{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:20:16Z","timestamp":1790223616261,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860151, 81400815, 81660063"],"award-info":[{"award-number":["81860151, 81400815, 81660063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20171BAB205041"],"award-info":[{"award-number":["20171BAB205041"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.01219","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T15:11:22Z","timestamp":1572534682000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Sophocarpine Suppresses NF-\u03baB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy"],"prefix":"10.3389","volume":"10","author":[{"given":"Fang","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.lfs.2019.02.017","article-title":"Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy","volume":"221","author":"Althunibat","year":"2019","journal-title":"Life Sci."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24030586","article-title":"The drug candidate BGP-15 delays the onset of diastolic dysfunction in the Goto-Kakizaki rat model of diabetic cardiomyopathy","volume":"24","author":"Bombicz","year":"2019","journal-title":"Molecules"},{"key":"B3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-59745-019-5_9","article-title":"Analysis of cardiac myocyte biology in transgenic mice: a protocol for preparation of neonatal mouse cardiac myocyte cultures","volume":"633","author":"Brand","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.yjmcc.2017.03.002","article-title":"miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes","volume":"105","author":"Feng","year":"2017","journal-title":"J. Mol. Cell Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.bbadis.2017.09.029","article-title":"Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-kappaB-mediated inflammation both in vitro and in vivo","volume":"1864","author":"Guo","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41586-018-0849-9","article-title":"Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease","volume":"566","author":"He","year":"2019","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3389\/fphar.2016.00256","article-title":"Inhibition of sophocarpine on poly I: C\/D-GalN-induced immunological liver injury in mice","volume":"7","author":"Huang","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5871431","DOI":"10.1155\/2018\/5871431","article-title":"Sophocarpine attenuates LPS-induced liver injury and improves survival of mice through suppressing oxidative stress, inflammation, and apoptosis","volume":"2018","author":"Jiang","year":"2018","journal-title":"Mediators Inflamm."},{"key":"B9","doi-asserted-by":"publisher","first-page":"H113","DOI":"10.1152\/ajpheart.00440.2018","article-title":"Right ventricular dysfunction and remodeling in diabetic cardiomyopathy","volume":"316","author":"Kang","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41401-018-0042-6","article-title":"Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy","volume":"40","author":"Knapp","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/heartjnl-2016-310342","article-title":"Diabetic cardiomyopathy","author":"Lee","year":"2018","journal-title":"Heart"},{"key":"B12","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.jep.2011.03.052","article-title":"Sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via NF-kappaB inactivation","volume":"135","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3109\/13880209.2013.877038","article-title":"Oral sophocarpine protects rat heart against pressure overload-induced cardiac fibrosis","volume":"52","author":"Li","year":"2014","journal-title":"Pharm. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s12026-018-9012-9","article-title":"Sophocarpine attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-kappaB activation","volume":"66","author":"Li","year":"2018","journal-title":"Immunol. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11010-016-2913-9","article-title":"Apigenin alleviates STZ-induced diabetic cardiomyopathy","volume":"428","author":"Liu","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1016\/j.ymthe.2017.05.008","article-title":"Targeting miR-21 with sophocarpine inhibits tumor progression and reverses epithelial-mesenchymal transition in head and neck cancer","volume":"25","author":"Liu","year":"2017","journal-title":"Mol. Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fphar.2017.00140","article-title":"Sophocarpine protects mice from ConA-induced hepatitis via inhibition of the IFN-Gamma\/STAT1 pathway","volume":"8","author":"Sang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B18","article-title":"Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys44 to prevent cardiac structural damage in diabetic cardiomyopathy","volume-title":"Br. J. Pharmacol.","author":"Sun","year":"2019"},{"key":"B19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/d41586-019-00393-6","article-title":"How broken sleep promotes cardiovascular disease","volume":"566","author":"Tall","year":"2019","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature21505","article-title":"Cardiovascular disease: commonality with cancer","volume":"543","author":"Tall","year":"2017","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1530\/JOE-17-0681","article-title":"Isosteviol ameliorates diabetic cardiomyopathy in rats by inhibiting ERK and NF-kappaB signaling pathways","volume":"238","author":"Tang","year":"2018","journal-title":"J. Endocrinol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.2337\/db08-0329","article-title":"Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy","volume":"58","author":"Westermann","year":"2009","journal-title":"Diabetes"},{"key":"B23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.intimp.2018.11.046","article-title":"The protective effect of sophocarpine in osteoarthritis: an in vitro and in vivo study","volume":"67","author":"Wu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1161\/CIRCULATIONAHA.118.033552","article-title":"Hyperglycemia-driven inhibition of AMP-activated protein kinase alpha2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo","volume":"139","author":"Wu","year":"2019","journal-title":"Circulation"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12579","article-title":"Melatonin differentially regulates pathological and physiological cardiac hypertrophy: crucial role of circadian nuclear receptor RORalpha signaling","volume":"67","author":"Xu","year":"2019","journal-title":"J. Pineal. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.lfs.2018.09.004","article-title":"Peroxisome proliferator-activated receptor-gamma activation attenuates diabetic cardiomyopathy via regulation of the TGF-beta\/ERK pathway and epithelial-to-mesenchymal transition","volume":"213","author":"Yan","year":"2018","journal-title":"Life Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"9786","DOI":"10.1002\/jcp.26946","article-title":"Exogenous hydrogen sulfide attenuates the development of diabetic cardiomyopathy via the FoxO1 pathway","volume":"233","author":"Ye","year":"2018","journal-title":"J. Cell Physiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3389\/fendo.2018.00774","article-title":"Phloretin prevents diabetic cardiomyopathy by dissociating Keap1\/Nrf2 complex and inhibiting oxidative stress","volume":"9","author":"Ying","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1111\/jcmm.13477","article-title":"An Aza resveratrol-chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress","volume":"22","author":"You","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.3389\/fphar.2018.01227","article-title":"Notoginsenoside R1 protects against diabetic cardiomyopathy through activating estrogen receptor alpha and its downstream signaling","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1080\/00498254.2018.1468047","article-title":"In vitro inhibitory effects of sophocarpine on human liver cytochrome P450 enzymes","volume":"49","author":"Zhang","year":"2018","journal-title":"Xenobiotica"},{"key":"B32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.canlet.2016.01.011","article-title":"Differentiation therapy of hepatocellular carcinoma by inhibiting the activity of AKT\/GSK-3beta\/beta-catenin axis and TGF-beta induced EMT with sophocarpine","volume":"376","author":"Zhang","year":"2016","journal-title":"Cancer Lett."},{"key":"B33","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/FJC.0b013e318262c932","article-title":"Sophocarpine attenuates the Na(+)-dependent Ca2(+) overload induced by Anemonia sulcata toxin-increased late sodium current in rabbit ventricular myocytes","volume":"60","author":"Zhang","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1159\/000481843","article-title":"H3 relaxin protects against myocardial injury in experimental diabetic cardiomyopathy by inhibiting myocardial apoptosis, fibrosis and inflammation","volume":"43","author":"Zhang","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1016\/j.intimp.2008.08.008","article-title":"Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice","volume":"8","author":"Zhang","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1111\/febs.14780","article-title":"Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy","volume":"286","author":"Zheng","year":"2019","journal-title":"FEBS J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3389\/fendo.2018.00729","article-title":"Physical exercise and its protective effects on diabetic cardiomyopathy: what is the evidence","volume":"9","author":"Zheng","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1111\/bph.14092","article-title":"Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-kappaB signalling pathway in a rat model","volume":"175","author":"Zhou","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1684\/ecn.2017.0400","article-title":"Sophocarpine suppress inflammatory response in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis","volume":"28","author":"Zhu","year":"2017","journal-title":"Eur. Cytokine Netw."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01219\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T15:11:29Z","timestamp":1572534689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01219\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":39,"alternative-id":["10.3389\/fphar.2019.01219"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.01219","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,31]]},"article-number":"1219"}}