{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:57:43Z","timestamp":1770454663735,"version":"3.49.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00691","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T10:33:49Z","timestamp":1560508429000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Targeting the Eph\/Ephrin System as Anti-Inflammatory Strategy in IBD"],"prefix":"10.3389","volume":"10","author":[{"given":"Andrea","family":"Grandi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Zini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Palese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Giorgio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Tognolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Marchesani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Flammini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Lodola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Fusari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Barocelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bertoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0014-2999(99)00558-0","article-title":"Opposing effects of rapamycin and cyclosporine a on activation-induced Ca2+ release","volume":"381","author":"Almawi","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1146\/annurev-pharmtox-011112-140226","article-title":"Eph receptors and ephrins: therapeutic opportunities","volume":"55","author":"Barquilla","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1128\/MCB.15.9.4921","article-title":"ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites","volume":"15","author":"Bergemann","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"G685","DOI":"10.1152\/ajpgi.90685.2008","article-title":"Role of serotonin in intestinal inflammation: knock out of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice","volume":"296","author":"Bischoff","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.4049\/jimmunol.1601066","article-title":"Epithelial TNF receptor signalling promotes mucosal repair in inflammatory bowel disease","volume":"199","author":"Bradford","year":"2017","journal-title":"J. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1097\/MIB.0000000000000369","article-title":"Quality of methods reporting in animal models of colitis","volume":"21","author":"Bramhall","year":"2015","journal-title":"Inflamm. Bowel. Dis."},{"key":"B7","first-page":"238","article-title":"Clinico-pathological study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab. Invest."},{"key":"B8","doi-asserted-by":"publisher","first-page":"G161","DOI":"10.1152\/ajpgi.00142.2014","article-title":"Redeeming an old foe: protective as well pathophysiological roles for tumor necrosis factor in inflammatory bowel disease","volume":"308","author":"Dub\u00e9","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver. Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.phrs.2012.10.008","article-title":"Ephs and ephrins resurface in inflammation, immunity and atherosclerosis","volume":"67","author":"Funk","year":"2013","journal-title":"Pharmacol. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.phrs.2019.01.011","article-title":"Inhibition of Eph\/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice","volume":"141","author":"Giorgio","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00809","article-title":"\u03b17 Nicotinic agonist AR-R17779 protects mice against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in a spleen-dependent way","volume":"8","author":"Grandi","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.3748\/wjg.v11.i26.4024","article-title":"Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn\u2019s disease and contributes to accelerated epithelial wound healing in vitro","volume":"11","author":"Hafner","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2013.10.008","article-title":"Effect of reduced EPHB4 expression in thymic epithelial cells on thymocyte development and peripheral T cell function","volume":"58","author":"Jin","year":"2014","journal-title":"Mol. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nrm.2015.16","article-title":"Mechanisms of ephrin-Eph signalling in development, physiology and disease","volume":"17","author":"Kania","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1002\/eji.201142175","article-title":"A novel feedback mechanism by Ephrin-B1\/B2 in T-cell activation involves a concentration-dependent switch from co-stimulation to inhibition","volume":"42","author":"Kawano","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1182\/blood-2005-04-1655","article-title":"The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth","volume":"107","author":"Kertesz","year":"2006","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel disease","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/15321810500403755","article-title":"Impact of different cell isolation techniques on lymphocyte viability and function","volume":"27","author":"Klein","year":"2006","journal-title":"J. Immunoassay Immunochem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3.1.1","DOI":"10.1002\/0471142735.im0301s39","article-title":"Isolation of mouse mononuclear cells","volume":"39","author":"Kruisbeek","year":"2001","journal-title":"Curr. Protoc. Immunol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144101","article-title":"Addition of berberine to 5-aminosalycilic acid for treatment of dextran sulphate sodium-induced chronic colitis in C57BL\/6 mice","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"B22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ejmech.2017.07.029","article-title":"Targeting Eph\/ephrin system in cancer therapy","volume":"142","author":"Lodola","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1111\/j.1440-1746.2008.05486.x","article-title":"Expression of a splice variant of CXCR3 in Crohn\u2019s disease patients: indication for a lymphocyte-epithelial cell interaction","volume":"23","author":"Manousou","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1593\/neo.121890","article-title":"Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b","volume":"15","author":"Matos","year":"2013","journal-title":"Neoplasia"},{"key":"B25","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/00024382-200406002-00179","article-title":"Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia\/reperfusion injury","volume":"23","author":"Moore-Olufemi","year":"2005","journal-title":"Shock"},{"key":"B26","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1242\/jcs.02777","article-title":"EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases","volume":"119","author":"Ogawa","year":"2006","journal-title":"J. Cell Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nrm1662","article-title":"Eph receptor signaling casts a wide net on cell behaviour","volume":"6","author":"Pasquale","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"327","DOI":"10.4161\/19336918.2014.970012","article-title":"Eph receptor and ephrin function in breast, gut, and skin epithelia","volume":"8","author":"Perez White","year":"2014","journal-title":"Cell Adh. Migr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.1242\/jcs.030627","article-title":"Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes","volume":"121","author":"Pfaff","year":"2008","journal-title":"J. Cell Sci."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00068","article-title":"Dual role of endogenous serotonin in 2,4,6-trinitrobenzene sulfonic acid-induced colitis","volume":"7","author":"Rapalli","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"G514","DOI":"10.1152\/ajpgi.90608.2008","article-title":"Cyclosporine regulates intestinal epithelial apoptosis via TGF-b-related signalling","volume":"297","author":"Satoh","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver. Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00424-007-0238-y","article-title":"Calcium-dependent transcription of cytokine genes in T lymphocytes","volume":"454","author":"Savignac","year":"2007","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1097\/01.mib.0000227817.54969.5e","article-title":"Critical appraisal of the current practice in murine TNBS-induced colitis","volume":"12","author":"te Velde","year":"2006","journal-title":"Inflamm. Bowel. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/313318a0","article-title":"Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester","volume":"313","author":"Truneh","year":"1985","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/SHK.0000000000000890","article-title":"Protection by the Eph\u2013ephrin system against mesenteric ischemia-reperfusion injury","volume":"48","author":"Vivo","year":"2017","journal-title":"Shock"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0555s46","article-title":"Chemically induced mouse models of colitis","volume":"5","author":"Waldner","year":"2009","journal-title":"Curr. Protoc. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4049\/jimmunol.171.1.106","article-title":"Ephrin B2 induces T cell costimulation","volume":"171","author":"Yu","year":"2003","journal-title":"J. Immunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00691\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T02:58:44Z","timestamp":1561517924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00691\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":37,"alternative-id":["10.3389\/fphar.2019.00691"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00691","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"article-number":"691"}}