{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:58:37Z","timestamp":1793843917900,"version":"4.6.1"},"reference-count":207,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009465","name":"Corporaci\u00f3n de Fomento de la Producci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.01008","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:38:12Z","timestamp":1568248692000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":678,"title":["Neuroinflammation as a Common Feature of Neurodegenerative Disorders"],"prefix":"10.3389","volume":"10","author":[{"given":"Leonardo","family":"Guzman-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo B.","family":"Maccioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Patricio","family":"Navarrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Gabriela","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Ramos-Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.68941","article-title":"Neuroimmune dynamics in Alzheimer","volume-title":"Mechanisms of neuroinflammation","author":"Andrade","year":"2017"},{"key":"B2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41531-018-0066-0","article-title":"Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat","volume":"4","author":"Anselmi","year":"2018","journal-title":"NPJ Parkinsons Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0006-8993(00)03082-1","article-title":"Alpha-synuclein-positive structures in cases with sporadic Alzheimer\u2019s disease: morphology and its relationship to tau aggregation","volume":"888","author":"Arai","year":"2001","journal-title":"Brain Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.brainresbull.2016.08.018","article-title":"Tau and tauopathies","volume":"126","author":"Arendt","year":"2016","journal-title":"Brain Res. Bull."},{"key":"B5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/B978-0-12-407824-6.00004-5","article-title":"Corticobasal degeneration and dementia","volume-title":"Diet and nutrition in dementia and cognitive decline","author":"Armstrong","year":"2015"},{"key":"B6","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1006\/exnr.2000.7392","article-title":"A quantitative study of the pathological lesions in the neocortex and hippocampus of twelve patients with corticobasal degeneration","volume":"163","author":"Armstrong","year":"2000","journal-title":"Exp. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jalz.2018.02.001","article-title":"2018 Alzheimer\u2019s disease facts and figures","volume":"14","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B9","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1136\/jnnp.2005.068239","article-title":"Visuospatial functions in atypical parkinsonian syndromes","volume":"77","author":"Bak","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0002-9440(10)63421-9","article-title":"Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein","volume":"165","author":"Bellucci","year":"2004","journal-title":"Am J Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3389\/fnins.2017.00672","article-title":"Loss of neuroprotective factors in neurodegenerative dementias: the end or the starting point","volume":"11","author":"Benussi","year":"2017","journal-title":"Front. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"R4","DOI":"10.1093\/hmg\/ddq142","article-title":"Current status on Alzheimer disease molecular genetics: from past, to present, to future","volume":"19","author":"Bettens","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/mds.25108","article-title":"Animal models of Parkinson\u2019s disease: limits and relevance to neuroprotection studies","volume":"28","author":"Bezard","year":"2013","journal-title":"Mov. Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1093\/brain\/awm056","article-title":"Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease","volume":"130","author":"Boeve","year":"2007","journal-title":"Brain"},{"key":"B16","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.nbd.2015.03.003","article-title":"Glia and alpha-synuclein in neurodegeneration: a complex interaction","volume":"85","author":"Bruck","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0306-4522(02)00942-9","article-title":"Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer\u2019s disease","volume":"117","author":"Bussiere","year":"2003","journal-title":"Neuroscience"},{"key":"B19","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s004010050978","article-title":"Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration","volume":"97","author":"Bussiere","year":"1999","journal-title":"Acta Neuropathol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/ana.20332","article-title":"In vivo detection of microglial activation in frontotemporal dementia","volume":"56","author":"Cagnin","year":"2004","journal-title":"Ann. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1046\/j.1471-4159.1995.64031288.x","article-title":"DMAP-85: a tau-like protein from Drosophila melanogaster larvae","volume":"64","author":"Cambiazo","year":"1995","journal-title":"J. Neurochem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.arcmed.2012.10.010","article-title":"Can nutraceuticals prevent Alzheimer\u2019s disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins","volume":"43","author":"Carrasco-Gallardo","year":"2012","journal-title":"Arch. Med. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.12659\/MSM.905064","article-title":"Genome-wide profiling of miRNA and mRNA expression in Alzheimer\u2019s disease","volume":"23","author":"Chang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"B24","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1126\/science.1067484","article-title":"Role of Escherichia coli curli operons in directing amyloid fiber formation","volume":"295","author":"Chapman","year":"2002","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3389\/fnins.2017.00217","article-title":"Amyloid \u03b2-exposed human astrocytes overproduce phospho-tau and overrelease it within exosomes, effects suppressed by calcilytic NPS 2143\u2014further implications for Alzheimer\u2019s therapy","volume":"11","author":"Chiarini","year":"2017","journal-title":"Front. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055848","article-title":"A powerful yeast model to investigate the synergistic interaction of \u03b1-synuclein and tau in neurodegeneration","volume":"8","author":"Ciaccioli","year":"2013","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrd2896","article-title":"Alzheimer\u2019s disease: strategies for disease modification","volume":"9","author":"Citron","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"B28","doi-asserted-by":"publisher","first-page":"9535","DOI":"10.1073\/pnas.1301175110","article-title":"Brain homogenates from human tauopathies induce tau inclusions in mouse brain","volume":"110","author":"Clavaguera","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1093\/brain\/awu213.","article-title":"Neuronal uptake of tau\/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease","volume":"137","author":"Collin","year":"2014","journal-title":"Brain"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1016\/j.neuropharm.2012.01.028","article-title":"Contributions of central and systemic inflammation to the pathophysiology of Parkinson\u2019s disease","volume":"62","author":"Collins","year":"2012","journal-title":"Neuropharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2174\/187152710791012053","article-title":"Assessing activation states in microglia","volume":"9","author":"Colton","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3233\/JAD-2011-110623","article-title":"Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer\u2019s disease","volume":"27","author":"Cornejo","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"956","DOI":"10.3390\/ijms19040956","article-title":"Neuroimmune tau mechanisms: their role in the progression of neuronal degeneration","volume":"19","author":"Cortes","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3389\/fgene.2018.00596","article-title":"Temporal integrative analysis of mRNA and microRNAs expression profiles and epigenetic alterations in female SAMP8, a model of age-related cognitive decline","volume":"9","author":"Cosin-Tomas","year":"2018","journal-title":"Front. Genet."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1212\/WNL.0000000000002638","article-title":"Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes","volume":"86","author":"Coyle-Gilchrist","year":"2016","journal-title":"Neurology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"II6","DOI":"10.1007\/BF03161076","article-title":"Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration","volume":"246","author":"Dickson","year":"1999","journal-title":"J. Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/alzrt274","article-title":"The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis","volume":"6","author":"Donaghy","year":"2014","journal-title":"Alzheimers Res. Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1091\/mbc.3.10.1141","article-title":"Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau","volume":"3","author":"Drechsel","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s12031-018-1100-8","article-title":"Postmortem brain, cerebrospinal fluid, and blood neurotrophic factor levels in Alzheimer\u2019s disease: a systematic review and meta-Analysis","volume":"65","author":"Du","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.1096\/fj.08-120410","article-title":"\u03b1-Synuclein contributes to GSK-3\u03b2-catalyzed tau phosphorylation in Parkinson\u2019s disease models","volume":"23","author":"Duka","year":"2009","journal-title":"FASEB J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1096\/fj.06-6092com","article-title":"Alpha-synuclein induces hyperphosphorylation of tau in the MPTP model of parkinsonism","volume":"20","author":"Duka","year":"2006","journal-title":"FASEB J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.parkreldis.2011.06.007","article-title":"Cytokine expression and microglial activation in progressive supranuclear palsy","volume":"17","author":"Fernandez-Botran","year":"2011","journal-title":"Parkinsonism Relat. Disord."},{"key":"B43","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3233\/JAD-2008-14307","article-title":"The damage signals hypothesis of Alzheimer\u2019s disease pathogenesis","volume":"14","author":"Fernandez","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/00005072-199603000-00001","article-title":"Neuropathology of Parkinson\u2019s disease","volume":"55","author":"Forno","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2174\/187152711794653751","article-title":"Targeting TNF-alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases","volume":"10","author":"Frankola","year":"2011","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B46","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.expneurol.2004.07.016","article-title":"Tau phosphorylation increases in symptomatic mice overexpressing A30P \u03b1-synuclein","volume":"192","author":"Frasier","year":"2005","journal-title":"Exp. Neurol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.celrep.2017.12.066","article-title":"Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer\u2019s disease not evident in mouse models","volume":"22","author":"Friedman","year":"2018","journal-title":"Cell Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/ncb1528","article-title":"Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo","volume":"9","author":"Fulga","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1212\/WNL.59.4.585","article-title":"REM sleep behavior disorder and REM sleep without atonia in Parkinson\u2019s disease","volume":"59","author":"Gagnon","year":"2002","journal-title":"Neurology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.expneurol.2013.07.015","article-title":"Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra","volume":"248","author":"Garcia-Reitboeck","year":"2013","journal-title":"Exp. Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"14820","DOI":"10.1523\/JNEUROSCI.3883-11.2011","article-title":"MicroRNA-137\/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer\u2019s disease","volume":"31","author":"Geekiyanage","year":"2011","journal-title":"J. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/nan.12213","article-title":"Invited review: frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging","volume":"41","author":"Ghetti","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1126\/science.1082324","article-title":"Initiation and synergistic fibrillization of tau and alpha-synuclein","volume":"300","author":"Giasson","year":"2003","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1093\/brain\/112.5.1171","article-title":"Corticobasal degeneration","volume":"112","author":"Gibb","year":"1989","journal-title":"Brain"},{"key":"B56","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/383550a0","article-title":"Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans","volume":"383","author":"Goedert","year":"1996","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"Goedert","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/alzrt5","article-title":"Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer\u2019s and other neurodegenerative diseases","volume":"1","author":"Golde","year":"2009","journal-title":"Alzheimers Res. Ther."},{"key":"B59","first-page":"530","article-title":"Total hip reconstruction in a woman with Cornelia de Lange syndrome: a case report","volume":"89","author":"Grant","year":"1997","journal-title":"J. Natl. Med. Assoc."},{"key":"B60","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","article-title":"Alzheimer\u2019s disease risk gene CD33 inhibits microglial uptake of amyloid beta","volume":"78","author":"Griciuc","year":"2013","journal-title":"Neuron"},{"key":"B61","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.tins.2015.08.008","article-title":"Innate immunity fights Alzheimer\u2019s disease","volume":"38","author":"Guillot-Sestier","year":"2015","journal-title":"Trends Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fneur.2013.00167","article-title":"Tau oligomers as potential targets for Alzheimer\u2019s diagnosis and novel drugs","volume":"4","author":"Guzman-Martinez","year":"2013","journal-title":"Front. Neurol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1111\/j.1460-9568.2011.07660.x","article-title":"Hyperphosphorylated tau in an \u03b1-synuclein-overexpressing transgenic model of Parkinson\u2019s disease","volume":"33","author":"Haggerty","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/BF00294461","article-title":"Ubiquitin-positive achromatic neurons in corticobasal degeneration","volume":"90","author":"Halliday","year":"1995","journal-title":"Acta Neuropathol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1093\/brain\/awn049","article-title":"Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia","volume":"131","author":"Harper","year":"2008","journal-title":"Brain"},{"key":"B66","doi-asserted-by":"publisher","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/beta-secretase expression","volume":"105","author":"Hebert","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B67","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ni.3102","article-title":"Innate immunity in Alzheimer\u2019s disease","volume":"16","author":"Heneka","year":"2015","journal-title":"Nat. Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1212\/01.WNL.0000078928.20107.52","article-title":"Survival in frontotemporal dementia","volume":"61","author":"Hodges","year":"2003","journal-title":"Neurology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ceb.2015.02.004","article-title":"Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system","volume":"32","author":"Hol","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1073\/pnas.050004797","article-title":"Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer\u2019s disease","volume":"97","author":"Holtzman","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1093\/brain\/awv133","article-title":"Improving response inhibition systems in frontotemporal dementia with citalopram","volume":"138","author":"Hughes","year":"2015","journal-title":"Brain"},{"key":"B72","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00401-014-1380-1","article-title":"Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine","volume":"129","author":"Irwin","year":"2015","journal-title":"Acta Neuropathol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00401-002-0644-3","article-title":"Dementia with Lewy bodies from the perspective of tauopathy","volume":"105","author":"Iseki","year":"2003","journal-title":"Acta Neuropathol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1038\/jcbfm.2012.53","article-title":"Noninvasive molecular imaging of neuroinflammation","volume":"32","author":"Jacobs","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B75","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: a critical update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00401-009-0613-1","article-title":"The neuropathologic substrate of Parkinson disease dementia","volume":"119","author":"Jellinger","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2010.10.006","article-title":"Interaction between \u03b1-synuclein and tau in Parkinson\u2019s disease: comment on Wills et al.: elevated tauopathy and \u03b1-synuclein pathology in postmortem Parkinson\u2019s disease brains with and without dementia. Exp Neurol 2010; 225: 210-218","volume":"227","author":"Jellinger","year":"2011","journal-title":"Exp. Neurol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"25481","DOI":"10.1074\/jbc.274.36.25481","article-title":"\u03b1-Synuclein binds to tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356","volume":"274","author":"Jensen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B79","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia\u2013astrocyte crosstalk: an intimate molecular conversation","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"key":"B80","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/ana.410220411","article-title":"Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders","volume":"22","author":"Joachim","year":"1987","journal-title":"Ann. Neurol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1365-2990.2004.00611.x","article-title":"Inflammatory myofibroblastic tumour of the sella turcica","volume":"30","author":"Jochum","year":"2004","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/B978-1-4160-6641-5.00022-2","article-title":"Corticobasal ganglionic degeneration","author":"Josephs","year":"2010","journal-title":"Blue books of neurology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1212\/01.wnl.0000191307.69661.c3","article-title":"Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP","volume":"66","author":"Josephs","year":"2006","journal-title":"Neurology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1001\/archneur.63.10.1427","article-title":"Visual hallucinations in posterior cortical atrophy","volume":"63","author":"Josephs","year":"2006","journal-title":"Arch. Neurol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"340","DOI":"10.2174\/1567205011666140331161027","article-title":"CSF ubiquitin as a specific biomarker in Alzheimer\u2019s disease","volume":"11","author":"Kandimalla","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2174\/156720511795256071","article-title":"Apo-epsilon4 allele in conjunction with Abeta42 and tau in CSF: biomarker for Alzheimer\u2019s disease","volume":"8","author":"Kandimalla","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neulet.2010.06.075","article-title":"Cerebrospinal fluid profile of amyloid beta42 (Abeta42), hTau and ubiquitin in North Indian Alzheimer\u2019s disease patients","volume":"487","author":"Kandimalla","year":"2011","journal-title":"Neurosci Lett"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1242\/bio.20135447","article-title":"CSF p-tau levels in the prediction of Alzheimer\u2019s disease","volume":"2","author":"Kandimalla","year":"2013","journal-title":"Biol. Open"},{"key":"B90","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2202-12-79","article-title":"Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson\u2019s disease","volume":"12","author":"Kaul","year":"2011","journal-title":"BMC Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"4895","DOI":"10.1111\/j.1742-4658.2011.08389.x","article-title":"Stimulatory effect of alpha-synuclein on the tau-phosphorylation by GSK-3beta","volume":"278","author":"Kawakami","year":"2011","journal-title":"FEBS J."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1093\/brain\/awm142","article-title":"Patterns of levodopa response in Parkinson\u2019s disease: a clinico-pathological study","volume":"130","author":"Kempster","year":"2007","journal-title":"Brain"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"B94","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00401-012-1050-0","article-title":"Mixed tau, TDP-43 and p62 pathology in FTLD associated with a C9ORF72 repeat expansion and p.Ala239Thr MAPT (tau) variant","volume":"125","author":"King","year":"2013","journal-title":"Acta Neuropathol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s12031-011-9538-y","article-title":"Estimating the number of persons with frontotemporal lobar degeneration in the US population","volume":"45","author":"Knopman","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"8240","DOI":"10.1523\/JNEUROSCI.1808-05.2005","article-title":"Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines","volume":"25","author":"Koenigsknecht-Talboo","year":"2005","journal-title":"J. Neurosci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nm1058","article-title":"Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-\u03b2 peptides","volume":"10","author":"Koistinaho","year":"2004","journal-title":"Nat. Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/B978-0-12-802395-2.00025-0","article-title":"Tauopathies","volume":"145","author":"Kovacs","year":"2017","journal-title":"Handb. Clin. Neurol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s00401-010-0658-1","article-title":"Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics","volume":"119","author":"Kovacs","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00401-003-0705-2","article-title":"Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson\u2019s disease","volume":"106","author":"Kovari","year":"2003","journal-title":"Acta Neuropathol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1212\/01.WNL.0000165987.89198.65","article-title":"Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both","volume":"64","author":"Kraybill","year":"2005","journal-title":"Neurology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fpsyt.2011.00059.eCollection2011.","article-title":"Mechanistic studies of antibody-mediated clearance of tau aggregates using an ex vivo brain slice model","volume":"21","author":"Krishnamurthy","year":"2011","journal-title":"Front. Psychiatry"},{"key":"B103","first-page":"1916","article-title":"PET studies on dopamine D1 receptors in the human brain with carbon-11-SCH 39166 and carbon-11-NNC 756","volume":"35","author":"Laihinen","year":"1994","journal-title":"J. Nucl. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1212\/WNL.43.10.1927","article-title":"Neurotransmitters in basal ganglia and cortex of Alzheimer\u2019s disease with and without Lewy bodies","volume":"43","author":"Langlais","year":"1993","journal-title":"Neurology"},{"key":"B105","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.tins.2004.01.007","article-title":"More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases","volume":"27","author":"Lee","year":"2004","journal-title":"Trends Neurosci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1212\/WNL.44.8.1374","article-title":"Dystonia after head trauma","volume":"44","author":"Lee","year":"1994","journal-title":"Neurology"},{"key":"B107","doi-asserted-by":"publisher","first-page":"R78","DOI":"10.1186\/gb-2013-14-7-r78","article-title":"A blood based 12-miRNA signature of Alzheimer disease patients","volume":"14","author":"Leidinger","year":"2013","journal-title":"Genome Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13024-017-0192-x","article-title":"Glial contributions to neurodegeneration in tauopathies","volume":"12","author":"Leyns","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"B109","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","article-title":"NF\u03baB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer\u2019s disease","volume":"85","author":"Lian","year":"2015","journal-title":"Neuron"},{"key":"B110","doi-asserted-by":"publisher","first-page":"3","DOI":"10.14802\/jmd.15060","article-title":"Clinical approach to progressive supranuclear palsy","volume":"9","author":"Ling","year":"2016","journal-title":"JMD"},{"key":"B111","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3390\/ijms17020206","article-title":"Genetic and transcriptomic profiles of inflammation in neurodegenerative diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and tauopathies","volume":"17","author":"Lopez Gonzalez","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"B113","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1179\/1743132812Y.0000000063","article-title":"Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson\u2019s disease subjects","volume":"34","author":"Maarouf","year":"2012","journal-title":"Neurol. Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"607","DOI":"10.2174\/156720511796717159","article-title":"Tau protein in Alzheimer\u2019s disease","volume":"8","author":"Maccioni","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.arcmed.2012.11.001","article-title":"Introductory remarks. Molecular, biological and clinical aspects of Alzheimer\u2019s disease","volume":"43","author":"Maccioni","year":"2012","journal-title":"Arch. Med. Res."},{"key":"B116","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1749-6632.2008.03972.x","article-title":"The role of neuroimmunomodulation in Alzheimer\u2019s disease","volume":"1153","author":"Maccioni","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","article-title":"Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update","volume":"119","author":"Mackenzie","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"4720","DOI":"10.1523\/JNEUROSCI.3076-10.2011","article-title":"In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer\u2019s disease and related disorders","volume":"31","author":"Maeda","year":"2011","journal-title":"J. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S1474-4422(04)00936-6","article-title":"Corticobasal degeneration","volume":"3","author":"Mahapatra","year":"2004","journal-title":"Lancet Neurol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cercor\/bhy323","article-title":"Aging-related changes in cognition and cortical integrity are associated with serum expression of candidate microRNAs for Alzheimer disease","volume":"2018","author":"Maldonado-Lasuncion","year":"2018","journal-title":"Cereb. Cortex."},{"key":"B121","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/prot.24988","article-title":"Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8","volume":"84","author":"Malia","year":"2016","journal-title":"Proteins"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1093\/brain\/awv081","article-title":"Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain","volume":"138","author":"Maphis","year":"2015","journal-title":"Brain"},{"key":"B123","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/glia.22935","article-title":"Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson\u2019s disease","volume":"64","author":"Martin","year":"2016","journal-title":"Glia"},{"key":"B124","doi-asserted-by":"publisher","first-page":"242","DOI":"10.4103\/1673-5374.244784","article-title":"MicroRNAs as diagnostic and therapeutic tools for Alzheimer\u2019s disease: advances and limitations","volume":"14","author":"Martinez","year":"2019","journal-title":"Neural Regen. Res."},{"key":"B125","first-page":"209","article-title":"Subcortical neurofibrillary tangles, neuropil threads, and argentophilic glial inclusions in corticobasal degeneration","volume":"15","author":"Matsumoto","year":"1996","journal-title":"Clin. Neuropathol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.brainres.2008.01.095","article-title":"Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice","volume":"1207","author":"McKee","year":"2008","journal-title":"Brain Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"B128","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0197-4580(01)00307-4","article-title":"Glial activation in Alzheimer\u2019s disease: the role of Abeta and its associated proteins","volume":"22","author":"Meda","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"B129","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.expneurol.2012.10.007","article-title":"Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony","volume":"239","author":"Medeiros","year":"2013","journal-title":"Exp. Neurol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/00005072-199904000-00004","article-title":"Tau pathology in a family with dementia and a P301L mutation in tau","volume":"58","author":"Mirra","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000258724","article-title":"Neuroimmunomodulation in the pathogenesis of Alzheimer\u2019s disease","volume":"17","author":"Morales","year":"2010","journal-title":"Neuroimmunomodulation"},{"key":"B132","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fncel.2014.00112","article-title":"Neuroinflammation in the pathogenesis of Alzheimer\u2019s disease. A rational framework for the search of novel therapeutic approaches","volume":"8","author":"Morales","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3233\/JAD-131843","article-title":"Tau oligomers and fibrils induce activation of microglial cells","volume":"37","author":"Morales","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"B134","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.expneurol.2011.11.001","article-title":"The effect of amyloid associated proteins on the expression of genes involved in amyloid-\u03b2 clearance by adult human astrocytes","volume":"233","author":"Mulder","year":"2012","journal-title":"Exp. Neurol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.neuroscience.2008.01.030","article-title":"Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies","volume":"152","author":"Muntane","year":"2008","journal-title":"Neuroscience"},{"key":"B136","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/nn.4018","article-title":"Three dimensions of the amyloid hypothesis: time, space and \u2018wingmen\u2019","volume":"18","author":"Musiek","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"16122","DOI":"10.18632\/oncotarget.15109","article-title":"Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer\u2019s disease patients from non-demented subjects","volume":"8","author":"Nagaraj","year":"2017","journal-title":"Oncotarget"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"B139","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1136\/jnnp.51.3.353","article-title":"Dementia of frontal-lobe type","volume":"51","author":"Neary","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B140","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3233\/JAD-2011-101641","article-title":"Human platelets tau: a potential peripheral marker for Alzheimer\u2019s disease","volume":"25","author":"Neumann","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"B142","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1750-1326-7-35","article-title":"Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with alpha-synuclein at the single molecule level","volume":"7","author":"Nubling","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060378","article-title":"Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function","volume":"8","author":"Oaks","year":"2013","journal-title":"PLoS One"},{"key":"B144","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1212\/WNL.51.2.351","article-title":"Cognitive decline is faster in Lewy body variant than in Alzheimer\u2019s disease","volume":"51","author":"Olichney","year":"1998","journal-title":"Neurology"},{"key":"B145","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ncl.2017.01.008","article-title":"Frontotemporal dementia","volume":"35","author":"Olney","year":"2017","journal-title":"Neurol. Clin."},{"key":"B146","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3109\/09540261.2013.776523","article-title":"The epidemiology of frontotemporal dementia","volume":"25","author":"Onyike","year":"2013","journal-title":"Int. Rev. Psychiatry"},{"key":"B147","doi-asserted-by":"crossref","first-page":"03","DOI":"10.1016\/j.tips.2017.03.011","article-title":"A brief overview of tauopathy: causes, consequences, and therapeutic strategies","volume":"38","author":"Orr","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1080\/01616412.2016.1249997","article-title":"Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson\u2019s disease","volume":"38","author":"Pal","year":"2016","journal-title":"Neurol. Res."},{"key":"B149","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fncel.2014.00129","article-title":"Fractalkine regulation of microglial physiology and consequences on the brain and behavior","volume":"8","author":"Paolicelli","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41593-018-0296-9","article-title":"Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE","volume":"22","author":"Parhizkar","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1042\/BST20140155","article-title":"Astrocytes and neuroinflammation in Alzheimer\u2019s disease","volume":"42","author":"Phillips","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"B152","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"B153","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: do M1 and M2 microglia exist","volume":"19","author":"Ransohoff","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"B155","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1001\/archneur.1968.00470310034003","article-title":"Corticodentatonigral degeneration with neuronal achromasia","volume":"18","author":"Rebeiz","year":"1968","journal-title":"Arch. Neurol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/s12031-009-9190-y","article-title":"\u03b1-Synuclein promotes the recruitment of tau to protein inclusions in oligodendroglial cells: effects of oxidative and proteolytic stress","volume":"39","author":"Riedel","year":"2009","journal-title":"J. Mol. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/00001756-200301200-00022","article-title":"Human immunoglobulins and Fc fragments promote microtubule assembly via tau proteins and induce conformational changes of neuronal microtubules in vitro","volume":"14","author":"Riederer","year":"2003","journal-title":"Neuroreport"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1212\/WNL.44.9.1629","article-title":"Nigral degeneration in neuroacanthocytosis","volume":"44","author":"Rinne","year":"1994","journal-title":"Neurology"},{"key":"B159","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/mds.870090303","article-title":"The neuropathological features of neuroacanthocytosis","volume":"9","author":"Rinne","year":"1994","journal-title":"Mov. Disord."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1093\/brain\/117.5.1183","article-title":"Corticobasal degeneration. A clinical study of 36 cases","volume":"117","author":"Rinne","year":"1994","journal-title":"Brain"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arcmed.2007.10.001","article-title":"Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer\u2019s disease","volume":"39","author":"Rojo","year":"2008","journal-title":"Arch. Med. Res."},{"key":"B162","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1053\/j.semnuclmed.2015.03.008","article-title":"Pitfalls and limitations of PET\/CT in brain imaging","volume":"45","author":"Salmon","year":"2015","journal-title":"Semin. Nucl. Med."},{"key":"B163","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0163-4453(94)95660-X","article-title":"Lyme borreliosis associated with complete flaccid paraplegia","volume":"28","author":"Salonen","year":"1994","journal-title":"J. Infect."},{"key":"B164","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00415-003-1087-z","article-title":"Metabolic correlates of behavioral and affective disturbances in frontal lobe pathologies","volume":"250","author":"Sarazin","year":"2003","journal-title":"J. Neurol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/jnen\/60.11.1075","article-title":"Spinal cord neurofibrillary pathology in Alzheimer disease and Guam parkinsonism\u2013dementia complex","volume":"60","author":"Schmidt","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/ana.20723","article-title":"Substantia nigra tangles are related to gait impairment in older persons","volume":"59","author":"Schneider","year":"2006","journal-title":"Ann. Neurol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1212\/WNL.48.4.959","article-title":"Corticobasal degeneration: neuropathologic and clinical heterogeneity","volume":"48","author":"Schneider","year":"1997","journal-title":"Neurology"},{"key":"B168","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/01.jnen.0000218441.00040.82","article-title":"Atypical protein kinase C in neurodegenerative disease II: PKCiota\/lambda in tauopathies and alpha-synucleinopathies","volume":"65","author":"Shao","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"342931","DOI":"10.1155\/2013\/342931","article-title":"Innate immunity and neuroinflammation","volume":"2013","author":"Shastri","year":"2013","journal-title":"Mediators Inflamm."},{"key":"B170","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00401-012-1029-x","article-title":"The genetics and neuropathology of frontotemporal lobar degeneration","volume":"124","author":"Sieben","year":"2012","journal-title":"Acta Neuropathol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer\u2019s disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat. Genet."},{"key":"B172","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/prca.201700100","article-title":"Mass spectrometric analysis of cerebrospinal fluid ubiquitin in Alzheimer\u2019s disease and Parkinsonian disorders","volume":"11","author":"Sjodin","year":"2017","journal-title":"Proteomics Clin. Appl."},{"key":"B173","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S1474-4422(13)70090-5","article-title":"Tau pathology and neurodegeneration","volume":"12","author":"Spillantini","year":"2013","journal-title":"Lancet Neurol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1002\/1531-8249(200012)48:6<939::AID-ANA17>3.0.CO;2-1","article-title":"A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies","volume":"48","author":"Spillantini","year":"2000","journal-title":"Ann. Neurol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1212\/01.WNL.0000086814.35352.B3","article-title":"Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction","volume":"61","author":"Tang-Wai","year":"2003","journal-title":"Neurology"},{"key":"B177","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1001\/archneur.60.12.1777","article-title":"Comparison of the short test of mental status and the mini-mental state examination in mild cognitive impairment","volume":"60","author":"Tang-Wai","year":"2003","journal-title":"Arch. Neurol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"R183","DOI":"10.1093\/hmg\/ddm159","article-title":"Parkinson\u2019s disease","volume":"16","author":"Thomas","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"B179","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1440-1789.2004.00591.x","article-title":"Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies","volume":"24","author":"Tolnay","year":"2004","journal-title":"Neuropathology"},{"key":"B180","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1093\/jnen\/60.12.1123","article-title":"Update on the neuropathological diagnosis of frontotemporal dementias","volume":"60","author":"Trojanowski","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s004010050728","article-title":"Distribution of cerebral cortical lesions in corticobasal degeneration: a clinicopathological study of five autopsy cases in Japan","volume":"94","author":"Tsuchiya","year":"1997","journal-title":"Acta Neuropathol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jns.2006.02.005","article-title":"Familial tauopathy mimicking corticobasal degeneration an autopsy study on three siblings","volume":"246","author":"Uchihara","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"B183","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1471-4159.2007.04764.x","article-title":"Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation","volume":"103","author":"Uversky","year":"2007","journal-title":"J. Neurochem."},{"key":"B184","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10930-009-9201-4","article-title":"Intrinsically disordered proteins and their environment: effects of strong denaturants, temperature, pH, counter ions, membranes, binding partners, osmolytes, and macromolecular crowding","volume":"28","author":"Uversky","year":"2009","journal-title":"Protein J."},{"key":"B185","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s11481-008-9142-2","article-title":"Imaging microglial activation during neuroinflammation and Alzheimer\u2019s disease","volume":"4","author":"Venneti","year":"2009","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fncel.2014.00084","article-title":"A major role for tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions","volume":"8","author":"Violet","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B187","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1159\/000110455","article-title":"Role of the toll-like receptor 4 in neuroinflammation in Alzheimer\u2019s disease","volume":"20","author":"Walter","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"B188","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076057","article-title":"Expression of Tau40 induces activation of cultured rat microglial cells","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"B190","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3978\/j.issn.2305-5839.2015.03.49","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease","volume":"3","author":"Wang","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"B191","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.neuropharm.2011.07.008","article-title":"Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain","volume":"61","author":"Wani","year":"2011","journal-title":"Neuropharmacology"},{"key":"B192","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.11.004","article-title":"Caspase inhibition augments dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation","volume":"258","author":"Wani","year":"2014","journal-title":"Neuroscience"},{"key":"B193","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1007\/s00415-018-8926-4","article-title":"Application value of serum biomarkers for choosing memantine therapy for moderate AD","volume":"265","author":"Wei","year":"2018","journal-title":"J. Neurol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","article-title":"A protein factor essential for microtubule assembly","volume":"72","author":"Weingarten","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B195","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1136\/jnnp.64.2.184","article-title":"Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination","volume":"64","author":"Wenning","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106050","article-title":"Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer\u2019s disease","volume":"9","author":"Wes","year":"2014","journal-title":"PLoS One"},{"key":"B197","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1093\/brain\/awm104","article-title":"Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson\u2019s syndrome","volume":"130","author":"Williams","year":"2007","journal-title":"Brain"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017953","article-title":"Tauopathic changes in the striatum of A53T alpha-synuclein mutant mouse model of Parkinson\u2019s disease","volume":"6","author":"Wills","year":"2011","journal-title":"PLoS One"},{"key":"B199","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.expneurol.2010.06.017","article-title":"Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson\u2019s disease brains with and without dementia","volume":"225","author":"Wills","year":"2010","journal-title":"Exp. Neurol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.clinimag.2012.02.023","article-title":"In vivo cell tracking via 18F-fluorodeoxyglucose labeling: a review of the preclinical and clinical applications in cell-based diagnosis and therapy","volume":"37","author":"Wu","year":"2013","journal-title":"Clin. Imaging"},{"key":"B201","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0896-6273(02)00794-8","article-title":"Inflammation in neurodegenerative disease\u2014a double-edged sword","volume":"35","author":"Wyss-Coray","year":"2002","journal-title":"Neuron"},{"key":"B202","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/neup.12143","article-title":"Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration","volume":"34","author":"Yoshida","year":"2014","journal-title":"Neuropathology"},{"key":"B203","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"B204","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3967\/bes2016.021","article-title":"Comparison of undernutrition prevalence of children under 5 years in China between 2002 and 2013","volume":"29","author":"Yu","year":"2016","journal-title":"Biomed. Environ. Sci."},{"key":"B205","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2174\/1567205014666170505101426","article-title":"Lipid biomarkers in Alzheimer\u2019s disease","volume":"15","author":"Zarrouk","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"B206","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12974-015-0236-5","article-title":"Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging","volume":"12","author":"Zhang","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B207","doi-asserted-by":"publisher","first-page":"938","DOI":"10.2174\/1567205015666180601090533","article-title":"Interplay between the APOE genotype and possible plasma biomarkers in Alzheimer\u2019s disease","volume":"15","author":"Zverova","year":"2018","journal-title":"Curr. Alzheimer Res."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01008\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T08:43:28Z","timestamp":1569141808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01008\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":207,"alternative-id":["10.3389\/fphar.2019.01008"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.01008","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,12]]},"article-number":"1008"}}