{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:37:10Z","timestamp":1790365030516,"version":"4.1.0"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2018.01547","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T23:59:31Z","timestamp":1548287971000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["A Guinea Pig Model of Airway Smooth Muscle Hyperreactivity Induced by Chronic Allergic Lung Inflammation: Contribution of Epithelium and Oxidative Stress"],"prefix":"10.3389","volume":"9","author":[{"given":"Luiz Henrique C\u00e9sar","family":"Vasconcelos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Concei\u00e7\u00e3o Correia","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana Cristina","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana Amanda de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iara Le\u00e3o Luna de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Ramos","family":"Queiroga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layanne Cabral da Cunha","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00eabia Alexa","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Fraga","family":"Righetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre S\u00e9rgio","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Mirella","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Roberta de Oliveira","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giciane Carvalho","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda de F\u00e1tima Lopes Calvo","family":"Tib\u00e9rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana de Andrade","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagn\u00f3lia Ara\u00fajo da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/j.1476-5381.1985.tb17380.x","article-title":"Some effects of nifedipine in guinea-pig isolated trachealis.","volume":"84","author":"Ahmed","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1111\/bph.12445","article-title":"The concise guide to pharmacology 2013\/14: G protein-coupled receptors.","volume":"170","author":"Alexander","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.5152\/ttd.2015.4942","article-title":"Allergic respiratory inflammation and remodeling.","volume":"16","author":"Amin","year":"2015","journal-title":"Turk. Thorac. J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1152\/ajplung.00199.2007","article-title":"Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic lung inflammation.","volume":"294","author":"Angeli","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1164\/ajrccm\/141.3.552","article-title":"Abnormalities in airway smooth muscle in fatal asthma.","volume":"143","author":"Bai","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-88-470-5647-3-3","article-title":"\u201cPathology of COPD and asthma,\u201d in","author":"Baraldo","year":"2014","journal-title":"Mechanics of Breathing"},{"key":"B7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000195094","article-title":"Adrenergic and non-adrenergic, non-cholinergic control of airways.","volume":"50","author":"Barnes","year":"1986","journal-title":"Respiration"},{"key":"B8","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1164\/ajrccm.152.3.7663795","article-title":"\u03b2-adrenergic receptors and their regulation.","volume":"152","author":"Barnes","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1476-5381.1993.tb13542.x","article-title":"Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP.","volume":"109","author":"Ben-Jebria","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1513\/pats.200808-089RM","article-title":"Remodeling in asthma.","volume":"6","author":"Bergeron","year":"2009","journal-title":"Proc. Am. Thor. Soc."},{"key":"B11","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.anai.2017.02.004","article-title":"Biomarkers of oxidative stress and antioxidants in severe asthma: a prospective case-control study.","volume":"118","author":"Bishopp","year":"2017","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1152\/physrev.1979.59.3.606","article-title":"Mechanisms of action of transmitters and other substances on smooth muscle.","volume":"59","author":"Bolton","year":"1979","journal-title":"Physiol. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ejphar.2005.10.064","article-title":"Protein kinase C potentiates homologous desensitization of the \u03b22-adrenoceptor in bovine tracheal smooth muscle.","volume":"529","author":"Boterman","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1378\/chest.125.4.1378","article-title":"Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma.","volume":"125","author":"Bousquet","year":"2004","journal-title":"Chest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1183\/09031936.06.00130004","article-title":"The contribution of transforming growth factor-\u03b2 and epidermal growth factor signalling to airway remodelling in chronic asthma.","volume":"27","author":"Boxall","year":"2006","journal-title":"Eur. Respir. J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-80005","article-title":"Use of a free radical method to evaluate antioxidant activity.","volume":"28","author":"Brand-Williams","year":"1995","journal-title":"Food Sci. Technol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1164\/rccm.201501-0037OC","article-title":"Stress and bronchodilator response in children with asthma.","volume":"192","author":"Brehm","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01835","article-title":"Effects of anti-IL-17 on inflammation, remodeling and oxidative stress in an experimental model of asthma exacerbated by LPS.","volume":"8","author":"Camargo","year":"2018","journal-title":"Front. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/S1471-4892(03)00045-6","article-title":"Modeling asthma and COPD in animals: a pointless exercise?","volume":"3","author":"Canning","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1164\/ajrccm\/147.2.405","article-title":"The structure of large and small airways in nonfatal and fatal asthma.","volume":"147","author":"Carroll","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01966600","article-title":"The schultz-dale reaction. a review.","volume":"8","author":"Chand","year":"1978","journal-title":"Agents Actions"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.jaci.2014.12.1872","article-title":"Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model.","volume":"135","author":"Chesn\u00e9","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1164\/rccm.200607-1062OC","article-title":"Epithelial cell proliferation contributes to airway remodeling in severe asthma.","volume":"176","author":"Cohen","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B24","first-page":"167","article-title":"The anaphylactic reaction of plain muscle in the guinea pig.","volume":"4","author":"Dale","year":"1913","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1152\/japplphysiol.01282.2003","article-title":"Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs.","volume":"97","author":"Danek","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0034-5687(86)90034-90034","article-title":"Ultrastructural studies on the neuromuscular control of human tracheal and bronchial muscle.","volume":"63","author":"Daniel","year":"1986","journal-title":"Respir. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1513\/pats.200907-067DP","article-title":"The role of the epithelium in airway remodeling in asthma.","volume":"6","author":"Davies","year":"2009","journal-title":"Ann. Am. Thorac. Soc."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/sj.bjp.0704191","article-title":"Role of nitric oxide and superoxide in allergen-induced airway hyperreactivity after the late asthmatic reaction in guinea-pigs.","volume":"133","author":"De Boer","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"30143","DOI":"10.1074\/jbc.M606541200","article-title":"Excitation-contraction coupling in airway smooth muscle.","volume":"281","author":"Du","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1152\/ajplung.00421.2007","article-title":"Airway smooth muscle cell tone amplifies contractile function in the presence of chronic cyclic strain.","volume":"295","author":"Fairbank","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B31","first-page":"79","article-title":"Understanding asthma pathophysiology.","volume":"24","author":"Fireman","year":"2003","journal-title":"Allergy Asthma Proc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/j.1365-2125.1986.tb02956.x","article-title":"In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.","volume":"22","author":"Goldie","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ejphar.2008.01.055","article-title":"Pharmacology of airway smooth muscle proliferation.","volume":"585","author":"Gosens","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1006\/pupt.2001.0319","article-title":"Reactive oxygen species as mediators in asthma.","volume":"14","author":"Henricks","year":"2001","journal-title":"Pulm. Pharmacol. Ther."},{"key":"B35","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.jaci.2004.04.039","article-title":"Proliferative aspects of airway smooth muscle.","volume":"114","author":"Hirst","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1067\/mai.2001.111928","article-title":"Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis.","volume":"107","author":"Hoshino","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"B37","author":"Howard","year":"2004","journal-title":"Histological Techniques for Marine Bivalve Mollusks and Crustaceans."},{"key":"B38","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1124\/mol.62.1.65","article-title":"SB-431542 is a potent and specific inhibitor of transforming growth factor \u03b2 superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.","volume":"62","author":"Inman","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1476-5381.1988.tb16578.x","article-title":"Antigen-induced contraction of guinea-pig isolated trachea: studies with novel inhibitors and antagonists of arachidonic acid metabolites.","volume":"95","author":"Jones","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"B40","first-page":"49","article-title":"\u201cLarge-conductance calcium-activated potassium channels,\u201d in","author":"Kume","year":"2013","journal-title":"Calcium Signaling in Airway Smooth Muscle Cells"},{"key":"B41","doi-asserted-by":"crossref","DOI":"10.5772\/60969","article-title":"\u201cCa2+ dynamics and Ca2+ sensitization in the regulation of airway smooth muscle tone,\u201d in","author":"Kume","year":"2015","journal-title":"Muscle Cell and Tissue"},{"key":"B42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma.","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"306","DOI":"10.12688\/f1000research.7422.1","article-title":"Airway hyperresponsiveness: smooth muscle as the principal actor.","volume":"5","author":"Lauzon","year":"2016","journal-title":"F1000Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1164\/ajrccm\/137.5.1198","article-title":"Endogenous Regulation of Bronchomotor Tone1-3.","volume":"137","author":"Leff","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1111\/cea.12309","article-title":"Epithelial function and dysfunction in asthma.","volume":"44","author":"Loxham","year":"2014","journal-title":"Clin. Exp. Allergy"},{"key":"B46","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1165\/rcmb.2015-0180OC","article-title":"Peripheral airway smooth muscle, but not the trachealis, is hypercontractile in an equine model of asthma.","volume":"54","author":"Matusovsky","year":"2016","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1254\/jjp.88.270","article-title":"Effects of various reactive oxygen species on the guinea pig trachea and its epithelium.","volume":"88","author":"M\u00e1ty\u00e1s","year":"2002","journal-title":"Jpn. J. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1365-2222.2004.01895.x","article-title":"Prolonged allergen challenge in mice leads to persistent airway remodeling.","volume":"34","author":"McMillan","year":"2004","journal-title":"Clin. Exp. Allergy"},{"key":"B49","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1183\/09031936.00023608","article-title":"Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models.","volume":"32","author":"Meurs","year":"2008","journal-title":"Eur. Respir. J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-3-0348-8358-0_6","article-title":"\u201cMuscarinic receptor-\u03b2-adrenoceptor cross-talk in airways smooth muscle,\u201d in","author":"Meurs","year":"2001","journal-title":"Muscarinic Receptors in Airways Diseases"},{"key":"B51","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.pupt.2008.12.011","article-title":"Airway smooth muscle contraction\u2013perspectives on past, present and future.","volume":"22","author":"Mitchell","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2174\/138955708784567395","article-title":"Leukotrienes, antileukotrienes and asthma.","volume":"8","author":"Montuschi","year":"2008","journal-title":"Mini. Rev. Med. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.drudis.2011.09.005","article-title":"New perspectives in pharmacological treatment of mild persistent asthma.","volume":"16","author":"Montuschi","year":"2011","journal-title":"Drug Discov. Today"},{"key":"B54","first-page":"73","article-title":"\u201cMeasurement of 8-isoprostane in exhaled breath condensate,\u201d in","author":"Montuschi","year":"2010","journal-title":"Advanced Protocols in Oxidative Stress II. Methods in Molecular Biology (Methods and Protocols)"},{"key":"B55","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1021\/jm5013227","article-title":"Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends.","volume":"58","author":"Montuschi","year":"2015","journal-title":"J. Med. Chem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1445-5994.2004.00801.x","article-title":"Aspirin-sensitive asthma.","volume":"35","author":"Morwood","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1152\/japplphysiol.00830.2007","article-title":"Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodeling induced by chronic allergic inflammation in guinea pigs.","volume":"104","author":"Nakashima","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1183\/09031936.94.07050914","article-title":"Relaxant effects and durations of action of formoterol and salmeterol on the isolated human bronchus.","volume":"7","author":"Naline","year":"1994","journal-title":"Eur. Respir. J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1039\/c4lc00688g","article-title":"Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation.","volume":"14","author":"Nesmith","year":"2014","journal-title":"Lab Chip"},{"key":"B60","doi-asserted-by":"publisher","first-page":"L187","DOI":"10.1152\/ajplung.1994.266.2.L187","article-title":"TGF-beta 1 modulates beta-adrenergic receptor number and function in cultured human tracheal smooth muscle cells.","volume":"266","author":"Nogami","year":"1994","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065580","article-title":"Bronchoconstriction induces TGF-beta release and airway remodelling in guinea pig lung slices.","volume":"8","author":"Oenema","year":"2013","journal-title":"PLoS One"},{"key":"B62","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S2221-1691(11)60060-9","article-title":"Modulatory effect of pineapple peel extract on lipid peroxidation, catalase activity and hepatic biomarker levels in blood plasma of alcohol\u2013induced oxidative stressed rats.","volume":"1","author":"Okafor","year":"2011","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.4172\/2161-105X.1000221","article-title":"Physiology of airway smooth muscle contraction: an overview.","volume":"4","author":"Ouedraogo","year":"2014","journal-title":"J. Pulm. Respir. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.rmed.2008.02.020","article-title":"Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma.","volume":"102","author":"Pelaia","year":"2008","journal-title":"Respir. Med."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0073-4","article-title":"Y-27632 is associated with corticosteroid potentiated control of pulmonar remodeling and inflammation in guinea pigs with chronic allergic inflammation.","volume":"15","author":"Pigati","year":"2015","journal-title":"BMC Pulm. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"L939","DOI":"10.1152\/ajplung.00034.2012","article-title":"Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation.","volume":"303","author":"Possa","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1183\/09031936.06.00004206","article-title":"Characterisation of guinea pig precision-cut lung slices: comparison with human tissues.","volume":"28","author":"Ressmeyer","year":"2006","journal-title":"Eur. Respir. J."},{"key":"B68","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1476-5381.1989.tb16898.x","article-title":"Effect of hydrogen peroxide on guinea-pig tracheal smooth muscle in vitro: role of cyclo-oxygenase and airway epithelium.","volume":"98","author":"Rhoden","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1080\/13543784.2016.1175434","article-title":"Investigational prostaglandin D2 receptor antagonists for airway inflammation.","volume":"25","author":"Santini","year":"2016","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"B70","doi-asserted-by":"publisher","first-page":"380","DOI":"10.4049\/jimmunol.171.1.380","article-title":"Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma.","volume":"171","author":"Schmidt","year":"2003","journal-title":"J. Immunol."},{"key":"B71","first-page":"549","article-title":"Physiological studies in anaphylaxis. I. The reaction of smooth muscle of the guinea pig sensitized with horse serum.","volume":"1","author":"Schultz","year":"1910","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B72","first-page":"527","article-title":"Effect of nebivolol on tone of tracheal muscle of guinea pig.","volume":"27","author":"Shaukat","year":"2015","journal-title":"J. Ayub Med. Coll. Abbottabad"},{"key":"B73","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0168-1591(02)00288-5","article-title":"Guidelines for the ethical use of animals in applied ethology studies.","volume":"81","author":"Sherwin","year":"2003","journal-title":"Appl. Anim. Behav. Sci."},{"key":"B74","author":"Silva","year":"2016","journal-title":"Guia Brasileiro de Produ\u00e7\u00e3o, Manuten\u00e7\u00e3o ou Utiliza\u00e7\u00e3o de Animais em Atividades de Ensino ou Pesquisa Cient\u00edfica: Fasc\u00edculo 1: Introdu\u00e7\u00e3o Geral"},{"key":"B75","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.exppara.2012.06.010","article-title":"Nitric oxide level, protein oxidation and antioxidant enzymes in rats infected by Trypanosoma evansi.","volume":"132","author":"Silva","year":"2012","journal-title":"Exp. Parasitol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1164\/rccm.201107-1281OC","article-title":"Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma.","volume":"185","author":"Sutcliffe","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1164\/ajrccm.155.5.9154886","article-title":"Effects of neurokinin depletion on airway inflammation induced by chronic antigen exposure.","volume":"155","author":"Tib\u00e9rio","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B78","first-page":"145","article-title":"A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets.","volume":"24","author":"Towbin","year":"1992","journal-title":"Biotechnology"},{"key":"B79","first-page":"310","article-title":"Arachidonic acid metabolites and airway epithelium-dependent relaxant factor.","volume":"11","author":"Tschirhart","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B80","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1034\/j.1399-3003.2000.016003514.x","article-title":"Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research.","volume":"16","author":"Van Schoor","year":"2000","journal-title":"Eur. Respir. J."},{"key":"B81","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/09629350124877","article-title":"Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity.","volume":"10","author":"Westerhof","year":"2001","journal-title":"Med. Inflamm."},{"key":"B82","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0952-0600(88)90007-90005","article-title":"Responsiveness of bronchial smooth muscle from asthmatic patients to relaxant and contractile agonists.","volume":"1","author":"Whicker","year":"1988","journal-title":"Pulm. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pupt.2012.08.006","article-title":"Models to study airway smooth muscle contraction in vivo, ex vivo and in vitro: implications in understanding asthma.","volume":"26","author":"Wright","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"B84","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/s1532-0456(02)00040-46","article-title":"Ca2+-activated K+ channel blockers induce PKC modulated oscillatory contractions in guinea pig trachea.","volume":"131","author":"Yagi","year":"2002","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1111\/j.1365-2222.2007.02740.x","article-title":"Animal models of asthma.","volume":"37","author":"Zosky","year":"2007","journal-title":"Clin. Exp. Allergy"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.01547\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T11:29:18Z","timestamp":1550143758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2018.01547\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":85,"alternative-id":["10.3389\/fphar.2018.01547"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2018.01547","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"article-number":"1547"}}