"Galvani","year":"2015","journal-title":"Sci. Signal."},{"key":"B35","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/biof.1342","article-title":"Inhibition of the SphK1\/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells.","volume":"43","author":"Gonzandez-Fernandez","year":"2017","journal-title":"Int. Union Biochem. Mol. Biol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081636","article-title":"A novel perspective on the ApoM-S1P axis, highlighting the metabolism of apom and its role in liver fibrosis and neuroinflammation.","volume":"18","author":"Hajny","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.bbalip.2014.01.008","article-title":"TLR2\/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts.","volume":"1841","author":"Hamidi","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1126\/science.1065323","article-title":"Lysophospholipids\u2013receptor revelations.","volume":"294","author":"Hla","year":"2001","journal-title":"Science"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1096\/fj.12-219634","article-title":"Targeting sphingosine kinase 1 attenuates bleomycininduced pulmonary fibrosis.","volume":"27","author":"Huang","year":"","journal-title":"FASEB J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1165\/rcmb.2013-0070OC","article-title":"Lysophosphatidic acid receptor\u20132 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.","volume":"49","author":"Huang","year":"","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1136\/thoraxjnl-2014-206684","article-title":"Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy.","volume":"70","author":"Huang","year":"2015","journal-title":"Thorax"},{"key":"B42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jbior.2014.09.008","article-title":"Sphingolipids in pulmonary fibrosis.","volume":"57","author":"Huang","year":"2015","journal-title":"Adv. Biol. Regul."},{"key":"B43","doi-asserted-by":"publisher","first-page":"46832","DOI":"10.1074\/jbc.M306577200","article-title":"Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis.","volume":"278","author":"Igarashi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1194\/jlr.M800496-JLR200","article-title":"Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.","volume":"50","author":"Ikeda","year":"2009","journal-title":"J. Lipid Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"25152","DOI":"10.1074\/jbc.M200137200","article-title":"Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)\/LP(B2)\/EDG-5 and S1P(3)\/LP(B3)\/EDG-3.","volume":"277","author":"Ishii","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.yjmcc.2007.04.007","article-title":"Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response.","volume":"43","author":"Kacimi","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1002\/hep.25780","article-title":"Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents.","volume":"56","author":"Kageyama","year":"2012","journal-title":"Hepatology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/FJC.0b013e3181926706","article-title":"Sphingosine kinase and sphingosine 1-phosphate in cardioprotection.","volume":"53","author":"Karliner","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003393","article-title":"Sphingosine-1-phosphate receptor 1 regulates cardiac function by modulating Ca2+ sensitivity and Na+\/H+ exchange and mediates protection by ischemic preconditioning.","volume":"5","author":"Keul","year":"2016","journal-title":"J. Am. Hear. Assoc."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1053\/j.gastro.2017.03.022","article-title":"Sphingosine-1-phosphate prevents egress of hematopoietic stem cells from liver to reduce fibrosis.","volume":"153","author":"King","year":"2017","journal-title":"Gastroenterology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1007\/s10753-014-9877-2","article-title":"FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells.","volume":"37","author":"Kong","year":"2014","journal-title":"Inflammation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1165\/rcmb.2007-0065OC","article-title":"Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1.","volume":"37","author":"Kono","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis.","volume":"225","author":"Krenning","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1194\/jlr.R059543","article-title":"Sources, metabolism, and regulation of circulating sphingosine-1-phosphate.","volume":"56","author":"Ksi\u0105\u017cek","year":"2015","journal-title":"J. Lipid Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/35018092","article-title":"A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development.","volume":"406","author":"Kupperman","year":"2000","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01065.2006","article-title":"Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions.","volume":"292","author":"Landeen","year":"2007","journal-title":"Am. J. Physiol. Hear. Circ. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"H736","DOI":"10.1152\/ajpheart.00316.2007","article-title":"Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes.","volume":"294","author":"Landeen","year":"2008","journal-title":"Am. J. Physiol. Hear. Circ. Physiol."},{"key":"B59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4161\/auto.3416","article-title":"Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?","volume":"3","author":"Lavieu","year":"2007","journal-title":"Autophagy"},{"key":"B60","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0009-8981(00)00240-0","article-title":"Molecular mechanism of diabetic nephropathy.","volume":"297","author":"Lehmann","year":"2000","journal-title":"Clin. Chim. Acta"},{"key":"B61","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1164\/rccm.201006-0894CI","article-title":"Clinical course and prediction of survival in idiopathic pulmonary fibrosis.","volume":"183","author":"Ley","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.2353\/ajpath.2009.090037","article-title":"Involvement of sphingosine 1-phosphate (SIP)\/S1P3 signaling in cholestasis-induced liver fibrosis.","volume":"175","author":"Li","year":"","journal-title":"Am. J. Pathol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.jhep.2009.01.028","article-title":"Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.","volume":"50","author":"Li","year":"","journal-title":"J. Hepatol."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-4-66","article-title":"Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model.","volume":"4","author":"Li","year":"","journal-title":"Radiat. Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.jhep.2010.08.028","article-title":"Sphingosine 1-phosphate (S1P)\/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility.","volume":"54","author":"Li","year":"2011","journal-title":"J. Hepatol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1161\/CIRCHEARTFAILURE.112.000123","article-title":"A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting nfat (nuclear factor of activated t-cells) signaling and periostinclinical perspective.","volume":"6","author":"Liu","year":"2013","journal-title":"Circ. Hear. Fail"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1002\/jcp.22572","article-title":"Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation.","volume":"226","author":"Liu","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1172\/JCI10905","article-title":"Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.","volume":"106","author":"Liu","year":"2000","journal-title":"J. Clin. Invest"},{"key":"B69","doi-asserted-by":"publisher","first-page":"35957","DOI":"10.1074\/jbc.M110.117945","article-title":"Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1\/2 in MDA-MB-453 breast cancer cells.","volume":"285","author":"Long","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/cvr\/cvp056","article-title":"Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-\u03b2-stimulated collagen production by cardiac fibroblasts.","volume":"82","author":"Lowe","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"B71","first-page":"3","article-title":"Long-term management of the successful adult liver transplant: 2013 practice guideline by the American Association for the study of liver diseases and the American Society of Transplantation.","volume":"19","author":"Lucey","year":"2013","journal-title":"J. Clin. Hepatol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.tcb.2011.09.003","article-title":"Sphingosine-1-phosphate signaling and its role in disease.","volume":"22","author":"Maceyka","year":"2012","journal-title":"Trends Cell Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease.","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"B74","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1590\/S0102-86502012000800013","article-title":"Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection.","volume":"27","author":"Marques","year":"2012","journal-title":"Acta Cir. Bras."},{"key":"B75","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.cell.2007.09.047","article-title":"Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.","volume":"131","author":"Massberg","year":"2007","journal-title":"Cell"},{"key":"B76","doi-asserted-by":"publisher","first-page":"H2944","DOI":"10.1152\/ajpheart.01331.2006","article-title":"Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury.","volume":"292","author":"Means","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1136\/thoraxjnl-2011-200026","article-title":"Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.","volume":"67","author":"Milara","year":"2012","journal-title":"Thorax"},{"key":"B78","doi-asserted-by":"publisher","first-page":"16394","DOI":"10.1073\/pnas.0603734103","article-title":"Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.","volume":"103","author":"Mitra","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B79","doi-asserted-by":"publisher","first-page":"11113","DOI":"10.1128\/MCB.25.24.11113-11121.2005","article-title":"Essential role for sphingosine kinases in neural and vascular development.","volume":"25","author":"Mizugishi","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1042\/bj3520809","article-title":"Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.","author":"Murata","year":"2000","journal-title":"Biochem. J."},{"key":"B81","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jbior.2013.10.001","article-title":"Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.","volume":"54","author":"Nagahashi","year":"2014","journal-title":"Adv. Biol. Regul."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1096\/fj.12-219618","article-title":"Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.","volume":"27","author":"Nagahashi","year":"2013","journal-title":"FASEB J."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1194\/jlr.R069286","article-title":"The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases.","volume":"57","author":"Nagahashi","year":"2016","journal-title":"J. Lipid Res."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-3-199802010-00007","article-title":"Update in pulmonary medicine.","volume":"128","author":"Niederman","year":"1998","journal-title":"Ann. Intern. Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.bbalip.2013.07.012","article-title":"Molecular and physiological functions of sphingosine 1-phosphate transporters.","volume":"1841","author":"Nishi","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182329","article-title":"Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.","volume":"12","author":"Ohkura","year":"2017","journal-title":"PLoS One"},{"key":"B87","doi-asserted-by":"publisher","first-page":"46452","DOI":"10.1074\/jbc.M308749200","article-title":"Sphingosine kinase type 1 induces G12\/13-mediated stress fiber formation, yet promotes growth and survival independent of g protein-coupled receptors.","volume":"278","author":"Olivera","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodelling.","volume":"367","author":"Opie","year":"2006","journal-title":"Lancet"},{"key":"B89","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.2147\/DDDT.S78496","article-title":"Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells.","volume":"9","author":"Pan","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"B90","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4062\/biomolther.2016.160","article-title":"Sphingosine 1-phosphate receptor modulators and drug discovery.","volume":"25","author":"Park","year":"2017","journal-title":"Biomol. Ther."},{"key":"B91","doi-asserted-by":"crossref","first-page":"d1720","DOI":"10.2741\/A875","article-title":"PDGF and signal transduction in hepatic stellate cells.","volume":"7","author":"Pinzani","year":"2002","journal-title":"Front. Biosci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.bbalip.2012.07.003","article-title":"Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis.","volume":"1831","author":"Pyne","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B93","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrc2875","article-title":"Sphingosine 1-phosphate and cancer.","volume":"10","author":"Pyne","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"B94","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.plipres.2016.03.001","article-title":"Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.","volume":"62","author":"Pyne","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1053\/j.gastro.2004.08.028","article-title":"From quiescence to activation: gene regulation in hepatic stellate cells.","volume":"127","author":"Rippe","year":"2004","journal-title":"Gastroenterology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1006\/jmcc.2001.1433","article-title":"EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes.","volume":"33","author":"Robert","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","article-title":"The bone marrow functionally contributes to liver fibrosis.","volume":"130","author":"Russo","year":"2006","journal-title":"Gastroenterology"},{"key":"B98","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/hh0302.104455","article-title":"Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells.","volume":"90","author":"Ryu","year":"2002","journal-title":"Circ. Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1194\/jlr.M039685","article-title":"Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.","volume":"54","author":"Salous","year":"2013","journal-title":"J. Lipid Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"47281","DOI":"10.1074\/jbc.M306896200","article-title":"Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.","volume":"278","author":"Sanchez","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/jcb.20127","article-title":"Structural and functional characteristics of S1P receptors.","volume":"92","author":"Sanchez","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1111\/j.1471-4159.2007.04958.x","article-title":"Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes.","volume":"103","author":"Sato","year":"2007","journal-title":"J. Neurochem."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/srep32119","article-title":"Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human.","volume":"6","author":"Sato","year":"2016","journal-title":"Sci. Rep."},{"key":"B104","doi-asserted-by":"publisher","first-page":"38471","DOI":"10.1074\/jbc.M313557200","article-title":"Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes.","volume":"279","author":"Sauer","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B105","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1159\/000341185","article-title":"Ceramide expression and cell homeostasis in chronic obstructive pulmonary disease.","volume":"85","author":"Scarpa","year":"2013","journal-title":"Respiration"},{"key":"B106","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.bbalip.2012.07.022","article-title":"Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases.","volume":"1831","author":"Schwalm","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1161\/01.RES.85.11.1000","article-title":"Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.","volume":"85","author":"Sekiguchi","year":"1999","journal-title":"Circ. Res."},{"key":"B108","doi-asserted-by":"publisher","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","article-title":"Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy.","volume":"134","author":"Selman","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"B109","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.advenzreg.2009.10.024","article-title":"Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.","volume":"50","author":"Serra","year":"2010","journal-title":"Adv. Enzyme Regul."},{"key":"B110","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1165\/rcmb.2009-0345OC","article-title":"Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.","volume":"43","author":"Shea","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/01.RES.86.12.1259","article-title":"Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro.","volume":"86","author":"Siwik","year":"2000","journal-title":"Circ. Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"14839","DOI":"10.1074\/jbc.M112.426726","article-title":"Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling.","volume":"288","author":"Sobel","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B113","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrm1103","article-title":"Sphingosine-1-phosphate: an enigmatic signalling lipid.","volume":"4","author":"Spiegel","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1074\/jbc.R600028200","article-title":"Functions of the multifaceted family of sphingosine kinases and some close relatives.","volume":"282","author":"Spiegel","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B115","doi-asserted-by":"publisher","first-page":"13457","DOI":"10.1074\/jbc.M111.268185","article-title":"Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells.","volume":"287","author":"Stanford","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B116","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.exer.2008.07.005","article-title":"Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye.","volume":"87","author":"Swaney","year":"2008","journal-title":"Exp. Eye Res."},{"key":"B117","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5483\/BMBRep.2006.39.2.113","article-title":"Sphingosine kinase: biochemical and cellular regulation and role in disease.","volume":"39","author":"Taha","year":"2006","journal-title":"J. Biochem. Mol. Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"10477","DOI":"10.1074\/jbc.M109.064162","article-title":"Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.","volume":"285","author":"Takabe","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1194\/jlr.R046656","article-title":"Export of sphingosine-1-phosphate and cancer progression.","volume":"55","author":"Takabe","year":"2014","journal-title":"J. Lipid Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/cvr\/cvp312","article-title":"S1P 3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.","volume":"85","author":"Takuwa","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"B121","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1136\/thoraxjnl-2015-207974","article-title":"Sphingosine-1-phosphate metabolism: can its enigmatic lyase promote the autophagy of fibrosis?","volume":"70","author":"Tatler","year":"2015","journal-title":"Thorax"},{"key":"B122","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000362992","article-title":"Sphingosine 1-phosphate in blood: function, metabolism, and fate.","volume":"34","author":"Thuy","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/j.ijrobp.2006.08.058","article-title":"Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research.","volume":"66","author":"Tsoutsou","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"B124","first-page":"17","article-title":"Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase.","volume":"51","author":"Urata","year":"2005","journal-title":"Kobe J. Med. Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder.","volume":"117","author":"Varga","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B126","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1042\/BJ20060251","article-title":"Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.","volume":"397","author":"Venkataraman","year":"2006","journal-title":"Biochem. J."},{"key":"B127","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1161\/01.RES.0000187469.82595.15","article-title":"Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.","volume":"97","author":"Wang","year":"2005","journal-title":"Circ. Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"30684","DOI":"10.1074\/jbc.M115.671735","article-title":"Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate dependent migration.","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B129","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1002\/hep.29076","article-title":"The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.","volume":"65","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"B130","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/j.1524-475X.2007.00292.x","article-title":"Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing.","volume":"15","author":"Watterson","year":"2007","journal-title":"Wound Repair Regen."},{"key":"B131","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1002\/eji.201343441","article-title":"Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration.","volume":"43","author":"Weichand","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"44645","DOI":"10.1074\/jbc.M112.423426","article-title":"Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (HDL)-S1P prolongs endothelial barrier enhancement as compared with albumin-S1P via effects on levels, trafficking, and signaling of S1P1.","volume":"287","author":"Wilkerson","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B133","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1146\/annurev-pathol-012513-104706","article-title":"Pathogenesis of idiopathic pulmonary fibrosis.","volume":"9","author":"Wolters","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1002\/hep.25828","article-title":"Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.","volume":"56","author":"Woodhoo","year":"2012","journal-title":"Hepatology"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis.","volume":"208","author":"Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease.","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"B137","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.ajpath.2014.09.023","article-title":"Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors.","volume":"185","author":"Xiu","year":"2015","journal-title":"Am. J. Pathol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/1440-1681.12494","article-title":"Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy.","volume":"43","author":"Yaghobian","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"53994","DOI":"10.1074\/jbc.M410144200","article-title":"Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-\u03b2 and mediates timp-1 up-regulation.","volume":"279","author":"Yamanaka","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B140","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-physiol-021014-071635","article-title":"Vascular and immunobiology of the circulatory sphingosine 1-phosphate gradient.","volume":"79","author":"Yanagida","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ajpath.2012.03.014","article-title":"Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-\u03b21 via sphingosine kinase\/sphingosine 1-phosphate (S1P)\/S1P receptors axis.","volume":"181","author":"Yang","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jhep.2013.02.021","article-title":"Sphingosine kinase\/sphingosine 1-phosphate (S1P)\/S1P receptor axis is involved in liver fibrosis-associated angiogenesis.","volume":"59","author":"Yang","year":"2013","journal-title":"J. Hepatol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0090-6980(01)00103-4","article-title":"Sphingosine 1-phosphate: synthesis and release.","volume":"64","author":"Yatomi","year":"2001","journal-title":"Prostaglandins"},{"key":"B144","doi-asserted-by":"publisher","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets.","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"H3150","DOI":"10.1152\/ajpheart.00587.2006","article-title":"Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia.","volume":"293","author":"Zhang","year":"2007","journal-title":"Am. J. Physiol. Hear. Circ. Physiol."},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2014.964400","article-title":"Increased expression of collagens, transforming growth factor-\u03b21, and -\u03b23 in gluteal muscle contracture.","volume":"11","author":"Zhao","year":"2010","journal-title":"BMC Musculoskelet. Disord."},{"key":"B147","doi-asserted-by":"crossref","first-page":"691","DOI":"10.33549\/physiolres.932441","article-title":"Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis.","volume":"62","author":"Zhao","year":"2013","journal-title":"Physiol. Res."},{"key":"B148","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1165\/rcmb.2010-0422OC","article-title":"Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.","volume":"45","author":"Zhao","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bbalip.2012.06.014","article-title":"Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.","volume":"1831","author":"Zhao","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"}],"updated-by":[{"DOI":"10.3389\/fphar.2020.594471","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000}}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2018.01504\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T14:42:03Z","timestamp":1603982523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2018.01504\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":149,"alternative-id":["10.3389\/fphar.2018.01504"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.01504","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fphar.2020.594471","asserted-by":"object"}]},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,8]]},"article-number":"1504"}}