{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:46:10Z","timestamp":1782816370413,"version":"3.54.5"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00266","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T15:21:12Z","timestamp":1553008872000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Potential Antitumor Effective Substances and Mechanism of Phellinus igniarius"],"prefix":"10.3389","volume":"10","author":[{"given":"Yu","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kequn","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.semnephrol.2016.04.001","article-title":"The role of BCL-2 family members in acute kidney injury.","volume":"36","author":"Borkan","year":"2016","journal-title":"Semin. Nephrol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00187","article-title":"Exploring the mechanism of dangguiliuhuang decoction against hepatic fibrosis by network pharmacology and experimental validation.","volume":"9","author":"Cao","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3892\/etm.2016.3994","article-title":"Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and -9.","volume":"13","author":"Chang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13225-012-0151-3","article-title":"Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action.","volume":"55","author":"De Silva","year":"2012","journal-title":"Fungal Divers."},{"key":"B6","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1615\/IntJMedMushrooms.v18.i8.60","article-title":"Metabolomic investigation of rat serum following oral administration of the willow bracket medicinal mushroom, phellinus igniarius (Agaricomycetes), by UPLC-HDMS.","volume":"18","author":"Dong","year":"2016","journal-title":"Int. J. Med. Mushrooms"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jssc.201401293","article-title":"Ultra high performance liquid chromatography with synapt high-definition mass spectrometry and a pattern recognition approach to characterize chemical constituents and rat metabolites after the oral administration of Phellinus igniarius.","volume":"38","author":"Dong","year":"2015","journal-title":"J. Sep. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1080\/11263504.2017.1301590","article-title":"Medicinal mushrooms: valuable biological resources of high exploitation potential.","volume":"151","author":"Gargano","year":"2017","journal-title":"Plant Biosyst."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.7314\/APJCP.2015.16.6.2129","article-title":"Molecular mechanisms of apoptosis and roles in cancer development and treatment.","volume":"16","author":"Goldar","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"6429","DOI":"10.1158\/0008-5472.CAN-17-1662","article-title":"Multiscale modeling of inflammation-induced tumorigenesis reveals competing oncogenic and oncoprotective roles for inflammation.","volume":"77","author":"Guo","year":"2017","journal-title":"Cancer Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.addr.2016.04.025","article-title":"Challenges and strategies in anti-cancer nanomedicine development: an industry perspective.","volume":"108","author":"Hare","year":"2017","journal-title":"Adv. Drug Deliver. Rev."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00270","article-title":"Uncovering the mechanisms of chinese herbal medicine (mazirenwan) for functional constipation by focused network pharmacology approach.","volume":"9","author":"Huang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/sj.onc.1204221","article-title":"Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.","volume":"20","author":"Janssen","year":"2001","journal-title":"Oncogene"},{"key":"B14","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S2221-1691(13)60156-2","article-title":"Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice.","volume":"3","author":"Jeon","year":"2013","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"B15","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.critrevonc.2013.12.012","article-title":"Cancer therapeutics: targeting the apoptotic pathway.","volume":"90","author":"Khan","year":"2014","journal-title":"Crit. Rev. Oncol. Hemat."},{"key":"B16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s10495-010-0557-x","article-title":"Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.","volume":"16","author":"Kim","year":"2011","journal-title":"Apoptosis"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/srep41711","article-title":"Therapeutic properties of scutellaria baicalensis in db\/db mice evaluated using connectivity map and network pharmacology.","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1365-2443.2011.01579.x","article-title":"Beyond apoptosis: caspase regulatory mechanisms and functions in vivo.","volume":"17","author":"Kuranaga","year":"2012","journal-title":"Genes Cells"},{"key":"B19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/ja.2011.2","article-title":"Styrylpyrone-class compounds from medicinal fungi phellinus and inonotus spp. and their medicinal importance.","volume":"64","author":"Lee","year":"2011","journal-title":"J. Antibiot."},{"key":"B20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional chinese medicine network pharmacology: theory, methodology and application.","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"17832","DOI":"10.18632\/oncotarget.4026","article-title":"Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors.","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1039\/c3mb70507b","article-title":"A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study.","volume":"10","author":"Liang","year":"2014","journal-title":"Mol. BioSyst."},{"key":"B23","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.imbio.2016.10.002","article-title":"Both intrinsic and extrinsic apoptotic pathways are involved in Toll-like receptor 4 (TLR4)-induced cell death in monocytic THP-1 cells.","volume":"222","author":"Liu","year":"2017","journal-title":"Immunobiology"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00279","article-title":"A root-preferential DFR-Like gene encoding dihydrokaempferol reductase involved in anthocyanin biosynthesis of purple-fleshed sweet potato.","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Plant Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1039\/c6fo00422a","article-title":"Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system.","volume":"7","author":"Ma","year":"2016","journal-title":"Food Funct."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1038\/sj.onc.1202581","article-title":"Caspases: the proteases of the apoptotic pathway.","volume":"17","author":"Nu\u00f1ez","year":"1998","journal-title":"Oncogene"},{"key":"B27","first-page":"151","article-title":"Edible mushroom pleurotus ostreatus (Oyster mushroom)-Its dietary significance and biological activity.","volume":"16","author":"Piska","year":"2017","journal-title":"Acta Sci. Pol Hortoru."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.ejca.2004.02.031","article-title":"The emerging role of reactive oxygen species in cancer therapy.","volume":"40","author":"Renschler","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.4314\/tjpr.v16i3.16","article-title":"Antibacterial and anti-breast cancer cell line activities of Sanghuangporus sp. 1 extracts.","volume":"16","author":"Sangdee","year":"2017","journal-title":"Trop. J. Pharm. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4873","DOI":"10.7314\/APJCP.2012.13.10.4873","article-title":"Apoptosis in cancer\u2013an update.","volume":"13","author":"Sankari","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163797","article-title":"Simultaneous quantification of antioxidant compounds in phellinus igniarius using ultra performance liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry.","volume":"11","author":"Shou","year":"2016","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016.","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"B33","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jep.2007.09.001","article-title":"Antiproliferative and antimetastatic effects of the ethanolic extract of Phellinus igniarius (Linnearus: Fries) quelet.","volume":"115","author":"Song","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"55920","DOI":"10.18632\/oncotarget.18473","article-title":"Niaoduqing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia.","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3261","DOI":"10.1016\/j.bmcl.2011.04.025","article-title":"Phenolic compounds with NF-\u03baB inhibitory effects from the fungus phellinus baumii.","volume":"21","author":"Wu","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B36","first-page":"1713","article-title":"Study on anti-tumor effect of medicinal fungi Phellinus igniarius extracts.","volume":"31","author":"Yang","year":"2006","journal-title":"Chin. J. Chinese Mater. Med."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171628","article-title":"Natural formulas and the nature of formulas: exploring potential therapeutic targets based on traditional Chinese herbal formulas.","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.7314\/APJCP.2014.15.8.3659","article-title":"Different immunology mechanisms of Phellinus igniarius in inhibiting growth of liver cancer and melanoma cells.","volume":"15","author":"Zhou","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.3892\/etm.2015.2827","article-title":"Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity.","volume":"10","author":"Zhu","year":"2015","journal-title":"Exp. Ther. Med."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00266\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T15:21:14Z","timestamp":1553008874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00266\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":39,"alternative-id":["10.3389\/fphar.2019.00266"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00266","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"article-number":"266"}}