{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:05:49Z","timestamp":1789877149679,"version":"4.0.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672176"],"award-info":[{"award-number":["81672176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871783"],"award-info":[{"award-number":["81871783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2018JJ2565"],"award-info":[{"award-number":["2018JJ2565"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    The unbalanced crosstalk between osteoclasts and osteoblasts could lead to disruptive bone homeostasis. Herein, we investigated the therapeutic effects of rubidium chloride (RbCl) on ovariectomized (OVX) and titanium (Ti) particle-induced calvaria osteolysis mouse models, showing that non-toxic RbCl attenuated RANKL-stimulated osteoclast formation and functionality while significantly enhancing osteogenesis\n                    <jats:italic>in vitro<\/jats:italic>\n                    . The expressions of osteoclast-specific genes were downregulated considerably by RbCl. Despite the direct inhibition of RANKL-induced activation of MAPK signaling, RbCl was able to target NF-\u03baB directly and indirectly. We found that after the co-stimulation of the c-Jun N-terminal kinase (Jnk)\/p38 activator and RANKL, RbCl inhibited the elevated expression of p-IKK\u03b1 and the degradation of I\u03baB\u03b1 in osteoclast precursors, indicating indirect NF-\u03baB inhibition\n                    <jats:italic>via<\/jats:italic>\n                    MAPK suppression. Furthermore, the two animal models demonstrated that RbCl attenuated tartrate-resistant acid phosphate (TRAP)-positive osteoclastogenesis and rescued bone loss caused by the hormonal dysfunction and wear particle\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Altogether, these findings suggest that RbCl can target Jnk\/p38-mediated NF-\u03baB activation to attenuate osteoclastogenesis, while facilitating osteoblastogenesis both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    , suggesting the possible future use of RbCl for surface coating of orthopedic implant biomaterials to protect against osteoporosis.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2019.00584","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T04:20:20Z","timestamp":1558498820000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Rubidium Chloride Targets Jnk\/p38-Mediated NF-\u03baB Activation to Attenuate Osteoclastogenesis and Facilitate Osteoblastogenesis"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhengxiao","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.bone.2014.04.033","article-title":"Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats","volume":"67","author":"Amugongo","year":"2014","journal-title":"Bone"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e3037","DOI":"10.1038\/cddis.2017.394","article-title":"Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"7920","DOI":"10.1074\/jbc.M112210200","article-title":"A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells","volume":"277","author":"Dhawan","year":"2002","journal-title":"J. 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