{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:55:21Z","timestamp":1787313321502,"version":"build-2736575974"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.01587","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T01:05:09Z","timestamp":1579655109000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice"],"prefix":"10.3389","volume":"10","author":[{"given":"Yunfei","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuangang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangming","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiake","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1242\/jcs.099986","article-title":"Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment","volume":"125","author":"Arai","year":"2012","journal-title":"J. Cell Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"B3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1074\/jbc.272.1.217","article-title":"Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation","volume":"272","author":"Bae","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1042\/bj20021806","article-title":"Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity","volume":"370","author":"Bardwell","year":"2003","journal-title":"Biochem. J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41413-017-0006-3","article-title":"Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling","volume":"6","author":"Bartelt","year":"2018","journal-title":"Bone Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00774-015-0656-4","article-title":"Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases","volume":"33","author":"Callaway","year":"2015","journal-title":"J. Bone Miner. Metab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.7150\/thno.30206","article-title":"Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1210\/er.2001-9002","article-title":"Meta-analyses of therapies for postmenopausal osteoporosis. IX: Summary of meta-analyses of therapies for postmenopausal osteoporosis","volume":"23","author":"Cranney","year":"2002","journal-title":"Endocr. Rev."},{"key":"B10","first-page":"527","article-title":"Physiopathology of osteoporosis: From risk factors analysis to treatment","volume":"29","author":"Del Puente","year":"2015","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"B11","doi-asserted-by":"publisher","first-page":"108638","DOI":"10.1016\/j.biopha.2019.108638","article-title":"Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats","volume":"112","author":"Goboza","year":"2019","journal-title":"BioMed. Pharmacother."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1128\/mcb.14.4.2593","article-title":"Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription","volume":"14","author":"Hansen","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrrheum.2009.260","article-title":"Osteoporosis: impact on health and economics","volume":"6","author":"Harvey","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. Int."},{"key":"B15","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2004.12.041","article-title":"Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases","volume":"120","author":"Kamata","year":"2005","journal-title":"Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ecl.2016.09.009","article-title":"Drug-Related Adverse Events of Osteoporosis Therapy","volume":"46","author":"Khan","year":"2017","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"B17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1210\/me.2007-0237","article-title":"NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP)","volume":"22","author":"Kim","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1038\/s41467-017-01527-y","article-title":"DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation","volume":"8","author":"Kim","year":"2017","journal-title":"Nat. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1359\/jbmr.060406","article-title":"Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation","volume":"21","author":"Koh","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","article-title":"Animal models for osteoporosis","volume":"759","author":"Komori","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1182\/blood-2004-09-3662","article-title":"A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation","volume":"106","author":"Lee","year":"2005","journal-title":"Blood"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1210\/endo.143.8.8954","article-title":"p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function","volume":"143","author":"Li","year":"2002","journal-title":"Endocrinology"},{"key":"B23","first-page":"1154","article-title":"Interleukin-27 prevents LPS-induced inflammatory osteolysis by inhibiting osteoclast formation and function","volume":"11","author":"Li","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/emboj.2008.73","article-title":"NF-kappaB dictates the degradation pathway of IkappaBalpha","volume":"27","author":"Mathes","year":"2008","journal-title":"EMBO J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1124\/mol.65.2.342","article-title":"Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells","volume":"65","author":"Nemeth","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/s0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"195","DOI":"10.4103\/0974-8490.65523","article-title":"Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats","volume":"2","author":"Rasineni","year":"2010","journal-title":"Pharmacogn. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.bone.2005.11.024","article-title":"Osteoporosis: a still increasing prevalence","volume":"38","author":"Reginster","year":"2006","journal-title":"Bone"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1038\/s41467-019-08778-x","article-title":"TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone","volume":"10","author":"Saito","year":"2019","journal-title":"Nat. Commun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.yexcr.2006.10.001","article-title":"RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation","volume":"313","author":"Sundaram","year":"2007","journal-title":"Exp. Cell Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/s1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00109-004-0612-6","article-title":"Mechanistic insight into osteoclast differentiation in osteoimmunology","volume":"83","author":"Takayanagi","year":"2005","journal-title":"J. Mol. Med. (Berl)"},{"key":"B33","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2353\/ajpath.2007.060834","article-title":"Osteoclasts: what do they do and how do they do it?","volume":"170","author":"Teitelbaum","year":"2007","journal-title":"Am. J. Pathol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1146\/annurev.immunol.20.100301.064753","article-title":"RANK-L and RANK: T cells, bone loss, and mammalian evolution","volume":"20","author":"Theill","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"i86","DOI":"10.1136\/ard.2009.119396","article-title":"Bone development and inflammatory disease is regulated by AP-1 (Fos\/Jun)","volume":"69","author":"Wagner","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"108850","DOI":"10.1016\/j.biopha.2019.108850","article-title":"Preliminary studies on the anti-osteoporosis activity of Baohuoside I","volume":"115","author":"Xi","year":"2019","journal-title":"BioMed. Pharmacother."},{"key":"B37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1172\/jci66947","article-title":"Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation","volume":"124","author":"Xiu","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1359\/jbmr.050324","article-title":"Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species production","volume":"20","author":"Yip","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e2002979","DOI":"10.1371\/journal.pbio.2002979","article-title":"A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and alphavbeta3 integrin for osteoporosis therapy","volume":"16","author":"Zur","year":"2018","journal-title":"PLoS Biol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01587\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T01:05:13Z","timestamp":1579655113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01587\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,22]]},"references-count":39,"alternative-id":["10.3389\/fphar.2019.01587"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.01587","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,22]]},"article-number":"1587"}}