{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T23:52:52Z","timestamp":1773532372181,"version":"3.50.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.00848","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T10:28:58Z","timestamp":1564482538000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite"],"prefix":"10.3389","volume":"10","author":[{"given":"Laura-Oana","family":"Albulescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taline","family":"Kazandjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Slagboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Bruyneel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Ainsworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaffer","family":"Alsolaiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon C.","family":"Wagstaff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Whiteley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Ulens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Kool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas R.","family":"Casewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jprot.2017.08.016","article-title":"The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms","volume":"172","author":"Ainsworth","year":"2018","journal-title":"J. Proteomics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s42003-018-0039-1","article-title":"The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms","volume":"1","author":"Ainsworth","year":"2018","journal-title":"Commun. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"29594","DOI":"10.1074\/jbc.M909746199","article-title":"Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal \u03b17-nicotinic acetylcholine receptor","volume":"275","author":"Antil-Delbeke","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"34851","DOI":"10.1074\/jbc.274.49.34851","article-title":"Variability among the sites by which curaremimetic toxins bind to Torpedo acetylcholine receptor, as revealed by identification of the functional residues of \u03b1-cobratoxin","volume":"274","author":"Antil","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1186\/s12859-014-0389-8","article-title":"VTBuilder: a tool for the assembly of multi isoform transcriptomes","volume":"15","author":"Archer","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/sj.emboj.7600620","article-title":"Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake \u03b1-neurotoxins and nicotinic receptors","volume":"24","author":"Bourne","year":"2005","journal-title":"EMBO J."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001034","article-title":"A Structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors","volume":"9","author":"Brams","year":"2011","journal-title":"PLoS Biol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/35077011","article-title":"Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors","volume":"411","author":"Brejc","year":"2001","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4320175","article-title":"Developing small molecule therapeutics for the initial and adjunctive treatment of snakebite","volume":"2018","author":"Bulfone","year":"2018","journal-title":"J. Trop. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"11539","DOI":"10.1038\/s41598-018-29791-y","article-title":"Venom complexity in a pitviper produced by facultative parthenogenesis","volume":"8","author":"Calvete","year":"2018","journal-title":"Sci. Rep."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000851","article-title":"Pre-clinical assays predict Pan-African Echis viper efficacy for a species-specific antivenom","volume":"4","author":"Casewell","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"9205","DOI":"10.1073\/pnas.1405484111","article-title":"Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms","volume":"111","author":"Casewell","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tree.2012.10.020","article-title":"Complex cocktails: the evolutionary novelty of venoms","volume":"28","author":"Casewell","year":"2013","journal-title":"Trends Ecol. Evol."},{"key":"B14","first-page":"309","volume-title":"The action of snake venoms on nerve and muscle BT\u2014snake venoms","author":"Chang","year":"1979"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(91)90116-9","article-title":"Snake venom variability: methods of study, results and interpretation","volume":"29","author":"Chippaux","year":"1991","journal-title":"Toxicon"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/bcp.12739","article-title":"Adverse reactions to snake antivenom, and their prevention and treatment","volume":"81","author":"de Silva","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1073\/pnas.042699899","article-title":"Experimentally based model of a complex between a snake toxin and the 7 nicotinic receptor","volume":"99","author":"Fruchart-Gaillard","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"Guti\u00e9rrez","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B21","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.toxicon.2003.11.005","article-title":"Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity","volume":"42","author":"Guti\u00e9rrez","year":"2003","journal-title":"Toxicon"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005969","article-title":"Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa","volume":"11","author":"Harrison","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/j.jprot.2012.01.006","article-title":"Comparative proteomic analysis of the venom of the Taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity","volume":"75","author":"Herrera","year":"2012","journal-title":"J. Proteomics"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.227","article-title":"Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor","volume":"28","author":"Hibbs","year":"2009","journal-title":"EMBO J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1042\/BJ20130636","article-title":"Complex between \u03b1-bungarotoxin and an \u03b17 nicotinic receptor ligand-binding domain chimaera","volume":"454","author":"Huang","year":"2013","journal-title":"Biochem. J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-12-1","article-title":"Venom gland transcriptomes of two elapid snakes (Bungarus multicinctus and Naja atra) and evolution of toxin genes","volume":"12","author":"Jiang","year":"2011","journal-title":"BMC Genomics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/jnc.13975","article-title":"The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions","volume":"142","author":"Kessler","year":"2017","journal-title":"J. Neurochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.neuro.2009.12.009","article-title":"Variations in the pharmacological profile of post-synaptic neurotoxins isolated from the venoms of the Papuan (Oxyuranus scutellatus canni) and coastal (Oxyuranus scutellatus scutellatus) taipans","volume":"31","author":"Kornhauser","year":"2010","journal-title":"Neurotoxicology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3390\/toxins10100380","article-title":"Delayed oral LY333013 rescues mice from highly neurotoxic, lethal doses of Papuan Taipan (Oxyuranus scutellatus) venom","volume":"10","author":"Lewin","year":"2018","journal-title":"Toxins (Basel)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/nn.2908","article-title":"Ligand-binding domain of an \u03b17-nicotinic receptor chimera and its complex with agonist","volume":"14","author":"Li","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611263200","article-title":"Bacterial expression, NMR, and electrophysiology analysis of chimeric short\/long-chain alpha-neurotoxins acting on neuronal nicotinic receptors","volume":"282","author":"Lyukmanova","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jprot.2013.11.012","article-title":"Proteomic analysis of Moroccan cobra Naja haje legionis venom using tandem mass spectrometry","volume":"96","author":"Malih","year":"2014","journal-title":"J. Proteomics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1186\/1471-2164-14-531","article-title":"The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms","volume":"14","author":"Margres","year":"2013","journal-title":"BMC Genomics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nature01748","article-title":"Structure and gating mechanism of the acetylcholine receptor pore","volume":"423","author":"Miyazawa","year":"2003","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"17811","DOI":"10.1074\/jbc.M111152200","article-title":"Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (\u03b1\u03b2\u03b3\u03b4) but a poorly reversible antagonist of neuronal \u03b17 nicotinic acetylcholine receptors","volume":"277","author":"Nirthanan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1254\/jphs.94.1","article-title":"Three-finger alpha-neurotoxins and the nicotinic acetylcholine receptor, forty years on","volume":"94","author":"Nirthanan","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jprot.2017.04.018","article-title":"Venomics of Bungarus caeruleus (Indian krait): comparable venom profiles, variable immunoreactivities among specimens from Sri Lanka, India and Pakistan","volume":"164","author":"Oh","year":"2017","journal-title":"J. Proteomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jprot.2018.10.016","article-title":"Venom proteome of Bungarus sindanus (Sind krait) from Pakistan and in vivo cross-neutralization of toxicity using an Indian polyvalent antivenom","volume":"193","author":"Oh","year":"2019","journal-title":"J. Proteomics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.bbagen.2017.01.020","article-title":"What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus","volume":"1861","author":"Pla","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/j.jchromb.2011.04.023","article-title":"Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands","volume":"879","author":"Pochet","year":"2011","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03113.x","article-title":"A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken alpha7 nicotinic acetylcholine receptors","volume":"269","author":"Poh","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-27794-3","article-title":"An in vitro potency assay using nicotinic acetylcholine receptor binding works well with antivenoms against Bungarus candidus and Naja naja","volume":"8","author":"Ratanabanangkoon","year":"2018","journal-title":"Sci. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-08962-3","article-title":"A novel in vitro potency assay of antisera against Thai Naja kaouthia based on nicotinic acetylcholine receptor binding","volume":"7","author":"Ratanabanangkoon","year":"2017","journal-title":"Sci. Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"8302","DOI":"10.1074\/jbc.M109.074161","article-title":"Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (King cobra)","volume":"285","author":"Roy","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0014-2999(00)00095-9","article-title":"Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors","volume":"393","author":"Servent","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.39.24279","article-title":"Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor","volume":"272","author":"Servent","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.toxicon.2018.04.022","article-title":"Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling","volume":"148","author":"Slagboom","year":"2018","journal-title":"Toxicon"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/35077000","article-title":"A glia-derived acetylcholine-binding protein that modulates synaptic transmission","volume":"411","author":"Smit","year":"2001","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"E2543","DOI":"10.1073\/pnas.1418289112","article-title":"Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the \u03b17 nicotinic acetylcholine receptor","volume":"112","author":"Spurny","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.cbpc.2015.09.015","article-title":"Comparison of the primary structures, cytotoxicities, and affinities to phospholipids of five kinds of cytotoxins from the venom of Indian cobra, Naja naja","volume":"179","author":"Suzuki-Matsubara","year":"2016","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"37299","DOI":"10.1038\/srep37299","article-title":"Assessing SABU (Serum Anti Bisa Ular), the sole Indonesian antivenom: a proteomic analysis and neutralization efficacy study","volume":"6","author":"Tan","year":"2016","journal-title":"Sci. Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jprot.2015.05.035","article-title":"Venomics of the beaked sea snake, Hydrophis schistosus: a minimalist toxin arsenal and its cross-neutralization by heterologous antivenoms","volume":"126","author":"Tan","year":"2015","journal-title":"J. Proteomics"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/toxins11010003","article-title":"Venom proteome of spine-bellied sea snake (Hydrophis curtus) from Penang, Malaysia: toxicity correlation, immunoprofiling and cross-neutralization by sea snake antivenom","volume":"11","author":"Tan","year":"2018","journal-title":"Toxins (Basel)"},{"key":"B55","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/toxins11020116","article-title":"Distinctive distribution of secretory phospholipases A2 in the venoms of Afro-Asian cobras (Subgenus: Naja, Afronaja, Boulengerina and Uraeus)","volume":"11","author":"Tan","year":"2019","journal-title":"Toxins (Basel)"},{"key":"B56","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3390\/toxins8040086","article-title":"Neutralization of the principal toxins from the venoms of Thai Naja kaouthia and Malaysian Hydrophis schistosus: insights into toxin-specific neutralization by two different antivenoms","volume":"8","author":"Tan","year":"2016","journal-title":"Toxins (Basel)"},{"key":"B57","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3390\/toxins9090290","article-title":"A review and database of snake venom proteomes","volume":"9","author":"Tasoulis","year":"2017","journal-title":"Toxins (Basel)"},{"key":"B58","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jmb.2004.12.031","article-title":"Refined structure of the nicotinic acetylcholine receptor at 4 \u00c5 resolution","volume":"346","author":"Unwin","year":"2005","journal-title":"J. Mol. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1042\/BCJ20180909","article-title":"Novel long-chain neurotoxins from Bungarus candidus distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors","volume":"476","author":"Utkin","year":"2019","journal-title":"Biochem. J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"15810","DOI":"10.1074\/jbc.M100788200","article-title":"\u201cWeak toxin\u201d from Naja kaouthia is a nontoxic antagonist of \u03b17 and muscle-type nicotinic acetylcholine receptors","volume":"276","author":"Utkin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jprot.2014.02.027","article-title":"Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A2","volume":"105","author":"Vergara","year":"2014","journal-title":"J. Proteomics"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115428","article-title":"Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2","volume":"9","author":"Vulfius","year":"2014","journal-title":"PLoS One"},{"key":"B63","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jprot.2018.09.019","article-title":"Defining the pathogenic threat of envenoming by South African shield-nosed and coral snakes (genus Aspidelaps), and revealing the likely efficacy of available antivenom","volume":"198","author":"Whiteley","year":"2018","journal-title":"J. Proteomics"},{"key":"B64","article-title":"WHO Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins","year":"2018"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/j.jprot.2011.05.027","article-title":"Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa","volume":"74","author":"Williams","year":"2011","journal-title":"J. Proteomics"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.4269\/ajtmh.15-0871","article-title":"Venom and purified toxins of the spectacled cobra (Naja naja) from Pakistan: insights into toxicity and antivenom neutralization","volume":"94","author":"Wong","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00848\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T18:37:44Z","timestamp":1569263864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.00848\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,30]]},"references-count":66,"alternative-id":["10.3389\/fphar.2019.00848"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.00848","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,30]]},"article-number":"848"}}