{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:34Z","timestamp":1791925714694,"version":"4.3.4"},"reference-count":130,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00202","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:14:40Z","timestamp":1552522480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":243,"title":["Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhouqian","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.pharep.2015.03.002","article-title":"Berberine and neurodegeneration: a review of literature.","volume":"67","author":"Ahmed","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1080\/00498250701767675","article-title":"Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.","volume":"38","author":"Bi","year":"2008","journal-title":"Xenobiotica"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/j.foodchem.2010.12.059","article-title":"Extraction and concentration of tanshinones in Salvia miltiorrhiza Bunge by task-specific non-ionic surfactant assistance.","volume":"126","author":"Bi","year":"2011","journal-title":"Food Chem."},{"key":"B4","first-page":"1618","article-title":"Construction of Saccharomyces cerevisiae whole-cell biocatalyst system for conversion miltiradiene.","volume":"48","author":"Cai","year":"2013","journal-title":"Acta Pharm. Sin."},{"key":"B5","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/0891-5849(95)02211-2","article-title":"Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells.","volume":"20","author":"Cao","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115149","article-title":"Computational identification and systematic classification of novel cytochrome P450 genes in Salvia miltiorrhiza.","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"5125","DOI":"10.2174\/1381612823666170822101112","article-title":"Danshen (Salvia miltiorrhiza Bunge): a prospective healing sage for cardiovascular diseases.","volume":"23","author":"Chen","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"B8","first-page":"876","article-title":"Pharmacology of Salvia miltiorrhiza.","volume":"19","author":"Chen","year":"1984","journal-title":"Acta Pharm. Sin."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1002\/jssc.201000234","article-title":"Infrared-assisted extraction coupled with high-performance liquid chromatography for simultaneous determination of eight active compounds in Radix Salviae miltiorrhizae.","volume":"33","author":"Chen","year":"2010","journal-title":"J. Sep. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1744-7909.2007.00395.x","article-title":"Plant terpenoids: biosynthesis and ecological functions.","volume":"49","author":"Cheng","year":"2007","journal-title":"J. Integr. Plant Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"7473","DOI":"10.3390\/molecules18077473","article-title":"Effects of combined elicitors on tanshinone metabolic profiling and SmCPS expression in Salvia miltiorrhiza hairy root cultures.","volume":"18","author":"Cheng","year":"2013","journal-title":"Molecules"},{"key":"B12","first-page":"236","article-title":"Cloning and induced expression analysis of 4-hydroxy-3-methyl-but-2-enyl diphosphate reductase gene (SmHDR) of Salvia miltiorrhiza.","volume":"48","author":"Cheng","year":"2013","journal-title":"Acta Pharm. Sin."},{"key":"B13","first-page":"231","article-title":"Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential.","volume":"25","author":"Chiu","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1104\/pp.15.00695","article-title":"Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza.","volume":"169","author":"Cui","year":"2015","journal-title":"Plant Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1007\/s11033-010-0383-9","article-title":"Candidate genes involved in tanshinone biosynthesis in hairy roots of Salvia miltiorrhiza revealed by cDNA microarray.","volume":"38","author":"Cui","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"B16","first-page":"785","article-title":"Molecular cloning and SNP analysis of a acetyl-CoA C-acetyltransferase gene (SmAACT) from Salvia miltiorrhiza.","volume":"45","author":"Cui","year":"2010","journal-title":"Acta Pharm. Sin."},{"key":"B17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jplph.2010.06.008","article-title":"Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation.","volume":"168","author":"Dai","year":"2011","journal-title":"J. Plant Physiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/j.1365-313X.2011.04529.x","article-title":"A P450-centric view of plant evolution.","volume":"66","author":"David","year":"2011","journal-title":"Plant J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jsbmb.2009.01.011","article-title":"The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS.","volume":"113","author":"Fan","year":"2009","journal-title":"J. Steroid Biochem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.atherosclerosis.2011.06.041","article-title":"Cardiovascular actions and therapeutic potential of tanshinone IIA.","volume":"220","author":"Gao","year":"2012","journal-title":"Atherosclerosis"},{"key":"B21","first-page":"3365","article-title":"Cloning and bioinformatics analysis of 2-c-methyl-D-erythritol 2,4-cyclodiphosphate synthase gene in Salvia miltiorrhiza.","volume":"37","author":"Gao","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1002\/jssc.201200267","article-title":"On-line ionic liquid-based dynamic microwave-assisted extraction-high performance liquid chromatography for the determination of lipophilic constituents in root of Salvia miltiorrhiza Bunge.","volume":"35","author":"Gao","year":"2015","journal-title":"J. Sep. Sci."},{"key":"B23","first-page":"2486","article-title":"Research progress of synthetic biology for tanshinones.","volume":"40","author":"Gao","year":"2015","journal-title":"China J. Chin. Mater. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.1021\/ol902051v","article-title":"A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.","volume":"11","author":"Gao","year":"2009","journal-title":"Org. Lett."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-73","article-title":"Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza.","volume":"15","author":"Gao","year":"2014","journal-title":"BMC Genomics"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01886","article-title":"Triterpene structural diversification by plant cytochrome P450 enzymes.","volume":"8","author":"Ghosh","year":"2017","journal-title":"Front. Plant Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1002\/ijc.25678","article-title":"Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.","volume":"129","author":"Gong","year":"2011","journal-title":"Int. J. Cancer"},{"key":"B28","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1210\/en.2008-0322","article-title":"The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism.","volume":"150","author":"Gong","year":"2009","journal-title":"Endocrinology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/nph.13790","article-title":"Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.","volume":"210","author":"Guo","year":"2016","journal-title":"New Phytol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"12108","DOI":"10.1073\/pnas.1218061110","article-title":"CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.","volume":"110","author":"Guo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B31","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.bcp.2007.06.044","article-title":"Inhibition of osteoclast differentiation and bone resorption by sauchinone.","volume":"74","author":"Han","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.plaphy.2013.05.010","article-title":"Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba.","volume":"70","author":"Hao","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00299-014-1568-9","article-title":"Metabolic engineering of Nicotiana benthamiana for the increased production of taxadiene.","volume":"33","author":"Hasan","year":"2014","journal-title":"Plant Cell Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1248\/cpb.36.408","article-title":"Isolation of an antidermatophytic substance from the root of Salvia miltiorrhiza.","volume":"36","author":"Honda","year":"1988","journal-title":"Chem. Pharm. Bull."},{"key":"B35","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/BF02541500","article-title":"The structure of rosmariquinone \u2014 a new antioxidant isolated from Rosmarinus officinalis L.","volume":"62","author":"Houlihan","year":"1985","journal-title":"J. Am. Oil Chem. Soc."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5775","DOI":"10.1007\/s11033-011-1388-8","article-title":"Molecular cloning and characterization of the promoter of SmGGPPs and its expression pattern in Salvia miltiorrhiza.","volume":"39","author":"Hua","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.intimp.2018.04.036","article-title":"Tanshinone IIA protects against subclinical lipopolysaccharide induced cardiac fibrosis in mice through inhibition of NADPH oxidase.","volume":"60","author":"Huang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B38","first-page":"37","article-title":"Application of synthetic biology to sustainable utilization of Chinese materia medica resources.","volume":"49","author":"Huang","year":"2014","journal-title":"Acta Pharm. Sin."},{"key":"B39","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1515\/revneuro-2016-0012","article-title":"Tanshinones and mental diseases: from chemistry to medicine.","volume":"27","author":"Javed","year":"2016","journal-title":"Rev. Neurosci."},{"key":"B40","first-page":"1614","article-title":"Cloning and prokaryotic expression analysis of HDS from Salvia miltiorrhiza bge.f.alba.","volume":"49","author":"Jiang","year":"2014","journal-title":"Acta Pharm. Sin."},{"key":"B41","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3892\/mmr.2014.2254","article-title":"Tanshinone IIA reduces the risk of Alzheimer\u2019s disease by inhibiting iNOS, MMP-2 and NF-\u03baBp65 transcription and translation in the temporal lobes of rat models of Alzheimer\u2019s disease.","volume":"10","author":"Jiang","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s11064-015-1751-6","article-title":"Neuroprotective effects of tanshinone I against 6-OHDA-induced oxidative stress in cellular and mouse model of Parkinson\u2019s disease through upregulating Nrf2.","volume":"41","author":"Jing","year":"2016","journal-title":"Neurochem. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s12257-009-0123-y","article-title":"Characterization, expression profiling, and functional identification of a gene encoding geranylgeranyl diphosphate synthase from Salvia miltiorrhiza.","volume":"15","author":"Kai","year":"2010","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"B44","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.ymben.2011.02.003","article-title":"Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures.","volume":"13","author":"Kai","year":"2011","journal-title":"Metab. Eng."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1016\/S0040-4039(00)89532-5","article-title":"Isolation and structures of new tanshinones.","volume":"9","author":"Kakisawa","year":"1968","journal-title":"Tetrahedron Lett."},{"key":"B46","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0040-4039(01)87676-0","article-title":"Structures of isotanshinones.","volume":"10","author":"Kakisawa","year":"1969","journal-title":"Tetrahedron Lett."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1021\/jf00095a007","article-title":"Antioxidative components of tanshen (Salvia miltiorhiza Bung).","volume":"38","author":"Ke","year":"1990","journal-title":"J. Agric. Food Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.copbio.2014.12.004","article-title":"Production of natural products through metabolic engineering of Saccharomyces cerevisiae.","volume":"35","author":"Krivoruchko","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S0006-2952(02)01250-9","article-title":"Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells.","volume":"64","author":"Kyoko","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3858\/emm.2009.41.7.056","article-title":"Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro.","volume":"41","author":"Le","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1271\/bbb.63.2236","article-title":"Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza Bunge.","volume":"63","author":"Lee","year":"1999","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/jssc.200600368","article-title":"Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography.","volume":"30","author":"Li","year":"2007","journal-title":"J. Sep. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00284-016-1023-y","article-title":"Phoma glomerata D14: an endophytic fungus from Salvia miltiorrhiza that produces Salvianolic acid C.","volume":"73","author":"Li","year":"2016","journal-title":"Curr. Microbiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ajps.2018.02.009","article-title":"Development of cryptotanshinone-loaded pellets for angina chronotherapy: in virto\/in vivo prediction and evaluation.","volume":"13","author":"Li","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s11738-010-0627-2","article-title":"Molecular cloning and expression analysis of a new putative gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase from Salvia miltiorrhiza.","volume":"33","author":"Lin","year":"2011","journal-title":"Acta Physiol. Plant."},{"key":"B56","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.seppur.2013.03.012","article-title":"Ionic liquid-based ultrahigh pressure extraction of five tanshinones from Salvia miltiorrhiza Bunge.","volume":"110","author":"Liu","year":"2013","journal-title":"Sep. Purif. Technol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0304-3835(00)00391-8","article-title":"Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG 2 cells.","volume":"153","author":"Liu","year":"2000","journal-title":"Cancer Lett."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00709-016-1045-0","article-title":"Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.","volume":"254","author":"Liu","year":"2017","journal-title":"Protoplasma"},{"key":"B59","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1194\/jlr.M040394","article-title":"Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1.","volume":"55","author":"Liu","year":"2014","journal-title":"J. Lipid Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1039\/c5cs00025d","article-title":"Engineered biosynthesis of natural products in heterologous hosts.","volume":"44","author":"Luo","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"16235","DOI":"10.3390\/molecules200916235","article-title":"The biosynthetic pathways of tanshinones and phenolic acids in Salvia miltiorrhiza.","volume":"20","author":"Ma","year":"2015","journal-title":"Molecules"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1093\/jxb\/err466","article-title":"Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza.","volume":"63","author":"Ma","year":"2012","journal-title":"J. Exp. Bot."},{"key":"B63","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.1093\/jxb\/ert342","article-title":"Elicitors from the endophytic fungus Trichoderma atroviride promote Salvia miltiorrhiza hairy root growth and tanshinone biosynthesis.","volume":"64","author":"Ming","year":"2013","journal-title":"J. Exp. Bot."},{"key":"B64","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/10715760000301471","article-title":"Tanshinone II-A inhibits low density lipoprotein oxidation in vitro.","volume":"33","author":"Niu","year":"2000","journal-title":"Free Radic. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/chromsci\/42.4.211","article-title":"Evaluation of pressurized liquid extraction and pressurized hot water extraction for tanshinone I and IIA in Salvia miltiorrhiza using LC and LC-ESI-MS.","volume":"42","author":"Ong","year":"2004","journal-title":"J. Chromatogr. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.2174\/0929867322666141212122352","article-title":"Flavonoids and dementia: an update.","volume":"22","author":"Orhan","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jplph.2010.06.008","article-title":"Molecular cloning, characterization and expression analysis of a new gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Salvia miltiorrhiza.","volume":"31","author":"Pan","year":"2009","journal-title":"Acta Physiol. Plant."},{"key":"B68","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0021-9673(01)00949-9","article-title":"Microwave-assisted extraction of tanshinones from Salvia miltiorrhiza Bunge with analysis by high-performance liquid chromatography.","volume":"922","author":"Pan","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"B69","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1369-703X(02)00039-6","article-title":"Comparison of microwave-assisted extraction and conventional extraction techniques for the extraction of tanshinones from Salvia miltiorrhiza Bunge.","volume":"12","author":"Pan","year":"2002","journal-title":"Biochem. Eng. J."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21010051","article-title":"Chemical analysis of the herbal medicine Salviae miltiorrhizae radix et Rhizoma (Danshen).","volume":"21","author":"Pang","year":"2016","journal-title":"Molecules"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1016\/j.fitote.2012.09.020","article-title":"Comparison of neuroprotective effects of five major lipophilic diterpenoids from Danshen extract against experimentally induced transient cerebral ischemic damage.","volume":"83","author":"Park","year":"2012","journal-title":"Fitoterapia"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1055\/s-0034-1382908","article-title":"Spaceflight environment-induced variation in root yield and active constituents of Salvia miltiorrhiza.","volume":"80","author":"Peng","year":"2014","journal-title":"Planta Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1146\/annurev-chembioeng-061010-114209","article-title":"Metabolic engineering for the production of natural products.","volume":"2","author":"Pickens","year":"2011","journal-title":"Annu. Rev. Chem. Biomol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: a systematic review and meta analysis.","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimers Dement."},{"key":"B75","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.aca.2007.03.005","article-title":"Coupling continuous ultrasound-assisted extraction with ultrasonic probe, solid-phase extraction and high-performance liquid chromatography for the determination of sodium Danshensu and four tanshinones in Salvia miltiorrhiza Bunge.","volume":"589","author":"Qiao","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"B76","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1055\/s-2004-815535","article-title":"Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza.","volume":"70","author":"Ren","year":"2004","journal-title":"Planta Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0163-7258(02)00327-3","article-title":"The many roles of cytochrome b5.","volume":"97","author":"Schenkman","year":"2003","journal-title":"Pharmacol. Therapeut."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1474170","article-title":"Bioactivities, biosynthesis and biotechnological production of phenolic acids in Salvia miltiorrhiza.","author":"Shi","year":"2018","journal-title":"Crit. Rev. Food Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1055\/s-2006-957696","article-title":"In vitro cytotoxicity of tanshinones from Salvia miltiorrhiza.","volume":"63","author":"Shi","year":"1997","journal-title":"Planta Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S1875-5364(15)30002-9","article-title":"Salvia miltiorrhiza: traditional medicinal uses, chemistry, and pharmacology.","volume":"13","author":"Su","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1016\/j.jchromb.2011.05.014","article-title":"Extraction and preparative purification of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography.","volume":"879","author":"Sun","year":"2011","journal-title":"J. Chromatogr. B"},{"key":"B82","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.vph.2007.01.001","article-title":"Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.","volume":"46","author":"Tang","year":"2007","journal-title":"Vasc. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"7765","DOI":"10.14233\/ajchem.2013.14597","article-title":"Ultrasonic-assisted extraction of tanshinones from Korean red ginseng by using amino-modified monolithic cartridge.","volume":"25","author":"Tao","year":"2013","journal-title":"Asian J. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0021-9673(01)01495-9","article-title":"Separation of tanshinones from Salvia miltiorrhiza Bunge by multidimensional counter-current chromatography.","volume":"945","author":"Tian","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"B85","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/j.1365-313X.2007.03273.x","article-title":"Geranyl diphosphate synthase is required for biosynthesis of gibberellins.","volume":"52","author":"van Schie","year":"2010","journal-title":"Plant J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jpba.2012.04.029","article-title":"Isolation and structure characterization of related impurities in Sodium Tanshinone IIA Sulfonate by LC\/ESI-MS(n) and NMR.","volume":"68","author":"Wang","year":"2012","journal-title":"J. Pharmaceut. Biomed."},{"key":"B87","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jphotobiol.2016.01.012","article-title":"Synergistic effects of ultraviolet-B and methyl jasmonate on tanshinone biosynthesis in Salvia miltiorrhiza hairy roots.","volume":"159","author":"Wang","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"B88","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/jssc.200700386","article-title":"Orthogonal array design for the optimization of supercritical fluid extraction of tanshinones from Danshen.","volume":"31","author":"Wang","year":"2015","journal-title":"J. Sep. Sci."},{"key":"B89","first-page":"517","article-title":"Tanshinone IIA prevents cardiac remodeling through attenuating NAD (P)H oxidase-derived reactive oxygen species production in hypertensive rats.","volume":"66","author":"Wang","year":"2011","journal-title":"Pharmazie"},{"key":"B90","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jep.2015.01.042","article-title":"Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson\u00d7s disease.","volume":"164","author":"Wang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"16031","DOI":"10.18632\/oncotarget.3648","article-title":"Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1\u03b1 accumulation in both endothelial and tumor cells.","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"B92","doi-asserted-by":"publisher","first-page":"5816","DOI":"10.1021\/jm040112r","article-title":"Antitumor agents. 239. isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.","volume":"47","author":"Wang","year":"2004","journal-title":"J. Med. Chem."},{"key":"B93","first-page":"1251","article-title":"A full length cDNA of 4-(cytidine 5\u2019-diphospho)-2-C-methyl-D-erythritol kinase cloning and analysis of introduced gene expression in Salvia miltiorrhiza.","volume":"43","author":"Wang","year":"2008","journal-title":"Acta Pharm. Sin."},{"key":"B94","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/ijms19030827","article-title":"Comparative transcriptome analyses reveal potential mechanisms of enhanced drought tolerance in transgenic Salvia Miltiorrhiza plants expressing AtDREB1A from Arabidopsis.","volume":"19","author":"Wei","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1139\/cjpp-2016-0036","article-title":"The cardioprotection of dihydrotanshinone I against myocardial ischemia-reperfusion injury via inhibition of arachidonic acid omega-hydroxylase.","volume":"94","author":"Wei","year":"2016","journal-title":"Can. J. Physiol. Pharm."},{"key":"B96","first-page":"1","article-title":"Molecular cloning and characterization of two 1-deoxy- d -xylulose-5-phosphate synthase genes involved in tanshinone biosynthesis in Salvia miltiorrhiza.","volume":"36","author":"Wei","year":"2016","journal-title":"Mol. Breed."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1021\/jf00020a007","article-title":"Antioxidant activity of quinones extracted from tanshen (Salvia miltiorrhiza Bunge).","volume":"40","author":"Weng","year":"1992","journal-title":"J. Agric. Food Chem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1248\/bpb.26.845","article-title":"Isolation and quantitative analysis of cryptotanshinone, an active quinoid diterpene formed in callus of Salvia miltiorrhiza BUNGE.","volume":"26","author":"Wu","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"B99","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.1002\/jssc.200900398","article-title":"Ionic liquid surfactant-mediated ultrasonic-assisted extraction coupled to HPLC: application to analysis of tanshinones in Salvia miltiorrhiza bunge.","volume":"32","author":"Wu","year":"2015","journal-title":"J. Sep. Sci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1038\/aps.2012.84","article-title":"Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC).","volume":"33","author":"Wu","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"B101","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1002\/jssc.201100993","article-title":"Modeling gradient elution in countercurrent chromatography: efficient separation of tanshinones from Salvia miltiorrhiza Bunge.","volume":"35","author":"Wu","year":"2012","journal-title":"J. Sep. Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1042\/BA20080004","article-title":"Cloning and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza (Chinese sage) hairy roots.","volume":"52","author":"Wu","year":"2011","journal-title":"Biotechnol. Appl. Biochem."},{"key":"B103","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1142\/S0192415X91000284","article-title":"Cytotoxic activities of tanshinones against human carcinoma cell lines.","volume":"19","author":"Wu","year":"1991","journal-title":"Am. J. Chin. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"5967","DOI":"10.1021\/cr200058f","article-title":"Constituents from Salvia species and their biological activities.","volume":"112","author":"Wu","year":"2016","journal-title":"Chem. Rev."},{"key":"B105","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3390\/molecules20010309","article-title":"Ag+ as a more effective elicitor for production of tanshinones than phenolic acids in Salvia miltiorrhiza hairy roots.","volume":"20","author":"Xing","year":"2014","journal-title":"Molecules"},{"key":"B106","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jep.2018.06.029","article-title":"Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: a review.","volume":"225","author":"Xu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s10404-009-0554-y","article-title":"Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid\u2013liquid interface area.","volume":"9","author":"Xuan","year":"2010","journal-title":"Microfluid. Nanofluid."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s11738-009-0320-5","article-title":"Molecular characterization and expression of 1-deoxy- d -xylulose 5-phosphate reductoisomerase (DXR) gene from Salvia miltiorrhiza.","volume":"31","author":"Yan","year":"2009","journal-title":"Acta Physiol. Plant."},{"key":"B109","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s12010-014-0876-4","article-title":"Effects of Streptomyces pactum Act12 on Salvia miltiorrhiza hairy root growth and tanshinone synthesis and its mechanisms.","volume":"173","author":"Yan","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046797","article-title":"Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots.","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/emm.2007.8","article-title":"Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK\/ERK pathway.","volume":"39","author":"Yang","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"B112","first-page":"204","article-title":"Anti-oxidation of Tanshinone II A and Prohibitin on cardiomyocytes.","volume":"2","author":"Yang","year":"2010","journal-title":"Chin. Herb. Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/FJC.0b013e3181671439","article-title":"Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation.","volume":"51","author":"Yang","year":"2008","journal-title":"J. Cardiovasc. Pharm."},{"key":"B114","first-page":"1086","article-title":"Bioinformatics and expression analysis of isopentenyl diphosphate isomerase (SmIPI) from Salvia miltiorrhiza Bunge.","volume":"47","author":"Yang","year":"2011","journal-title":"Plant Physiol. J."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01493","article-title":"Identification of pharmacokinetic markers for Guanxin Danshen drop pills in rats by combination of pharmacokinetics, systems pharmacology, and pharmacodynamic assays.","volume":"9","author":"Yao","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jep.2016.12.051","article-title":"Apoptosis induced by the methanol extract of Salvia miltiorrhiza Bunge in non\u2013small cell lung cancer through PTEN-mediated inhibition of PI3K\/Akt pathway.","volume":"200","author":"Ye","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"B117","first-page":"1363","article-title":"Anticancer effect of tanshinone and its mechanisms.","volume":"22","author":"Yuan","year":"2003","journal-title":"Chin. J. Cancer"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02694","article-title":"Endophyte Chaetomium globosum D38 promotes bioactive constituents accumulation and root production in Salvia miltiorrhiza.","volume":"8","author":"Zhai","year":"2017","journal-title":"Front. Microbiol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00221-008-1600-9","article-title":"Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase\/Akt signaling pathway.","volume":"193","author":"Zhang","year":"2009","journal-title":"Exp. Brain Res."},{"key":"B120","first-page":"2704","article-title":"Cloning and characterization of geranylgeranyl diphosphate synthase gene of Salvia miltiorrhia.","volume":"34","author":"Zhang","year":"2009","journal-title":"China J. Chin. Mater. Med."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.3978\/j.issn.2072-1439.2014.12.37","article-title":"Sodium tanshinone IIA silate as an add-on therapy in patients with unstable angina pectoris.","volume":"6","author":"Zhang","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"B122","article-title":"Compound Salvia droplet pill, a traditional Chinese medicine, for the treatment of unstable angina pectoris: a systematic review.","volume":"14","author":"Zhang","year":"2008","journal-title":"Med. Sci. Monit."},{"key":"B123","first-page":"2378","article-title":"Cloning and expression analysis of a new 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza (SmHMGR3).","volume":"37","author":"Zhang","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.3390\/molecules16032259","article-title":"Diterpenoid tanshinones and phenolic acids from cultured hairy roots of Salvia miltiorrhiza Bunge and their antimicrobial activities.","volume":"16","author":"Zhao","year":"2011","journal-title":"Molecules"},{"key":"B125","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00253-010-2443-4","article-title":"Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures.","volume":"87","author":"Zhao","year":"2010","journal-title":"Appl. Microbiol. Biot."},{"key":"B126","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nbt.3095","article-title":"Distributing a metabolic pathway among a microbial consortium enhances production of natural products.","volume":"33","author":"Zhou","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/ijms19010270","article-title":"The plant growth-promoting fungus (PGPF) Alternaria sp A13 markedly enhances Salvia miltiorrhiza root growth and active ingredient accumulation under greenhouse and field conditions.","volume":"19","author":"Zhou","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.fct.2013.08.084","article-title":"Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity.","volume":"62","author":"Zhou","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1021\/ja2114486","article-title":"Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production.","volume":"134","author":"Zhou","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"B130","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1146\/annurev-arplant-050213-035705","article-title":"To gibberellins and beyond! surveying the evolution of (Di)Terpenoid metabolism.","volume":"65","author":"Zi","year":"2014","journal-title":"Annu. Rev. Plant Biol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00202\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:14:44Z","timestamp":1552522484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00202\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":130,"alternative-id":["10.3389\/fphar.2019.00202"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00202","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,14]]},"article-number":"202"}}