{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:03:35Z","timestamp":1785942215758,"version":"3.56.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00397","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T01:09:11Z","timestamp":1555376951000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["lncRNA ZEB1-AS1 Mediates Oxidative Low-Density Lipoprotein-Mediated Endothelial Cells Injury by Post-transcriptional Stabilization of NOD2"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiaohui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congmin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22819-3","article-title":"Loss of the adaptor protein shca in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.","volume":"8","author":"Abou-Jaoude","year":"2018","journal-title":"Sci. Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1042\/cs0970119","article-title":"Endothelial cell damage and the development or progression of atherosclerosis.","volume":"97","author":"Blann","year":"1999","journal-title":"Clin. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","article-title":"NOD1 and NOD2: signaling, host defense, and inflammatory disease.","volume":"41","author":"Caruso","year":"2014","journal-title":"Immunity"},{"key":"B4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.carpath.2017.08.001","article-title":"Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K\/Akt\/mTOR pathway in human endothelial cells.","volume":"31","author":"Che","year":"2017","journal-title":"Cardiovasc. Pathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"4836","DOI":"10.7150\/thno.20942","article-title":"Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression.","volume":"7","author":"Chen","year":"2017","journal-title":"Theranostics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/s0163-7258(02)00236-x","article-title":"LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.","volume":"95","author":"Chen","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ymthe.2018.12.015","article-title":"DANCR promotes metastasis and proliferation in bladder cancer cells by enhancing il-11-stat3 signaling and ccnd1 expression.","volume":"27","author":"Chen","year":"2019","journal-title":"Mol. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"8033","DOI":"10.1093\/nar\/gks506","article-title":"LRPPRC\/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria.","volume":"40","author":"Chujo","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1021\/acs.accounts.6b00326","article-title":"Rational design of small molecules targeting oncogenic noncoding rnas from sequence.","volume":"49","author":"Disney","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrg3606","article-title":"Long non-coding RNAs: new players in cell differentiation and development.","volume":"15","author":"Fatica","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1093\/cvr\/cvy202","article-title":"Immune system-mediated atherosclerosis caused by deficiency of long noncoding RNA MALAT1 in ApoE-\/- mice.","volume":"115","author":"Gast","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"B12","first-page":"1169","article-title":"Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-kappaB\/ZEB1 signal pathway.","volume":"5","author":"Gu","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00145","article-title":"Long noncoding RNA ANRIL: lnc-ing genetic variation at the chromosome 9p21 locus to molecular mechanisms of atherosclerosis.","volume":"5","author":"Holdt","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3400\/avd.oa.10.01044","article-title":"Improve morbidity and mortality in coronary artery bypass graft surgery for severe atherosclerosis.","volume":"4","author":"Kanemitsu","year":"2011","journal-title":"Ann. Vasc. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"479","DOI":"10.4196\/kjpp.2015.19.6.479","article-title":"Role of nucleotide-binding and oligomerization domain 2 protein (NOD2) in the development of atherosclerosis.","volume":"19","author":"Kim","year":"2015","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-11-59","article-title":"Gene regulation by the act of long non-coding RNA transcription.","volume":"11","author":"Kornienko","year":"2013","journal-title":"BMC Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1089\/dna.2017.3779","article-title":"Endothelial-to-mesenchymal transition: a potential mechanism for atherosclerosis plaque progression and destabilization.","volume":"36","author":"Li","year":"2017","journal-title":"DNA Cell Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1038\/onc.2015.223","article-title":"Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma.","volume":"35","author":"Li","year":"2016","journal-title":"Oncogene"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1161\/ATVBAHA.113.301715","article-title":"NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis.","volume":"33","author":"Liu","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0090-4","article-title":"Functions of lncRNA hotair in lung cancer.","volume":"7","author":"Loewen","year":"2014","journal-title":"J. Hematol. Oncol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1111\/jcmm.13420","article-title":"LncRNA-DANCR contributes to lung adenocarcinoma progression by sponging miR-496 to modulate mTOR expression.","volume":"22","author":"Lu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091431","article-title":"A long noncoding rna zeb1-as1 promotes tumorigenesis and predicts poor prognosis in glioma.","volume":"17","author":"Lv","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbagrm.2013.10.009","article-title":"Nuclear lncRNAs as epigenetic regulators-beyond skepticism.","volume":"1839","author":"Nakagawa","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0449-4","article-title":"A novel lncRNA uc.134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1.","volume":"10","author":"Ni","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cellimm.2005.09.006","article-title":"Induction and localization of NOD2 protein in human endothelial cells.","volume":"237","author":"Oh","year":"2005","journal-title":"Cell Immunol."},{"key":"B26","first-page":"322","article-title":"LncRNA H19 promotes atherosclerosis by regulating MAPK and NF-kB signaling pathway.","volume":"21","author":"Pan","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/0008-6363(96)00059-4","article-title":"Enhanced modifications of low-density lipoproteins (LDL) by endothelial cells from smokers: a possible mechanism of smoking-related atherosclerosis.","volume":"31","author":"Pech-Amsellem","year":"1996","journal-title":"Cardiovasc. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2217\/fon.10.157","article-title":"Epigenetic factors in cancer development: polycomb group proteins.","volume":"7","author":"Piunti","year":"2011","journal-title":"Future Oncol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/emboj.2011.392","article-title":"LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.","volume":"31","author":"Ruzzenente","year":"2012","journal-title":"EMBO J."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01221-z","article-title":"LRPPRC-mediated folding of the mitochondrial transcriptome.","volume":"8","author":"Siira","year":"2017","journal-title":"Nat. Commun."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0711-y","article-title":"Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer.","volume":"16","author":"Su","year":"2017","journal-title":"Mol. Cancer"},{"key":"B32","first-page":"515","article-title":"Endothelial injury as an initiating factor: mechanism and significance of endothelial cell injury in the etiology of atherosclerosis.","volume":"46","author":"Sumiyoshi","year":"1988","journal-title":"Nihon Rinsho"},{"key":"B33","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.bbrc.2004.03.103","article-title":"LRP130, a single-stranded DNA\/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo.","volume":"317","author":"Tsuchiya","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms.","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"B35","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.1073\/pnas.1523975113","article-title":"Design of a small molecule against an oncogenic noncoding RNA.","volume":"113","author":"Velagapudi","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1261\/rna.060137.116","article-title":"A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.","volume":"23","author":"Volpon","year":"2017","journal-title":"RNA"},{"key":"B37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-1-60327-369-5_2","article-title":"Monitoring gene expression: quantitative real-time rt-PCR.","volume":"1027","author":"Wagner","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.omtn.2018.07.012","article-title":"lncRNA ZEB1-AS1 Was Suppressed by p53 for renal fibrosis in diabetic nephropathy.","volume":"12","author":"Wang","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B39","first-page":"605","article-title":"Interplay between long noncoding RNA ZEB1-AS1 and miR-101\/ZEB1 axis regulates proliferation and migration of colorectal cancer cells.","volume":"10","author":"Xiong","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.205","article-title":"E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR\/STAU1\/CDKN2B signaling axis.","volume":"8","author":"Xu","year":"2017","journal-title":"Cell Death Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.bbrc.2018.06.042","article-title":"Knockdown of long noncoding RNA XIST alleviates oxidative low-density lipoprotein-mediated endothelial cells injury through modulation of miR-320\/NOD2 axis.","volume":"503","author":"Xu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"E5059","DOI":"10.1073\/pnas.1320862110","article-title":"Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss.","volume":"110","author":"Yuan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00397\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T01:09:13Z","timestamp":1555376953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00397\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":42,"alternative-id":["10.3389\/fphar.2019.00397"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00397","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"article-number":"397"}}