{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:20:38Z","timestamp":1793038838992,"version":"4.5.0"},"reference-count":120,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY18H270008"],"award-info":[{"award-number":["LY18H270008"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00551","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T10:28:21Z","timestamp":1559298501000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":89,"title":["The Role of Autophagy in Acute Myocardial Infarction"],"prefix":"10.3389","volume":"10","author":[{"given":"Du","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"ref1","first-page":"3705","article-title":"Effect of autophagy on myocardial infarction and its mechanism","volume":"21","author":"Aisa","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref2","first-page":"778","article-title":"Chaperone mediated autophagy in the crosstalk of neurodegenerative diseases and metabolic disorders","volume-title":"Front. Endocrinol.","author":"Alfaro","year":"2018"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41556-017-0007-x","article-title":"Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy","volume":"20","author":"An","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1161\/CIRCULATIONAHA.114.014821","article-title":"Sirt7 Contributes to myocardial tissue repair by maintaining transforming growth factor-beta signaling pathway","volume":"132","author":"Araki","year":"2015","journal-title":"Circulation"},{"key":"ref6","first-page":"3402809","article-title":"Hydrogen sulfide alleviates acute myocardial ischemia injury by modulating autophagy and inflammation response under oxidative stress","volume-title":"Oxid. Med. Cell. Longev.","author":"Bai","year":"2018"},{"key":"ref7","first-page":"151","article-title":"Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning","volume-title":"Cardiovasc. Diabetol.","author":"Baranyai","year":"2015"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-biochem-060815-014556","article-title":"Mammalian autophagy: how does it work?","volume":"85","author":"Bento","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bcp.2017.11.021","article-title":"Modulating autophagy in cancer therapy: advancements and challenges for cancer cell death sensitization","volume":"147","author":"Bhat","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"5284","DOI":"10.1172\/JCI70877","article-title":"Enhanced autophagy ameliorates cardiac proteinopathy","volume":"123","author":"Bhuiyan","year":"2013","journal-title":"J. Clin. Invest."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"pii: dev146506","DOI":"10.1242\/dev.146506","article-title":"Autophagy in stem cells: repair, remodelling and metabolic reprogramming","volume":"145","author":"Boya","year":"2018","journal-title":"Development"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.tplants.2018.02.010","article-title":"Mitophagy: a mechanism for plant growth and survival","volume":"23","author":"Broda","year":"2018","journal-title":"Trends Plant Sci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.carpath.2005.03.006","article-title":"Myocardial ischemia and reperfusion injury","volume":"14","author":"Buja","year":"2005","journal-title":"Cardiovasc. Pathol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1089\/ars.2016.6970","article-title":"Could NLRP3-inflammasome be a cardiovascular risk biomarker in acute myocardial infarction patients?","volume":"27","author":"Bullon","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.chom.2018.01.001","article-title":"Loss of Paneth cell autophagy causes acute susceptibility to Toxoplasma gondii-mediated inflammation","volume":"23","author":"Burger","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.mcna.2007.03.005","article-title":"Pathophysiology of acute myocardial infarction","volume":"91","author":"Burke","year":"2007","journal-title":"Med. Clin. North Am."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1080\/15548627.2017.1325062","article-title":"Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure","volume":"13","author":"Campos","year":"2017","journal-title":"Autophagy"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1016\/j.biotechadv.2018.03.012","article-title":"Natural products with anti-aging potential: affected targets and molecular mechanisms","volume":"36","author":"Catana","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10286020.2019.1586677","article-title":"Enhancement of autophagy flux by isopsoralen ameliorates interleukin-1beta-stimulated apoptosis in rat chondrocytes","volume":"8","author":"Chen","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1161\/CIRCIMAGING.112.000074","article-title":"Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo","volume":"6","author":"Chen","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41467-017-00213-3","article-title":"Hypoxia ameliorates intestinal inflammation through NLRP3\/mTOR downregulation and autophagy activation","volume":"8","author":"Cosin-Roger","year":"2017","journal-title":"Nat. Commun."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1161\/CIRCULATIONAHA.117.029870","article-title":"Acute coronary syndromes: the way forward from mechanisms to precision treatment","volume":"136","author":"Crea","year":"2017","journal-title":"Circulation"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrneurol.2016.81","article-title":"The mTOR signalling cascade: paving new roads to cure neurological disease","volume":"12","author":"Crino","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4149\/BLL_2018_019","article-title":"Role of autophagy in the progress of coronary total occlusion","volume":"119","author":"Demircan","year":"2018","journal-title":"Bratisl. Lek. Listy"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"779","DOI":"10.2337\/db16-0776","article-title":"Placental and cord blood methylation of genes involved in energy homeostasis: association with fetal growth and neonatal body composition","volume":"66","author":"Diaz","year":"2017","journal-title":"Diabetes"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.freeradbiomed.2013.05.014","article-title":"Cellular metabolic and autophagic pathways: traffic control by redox signaling","volume":"63","author":"Dodson","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.bbrc.2018.03.047","article-title":"Djhsp90s are crucial regulators during planarian regeneration and tissue homeostasis","volume":"498","author":"Dong","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref28","first-page":"e0189307","article-title":"EphrinA1-Fc attenuates myocardial ischemia\/reperfusion injury in mice","volume-title":"PLoS One","author":"DuSablon","year":"2017"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/jcp.25576","article-title":"HMGB1 inhibits apoptosis following MI and induces autophagy via mTORC1 inhibition","volume":"232","author":"Foglio","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.3892\/ol.2018.7922","article-title":"NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia\/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis","volume":"15","author":"Fu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1083\/jcb.200604129","article-title":"Role of FIP200\u00a0in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways","volume":"175","author":"Gan","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/imm.12790","article-title":"Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation","volume":"152","author":"Germic","year":"2017","journal-title":"Immunology"},{"key":"ref33","first-page":"8602041","article-title":"Macroautophagy and chaperone-mediated autophagy in heart failure: the known and the unknown","volume-title":"Oxidative Med. Cell. Longev.","author":"Ghosh","year":"2018"},{"key":"ref34","first-page":"e005622","article-title":"Endothelial leptin receptor deletion promotes cardiac autophagy and angiogenesis following pressure overload by suppressing Akt\/mTOR signaling","volume-title":"Circ. Heart Fail.","author":"Gogiraju","year":"2019"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pneurobio.2016.06.006","article-title":"Mitochondrial function in hypoxic ischemic injury and influence of aging","volume":"157","author":"Ham","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bj.2016.12.004","article-title":"From Christian de Duve to Yoshinori Ohsumi: more to autophagy than just dining at home","volume":"40","author":"Harnett","year":"2017","journal-title":"Biom. J."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.tcb.2016.11.011","article-title":"Repair, reuse, recycle: the expanding role of autophagy in genome maintenance","volume":"27","author":"Hewitt","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-pharmtox-010611-134537","article-title":"AMPK and mTOR in cellular energy homeostasis and drug targets","volume":"52","author":"Inoki","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/res.35.3_supplement.iii-156","article-title":"Structural changes in myocardium during acute ischemia","volume":"35","author":"Jennings","year":"1974","journal-title":"Circ. Res."},{"key":"ref40","first-page":"47","article-title":"Myocardial ischemia and reperfusion","volume":"37","author":"Jennings","year":"1995","journal-title":"Monogr. Pathol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1128\/MCB.01005-15","article-title":"Atg13 is essential for autophagy and cardiac development in mice","volume":"36","author":"Kaizuka","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00709-016-0963-1","article-title":"Microautophagy in nutritive phagocytes of sea urchins","volume":"254","author":"Kalachev","year":"2017","journal-title":"Protoplasma"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"H2261","DOI":"10.1152\/ajpheart.01056.2010","article-title":"Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion","volume":"300","author":"Kanamori","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10787-017-0336-1","article-title":"Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases","volume":"25","author":"Kaur","year":"2017","journal-title":"InflammoPharmacology"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000495527","article-title":"Vimentin-induced cardiac mesenchymal stem cells proliferate in the acute ischemic myocardium","volume":"206","author":"Klopsch","year":"2019","journal-title":"Cells Tissues Organs"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1080\/15548627.2017.1367473","article-title":"In praise of M. Anselmier who first used the term \u201cautophagie\u201d in 1859","volume":"13","author":"Ktistakis","year":"2017","journal-title":"Autophagy"},{"key":"ref48","first-page":"96","article-title":"Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic beta-cell apoptosis","volume-title":"Cell Death Dis.","author":"Lambelet","year":"2018"},{"key":"ref49","first-page":"4160","article-title":"AMPK-mediated cardioprotection of atorvastatin relates to the reduction of apoptosis and activation of autophagy in infarcted rat hearts","volume":"8","author":"Li","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1113\/EP086192","article-title":"Tongxinluo exerts protective effects via anti-apoptotic and pro-autophagic mechanisms by activating AMPK pathway in infarcted rat hearts","volume":"102","author":"Li","year":"2017","journal-title":"Exp. Physiol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/7651_2018_124","article-title":"Immunofluorescence staining protocols for major autophagy proteins including LC3, P62, and ULK1\u00a0in mammalian cells in response to normoxia and hypoxia","volume":"1854","author":"Li","year":"","journal-title":"Methods Mol. Biol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"13649","DOI":"10.1002\/jcp.28045","article-title":"Early diagnostic value of circulating microRNAs in patients with suspected acute myocardial infarction","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bbrc.2018.02.200","article-title":"Blockage of AKAP12 accelerates angiotensin II (Ang II)-induced cardiac injury in mice by regulating the transforming growth factor beta1 (TGF-beta1) pathway","volume":"499","author":"Li","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"pii: E279","DOI":"10.3390\/cells7120279","article-title":"Role of autophagy in proteostasis: friend and foe in cardiac diseases","volume":"7","author":"Li","year":"","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.yjmcc.2018.03.018","article-title":"MicroRNA-223 protects neonatal rat cardiomyocytes and H9c2 cells from hypoxia-induced apoptosis and excessive autophagy via the Akt\/mTOR pathway by targeting PARP-1","volume":"118","author":"Liu","year":"","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.omtn.2018.01.010","article-title":"miR-93-5p-containing exosomes treatment attenuates acute myocardial infarction-induced myocardial damage","volume":"11","author":"Liu","year":"","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/abbs\/gmx035","article-title":"Novel pathogenesis: regulation of apoptosis by Apelin\/APJ system","volume":"49","author":"Liu","year":"2017","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref58","first-page":"29","article-title":"LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription","volume-title":"Nat. Commun.","author":"Liu","year":""},{"key":"ref59","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1161\/CIRCRESAHA.117.311326","article-title":"Intra-cardiac release of extracellular vesicles shapes inflammation following myocardial infarction","volume":"123","author":"Loyer","year":"2018","journal-title":"Circ. Res."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1536\/ihj.17-003","article-title":"Alterations of cardiac KATP channels and autophagy contribute in the late cardioprotective phase of exercise preconditioning","volume":"59","author":"Lu","year":"2018","journal-title":"Int. Heart J."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/eurheartj\/ehq253","article-title":"Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia\/reperfusion injury: role of autophagy paradox and toxic aldehyde","volume":"32","author":"Ma","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1161\/CIRCULATIONAHA.111.041814","article-title":"Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia\/reperfusion injury","volume":"125","author":"Ma","year":"2012","journal-title":"Circulation"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/15548627.2016.1267075","article-title":"Xenophagy: a battlefield between host and microbe, and a possible avenue for cancer treatment","volume":"13","author":"Mao","year":"2017","journal-title":"Autophagy"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.critrevonc.2017.12.005","article-title":"Protective effects of curcumin against doxorubicin-induced toxicity and resistance: a review","volume":"122","author":"Mohajeri","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1056\/NEJMra1808137","article-title":"Acute infection and myocardial infarction","volume":"380","author":"Musher","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","article-title":"Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities","volume":"186","author":"Ong","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref67","first-page":"73","article-title":"MiRroring the multiple potentials of MicroRNAs in acute myocardial infarction","volume-title":"Front. Cardiovasc. Med.","author":"Paiva","year":"2017"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1714\/1848.20186","article-title":"Metformin and left ventricular remodeling after acute myocardial infarction: molecular mechanisms and clinical implications","volume":"16","author":"Paneni","year":"2015","journal-title":"G. Ital. Cardiol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1161\/CIRCRESAHA.117.311428","article-title":"MicroRNA-100 suppresses chronic vascular inflammation by stimulation of endothelial autophagy","volume":"122","author":"Pankratz","year":"2018","journal-title":"Circ. Res."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1161\/CIRCRESAHA.110.237339","article-title":"Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes","volume":"109","author":"Pattison","year":"2011","journal-title":"Circ. Res."},{"key":"ref71","doi-asserted-by":"crossref","first-page":"821","DOI":"10.4161\/auto.6502","article-title":"Protein misfolding and cardiac disease: establishing cause and effect","volume":"4","author":"Pattison","year":"2008","journal-title":"Autophagy"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.biopha.2018.12.095","article-title":"Effect of intravenous transplantation of hUCB-MSCs on M1\/M2 subtype conversion in monocyte\/macrophages of AMI mice","volume":"111","author":"Peng","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref73","first-page":"60","article-title":"Role of mTORC1 controlling proteostasis after brain ischemia","volume-title":"Front. Neurosci.","author":"Perez-Alvarez","year":"2018"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ceb.2015.04.016","article-title":"Secretory autophagy","volume":"35","author":"Ponpuak","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.chom.2017.12.017","article-title":"Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice","volume":"23","author":"Pott","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4161\/auto.7.4.14395","article-title":"Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter","volume":"7","author":"Przyklenk","year":"2011","journal-title":"Autophagy"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1161\/CIRCRESAHA.109.200378","article-title":"Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia\/reperfusion injury by suppressed autophagy and increased cell death","volume":"105","author":"Qian","year":"2009","journal-title":"Circ. Res."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1691\/ph.2018.8329","article-title":"Ginsenoside Rg1 protects cardiomyocytes from hypoxia-induced injury through the PI3K\/AKT\/mTOR pathway","volume":"73","author":"Qin","year":"2018","journal-title":"Pharmazie"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1089\/ars.2018.7518","article-title":"Autophagy: a lysosome-dependent process with implications in cellular redox homeostasis and human disease","volume":"30","author":"Ryter","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"S179","DOI":"10.1161\/CIRCULATIONAHA.109.928242","article-title":"Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury","volume":"122","author":"Sala-Mercado","year":"2010","journal-title":"Circulation"},{"key":"ref81","first-page":"e0140576","article-title":"Genetic variants on chromosome 1p13.3 are associated with non-ST elevation myocardial infarction and the expression of DRAM2\u00a0in the Finnish population","volume-title":"PLoS One","author":"Salo","year":"2015"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1177\/0271678X16657093","article-title":"Amylin alters human brain pericyte viability and NG2 expression","volume":"37","author":"Schultz","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1136\/gutjnl-2015-310382","article-title":"Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann\u2013Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn\u2019s disease","volume":"66","author":"Schwerd","year":"2017","journal-title":"Gut"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3978\/j.issn.2223-3652.2015.07.02","article-title":"Boosting autophagy in the diabetic heart: a translational perspective","volume":"5","author":"Sciarretta","year":"2015","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1161\/CIRCRESAHA.117.311147","article-title":"New insights into the role of mTOR signaling in the cardiovascular system","volume":"122","author":"Sciarretta","year":"2018","journal-title":"Circ. Res."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s40292-013-0029-9","article-title":"The importance of autophagy in cardioprotection","volume":"21","author":"Sciarretta","year":"2014","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1161\/CIRCULATIONAHA.111.078212","article-title":"Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome","volume":"125","author":"Sciarretta","year":"2012","journal-title":"Circulation"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"7468","DOI":"10.1074\/jbc.M110.179242","article-title":"FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress","volume":"286","author":"Sengupta","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/aps.2015.87","article-title":"The roles of macrophage autophagy in atherosclerosis","volume":"37","author":"Shao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.2169\/internalmedicine.2083-18","article-title":"In-stent massive thrombi formation during primary percutaneous coronary intervention in a patient with acute myocardial infarction complicated with essential thrombocythemia","volume":"58","author":"Shoji","year":"2019","journal-title":"Intern. Med."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"256","DOI":"10.21037\/atm.2018.06.21","article-title":"Mitochondria and cardiovascular diseases-from pathophysiology to treatment","volume":"6","author":"Siasos","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/j.bbadis.2016.11.015","article-title":"CREG protects from myocardial ischemia\/reperfusion injury by regulating myocardial autophagy and apoptosis","volume":"1863","author":"Song","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"ref93","first-page":"S3","article-title":"Cardiac energetics during ischaemia and the rationale for metabolic interventions","volume":"12","author":"Stanley","year":"2001","journal-title":"Coron. Artery Dis."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"8122","DOI":"10.1002\/jcp.27597","article-title":"Mitochondrial quality control in cardiac cells: mechanisms and role in cardiac cell injury and disease","volume":"234","author":"Tahrir","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1582-4934.2006.tb00291.x","article-title":"Morphological aspects of apoptosis in heart diseases","volume":"10","author":"Takemura","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1161\/CIRCULATIONAHA.107.763870","article-title":"Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy","volume":"117","author":"Tannous","year":"2008","journal-title":"Circulation"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000430342","article-title":"Exercise training protects against acute myocardial infarction via improving myocardial energy metabolism and mitochondrial biogenesis","volume":"37","author":"Tao","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/2211-5463.12385","article-title":"p62\/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy","volume":"8","author":"Tsuchiya","year":"2018","journal-title":"FEBS Open Bio"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/nature.2016.20721","article-title":"Medicine Nobel for research on how cells \u2018eat themselves\u2019","volume":"538","author":"Van Noorden","year":"2016","journal-title":"Nature"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/s41419-018-0445-9","article-title":"Decreased autophagy induced by beta1-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis","volume":"9","author":"Wang","year":"","journal-title":"Cell Death Dis."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1161\/CIRCRESAHA.117.312317","article-title":"AMPKalpha2 protects against the development of heart failure by enhancing mitophagy via PINK1 phosphorylation","volume":"122","author":"Wang","year":"","journal-title":"Circ. Res."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","article-title":"Autophagy in ischemic stroke","author":"Wang","year":"","journal-title":"Prog. Neurobiol."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1111\/bph.13516","article-title":"Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1alpha\/X box-binding protein-1 pathway","volume":"173","author":"Wang","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/mi.2016.65","article-title":"The ATG16L1 risk allele associated with Crohn\u2019s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines","volume":"10","author":"Wildenberg","year":"2017","journal-title":"Mucosal Immunol."},{"key":"ref105","first-page":"e112891","article-title":"Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction","volume-title":"PLoS One","author":"Wu","year":"2014"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.bbrc.2017.08.064","article-title":"Nobiletin attenuates adverse cardiac remodeling after acute myocardial infarction in rats via restoring autophagy flux","volume":"492","author":"Wu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1161\/CIRCRESAHA.118.312758","article-title":"Transplanted mesenchymal stem cells reduce autophagic flux in infarcted hearts via the exosomal transfer of mir-125b","volume":"123","author":"Xiao","year":"2018","journal-title":"Circ. Res."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00109-016-1387-2","article-title":"Exosomal transfer of miR-30a between cardiomyocytes regulates autophagy after hypoxia","volume":"94","author":"Yang","year":"2016","journal-title":"J. Mol. Med."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1042\/EBC20170021","article-title":"The mammalian ULK1 complex and autophagy initiation","volume":"61","author":"Zachari","year":"2017","journal-title":"Essays Biochem."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.bbrc.2013.05.070","article-title":"NF-kappaB-mediated induction of autophagy in cardiac ischemia\/reperfusion injury","volume":"436","author":"Zeng","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref111","first-page":"37448","article-title":"Simulated ischemia\/reperfusion-induced p65-Beclin 1-dependent autophagic cell death in human umbilical vein endothelial cells","volume-title":"Sci. Rep.","author":"Zeng","year":"2016"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/MOL.0000000000000509","article-title":"Classical and alternative roles for autophagy in lipid metabolism","volume":"29","author":"Zhang","year":"","journal-title":"Curr. Opin. Lipidol."},{"key":"ref113","doi-asserted-by":"publisher","first-page":"839","DOI":"10.4103\/0366-6999.228249","article-title":"Hydrogen sulfide regulating myocardial structure and function by targeting cardiomyocyte autophagy","volume":"131","author":"Zhang","year":"","journal-title":"Chin. Med. J."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.12659\/MSM.902936","article-title":"Knockdown of MicroRNA-122 protects H9c2 cardiomyocytes from hypoxia-induced apoptosis and promotes autophagy","volume":"23","author":"Zhang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref115","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.molimm.2018.12.014","article-title":"IL-17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPKalpha\/p38MAPK\/ERK1\/2 signal pathway in mice","volume":"105","author":"Zhang","year":"","journal-title":"Mol. Immunol."},{"key":"ref116","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/1440-1681.12309","article-title":"Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: role of autophagy","volume":"41","author":"Zhang","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref117","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/cbin.10604","article-title":"Autophagy regulates the apoptosis of bone marrow-derived mesenchymal stem cells under hypoxic condition via AMP-activated protein kinase\/mammalian target of rapamycin pathway","volume":"40","author":"Zhang","year":"2016","journal-title":"Cell Biol. Int."},{"key":"ref118","doi-asserted-by":"publisher","first-page":"5538","DOI":"10.1002\/jcb.26723","article-title":"Compound C induces protective autophagy in human cholangiocarcinoma cells via Akt\/mTOR-independent pathway","volume":"119","author":"Zhao","year":"","journal-title":"J. Cell. Biochem."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1182\/blood-2017-04-777128","article-title":"mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8","volume":"131","author":"Zhao","year":"","journal-title":"Blood"},{"key":"ref120","first-page":"293","article-title":"Rosiglitazone exerts an anti-depressive effect in unpredictable chronic mild-stress-induced depressive mice by maintaining essential neuron autophagy and inhibiting excessive astrocytic apoptosis","volume-title":"Front. Mol. Neurosci.","author":"Zhao","year":"2017"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00551\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:08:41Z","timestamp":1663546121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00551\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,31]]},"references-count":120,"alternative-id":["10.3389\/fphar.2019.00551"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00551","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,31]]},"article-number":"551"}}