{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:24:38Z","timestamp":1779927878969,"version":"3.53.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.01118","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T08:51:34Z","timestamp":1569574294000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect Of Dual sEH\/COX-2 Inhibition on Allergen-Induced Airway Inflammation"],"prefix":"10.3389","volume":"10","author":[{"given":"Mythili","family":"Dileepan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Rastle-Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayanjan S.","family":"Wijesinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naren Gajenthra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sriramarao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita P.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"B1","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff","year":"2004","journal-title":"Biophotonics Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"17406","DOI":"10.1074\/jbc.R113.546218","article-title":"Eosinophil granule proteins: form and function","volume":"289","author":"Acharya","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120157","article-title":"Increased eicosanoid levels in the Sugen\/chronic hypoxia model of severe pulmonary hypertension","volume":"10","author":"Al-Husseini","year":"2015","journal-title":"PloS One"},{"key":"B4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-319-77658-3_6","article-title":"Pro-resolving mediators","volume-title":"Immunopharmacology and inflammation","author":"Antonio Gon\u00e7alves","year":"2018"},{"key":"B5","doi-asserted-by":"publisher","first-page":"38231","DOI":"10.1074\/jbc.M111.279554","article-title":"N-glycans differentially regulate eosinophil and neutrophil recruitment during allergic airway inflammation","volume":"286","author":"Bahaie","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.4049\/jimmunol.1102253","article-title":"Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation","volume":"188","author":"Bahaie","year":"2012","journal-title":"J. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1042\/CS20040342","article-title":"Structural changes in the airways in asthma: observations and consequences","volume":"108","author":"Bai","year":"2005","journal-title":"Clin. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"174ra26","DOI":"10.1126\/scitranslmed.3004812","article-title":"Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma","volume":"5","author":"Barnig","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/JLB.3MA1017-423R","article-title":"Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation","volume":"104","author":"Bastan","year":"2018","journal-title":"J. Leuk. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/sj.bjp.0700963","article-title":"Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type","volume":"120","author":"Belvisi","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"L965","DOI":"10.1152\/ajplung.2001.280.5.L965","article-title":"EETs relax airway smooth muscle via an EpDHF effect: BKCa channel activation and hyperpolarization","volume":"280","author":"Benoit","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1164\/rccm.200211-1383OC","article-title":"Accentuated T helper Type 2 airway response after allergen challenge in cyclooxygenase-1\u2013\/\u2013 but not cyclooxygenase-2\u2013\/\u2013 mice","volume":"167","author":"Carey","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"21172","DOI":"10.1038\/srep21172","article-title":"Blue light modulates murine microglial gene expression in the absence of optogenetic protein expression","volume":"6","author":"Cheng","year":"2016","journal-title":"Sci. Rep."},{"key":"B14","first-page":"163","article-title":"Role of cytochrome P450s in inflammation","volume-title":"Advances in pharmacology","author":"Christmas","year":"2015"},{"key":"B15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1586\/17476348.2015.992783","article-title":"The role of prostaglandins in allergic lung inflammation and asthma","volume":"9","author":"Claar","year":"2015","journal-title":"Expert Rev. Respir. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3389\/fimmu.2014.00570","article-title":"Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity","volume":"5","author":"Davoine","year":"2014","journal-title":"Front. Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.3389\/fimmu.2018.02006","article-title":"Eicosanoid control over antigen presenting cells in asthma","volume":"9","author":"Debeuf","year":"2018","journal-title":"Front. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/j.jaci.2018.02.034","article-title":"Lipid regulation of group 2 innate lymphoid cell function: moving beyond epithelial cytokines","volume":"141","author":"Doherty","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12931-018-0893-x","article-title":"The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation","volume":"19","author":"Domingo","year":"2018","journal-title":"Respir. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.4049\/jimmunol.181.6.4004","article-title":"Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow","volume":"181","author":"Dyer","year":"2008","journal-title":"J. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1016\/j.jaci.2013.01.035","article-title":"Prostaglandin D\u2082 pathway upregulation: relation to asthma severity, control, and TH2 inflammation","volume":"131","author":"Fajt","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1056\/NEJMp048288","article-title":"Coxibs and cardiovascular disease","volume":"351","author":"FitzGerald","year":"2004","journal-title":"New Eng. J. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.envint.2016.01.003","article-title":"Alternaria alternata allergens: markers of exposure, phylogeny and risk of fungi-induced respiratory allergy","author":"Gabriel","year":"2016","journal-title":"Environ. Int."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1073\/pnas.1803999116","article-title":"Suppression of chemotherapy-induced cytokine\/lipid mediator surge and ovarian cancer by a dual COX-2\/sEH inhibitor","volume":"116","author":"Gartung","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.4049\/jimmunol.1000039","article-title":"Allergen-induced airway remodeling is impaired in galectin-3 deficient mice","volume":"185","author":"Ge","year":"2010","journal-title":"J. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3109\/01902148.2013.829537","article-title":"High-fat diet promotes lung fibrosis and attenuates airway eosinophilia after exposure to cockroach allergen in mice","volume":"39","author":"Ge","year":"2013","journal-title":"Exp. Lung Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fphar.2013.00037","article-title":"Eosinophil-expressed galectin-3 regulates cell trafficking and migration","volume":"4","author":"Ge","year":"2013","journal-title":"Front. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"E4837","DOI":"10.1073\/pnas.1601958113","article-title":"Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1","volume":"113","author":"Ge","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B29","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1177\/2040622315609251","article-title":"Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease","volume":"7","author":"George","year":"2016","journal-title":"Ther. Adv. Chronic Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1038\/ncomms3479","article-title":"ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48","volume":"4","author":"Ha","year":"2013","journal-title":"Nat. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev.physiol.010908.163200","article-title":"Immunobiology of asthma","volume":"71","author":"Hamid","year":"2009","journal-title":"Ann. Rev. Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jare.2018.03.005","article-title":"Synopsis of arachidonic acid metabolism: a review","volume":"11","author":"Hanna","year":"2018","journal-title":"J. Adv. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1476-9255-6-30","article-title":"Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E2","volume":"6","author":"Herrerias","year":"2009","journal-title":"J. Inflamm."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1021\/jm070270t","article-title":"Orally bioavailable potent soluble epoxide hydrolase inhibitors","volume":"50","author":"Hwang","year":"2007","journal-title":"J. Med. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1021\/jm2001376","article-title":"Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase","volume":"54","author":"Hwang","year":"2011","journal-title":"J. Med. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.prostaglandins.2016.07.003","article-title":"A dual COX-2\/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat","volume":"125","author":"Hye Khan","year":"2016","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"B37","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1194\/jlr.M031914","article-title":"Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo","volume":"54","author":"Kundu","year":"2013","journal-title":"J. Lipid Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.immuni.2019.03.018","article-title":"The cytokines of asthma","volume":"50","author":"Lambrecht","year":"2019","journal-title":"Immunity"},{"key":"B40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1164\/rccm.201010-1637OC","article-title":"Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation","volume":"184","author":"Li","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"87353","DOI":"10.18632\/oncotarget.20928","article-title":"COX-2\/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"B42","doi-asserted-by":"publisher","first-page":"6518","DOI":"10.4049\/jimmunol.1101806","article-title":"Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation","volume":"187","author":"Luna-Gomes","year":"2011","journal-title":"J. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1165\/rcmb.2007-0232OC","article-title":"EET displays anti-inflammatory effects in TNF-\u03b1\u2013stimulated human bronchi","volume":"38","author":"Morin","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1165\/rcmb.2009-0155OC","article-title":"17,18-epoxyeicosatetraenoic acid targets PPARg and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung","volume":"43","author":"Morin","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1146\/annurev-pharmtox-011112-140244","article-title":"Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health","volume":"53","author":"Morisseau","year":"2013","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/sj.bjp.0703232","article-title":"Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence","volume":"129","author":"Muscar\u00e1","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.3389\/fimmu.2018.02220","article-title":"Involvement and possible role of eosinophils in asthma exacerbation","volume":"9","author":"Nakagome","year":"2018","journal-title":"Front. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.jaci.2012.04.023","article-title":"Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthma","volume":"130","author":"Norton","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1164\/ajrccm.165.3.2103093","article-title":"Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs","volume":"165","author":"Oguma","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/1756-9966-27-66","article-title":"Antitumor enhancement of celecoxib, a selective cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing cyclooxygenase-2","volume":"27","author":"Park","year":"2008","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2018.08.001","article-title":"Prostaglandins in asthma and allergic diseases","volume":"193","author":"Peebles","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.4049\/jimmunol.175.8.5341","article-title":"The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia","volume":"175","author":"Pope","year":"2005","journal-title":"J. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0091-6749(03)01889-X","article-title":"Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia","volume":"112","author":"Profita","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"481","DOI":"10.4168\/aair.2016.8.6.481","article-title":"Eicosanoid mediators in the airway inflammation of asthmatic patients: what is new","volume":"8","author":"Sanak","year":"2016","journal-title":"Allergy Asthma Imm. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"C278","DOI":"10.1152\/ajpcell.00386.2011","article-title":"Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor","volume":"303","author":"Sanders","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11882-016-0628-3","article-title":"Lipid mediators of allergic disease: pathways, treatments, and emerging therapeutic targets","volume":"16","author":"Schauberger","year":"2016","journal-title":"Curr. Allergy Asthma Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"B58","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"541","DOI":"10.4049\/jimmunol.180.1.541","article-title":"Cyclooxygenase-2\/prostaglandin D2\/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation","volume":"180","author":"Shiraishi","year":"2008","journal-title":"J. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1136\/thx.52.11.940","article-title":"Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma","volume":"52","author":"Sousa","year":"1997","journal-title":"Thorax"},{"key":"B61","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.prostaglandins.2010.02.004","article-title":"Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant","volume":"92","author":"Swedin","year":"2010","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"B62","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1165\/rcmb.2013-0440OC","article-title":"Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice","volume":"52","author":"Yang","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"11127","DOI":"10.1073\/pnas.1410432111","article-title":"Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.plipres.2013.11.003","article-title":"Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer","volume":"53","author":"Zhang","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"10071","DOI":"10.1038\/s41598-017-09520-7","article-title":"Celecoxib normalizes the tumor microenvironment and enhances small nanotherapeutics delivery to A549 tumors in nude mice","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.4049\/jimmunol.0901604","article-title":"Deficiency of endothelial heparan sulfates attenuates allergic airway inflammation","volume":"183","author":"Zuberi","year":"2009","journal-title":"J. Immunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01118\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T08:51:37Z","timestamp":1569574297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01118\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,27]]},"references-count":66,"alternative-id":["10.3389\/fphar.2019.01118"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.01118","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,27]]},"article-number":"1118"}}