{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:23:53Z","timestamp":1790429033206,"version":"4.1.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00740","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T14:38:12Z","timestamp":1562164692000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":51,"title":["Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury"],"prefix":"10.3389","volume":"10","author":[{"given":"Alfonso","family":"Rubio-Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"V\u00e1zquez-Carballo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Guerrero-Hue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Garc\u00eda-Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Herencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Yuste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Sevillano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Praga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Egea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cannata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cortegano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"de Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Cadenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Michalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00467-017-3623-6","article-title":"Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis","volume":"32","author":"Baddam","year":"2017","journal-title":"Pediatr. Nephrol."},{"key":"B2","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1016\/S0021-9258(19)37165-0","article-title":"Ferritin: a cytoprotective antioxidant strategem of endothelium","volume":"267","author":"Balla","year":"1992","journal-title":"J. Biol. Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"9285","DOI":"10.1073\/pnas.90.20.9285","article-title":"Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage","volume":"90","author":"Balla","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1093\/ndt\/gfr391","article-title":"Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression","volume":"26","author":"Ballarin","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"B5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00345-008-0253-4","article-title":"Curcumin protects against ischemia\/reperfusion injury in rat kidneys","volume":"26","author":"Bayrak","year":"2008","journal-title":"World J. Urol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1089\/ars.2015.6571","article-title":"Control of oxidative stress and inflammation in sickle cell disease with the Nrf2 activator dimethyl fumarate","volume":"26","author":"Belcher","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"B7","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/MOH.0000000000000458","article-title":"When might transferrin, hemopexin or haptoglobin administration be of benefit following the transfusion of red blood cells","volume":"25","author":"Buehler","year":"2018","journal-title":"Curr. Opin. Hematol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.molmed.2010.07.006","article-title":"Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design","volume":"16","author":"Buehler","year":"2010","journal-title":"Trends Mol. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.4155\/fmc.15.99","article-title":"New melatonin-cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection","volume":"7","author":"Buendia","year":"2015","journal-title":"Future Med. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"13943","DOI":"10.1073\/pnas.93.24.13943","article-title":"NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development","volume":"93","author":"Chan","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B11","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41419-017-0250-x","article-title":"ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells","volume":"9","author":"Chang","year":"2018","journal-title":"Cell Death Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"20108","DOI":"10.1074\/jbc.M314219200","article-title":"PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress","volume":"279","author":"Cullinan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e2064","DOI":"10.1038\/cddis.2015.392","article-title":"Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response","volume":"7","author":"Deuel","year":"2016","journal-title":"Cell Death Dis."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152895","article-title":"Phase 1 study of a sulforaphane-containing broccoli sprout homogenate for sickle cell disease","volume":"11","author":"Doss","year":"2016","journal-title":"PLoS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.avsg.2016.12.018","article-title":"Risk of acute kidney injury after percutaneous pharmacomechanical thrombectomy using AngioJet in venous and arterial thrombosis","volume":"42","author":"Escobar","year":"2017","journal-title":"Ann. Vasc. Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3389\/fphar.2018.00274","article-title":"Selective histone deacetylase 6 inhibitor 23BB alleviated rhabdomyolysis-induced acute kidney injury by regulating endoplasmic reticulum stress and apoptosis","volume":"9","author":"Feng","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1053\/j.ajkd.2008.07.012","article-title":"Induction of heme oxygenase-1 and ferritin in the kidney in warm antibody hemolytic anemia","volume":"52","author":"Fervenza","year":"2008","journal-title":"Am. J. Kidney Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.3389\/fphys.2018.01595","article-title":"Heme induces endoplasmic reticulum stress (HIER stress) in human aortic smooth muscle cells","volume":"9","author":"Gall","year":"2018","journal-title":"Front. Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/bjh.15401","article-title":"Augmented NRF2 activation protects adult sickle mice from lethal acute chest syndrome","volume":"182","author":"Ghosh","year":"2018","journal-title":"Br. J. Haematol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.81090","article-title":"Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice","volume":"1","author":"Ghosh","year":"2016","journal-title":"JCI Insight"},{"key":"B21","doi-asserted-by":"publisher","first-page":"F370","DOI":"10.1152\/ajprenal.00300.2003","article-title":"Heme: a determinant of life and death in renal tubular epithelial cells","volume":"286","author":"Gonzalez-Michaca","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.2174\/0929867324666170511120814","article-title":"Targeting Nrf2 in protection against renal disease","volume":"24","author":"Guerrero-Hue","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nefro.2017.05.009","article-title":"Adverse effects of the renal accumulation of haem proteins","volume":"38","author":"Guerrero-Hue","year":"2018","journal-title":"Nefrologia"},{"key":"B24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0014-5793(86)80626-3","article-title":"Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides","volume":"201","author":"Gutteridge","year":"1986","journal-title":"FEBS Lett."},{"key":"B25","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.freeradbiomed.2004.02.074","article-title":"Nrf2 signaling in coordinated activation of antioxidant gene expression","volume":"36","author":"Jaiswal","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4894","DOI":"10.1074\/jbc.M609955200","article-title":"Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway","volume":"282","author":"Jia","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1006\/abio.2000.4765","article-title":"Monochlorobimane fluorometric method to measure tissue glutathione","volume":"286","author":"Kamencic","year":"2000","journal-title":"Anal. Biochem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"12169","DOI":"10.1073\/pnas.1509158112","article-title":"Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation","volume":"112","author":"Keleku-Lukwete","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"B31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.advenzreg.2006.01.007","article-title":"Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species","volume":"46","author":"Kobayashi","year":"2006","journal-title":"Adv. Enzyme Regul."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96409","article-title":"Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease","volume":"2","author":"Krishnamoorthy","year":"2017","journal-title":"JCI Insight"},{"key":"B33","doi-asserted-by":"publisher","first-page":"9751","DOI":"10.1073\/pnas.0403620101","article-title":"Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia","volume":"101","author":"Lee","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejphar.2015.12.042","article-title":"Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation","volume":"772","author":"Li","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1152\/ajpcell.00164.2003","article-title":"Methemoglobin is a potent activator of endothelial cells by stimulating IL-6 and IL-8 production and E-selectin membrane expression","volume":"285","author":"Liu","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/ki.2009.157","article-title":"Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice","volume":"76","author":"Liu","year":"2009","journal-title":"Kidney Int."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2746521","DOI":"10.1155\/2019\/2746521","article-title":"Excessive oxidative stress contributes to increased acute ER stress kidney injury in aged mice","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s00467-017-3650-3","article-title":"Acute kidney injury in children with sickle cell disease\u2014compounding a chronic problem","volume":"32","author":"Mammen","year":"2017","journal-title":"Pediatr. Nephrol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s00467-003-1384-x","article-title":"Heme oxygenase 1 expression in young uremic patients on hemodialysis","volume":"19","author":"Maroti","year":"2004","journal-title":"Pediatr. Nephrol."},{"key":"B40","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood.V84.9.3175.3175","article-title":"Hemoglobin stimulates mononuclear leukocytes to release interleukin-8 and tumor necrosis factor alpha","volume":"84","author":"McFaul","year":"1994","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3389\/fimmu.2018.00179","article-title":"Characterization of renal injury and inflammation in an experimental model of intravascular hemolysis","volume":"9","author":"Merle","year":"2018","journal-title":"Front. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1681\/ASN.2010101073","article-title":"The inflammatory cytokines TWEAK and TNFalpha reduce renal Klotho expression through NFkappaB","volume":"22","author":"Moreno","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2215\/CJN.01970211","article-title":"AKI associated with macroscopic glomerular hematuria: clinical and pathophysiologic consequences","volume":"7","author":"Moreno","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1073\/pnas.1714056115","article-title":"Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish","volume":"115","author":"Mukaigasa","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1001\/jama.2014.15063","article-title":"Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans","volume":"312","author":"Naik","year":"2014","journal-title":"JAMA"},{"key":"B46","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1172\/JCI115847","article-title":"Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat","volume":"90","author":"Nath","year":"1992","journal-title":"J. Clin. Invest."},{"key":"B47","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/ki.1995.75","article-title":"Heme protein-mediated renal injury: a protective role for 21-aminosteroids in vitro and in vivo","volume":"47","author":"Nath","year":"1995","journal-title":"Kidney Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1046\/j.1523-1755.1998.00731.x","article-title":"Intracellular targets in heme protein-induced renal injury","volume":"53","author":"Nath","year":"1998","journal-title":"Kidney Int."},{"key":"B49","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S0002-9440(10)64037-0","article-title":"Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease","volume":"158","author":"Nath","year":"2001","journal-title":"Am. J. Pathol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12879-017-2373-1","article-title":"Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study","volume":"17","author":"Plewes","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1089\/ars.2016.6638","article-title":"Oral monomethyl fumarate therapy ameliorates retinopathy in a humanized mouse model of sickle cell disease","volume":"25","author":"Promsote","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1038\/nm799","article-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","volume":"8","author":"Reiter","year":"2002","journal-title":"Nat. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"896","DOI":"10.7150\/thno.14915","article-title":"CD163-macrophages are involved in rhabdomyolysis-induced kidney injury and may be detected by MRI with targeted gold-coated iron oxide nanoparticles","volume":"6","author":"Rubio-Navarro","year":"2016","journal-title":"Theranostics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/path.5011","article-title":"Podocytes are new cellular targets of haemoglobin-mediated renal damage","volume":"244","author":"Rubio-Navarro","year":"2018","journal-title":"J. Pathol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083713","article-title":"Hyperlipidemia-associated renal damage decreases Klotho expression in kidneys from ApoE knockout mice","volume":"8","author":"Sastre","year":"2013","journal-title":"PLoS One"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/ki.2013.248","article-title":"Role of Nrf2 in protection against acute kidney injury","volume":"84","author":"Shelton","year":"2013","journal-title":"Kidney Int."},{"key":"B58","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3109\/10715769009148577","article-title":"Induction of haem oxygenase as a defence against oxidative stress","volume":"9","author":"Stocker","year":"1990","journal-title":"Free Radic Res. Commun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1681\/ASN.2006080894","article-title":"Physiology and pathophysiology of heme: implications for kidney disease","volume":"18","author":"Tracz","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.redox.2013.09.003","article-title":"Renoprotective effect of the antioxidant curcumin: recent findings","volume":"1","author":"Trujillo","year":"2013","journal-title":"Redox Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"5818","DOI":"10.1128\/MCB.20.16.5818-5827.2000","article-title":"Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress","volume":"20","author":"Tsuji","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"E7474","DOI":"10.1073\/pnas.1608928113","article-title":"Protein aggregation as a cellular response to oxidative stress induced by heme and iron","volume":"113","author":"Vasconcellos","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B63","first-page":"474","article-title":"Acquired resistance to acute oxidative stress","volume":"72","author":"Vogt","year":"1995","journal-title":"Lab. Invest."},{"key":"B64","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/ki.2014.65","article-title":"Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury","volume":"86","author":"Wang","year":"2014","journal-title":"Kidney Int."},{"key":"B65","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/0310057X1704500109","article-title":"Haptoglobin and free haemoglobin during cardiac surgery-is there a link to acute kidney injury","volume":"45","author":"Wetz","year":"2017","journal-title":"Anaesth. Intensive Care"},{"key":"B66","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1172\/JCI4165","article-title":"Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency","volume":"103","author":"Yachie","year":"1999","journal-title":"J. Clin. Invest."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1016\/j.bcp.2008.02.029","article-title":"Sulforaphane protects kidneys against ischemia\u2013reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme","volume":"75","author":"Yoon","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1172\/JCI67867","article-title":"Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury","volume":"123","author":"Zarjou","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151158","article-title":"Penehyclidine hydrochloride pretreatment ameliorates rhabdomyolysis-induced AKI by activating the Nrf2\/HO-1 pathway and alleviating [corrected] endoplasmic reticulum stress in rats","volume":"11","author":"Zhao","year":"2016","journal-title":"PLoS One"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00740\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T17:49:30Z","timestamp":1610214570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00740\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":69,"alternative-id":["10.3389\/fphar.2019.00740"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00740","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,3]]},"article-number":"740"}}