{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:15:57Z","timestamp":1792836957685,"version":"4.5.0"},"reference-count":134,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2019.01667","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T23:20:11Z","timestamp":1580340011000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":131,"title":["Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives"],"prefix":"10.3389","volume":"10","author":[{"given":"Siyu","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoyou","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1111\/liv.12836","article-title":"Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practice","volume":"35","author":"Aithal","year":"2015","journal-title":"Liver Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.gastro.2005.05.006","article-title":"Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period","volume":"129","author":"Andrade","year":"2005","journal-title":"Gastroenterology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/toxsci\/kfp235","article-title":"High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo","volume":"112","author":"Antoine","year":"2009","journal-title":"Toxicol. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jhep.2011.12.019","article-title":"Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity","volume":"56","author":"Antoine","year":"2012","journal-title":"J. Hepatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/hep.26294","article-title":"Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital","volume":"58","author":"Antoine","year":"2013","journal-title":"Hepatology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1080\/00365520510024061","article-title":"Serum osteopontin levels in patients with acute liver dysfunction","volume":"41","author":"Arai","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/gutjnl-2015-310752","article-title":"Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury","volume":"66","author":"Arriazu","year":"2017","journal-title":"Gut"},{"key":"B8","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/S0016-5085(63)80026-8","article-title":"Sorbitol Dehydrogenase and Hepatocellular Injury - an Experimental and Clinical Study","volume":"44","author":"Asada","year":"1963","journal-title":"Gastroenterology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1365-2036.2011.04674.x","article-title":"Review article: drug-induced liver injury\u2013its pathophysiology and evolving diagnostic tools","volume":"34","author":"Au","year":"2011","journal-title":"Aliment Pharmacol. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/toxsci\/kfs243","article-title":"A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase","volume":"130","author":"Bailey","year":"2012","journal-title":"Toxicol. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/s0074-7696(08)61733-7","article-title":"The cellular fatty acid binding proteins: aspects of structure, regulation, and function","volume":"111","author":"Bass","year":"1988","journal-title":"Int. Rev. Cytol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1053\/j.gastro.2013.02.006","article-title":"Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland","volume":"144","author":"Bjornsson","year":"2013","journal-title":"Gastroenterology"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128643","article-title":"Meta-analysis-based preliminary exploration of the connection between ATDILI and schizophrenia by GSTM1\/T1 gene polymorphisms","volume":"10","author":"Cai","year":"2015","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1083\/jcb.138.6.1379","article-title":"Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis","volume":"138","author":"Caulin","year":"1997","journal-title":"J. Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.taap.2017.11.007","article-title":"Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition","volume":"338","author":"Cepa","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1053\/j.gastro.2015.03.006","article-title":"Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study","volume":"148","author":"Chalasani","year":"2015","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/jcpt.12211","article-title":"The association between HLA-DQB1 polymorphism and antituberculosis drug-induced liver injury: a case-control study","volume":"40","author":"Chen","year":"2015","journal-title":"J. Clin. Pharm. Ther."},{"key":"B18","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s12094-016-1533-x","article-title":"M30\/M65 ratio predicts the outcome of paclitaxel chemotherapy for NSCLC","volume":"19","author":"Chu","year":"2017","journal-title":"Clin. Transl. Oncol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1053\/j.gastro.2019.01.034","article-title":"A missense variant in PTPN22 is a risk factor for drug-induced liver injury","volume":"156","author":"Cirulli","year":"2019","journal-title":"Gastroenterology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1158\/1535-7163.MCT-07-2136","article-title":"Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity","volume":"7","author":"Cummings","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/0895-4356(93)90101-6","article-title":"Causality assessment of adverse reactions to drugs\u2013I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries","volume":"46","author":"Danan","year":"1993","journal-title":"J. Clin. Epidemiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s40264-018-0654-2","article-title":"Drug-induced liver injury: why is the Roussel Uclaf Causality Assessment Method (RUCAM) still used 25 years after its launch","volume":"41","author":"Danan","year":"2018","journal-title":"Drug Saf."},{"key":"B23","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1053\/j.gastro.2014.04.022","article-title":"Genome-wide association study identifies variants associated with autoimmune hepatitis type 1","volume":"147","author":"de Boer","year":"2014","journal-title":"Gastroenterology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S2468-1253(17)30266-2","article-title":"Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies","volume":"3","author":"Dear","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.jhep.2010.05.033","article-title":"Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury","volume":"53","author":"Donaldson","year":"2010","journal-title":"J. Hepatol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00699","article-title":"Proteomics analysis of monocyte-derived hepatocyte-like cells identifies integrin beta 3 as a specific biomarker for drug-induced liver injury by diclofenac","volume":"9","author":"Dragoi","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.taap.2011.04.003","article-title":"Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1","volume":"253","author":"Dragomir","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL Clinical Practice Guidelines: Drug-induced liver injury","volume":"70","year":"2019","journal-title":"J. Hepatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1158\/0008-5472.CAN-14-0615","article-title":"Intracellular osteopontin inhibits toll-like receptor signaling and impedes liver carcinogenesis","volume":"75","author":"Fan","year":"2015","journal-title":"Cancer Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1182\/blood-2002-05-1300","article-title":"Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells","volume":"101","author":"Fiuza","year":"2003","journal-title":"Blood"},{"key":"B31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.nmd.2013.09.004","article-title":"Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: results of a double-blind randomized clinical trial","volume":"24","author":"Flanigan","year":"2014","journal-title":"Neuromuscul. Disord."},{"key":"B32","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/hep.23696","article-title":"Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop","volume":"52","author":"Fontana","year":"2010","journal-title":"Hepatology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/cdd.2011.96","article-title":"Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death 2012","volume":"19","author":"Galluzzi","year":"2012","journal-title":"Cell Death Differ."},{"key":"B34","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.jhep.2011.02.007","article-title":"Causality assessment methods in drug induced liver injury: strengths and weaknesses","volume":"55","author":"Garcia-Cortes","year":"2011","journal-title":"J. Hepatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1093\/embo-reports\/kvf198","article-title":"The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway","volume":"3","author":"Gardella","year":"2002","journal-title":"Embo Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"CMAJ"},{"key":"B37","first-page":"1105","article-title":"Mildly elevated liver transaminase levels in the asymptomatic patient","volume":"71","author":"Giboney","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"B38","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/01926230252929945","article-title":"Alpha-glutathione S-transferase in the assessment of hepatotoxicity\u2013its diagnostic utility in comparison with other recognized markers in the Wistar Han rat","volume":"30","author":"Giffen","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/pds.3603","article-title":"A detection algorithm for drug-induced liver injury in medical information databases using the Japanese diagnostic scale and its comparison with the Council for International Organizations of Medical Sciences\/the Roussel Uclaf Causality Assessment Method scale","volume":"23","author":"Hanatani","year":"2014","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"B40","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/clpt.2012.40","article-title":"The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers","volume":"92","author":"Harrill","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/aps.2012.47","article-title":"The dual role of osteopontin in acetaminophen hepatotoxicity","volume":"33","author":"He","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119481","article-title":"Involvement of cytochrome P450 1A1 and glutathione S-transferase P1 polymorphisms and promoter hypermethylation in the progression of anti-tuberculosis drug-induced liver injury: a case-control study","volume":"10","author":"He","year":"2015","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1210\/endo-93-4-985","article-title":"Enzymes as markers of testicular growth and development in Rat","volume":"93","author":"Hodgen","year":"1973","journal-title":"Endocrinology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1056\/NEJMra1816149","article-title":"Drug-induced liver injury - types and phenotypes","volume":"381","author":"Hoofnagle","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1172\/JCI76887","article-title":"The HMGB1\/RAGE axis triggers neutrophil-mediated injury amplification following necrosis","volume":"125","author":"Huebener","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e0131010","DOI":"10.1371\/journal.pone.0131010","article-title":"Comparison of bile acids and acetaminophen protein adducts in children and adolescents with acetaminophen toxicity","volume":"10","author":"James","year":"2015","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198099","article-title":"Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer","volume":"13","author":"Jarzabek","year":"2018","journal-title":"PLoS One"},{"key":"B48","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/hep.24734","article-title":"Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis","volume":"55","author":"Joka","year":"2012","journal-title":"Hepatology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/toxsci\/kfy200","article-title":"Identification of Specific MicroRNA biomarkers in early stages of hepatocellular injury, cholestasis, and steatosis in rats","volume":"166","author":"Kagawa","year":"2018","journal-title":"Toxicol. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.molmet.2014.03.004","article-title":"Osteopontin: a novel regulator at the cross roads of inflammation, obesity and diabetes","volume":"3","author":"Kahles","year":"2014","journal-title":"Mol. Metab."},{"key":"B51","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/hep.28945","article-title":"Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure","volume":"65","author":"Karvellas","year":"2017","journal-title":"Hepatology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/sj.tpj.6500458","article-title":"Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis","volume":"8","author":"Kindmark","year":"2008","journal-title":"Pharmacogenomics J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1471-2407-9-88","article-title":"Circulating cell death products predict clinical outcome of colorectal cancer patients","volume":"9","author":"Koelink","year":"2009","journal-title":"BMC Cancer"},{"key":"B54","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/toxsci\/kfu232","article-title":"Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury","volume":"143","author":"Krauskopf","year":"2015","journal-title":"Toxicol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1365-2893.2005.00594.x","article-title":"Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C","volume":"12","author":"Kronenberger","year":"2005","journal-title":"J. Viral Hepat."},{"key":"B56","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1002\/hep.28493","article-title":"Keratins: biomarkers and modulators of apoptotic and necrotic cell death in the liver","volume":"64","author":"Ku","year":"2016","journal-title":"Hepatology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/s0960-9822(02)00809-6","article-title":"Identification of tissue-specific microRNAs from mouse","volume":"12","author":"Lagos-Quintana","year":"2002","journal-title":"Curr. Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1124\/dmd.113.052670","article-title":"MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1)","volume":"42","author":"Li","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"B59","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1093\/toxsci\/kfy253","article-title":"Quantitative systems toxicology analysis of in\u00a0vitro mechanistic assays reveals importance of bile acid accumulation and mitochondrial dysfunction in TAK-875-induced liver injury","volume":"167","author":"Longo","year":"2019","journal-title":"Toxicol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1002\/hep.22895","article-title":"Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex","volume":"49","author":"Lucena","year":"2009","journal-title":"Hepatology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1002\/hep.28736","article-title":"A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice","volume":"64","author":"Lundback","year":"2016","journal-title":"Hepatology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/hep.510260319","article-title":"Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis","volume":"26","author":"Maria","year":"1997","journal-title":"Hepatology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1006\/abbi.1995.1299","article-title":"Comparison of the primary structure of nuclear and mitochondrial glutamate dehydrogenase from bovine liver","volume":"319","author":"McDaniel","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1007\/s11095-013-1007-6","article-title":"Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis","volume":"30","author":"McGill","year":"2013","journal-title":"Pharm. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1172\/JCI59755","article-title":"The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation","volume":"122","author":"McGill","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1002\/hep.27265","article-title":"Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome","volume":"60","author":"McGill","year":"2014","journal-title":"Hepatology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1021\/tx300341r","article-title":"Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats","volume":"25","author":"Metushi","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/hep.26564","article-title":"Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure","volume":"59","author":"Metushi","year":"2014","journal-title":"Hepatology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11010-014-2065-8","article-title":"D-penicillamine-induced granulomatous hepatitis in brown Norway rats","volume":"393","author":"Metushi","year":"2014","journal-title":"Mol. Cell Biochem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/bcp.12885","article-title":"Mechanism of isoniazid-induced hepatotoxicity: then and now","volume":"81","author":"Metushi","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/liv.13174","article-title":"Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury","volume":"37","author":"Mikus","year":"2017","journal-title":"Liver Int."},{"key":"B72","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.toxlet.2016.10.002","article-title":"MicroRNA-877-5p is involved in the trovafloxacin-induced liver injury","volume":"263","author":"Mitsugi","year":"2016","journal-title":"Toxicol. Lett."},{"key":"B73","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1002\/hep.26077","article-title":"Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury","volume":"57","author":"Monshi","year":"2013","journal-title":"Hepatology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/toxsci\/kfx206","article-title":"miR-122 release in exosomes precedes overt tolvaptan-induced necrosis in a primary human hepatocyte micropatterned coculture model","volume":"161","author":"Mosedale","year":"2018","journal-title":"Toxicol. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s40520-014-0296-x","article-title":"Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover","volume":"27","author":"Mukaiyama","year":"2015","journal-title":"Aging Clin. Exp. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1111\/liv.12420","article-title":"Soluble thrombomodulin attenuates sinusoidal obstruction syndrome in rat through suppression of high mobility group box 1","volume":"34","author":"Nakamura","year":"2014","journal-title":"Liver Int."},{"key":"B77","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/hep.20548","article-title":"Serum alanine aminotransferase in skeletal muscle diseases","volume":"41","author":"Nathwani","year":"2005","journal-title":"Hepatology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"16576","DOI":"10.1074\/jbc.M114.559468","article-title":"Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes","volume":"289","author":"Neumann","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1053\/j.gastro.2016.12.016","article-title":"Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study","volume":"152","author":"Nicoletti","year":"2017","journal-title":"Gastroenterology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"F21","DOI":"10.1097\/QAD.0b013e328355fe8f","article-title":"Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity","volume":"26","author":"Norcross","year":"2012","journal-title":"AIDS"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1002\/hep.24229","article-title":"Drug-induced cholestasis","volume":"53","author":"Padda","year":"2011","journal-title":"Hepatology"},{"key":"B82","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1083\/jcb.200304135","article-title":"Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation","volume":"164","author":"Palumbo","year":"2004","journal-title":"J. Cell Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3892\/ijmm.2016.2461","article-title":"Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription","volume":"37","author":"Park","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jhep.2005.03.017","article-title":"Enterohepatic transport of bile salts and genetics of cholestasis","volume":"43","author":"Pauli-Magnus","year":"2005","journal-title":"J. Hepatol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1097\/CCM.0b013e31829791a2","article-title":"Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*","volume":"41","author":"Possamai","year":"2013","journal-title":"Crit. Care Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1021\/acs.molpharmaceut.5b00659","article-title":"Disruption of BSEP function in HepaRG cells alters bile acid disposition and is a susceptive factor to drug-induced cholestatic injury","volume":"13","author":"Qiu","year":"2016","journal-title":"Mol. Pharm."},{"key":"B87","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/sj.embor.7400205","article-title":"HMGB1 is an endogenous immune adjuvant released by necrotic cells","volume":"5","author":"Rovere-Querini","year":"2004","journal-title":"Embo Rep."},{"key":"B88","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1111\/liv.13312","article-title":"Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance","volume":"37","author":"Russo","year":"2017","journal-title":"Liver Int."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e0192709","DOI":"10.1371\/journal.pone.0192709","article-title":"Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection","volume":"13","author":"Sampayo-Escobar","year":"2018","journal-title":"PLoS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.clinre.2015.12.017","article-title":"Bile acids in drug induced liver injury: key players and surrogate markers","volume":"40","author":"Schadt","year":"2016","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0009-8981(88)90356-7","article-title":"Glutamate dehydrogenase: biochemical and clinical aspects of an interesting enzyme","volume":"173","author":"Schmidt","year":"1988","journal-title":"Clin. Chim. Acta"},{"key":"B92","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/toxsci\/kft009","article-title":"Assessment of emerging biomarkers of liver injury in human subjects","volume":"132","author":"Schomaker","year":"2013","journal-title":"Toxicol. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1182\/blood-2004-10-3906","article-title":"NK\/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1","volume":"106","author":"Semino","year":"2005","journal-title":"Blood"},{"key":"B94","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/jcb.20661","article-title":"Interleukin-1beta induces osteopontin expression in pulmonary fibroblasts","volume":"97","author":"Serlin","year":"2006","journal-title":"J. Cell Biochem."},{"key":"B95","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1053\/jhep.2002.34857","article-title":"Incidence of drug-induced hepatic injuries: a French population-based study","volume":"36","author":"Sgro","year":"2002","journal-title":"Hepatology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1053\/j.gastro.2019.02.002","article-title":"Incidence and Etiology of drug-induced liver injury in Mainland China","volume":"156","author":"Shen","year":"2019","journal-title":"Gastroenterology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/2050-6511-15-42","article-title":"Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine","volume":"15","author":"Singhal","year":"2014","journal-title":"BMC Pharmacol. Toxicol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.tube.2014.02.003","article-title":"Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity","volume":"94","author":"Singla","year":"2014","journal-title":"Tuberculosis (Edinb)"},{"key":"B99","doi-asserted-by":"publisher","first-page":"889","DOI":"10.3892\/etm.2016.3375","article-title":"Ratio of microRNA-122\/155 in isoniazid-induced acute liver injury in mice","volume":"12","author":"Song","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.cyto.2015.02.021","article-title":"Plasma osteopontin in acute liver failure","volume":"73","author":"Srungaram","year":"2015","journal-title":"Cytokine"},{"key":"B101","doi-asserted-by":"publisher","first-page":"16997","DOI":"10.1038\/s41598-018-35278-7","article-title":"The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer","volume":"8","author":"Sugimoto","year":"2018","journal-title":"Sci. Rep."},{"key":"B102","first-page":"994","article-title":"Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: a meta-analysis","volume":"12","author":"Sun","year":"2008","journal-title":"Int. J. Tuberc. Lung. Dis."},{"key":"B103","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/hepr.12777","article-title":"High promoter methylation levels of glutathione-S-transferase M3 predict poor prognosis of acute-on-chronic hepatitis B liver failure","volume":"47","author":"Sun","year":"2017","journal-title":"Hepatol. Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1002\/hep.24481","article-title":"The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury","volume":"54","author":"Suzuki","year":"2011","journal-title":"Hepatology"},{"key":"B105","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nrgastro.2013.87","article-title":"MicroRNAs in liver disease","volume":"10","author":"Szabo","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"6774","DOI":"10.3748\/wjg.14.6774","article-title":"Practical guidelines for diagnosis and early management of drug-induced liver injury","volume":"14","author":"Tajiri","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/1440-1681.12074","article-title":"Lack of association between genetic polymorphisms of CYP3A4, CYP2C9 and CYP2C19 and antituberculosis drug-induced liver injury in a community-based Chinese population","volume":"40","author":"Tang","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/toxsci\/kfy015","article-title":"Optimized methods to explore the mechanistic and biomarker potential of hepatocyte-derived exosomes in drug-induced liver injury","volume":"163","author":"Thacker","year":"2018","journal-title":"Toxicol. Sci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/liv.12322","article-title":"Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts","volume":"34","author":"Thulin","year":"2014","journal-title":"Liver Int."},{"key":"B110","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1080\/1354750X.2016.1269131","article-title":"A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat","volume":"22","author":"Thulin","year":"2017","journal-title":"Biomarkers"},{"key":"B111","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3945\/jn.116.240358","article-title":"Identification of potential plasma biomarkers for nonalcoholic fatty liver disease by integrating transcriptomics and proteomics in laying hens","volume":"147","author":"Tsai","year":"2017","journal-title":"J. Nutr."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00335","article-title":"Susceptibility-related factor and biomarkers of dietary supplement polygonum multiflorum-induced liver injury in rats","volume":"10","author":"Tu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1136\/bmj.2.6101.1508","article-title":"Glutamate dehydrogenase: a reliable marker of liver cell necrosis in the alcoholic","volume":"2","author":"Van Waes","year":"1977","journal-title":"Br. Med. J."},{"key":"B114","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s40264-017-0547-9","article-title":"The incidence of drug- and herbal and dietary supplement-induced liver injury: preliminary findings from gastroenterologist-based surveillance in the population of the state of delaware","volume":"40","author":"Vega","year":"2017","journal-title":"Drug Saf."},{"key":"B115","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.phrs.2016.06.031","article-title":"HMGB1 as biomarker and drug target","volume":"111","author":"Venereau","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B116","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1111\/bcp.13282","article-title":"MicroRNA-122 can be measured in capillary blood which facilitates point-of-care testing for drug-induced liver injury","volume":"83","author":"Vliegenthart","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1073\/pnas.0813371106","article-title":"Circulating microRNAs, potential biomarkers for drug-induced liver injury","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B118","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/hep.25982","article-title":"High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: interaction of gammadelta T cells with macrophages","volume":"57","author":"Wang","year":"2013","journal-title":"Hepatology"},{"key":"B119","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.hepres.2004.08.005","article-title":"Validity study of a new diagnostic scale for drug-induced liver injury in Japan-comparison with two previous scales","volume":"30","author":"Watanabe","year":"2004","journal-title":"Hepatol. Res."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006807","article-title":"Cell death biomarker M65 is a useful indicator of liver inflammation and fibrosis in chronic hepatitis B: a cross-sectional study of diagnostic accuracy","volume":"96","author":"Wei","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"B121","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1647\/2011-016.1","article-title":"Improved clinicopathologic assessments of acute liver damage due to trauma in Indian ring-necked parakeets (Psittacula krameri manillensis)","volume":"26","author":"Williams","year":"2012","journal-title":"J.\u00a0Avian. Med. Surg."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157478","article-title":"Genetic polymorphisms of glutathione S-Transferase P1 (GSTP1) and the incidence of anti-tuberculosis drug-induced hepatotoxicity","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1128\/JVI.02604-15","article-title":"Hepatitis B virus X protein induces hepatic steatosis by enhancing the expression of liver fatty acid binding protein","volume":"90","author":"Wu","year":"2016","journal-title":"J. Virol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1159\/000486058","article-title":"Multiple MicroRNAs ameliorate hepatocyte steatosis and injury by suppressing FABP1 expression","volume":"44","author":"Wu","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1021\/acs.jproteome.9b00047","article-title":"Metabolomics and cytokine analysis for identification of severe drug-induced liver injury","volume":"18","author":"Xie","year":"2019","journal-title":"J. Proteome Res."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00083","article-title":"Fortunellin-induced modulation of phosphatase and tensin homolog by MicroRNA-374a decreases inflammation and maintains intestinal barrier function in colitis","volume":"9","author":"Xiong","year":"2018","journal-title":"Front. Immunol."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/srep30073","article-title":"Identification of a diazinon-metabolizing glutathione S-transferase in the silkworm, Bombyx mori","volume":"6","author":"Yamamoto","year":"2016","journal-title":"Sci. Rep."},{"key":"B128","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.taap.2013.01.018","article-title":"Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats","volume":"268","author":"Yamazaki","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"e027940","DOI":"10.1136\/bmjopen-2018-027940","article-title":"Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis","volume":"9","author":"Yang","year":"2019","journal-title":"BMJ Open"},{"key":"B130","doi-asserted-by":"publisher","first-page":"8097","DOI":"10.1021\/acs.analchem.7b01659","article-title":"Efficient two-photon fluorescent probe for glutathione s-transferase detection and imaging in drug-induced liver injury sample","volume":"89","author":"Zhang","year":"2017","journal-title":"Anal. Chem."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01464","article-title":"Exosome-induced regulation in inflammatory bowel disease","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Immunol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.toxlet.2012.08.005","article-title":"Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo","volume":"214","author":"Zhao","year":"2012","journal-title":"Toxicol. Lett."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00236","article-title":"Integrated expression profiles of mRNA and microRNA in the liver of Fructus Meliae Toosendan water extract injured mice","volume":"6","author":"Zheng","year":"2015","journal-title":"Front. Pharmacol."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01468","article-title":"Inhibition of Epithelial TNF-alpha receptors by purified Fruit Bromelain Ameliorates intestinal inflammation and barrier dysfunction in colitis","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Immunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01667\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T23:20:15Z","timestamp":1580340015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2019.01667\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,30]]},"references-count":134,"alternative-id":["10.3389\/fphar.2019.01667"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2019.01667","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,30]]},"article-number":"1667"}}