{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:04:06Z","timestamp":1768514646955,"version":"3.49.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00102","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T04:45:41Z","timestamp":1550551541000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Lipid Nanoparticles-Encapsulated YF4: A Potential Therapeutic Oral Peptide Delivery System for Hypertension Treatment"],"prefix":"10.3389","volume":"10","author":[{"given":"Shengnan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.bcp.2009.05.018","article-title":"The biochemical pharmacology of renin inhibitors: implications for translational medicine in hypertension, diabetic nephropathy and heart failure: expectations and reality.","volume":"78","author":"Abassi","year":"2009","journal-title":"Biochem. Pharm."},{"key":"B2","first-page":"3349","article-title":"Development and characterization of nanoparticle based oral delivery of insulin.","volume":"44","author":"Agrawal","year":"2015","journal-title":"J. Mater. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.15171\/apb.2017.002","article-title":"Application of various types of liposomes in drug delivery systems.","volume":"7","author":"Alavi","year":"2017","journal-title":"Adv. Pharm. Bull."},{"key":"B4","doi-asserted-by":"publisher","first-page":"8733","DOI":"10.1021\/jf201314u","article-title":"Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nano dispersions.","volume":"59","author":"Anarjan","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-9-52","article-title":"Ipp-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial.","volume":"9","author":"Boelsma","year":"2010","journal-title":"Nutr. J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3109\/02652048.2015.1065920","article-title":"Enhanced stability of oral insulin in targeted peptide ligand trimethyl chitosan nanoparticles against trypsin.","volume":"32","author":"Chen","year":"2015","journal-title":"J. Microencapsul."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1002\/jps.23229","article-title":"A novel long-acting human growth hormone fusion protein (vrs-317), enhanced in vivo potency and half-life.","volume":"101","author":"Cleland","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.addr.2011.12.009","article-title":"Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.","volume":"64","author":"Ensign","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.meatsci.2012.02.008","article-title":"Antihypertensive effect and antioxidant activity of peptide fractions extracted from spanish dry-cured ham.","volume":"91","author":"Escudero","year":"2012","journal-title":"Meat Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.idairyj.2013.04.002","article-title":"Angiotensin I-converting enzyme inhibitory activity of enzymatic hydrolysates of goat milk protein fractions.","volume":"32","author":"Espejo-Carpio","year":"2013","journal-title":"Int. Dairy J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.3390\/ijms15033373","article-title":"Development of lipid-shell and polymer core nanoparticles with water-soluble salidroside for anti-cancer therapy.","volume":"15","author":"Fang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s11095-010-0130-x","article-title":"Phospholipids and lipid-based formulations in oral drug delivery.","volume":"27","author":"Fricker","year":"2010","journal-title":"Pharm. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1023\/A:1015842609565","article-title":"Oral absorption of peptides: influence of pH and inhibitors on the intestinal hydrolysis of leu-enkephalin and analogues.","volume":"8","author":"Friedman","year":"1991","journal-title":"Pharm. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"20492","DOI":"10.3390\/ijms160920492","article-title":"Influence of parathyroid hormone-loaded PLGA nanoparticles in porous scaffolds for bone regeneration.","volume":"16","author":"Gentile","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1111\/1750-3841.13272","article-title":"Antihypertensive properties of a pea protein hydrolysate during short- and long-term oral administration to spontaneously hypertensive rats.","volume":"81","author":"Girgih","year":"2016","journal-title":"J. Food Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5675","DOI":"10.1021\/nn401905g","article-title":"Nanoparticle encapsulation of mitaplatin and the effect thereof on\/ in vivo properties.","volume":"7","author":"Johnstone","year":"2013","journal-title":"ACS Nano"},{"key":"B17","doi-asserted-by":"publisher","first-page":"5084","DOI":"10.1016\/j.ces.2011.06.065","article-title":"Formation of o\/w emulsions by static mixers for pharmaceutical applications.","volume":"66","author":"Kiss","year":"2011","journal-title":"Chem. Eng. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.phrs.2017.11.003","article-title":"Hypertension and cardiovascular risk: general aspects.","volume":"129","author":"Kjeldsen","year":"2017","journal-title":"Pharm. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","article-title":"Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.biomaterials.2012.10.072","article-title":"A mesoporous silica nanoparticle\u2013PEI\u2013Fusogenic peptide system for siRNA delivery in cancer therapy.","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"B21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ejps.2017.12.009","article-title":"PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.","volume":"115","author":"Lozoya-Agullo","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ijpharm.2016.06.130","article-title":"Preparation and characterization of Chinese yam polysaccharide PLGA nanoparticles and their immunological activity.","volume":"511","author":"Luo","year":"2016","journal-title":"Int. J. Pharm."},{"key":"B23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jconrel.2006.05.010","article-title":"Solid lipid nanoparticles for enhancing vinpocetine\u2019s oral bioavailability.","volume":"114","author":"Luo","year":"2006","journal-title":"J. Control. Release"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082829","article-title":"Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats.","volume":"8","author":"Majumder","year":"2013","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.rinphs.2012.11.001","article-title":"Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres.","volume":"2","author":"Moralescruz","year":"2012","journal-title":"Results Pharma Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jbiotec.2004.06.007","article-title":"Challenges and solutions for the delivery of biotech drugs \u2013 a review of drug nanocrystal technology and lipid nanoparticles.","volume":"113","author":"Muller","year":"2004","journal-title":"J. Biotechnol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s13346-016-0326-7","article-title":"Effect of PEG and water-soluble chitosan coating on moxifloxacin-loaded PLGAlong-circulating nanoparticles.","volume":"7","author":"Mustafa","year":"2017","journal-title":"Drug Deliv. Transl. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ijpharm.2006.06.023","article-title":"PLA\/ PLGA nanoparticles for sustained release of docetaxel.","volume":"325","author":"Musumeci","year":"2006","journal-title":"Int. J. Pharm."},{"key":"B29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jconrel.2018.03.004","article-title":"PEG-PGA enveloped octaarginine-peptide nanocomplexes: an oral peptide delivery strategy.","volume":"276","author":"Niu","year":"2018","journal-title":"J. Control. Release"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.97.157203","article-title":"Shell-driven magnetic stability in core-shell nanoparticles.","volume":"97","author":"Nogu\u00e9s","year":"2006","journal-title":"Phys. Rev. Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/S0024-3205(00)00471-9","article-title":"\u03b1-lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats.","volume":"66","author":"Nurminen","year":"2000","journal-title":"Life Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0168-3659(01)00506-5","article-title":"Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA.","volume":"77","author":"Olbrich","year":"2001","journal-title":"J. Control. Release"},{"key":"B33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1504\/PCFD.2007.013013","article-title":"Preparation of insulin micro-\/nanoparticles: effect of external water phase on dispersion of particles in colloid.","volume":"20","author":"Peng","year":"2007","journal-title":"Chin. J. Biologicals"},{"key":"B34","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/s0308-8146(03)00203-6","article-title":"Fractionation, solubility and functional properties of cowpea (Vigna unguiculata) proteins as affected by pH and\/or salt concentration.","volume":"84","author":"Ragab","year":"2004","journal-title":"Food Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.colsurfa.2010.11.056","article-title":"Influence of external electric field on the polarity of water droplets in water-in-oil emulsion phase transition.","volume":"375","author":"Rayat","year":"2011","journal-title":"Colloids Surf A Physicochem. Eng. Asp."},{"key":"B36","doi-asserted-by":"publisher","first-page":"663","DOI":"10.4155\/tde-2017-0024","article-title":"Challenges in oral peptide delivery: lessons learnt from the clinic and future prospects.","volume":"8","author":"Richard","year":"2017","journal-title":"Ther. Deliv."},{"key":"B37","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0376-7388(99)00182-9","article-title":"Effect of volume ratio of internal aqueous phase to organic membrane phase (w\/o ratio) of water-in-oil emulsion on penicillin g extraction by emulsion liquid membrane.","volume":"163","author":"Sang","year":"1999","journal-title":"J. Memb. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.ejpb.2012.11.006","article-title":"Optimization of encapsulation of a synthetic long peptide in plga nanoparticles: low-burst release is crucial for efficient CD8(+) T cell activation.","volume":"83","author":"Silva","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"B39","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ijpharm.2007.08.034","article-title":"PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiency.","volume":"350","author":"Song","year":"2008","journal-title":"Int. J. Pharm."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.2147\/DDDT.S108185","article-title":"Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology.","volume":"10","author":"Sun","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.peptides.2009.10.002","article-title":"Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery.","volume":"31","author":"Tan","year":"2009","journal-title":"Peptides"},{"key":"B42","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S0895-7061(00)00268-5","article-title":"Intermediate but not low doses of aspirin can suppress angiotensin-converting enzyme inhibitor-induced cough.","volume":"13","author":"Tenenbaum","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"B43","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nature14442","article-title":"Lipid nanoparticle sirna treatment of ebola-virus-makona-infected nonhuman primates.","volume":"521","author":"Thi","year":"2015","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1208\/s12249-013-0048-9","article-title":"Formulation and optimization of nonionic surfactants emulsified nimesulide-loaded PLGA-based nanoparticles by design of experiments.","volume":"15","author":"Turk","year":"2014","journal-title":"AAPS PharmsciTech."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00091","article-title":"Nanoliposome-encapsulated brinzolamide-hydropropyl-\u03b2-cyclodextrin inclusion complex: a potential therapeutic ocular drug-delivery system.","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"12375","DOI":"10.1039\/C3NR04143C","article-title":"Nanodiamond decorated liposomes as highly biocompatible delivery vehicles and a comparison with carbon nanotubes and graphene oxide.","volume":"5","author":"Wang","year":"2013","journal-title":"Nanoscale"},{"key":"B47","doi-asserted-by":"publisher","first-page":"6822","DOI":"10.1021\/ie303460c","article-title":"Modeling interfacial tension in liquid\u2013liquid systems containing electrolytes.","volume":"52","author":"Wang","year":"2013","journal-title":"Ind. Eng. Chem. Res."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-018-2357-x","article-title":"Progesterone PLGA\/mPEG-PLGA hybrid nanoparticle sustained-release system by intramuscular injection.","volume":"35","author":"Xie","year":"2018","journal-title":"Pharm. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ijpharm.2013.04.077","article-title":"Development of a pulmonary peptide delivery system using porous nanoparticle-aggregate particles for systemic application.","volume":"451","author":"Yang","year":"2013","journal-title":"Int. J. Pharm."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1080\/00021369.1986.10867763","article-title":"Opioid peptides from milk proteins.","volume":"50","author":"Yoshikawa","year":"1986","journal-title":"J. Agric. Chem. Soc. Jpn"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17121977","article-title":"Enhanced and extended anti-hypertensive effect of VP5 nanoparticles.","volume":"17","author":"Yu","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1021\/nn800275r","article-title":"Self-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platform.","volume":"2","author":"Zhang","year":"2008","journal-title":"ACS Nano"},{"key":"B53","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ijpharm.2010.04.039","article-title":"The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats.","volume":"394","author":"Zhang","year":"2010","journal-title":"Int. J. Pharm."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00102\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T04:45:43Z","timestamp":1550551543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00102\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,19]]},"references-count":53,"alternative-id":["10.3389\/fphar.2019.00102"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00102","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,19]]},"article-number":"102"}}