{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:30:37Z","timestamp":1792513837489,"version":"4.5.0"},"reference-count":160,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00820","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T09:54:17Z","timestamp":1564134857000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":256,"title":["Formononetin: A Review of Its Anticancer Potentials and Mechanisms"],"prefix":"10.3389","volume":"10","author":[{"given":"Kai-Ching","family":"Tay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loh Teng-Hern","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chim Kei","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sok Lai","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok-Gan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Hsum","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyia","family":"Pusparajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Learn-Han","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bey-Hing","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1271\/bbb.64.2276","article-title":"New scheme of the biosynthesis of formononetin involving 2,7,4\u2032-trihydroxyisoflavanone but not daidzein as the methyl acceptor","volume":"64","author":"Akashi","year":"2000","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"7900","DOI":"10.1073\/pnas.89.17.7900","article-title":"Phosphorylation of the retinoblastoma protein by cdk2","volume":"89","author":"Akiyama","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nbt.2284","article-title":"Combinatorial drug therapy for cancer in the post-genomic era","volume":"30","author":"Al-Lazikani","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"8483","DOI":"10.1007\/s13277-014-2421-z","article-title":"Metastasis review: from bench to bedside","volume":"35","author":"Alizadeh","year":"2014","journal-title":"Tumour Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3892\/ijo.29.3.549","article-title":"CoCl2-induced HIF-1\u03b1 expression correlates with proliferation and apoptosis in MKN-1 cells: a possible role for the PI3K\/Akt pathway","volume":"29","author":"Ardyanto","year":"2006","journal-title":"Int. J. Oncol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12859-017-1522-2","article-title":"Towards targeted combinatorial therapy design for the treatment of castration-resistant prostate cancer","volume":"18","author":"Arshad","year":"2017","journal-title":"BMC Bioinf."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","article-title":"Death receptors: signaling and modulation","volume":"281","author":"Ashkenazi","year":"1998","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10637-008-9207-3","article-title":"Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell","volume":"28","author":"Auyeung","year":"2010","journal-title":"Invest. New Drugs"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.3892\/or.2012.2056","article-title":"Novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft","volume":"28","author":"Auyeung","year":"2012","journal-title":"Oncol. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1124\/mol.59.4.901","article-title":"Cyclooxygenase inhibitors regulate the expression of a TGF-\u03b2 superfamily member that has proapoptotic and antitumorigenic activities","volume":"59","author":"Baek","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.2174\/1566524023362456","article-title":"The role of STATs in apoptosis","volume":"2","author":"Battle","year":"2002","journal-title":"Curr. Mol. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00262-008-0576-4","article-title":"Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy","volume":"58","author":"Baxevanis","year":"2009","journal-title":"Cancer Immunol. Immunother."},{"key":"B13","first-page":"615","article-title":"Isoflavonoids from Glychrrhiza sp. and Ononis spinosa","volume":"60","author":"Benedec","year":"2012","journal-title":"Farmacia"},{"key":"B14","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"B15","first-page":"236","article-title":"The chemistry of Brazilian Myristicaceae. IX. Isoflavonoids from Amazonian species","volume":"40","author":"Braz Filho","year":"1977","journal-title":"Lloydia"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1172\/JCI15617","article-title":"Stat proteins and oncogenesis","volume":"109","author":"Bromberg","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.3390\/molecules23102471","article-title":"Binding of red clover isoflavones to actin as a potential mechanism of anti-metastatic activity restricting the migration of cancer cells","volume":"23","author":"Budryn","year":"2018","journal-title":"Molecules"},{"key":"B18","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2174\/156800908784293659","article-title":"The PTEN\/PI3K\/AKT signalling pathway in cancer, therapeutic implications","volume":"8","author":"Carnero","year":"2008","journal-title":"Curr. Cancer Drug Targets"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1021\/jf00045a007","article-title":"Microwave-mediated synthesis of anticarcinogenic isoflavones from soybeans","volume":"42","author":"Chang","year":"1994","journal-title":"J. Agric. Food Chem."},{"key":"B20","first-page":"529","article-title":"Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities","volume-title":"Molecules","author":"Chan","year":"2016"},{"key":"B21","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1055\/s-0032-1321818","article-title":"Formononetin-induced apoptosis by activation of Ras\/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells","volume":"44","author":"Chen","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1055\/s-0031-1286306","article-title":"Formononetin induces cell cycle arrest of human breast cancer cells via IGF1\/PI3K\/Akt pathways in vitro and in vivo","volume":"43","author":"Chen","year":"2011","journal-title":"Horm. Metab. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1002\/mc.22531","article-title":"Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERalpha","volume":"57","author":"Chen","year":"2018","journal-title":"Mol. Carcinog."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1159\/000356612","article-title":"Estrogen receptor beta-mediated proliferative inhibition and apoptosis in human breast cancer by calycosin and formononetin","volume":"32","author":"Chen","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"100","DOI":"10.7150\/ijbs.22555","article-title":"MiR-21-mediated metabolic alteration of cancer-associated fibroblasts and its effect on pancreatic cancer cell behavior","volume":"14","author":"Chen","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3109\/1061186X.2015.1064435","article-title":"Preparation and in vivo\/in vitro evaluation of formononetin phospholipid\/vitamin E TPGS micelles","volume":"24","author":"Cheng","year":"2016","journal-title":"J. Drug Target"},{"key":"B27","doi-asserted-by":"publisher","first-page":"32401","DOI":"10.1074\/jbc.272.51.32401","article-title":"TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis","volume":"272","author":"Chicheportiche","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1071\/CH9640379","article-title":"Isoflavonoids. I. Some new constituents of Pterocarpus indicus heartwood","volume":"17","author":"Cooke","year":"1964","journal-title":"Aust. J. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1351\/pac200577010007","article-title":"Biodiversity: a continuing source of novel drug leads","volume":"77","author":"Cragg","year":"2005","journal-title":"Pure Appl. Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jep.2005.05.011","article-title":"Plants as a source of anti-cancer agents","volume":"100","author":"Cragg","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.jfda.2016.10.006","article-title":"Analysis of bioactive constituents from the leaves of Amorpha fruticosa L","volume":"25","author":"Cui","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3390\/ijms11041321","article-title":"Bioavailability of the polyphenols: status and controversies","volume":"11","author":"D\u2019archivio","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1104\/pp.101.3.819","article-title":"Alfalfa (Medicago sativa L). Root exudates contain lsof lavonoids in the presence of Rhizobium meliloti","volume":"101","author":"Dakora","year":"1993","journal-title":"Plant Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/0031-9422(75)83053-6","article-title":"Flavonoids from Dalbergia ecastophyllum","volume":"14","author":"De Abreu Matos","year":"1975","journal-title":"Phytochemistry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1016\/j.bbagen.2012.09.018","article-title":"Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes","volume":"1830","author":"Deponte","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1210\/me.2012.1227","article-title":"Estrogen receptors \u03b21 and \u03b22 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3","volume":"26","author":"Dey","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","article-title":"MAP kinase signalling pathways in cancer","volume":"26","author":"Dhillon","year":"2007","journal-title":"Oncogene"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.2527\/jas1988.6681969x","article-title":"In vitro metabolism of formononetin and biochanin A in bovine rumen fluid","volume":"66","author":"Dickinson","year":"1988","journal-title":"J. Anim. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1039\/p19730001737","article-title":"Dalbergia species. Part IX. Phytochemical examination of Dalbergia stevensonii standl","volume":"16","author":"Donnelly","year":"1973","journal-title":"J. Chem. Soc. Perkin I"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008904","article-title":"Signaling pathways that control cell proliferation","volume":"5","author":"Duronio","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.intimp.2018.06.016","article-title":"Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ER\u03b2) protein expression in BV2 microglia","volume":"61","author":"El-Bakoush","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"649","DOI":"10.5483\/BMBRep.2006.39.6.649","article-title":"NSAID activated gene (NAG-1), a modulator of tumorigenesis","volume":"39","author":"Eling","year":"2006","journal-title":"BMB Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.phytochem.2004.02.011","article-title":"Antimicrobial and antioxidant flavonoids from the root wood of Bolusanthus speciosus","volume":"65","author":"Erasto","year":"2004","journal-title":"Phytochemistry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs\u2014microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0092-8674(93)90136-E","article-title":"Functional interactions of the retinoblastoma protein with mammalian D-type cyclins","volume":"73","author":"Ewen","year":"1993","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1002\/jssc.201600073","article-title":"Structural characterization and identification of flavonoid aglycones in three Glycyrrhiza species by liquid chromatography with photodiode array detection and quadrupole time-of-flight mass spectrometry","volume":"39","author":"Fang","year":"2016","journal-title":"J. Sep. Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ejmech.2016.12.027","article-title":"Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK\/Wnt signaling pathways","volume":"127","author":"Fu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"B49","volume-title":"Method for synthesis of formononetin.","author":"Fu","year":"2011"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.2147\/DDDT.S169767","article-title":"Preliminary study on conjugation of formononetin with multiwalled carbon nanotubes for inducing apoptosis via ROS production in HeLa cells","volume":"12","author":"Guo","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"B51","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3390\/cancers11060867","article-title":"Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention","volume":"11","author":"Goh","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jddst.2017.08.010","article-title":"Characterization and cytotoxicity of PLGA nanoparticles loaded with formononetin cyclodextrin complex","volume":"41","author":"Guo","year":"2017","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"B53","volume-title":"Method for total synthesis of formononetin from resorcinol and p-methoxyphenylacetic acid.","author":"Guo","year":"2011"},{"key":"B54","doi-asserted-by":"publisher","first-page":"100045","DOI":"10.18632\/oncotarget.21923","article-title":"Low concentration of formononetin promotes proliferation of estrogen receptor-positive cells through an ER\u03b1-miR-375-PTEN-ERK1\/2-bcl-2 pathway","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.3109\/13880209.2015.1129546","article-title":"Low concentration of formononetin stimulates the proliferation of nasopharyngeal carcinoma cell line CNE2 by upregulating bcl-2 and p-ERK1\/2 expression","volume":"54","author":"Guo","year":"2016","journal-title":"Pharm. Biol."},{"key":"B56","first-page":"367","article-title":"In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells","volume":"19","author":"Gy\u00e9m\u00e1nt","year":"2005","journal-title":"In Vivo"},{"key":"B57","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10585-016-9828-4","article-title":"Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China","volume":"34","author":"He","year":"2017","journal-title":"Clin. Exp. Metastasis"},{"key":"B58","doi-asserted-by":"publisher","first-page":"6802","DOI":"10.1021\/jf0492767","article-title":"Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects","volume":"52","author":"Heinonen","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1074\/jbc.274.9.5654","article-title":"Mitochondrial depolarization accompanies cytochromec release during apoptosis in PC6 cells","volume":"274","author":"Heiskanen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/0092-8674(92)90249-C","article-title":"Regulation of retinoblastoma protein functions by ectopic expression of human cyclins","volume":"70","author":"Hinds","year":"1992","journal-title":"Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/nrc3037","article-title":"PTEN loss in the continuum of common cancers, rare syndromes and mouse models","volume":"11","author":"Hollander","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"B62","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1159\/000430220","article-title":"Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo","volume":"37","author":"Hu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"17305","DOI":"10.1002\/jcp.28349","article-title":"In vitro and in vivo studies of antiosteosarcoma activities of formononetin","volume":"234","author":"Hu","year":"2019","journal-title":"J. Cell. Physiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.procbio.2015.03.001","article-title":"Antiproliferative effects of formononetin on human colorectal cancer via suppressing cell growth in vitro and in vivo","volume":"50","author":"Huang","year":"2015","journal-title":"Process Biochem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s00217-016-2820-z","article-title":"TLC bioautography-guided isolation of antioxidant activity components of extracts from Sophora flavescens Ait","volume":"243","author":"Huang","year":"2017","journal-title":"Eur. Food Res. Technol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3109\/13880209.2013.842600","article-title":"Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1\/IGF-1R signaling pathway","volume":"52","author":"Huang","year":"2014","journal-title":"Pharm. Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1439-0434.1976.tb01741.x","article-title":"Induced and constitutive isoflavonoids from stems of chickpeas (Cicer arietinum L). inoculated with spores of Helminthosporium carbonum Ullstrup","volume":"87","author":"Ingham","year":"1976","journal-title":"J. Phytopathol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.18632\/oncotarget.716","article-title":"PIK3CA mutations in advanced cancers: characteristics and outcomes","volume":"3","author":"Janku","year":"2012","journal-title":"Oncotarget"},{"key":"B69","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.phymed.2005.06.007","article-title":"Analysis of formononetin from black cohosh (Actaea racemosa)","volume":"13","author":"Jiang","year":"2006","journal-title":"Phytomedicine"},{"key":"B70","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/annonc\/mdp499","article-title":"Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway","volume":"21","author":"Jin","year":"2010","journal-title":"Ann. Oncol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1007\/s13277-013-1302-1","article-title":"In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa","volume":"35","author":"Jin","year":"2014","journal-title":"Tumour Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0928-4680(00)00053-5","article-title":"Oxidative stress and apoptosis","volume":"7","author":"Kannan","year":"2000","journal-title":"Pathophysiology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1101\/gad.7.3.331","article-title":"Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4","volume":"7","author":"Kato","year":"1993","journal-title":"Genes Dev."},{"key":"B74","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/332083a0","article-title":"Autocrine generation and requirement of BSF-2\/IL-6 for human multiple myelomas","volume":"332","author":"Kawano","year":"1988","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.canlet.2018.05.038","article-title":"Formononetin-induced oxidative stress abrogates the activation of STAT3\/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model","volume":"431","author":"Kim","year":"2018","journal-title":"Cancer Lett."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1080\/14756366.2018.1477776","article-title":"Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens","volume":"33","author":"Kim","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/j.fct.2011.04.038","article-title":"Flavanones and rotenoids from the roots of Amorpha fruticosa L. that inhibit bacterial neuraminidase","volume":"49","author":"Kim","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"B78","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1182\/blood.V85.4.863.bloodjournal854863","article-title":"Interleukin-6 in human multiple myeloma","volume":"85","author":"Klein","year":"1995","journal-title":"Blood"},{"key":"B79","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/jphp.12872","article-title":"Phenolic fractions from nine Trifolium species modulate the coagulant properties of blood plasma in vitro without cytotoxicity towards blood cells","volume":"70","author":"Kolodziejczyk-Czepas","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1158\/1055-9965.EPI-08-0405","article-title":"Childhood soy intake and breast cancer risk in Asian American women","volume":"18","author":"Korde","year":"2009","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B81","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0378-8741(00)00285-3","article-title":"Antiplasmodial activity of isoflavones from Andira inermis","volume":"73","author":"Kraft","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.1038\/sj.onc.1204541","article-title":"Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion","volume":"20","author":"Krueger","year":"2001","journal-title":"Oncogene"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1080\/10408398.2013.789823","article-title":"Bioactivation of phytoestrogens: intestinal bacteria and health","volume":"56","author":"Landete","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/S0031-9422(00)82901-5","article-title":"Flavonoids of Baptisia australis (Leguminosae)","volume":"6","author":"Lebreton","year":"1967","journal-title":"Phytochemistry"},{"key":"B85","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jchromb.2017.10.046","article-title":"Quantification of isoflavonoids and triterpene saponins in Astragali Radix, the root of Astragalus membranaceus, via reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection","volume":"1070","author":"Lee","year":"2017","journal-title":"J. Chromatogr. B"},{"key":"B86","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3389\/fpls.2016.00861","article-title":"An alternative pathway for formononetin biosynthesis in Pueraria lobata","volume":"7","author":"Li","year":"2016","journal-title":"Front. Plant Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1016\/j.tetlet.2009.02.159","article-title":"Synthesis of haginin E, equol, daidzein, and formononetin from resorcinol viaan isoflavene intermediate","volume":"50","author":"Li","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1159\/000366342","article-title":"Formononetin promotes cell cycle arrest via downregulation of Akt\/cyclin D1\/CDK4 in human prostate cancer cells","volume":"34","author":"Li","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0031-9422(02)00093-6","article-title":"Flavonoids from Glycyrrhiza pallidiflora hairy root cultures","volume":"60","author":"Li","year":"2002","journal-title":"Phytochemistry"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1093\/chromsci\/bmw110","article-title":"Simultaneous determination of formononetin, calycosin and rhamnocitrin from Astragalus complanatus by UHPLC\u2013MS-MS in rat plasma: application to a pharmacokinetic study","volume":"54","author":"Li","year":"2016","journal-title":"J. Chromatogr. Sci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.biopha.2018.06.041","article-title":"Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons","volume":"106","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B92","doi-asserted-by":"publisher","first-page":"48404","DOI":"10.1039\/C7RA09825A","article-title":"Synthesis, characterization and biological evaluation of formononetin derivatives as novel EGFR inhibitors via inhibiting growth, migration and inducing apoptosis in breast cancer cell line","volume":"7","author":"Lin","year":"2017","journal-title":"RSC Adv."},{"key":"B93","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrd2926","article-title":"Targeting the phosphoinositide 3-kinase pathway in cancer","volume":"8","author":"Liu","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"B94","doi-asserted-by":"publisher","first-page":"868","DOI":"10.14336\/AD.2017.0816","article-title":"Anti-aging implications of Astragalus membranaceus (Huangqi): a well-known Chinese tonic","volume":"8","author":"Liu","year":"2017","journal-title":"Aging Dis."},{"key":"B95","first-page":"6434","article-title":"Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.7314\/APJCP.2014.15.6.2835","article-title":"Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro","volume":"15","author":"Liu","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"B97","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jddst.2017.11.018","article-title":"Development of a promising drug delivery for formononetin: cyclodextrin-modified single-walled carbon nanotubes","volume":"43","author":"Liu","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1159\/000363029","article-title":"The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and Akt pathways","volume":"34","author":"Liu","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.cbi.2013.07.003","article-title":"Formononetin potentiates epirubicin-induced apoptosis via ROS production in HeLa cells in vitro","volume":"205","author":"Lo","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1021\/acs.jafc.8b00035","article-title":"Pharmacokinetics and bioavailability of the isoflavones formononetin and ononin and their in vitro absorption in using chamber and Caco-2 cell models","volume":"66","author":"Luo","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1023\/A:1022945107762","article-title":"The mitochondrial membrane potential (D\u03c8m) in apoptosis; an update","volume":"8","author":"Ly","year":"2003","journal-title":"Apoptosis"},{"key":"B102","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3389\/fphar.2018.00102","article-title":"Resveratrol\u00a1\u00aapotential antibacterial agent against foodborne pathogens","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Pharmacol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1055\/s-2004-827231","article-title":"A new sesquiterpene-coumarin ether and a new abietane diterpene and their effects as inhibitors of P-glycoprotein","volume":"70","author":"Madureira","year":"2004","journal-title":"Planta Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1002\/ptr.3498","article-title":"Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells","volume":"25","author":"Mansoor","year":"2011","journal-title":"Phytother. Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/jsfa.2740370402","article-title":"The effect of plant development and environment on formononetin concentration in red clover (Trifolium pratense L)","volume":"37","author":"Mcmurray","year":"1986","journal-title":"J. Sci. Food Agric."},{"key":"B106","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1053\/j.gastro.2007.05.022","article-title":"MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer","volume":"133","author":"Meng","year":"2007","journal-title":"Gastroenterology"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1093\/jnci\/djj356","article-title":"Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings","volume":"98","author":"Messina","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"B108","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.foodchem.2018.06.068","article-title":"Peptides and isoflavones in gastrointestinal digests contribute to the anti-inflammatory potential of cooked or germinated desi and kabuli chickpea (Cicer arietinum L)","volume":"268","author":"Mil\u00e1n-Noris","year":"2018","journal-title":"Food Chem."},{"key":"B109","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fonc.2015.00024","article-title":"PTEN: multiple functions in human malignant tumors","volume":"5","author":"Milella","year":"2015","journal-title":"Front. Oncol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1002\/ijc.27595","article-title":"Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells","volume":"131","author":"Oak","year":"2012","journal-title":"Int. J. Cancer"},{"key":"B112","doi-asserted-by":"publisher","first-page":"7377","DOI":"10.1002\/jcb.27041","article-title":"The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0\/G1 cell phase arrest through PI3K\/AKT and ERK1\/2 inactivation","volume":"119","author":"Park","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"B113","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0952-7915(98)80222-7","article-title":"Mechanisms of CD95 (APO-1\/Fas)-mediated apoptosis","volume":"10","author":"Peter","year":"1998","journal-title":"Curr. Opin. Immunol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.pharmthera.2013.12.004","article-title":"Molecular targets for cancer therapy in the PI3K\/AKT\/mTOR pathway","volume":"142","author":"Polivka","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"B115","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fonc.2014.00064","article-title":"Targeting PI3K\/Akt\/mTOR signaling in cancer","volume":"4","author":"Porta","year":"2014","journal-title":"Front. Oncol."},{"key":"B116","first-page":"1180","article-title":"Formononetin targets the MAPK and PI3K\/Akt pathways to induce apoptosis in human nasopharyngeal carcinoma cells in vitro and in vivo","volume":"9","author":"Qi","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejmech.2012.04.039","article-title":"Synthesis and antitumor activity of formononetin nitrogen mustard derivatives","volume":"54","author":"Ren","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"B118","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1182\/blood-2005-05-2013","article-title":"Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes","volume":"106","author":"Rubio-Moscardo","year":"2005","journal-title":"Blood"},{"key":"B119","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1038\/sj.onc.1207523","article-title":"Toxic proteins released from mitochondria in cell death","volume":"23","author":"Saelens","year":"2004","journal-title":"Oncogene"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/S0031-9422(00)98663-1","article-title":"Flavonoids from Dalbergia cearensis","volume":"14","author":"Salignac De Souza","year":"1975","journal-title":"Phytochemistry"},{"key":"B121","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1517\/14728222.2011.645805","article-title":"Targeting the MAPK\u2013RAS\u2013RAF signaling pathway in cancer therapy","volume":"16","author":"Santarpia","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"B122","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1080\/14786419.2016.1188094","article-title":"Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity","volume":"31","author":"Shults","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"9175","DOI":"10.1158\/0008-5472.CAN-10-1318","article-title":"Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor \u03b1 in breast cancer cells","volume":"70","author":"Simonini","year":"2010","journal-title":"Cancer Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.fct.2011.01.012","article-title":"PAMPA permeability, plasma protein binding, blood partition, pharmacokinetics and metabolism of formononetin, a methoxylated isoflavone","volume":"49","author":"Singh","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.fitote.2014.01.027","article-title":"Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L). extracts: an in vitro study in MCF-7 cells","volume":"94","author":"Spagnuolo","year":"2014","journal-title":"Fitoterapia"},{"key":"B126","doi-asserted-by":"publisher","first-page":"5310","DOI":"10.1021\/jf010600x","article-title":"Alfalfa (Medicago sativa L). Flavonoids. 2. Tricin and Chrysoeriol Glycosides from Aerial Parts","volume":"49","author":"Stochmal","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"B127","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.canlet.2013.11.019","article-title":"p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents","volume":"344","author":"Sui","year":"2014","journal-title":"Cancer Lett."},{"key":"B128","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1038\/sj.onc.1204282","article-title":"Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways","volume":"20","author":"Suliman","year":"2001","journal-title":"Oncogene"},{"key":"B129","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fphar.2017.00012-","article-title":"Targeting Membrane Lipid a Potential Cancer Cure","volume":"8","author":"Tan","year":"2017","journal-title":"Front Pharmacol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"896314","DOI":"10.1155\/2015\/896314","article-title":"Traditional Uses, Phytochemistry, and Bioactivities of Cananga odorata (Ylang-Ylang)","volume":"2015","author":"Tan","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"B131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.36877\/pddbs.a0000017","article-title":"A reliable and affordable 3D tumor spheroid model for natural product drug discovery: A case study of curcumin","volume":"2","author":"Tan","year":"2019","journal-title":"Progress in Drug Discovery & Biomedical Science"},{"key":"B132","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3389\/fphar.2016.00474","article-title":"Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties","volume":"7","author":"Tang","year":"2016","journal-title":"Front Pharmacol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1002\/cbdv.201500360","article-title":"Isoflavone content in subterranean clover germplasm from Sardinia","volume":"13","author":"Tava","year":"2016","journal-title":"Chem. Biodivers."},{"key":"B134","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.1021\/jf025549r","volume":"50","author":"Tolleson","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"B135","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.2174\/1381612824666181106095959","article-title":"A network-based cancer drug discovery: from integrated multi-omics approaches to precision medicine","volume":"24","author":"Turanli","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"B136","doi-asserted-by":"publisher","first-page":"168","DOI":"10.5530\/jyp.2017.9.33","article-title":"In-silico screening of flavonoids targeted for death receptors in cancer by using Hex molecular docking","volume":"9","author":"Vishnuvarthan","year":"2017","journal-title":"J. Young Pharm."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2018-LB-130","article-title":"Abstract LB-130: combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of preclinical cancer models","volume":"78","author":"Wagenaar","year":"2018","journal-title":"Cancer Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.foodchem.2018.10.008","article-title":"Identifying an isoflavone from the root of Pueraria lobata as a potent tyrosinase inhibitor","volume":"276","author":"Wagle","year":"2019","journal-title":"Food Chem."},{"key":"B139","doi-asserted-by":"publisher","first-page":"5386","DOI":"10.1093\/emboj\/16.17.5386","article-title":"TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL","volume":"16","author":"Walczak","year":"1997","journal-title":"EMBO J."},{"key":"B140","doi-asserted-by":"publisher","first-page":"7721","DOI":"10.3892\/mmr.2018.8857","article-title":"Formononetin inhibits colon carcinoma cell growth and invasion by microRNA-149-mediated EphB3 downregulation and inhibition of PI3K\/AKT and STAT3 signaling pathways","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"B141","doi-asserted-by":"publisher","first-page":"9652789","DOI":"10.1155\/2016\/9652789","article-title":"miR-375 and miR-205 regulate the invasion and migration of laryngeal squamous cell carcinoma synergistically via AKT-mediated EMT","volume":"2016","author":"Wang","year":"2016","journal-title":"Biomed Res. Int."},{"key":"B142","doi-asserted-by":"publisher","first-page":"E107","DOI":"10.1002\/mc.22052","article-title":"Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1\u03b1 and glycolysis, by inhibiting PI3K\/Akt signaling pathway","volume":"53","author":"Wang","year":"2014","journal-title":"Mol. Carcinog."},{"key":"B143","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/S0753-3322(02)00182-8","article-title":"Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation","volume":"56","author":"Watanabe","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"B144","doi-asserted-by":"publisher","first-page":"44563","DOI":"10.18632\/oncotarget.6310","article-title":"Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models","volume":"6","author":"Wu","year":"2015","journal-title":"Oncotarget"},{"key":"B145","first-page":"1117","article-title":"Formononetin suppresses hypoxia inducible factor-1\u03b1\/inflammatory cytokines expression via inhibiting Akt signal pathway in multiple myeloma cells","volume":"9","author":"Wu","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1039\/C6FO01535B","article-title":"Formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of miR-21 and PTEN","volume":"8","author":"Wu","year":"2017","journal-title":"Food Funct."},{"key":"B147","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/j.biopha.2018.09.033","article-title":"Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro","volume":"109","author":"Xin","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B148","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.3892\/or.2015.3931","article-title":"Overexpression of miR-21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN","volume":"33","author":"Xu","year":"2015","journal-title":"Oncol. Rep."},{"key":"B149","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1002\/ijc.28563","article-title":"The emerging role of miR-375 in cancer","volume":"135","author":"Yan","year":"2014","journal-title":"Int. J. Cancer"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2008\/209830","article-title":"Synthesis and biological evaluation of 7-O-modified formononetin derivatives","volume":"2008","author":"Yang","year":"2008","journal-title":"Lett. Org. Chem."},{"key":"B151","first-page":"8453","article-title":"Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis","volume":"7","author":"Yang","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1055\/s-0032-1301922","article-title":"Formononetin-induced apoptosis of human prostate cancer cells through ERK1\/2 mitogen-activated protein kinase inactivation","volume":"44","author":"Ye","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"B153","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jep.2004.12.027","article-title":"Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by l-glutamate","volume":"98","author":"Yu","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1084\/jem.182.2.367","article-title":"Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death","volume":"182","author":"Zamzami","year":"1995","journal-title":"J. Exp. Med."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1002\/mnfr.201500692","article-title":"Disposition of flavonoids via recycling: direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides","volume":"60","author":"Zeng","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jep.2018.04.014","article-title":"Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells","volume":"221","author":"Zhang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1080\/01635581.2014.894098","article-title":"Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax\/Bcl-2 ratios and regulating the p38\/Akt pathway","volume":"66","author":"Zhang","year":"2014","journal-title":"Nutr. Cancer"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1248\/bpb.b18-00002","article-title":"Synergistic anticancer effects of formononetin and temozolomide on glioma C6 cells","volume":"41","author":"Zhang","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"B159","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1055\/s-0034-1376977","article-title":"Formononetin inhibits migration and invasion of MDA-MB-231 and 4T1 breast cancer cells by suppressing MMP-2 and MMP-9 through PI3K\/AKT signaling pathways","volume":"46","author":"Zhou","year":"2014","journal-title":"Horm. Metab. Res."},{"key":"B160","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2174\/1568009616666151207105720","article-title":"S-equol, a secondary metabolite of natural anticancer isoflavone daidzein, inhibits prostate cancer growth in vitro and in vivo, though activating the Akt\/FOXO3a pathway","volume":"16","author":"Zongliang","year":"2016","journal-title":"Curr. Cancer Drug Targets"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00820\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T19:28:11Z","timestamp":1610652491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00820\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":160,"alternative-id":["10.3389\/fphar.2019.00820"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00820","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,26]]},"article-number":"820"}}