{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:51:18Z","timestamp":1768531878107,"version":"3.49.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG046153"],"award-info":[{"award-number":["AG046153"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG054714"],"award-info":[{"award-number":["AG054714"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS106305"],"award-info":[{"award-number":["NS106305"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI104034"],"award-info":[{"award-number":["AI104034"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 014195"],"award-info":[{"award-number":["P30 014195"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00208","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T06:51:36Z","timestamp":1583823096000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer\u2019s Disease, a Case Made With the Genus Eriodictyon"],"prefix":"10.3389","volume":"11","author":[{"given":"Pamela","family":"Maher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Soriano-Castell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio F. M.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Rebman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Currais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1055\/s-2006-959601","article-title":"Isolation and biological effects of 7-O-methyleriodictyol, a flavanone isolated from Artemisia monosperma, on rat isolated smooth muscles.","volume":"59","author":"Abu-Niaaj","year":"1993","journal-title":"Planta Med."},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1525\/9780520933101","author":"Anderson","year":"2005","journal-title":"Tending the Wild: Native American Knowledge and the Management of California\u2019s Natural Resources."},{"key":"B3","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/0305-1978(86)90039-6","article-title":"Chemosystematics of the hydrophyllaceae: Flavonoids of three species of Eriodictyon.","volume":"14","author":"Bacon","year":"1986","journal-title":"Biochem. Syst. Ecol."},{"key":"B4","author":"Bean","year":"1972","journal-title":"Temalpakh: Cahuilla Indian Knowledge and Usage of Plants."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027865","article-title":"A novel neurotrophic drug for cognitive enhancement and Alzheimer\u2019s disease.","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1021\/jm2012563","article-title":"Chemical modification of the multitarget neuroprotective compound fisetin.","volume":"55","author":"Chiruta","year":"2012","journal-title":"J. Med. Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.arr.2015.02.001","article-title":"Ageing and inflammation - A central role for mitochondria in brain health and disease.","volume":"21","author":"Currais","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.jep.2014.06.046","article-title":"Screening and identification of neuroprotective compounds relevant to Alzheimers disease from medicinal plants of S. Tome e Principe.","volume":"155","author":"Currais","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/gerona\/glx104","article-title":"Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse.","volume":"73","author":"Currais","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.18632\/aging.100838","article-title":"A comprehensive multiomics approach toward understanding the relationship between aging and dementia.","volume":"7","author":"Currais","year":"2015","journal-title":"Aging"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47866","article-title":"Elevating acetyl-CoA levels reduces aspects of brain aging.","volume":"8","author":"Currais","year":"2019","journal-title":"eLife"},{"key":"B12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1089\/ars.2012.4996","article-title":"Functional consequences of age-dependent changes in glutathione status in the brain.","volume":"19","author":"Currais","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"B13","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/acel.12185","article-title":"Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer\u2019s disease transgenic mice.","volume":"13","author":"Currais","year":"","journal-title":"Aging Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death.","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.101089","article-title":"Old age-associated phenotypic screening for Alzheimer\u2019s disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa.","volume":"21","author":"Fischer","year":"2019","journal-title":"Redox Biol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12715","article-title":"The mitochondrial ATP synthase is a shared drug target for aging and dementia.","volume":"17","author":"Goldberg","year":"2018","journal-title":"Aging Cell"},{"key":"B17","first-page":"1491","article-title":"Thymus mastichina: chemical constituents and their anti-cancer activity.","volume":"7","author":"Gordo","year":"2012","journal-title":"Nat. Prod. Commun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1002\/j.1537-2197.1988.tb13477.x","article-title":"Evaluation of relationships within Eriodictyon (Hydrophyllaceae) using trichome characteristics.","volume":"75","author":"Hannan","year":"1988","journal-title":"Am. J. Bot."},{"key":"B19","author":"Hedges","year":"1886","journal-title":"Santa Ysabel Ethnobotany."},{"key":"B20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.phytochem.2005.11.022","article-title":"Flavonoid 3\u2019-O-methyltransferase from rice: cDNA cloning, characterization and functional expression.","volume":"67","author":"Kim","year":"2006","journal-title":"Phytochemistry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1021\/acs.jnatprod.6b01164","article-title":"Biotechnological production of dimethoxyflavonoids using a fusion flavonoid O-methyltransferase possessing both 3\u2019- and 7-O-methyltransferase activities.","volume":"80","author":"Lee","year":"2017","journal-title":"J. Nat. Prod."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00214","article-title":"Oxytosis\/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system.","volume":"12","author":"Lewerenz","year":"2018","journal-title":"Front. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.jbiotec.2013.07.025","article-title":"Biosynthesis of homoeriodictyol from eriodictyol by flavone 3\u2019-O-methyltransferase from recombinant Yarrowia lioplytica: heterologous expression, biochemical characterization, and optimal transformation.","volume":"167","author":"Liu","year":"2013","journal-title":"J. Biotechnol."},{"key":"B24","author":"Moerman","year":"2009","journal-title":"Native American Medicinal Plants, An Ethnobotanical Dictionary."},{"key":"B25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1021\/cn500051h","article-title":"Back to the future with phenotypic screening.","volume":"5","author":"Prior","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.tips.2018.09.008","article-title":"Geroneuroprotectors: effective geroprotectors for the brain.","volume":"39","author":"Schubert","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"19315","DOI":"10.1074\/jbc.M112.351270","article-title":"Purification and identification of naringenin 7-O-methyltransferase, a key enzyme in biosynthesis of flavonoid phytoalexin sakuranetin in rice.","volume":"287","author":"Shimizu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.2174\/1568026013394741","article-title":"Oxytosis: A novel form of programmed cell death.","volume":"1","author":"Tan","year":"2001","journal-title":"Curr. Top. Med. Chem"},{"key":"B29","author":"Timbrook","year":"2007","journal-title":"Chumash Ethnobotany: Plant Knowledge Among the Chumash People of Southern California."},{"key":"B30","author":"Wilken-Robertson","year":"2017","journal-title":"Kumeyaay Ethnobotany: Shared Heritage of the Californias."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006346","article-title":"Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature.","volume":"2","author":"Wyss-Coray","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4.","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00208\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T11:19:59Z","timestamp":1614770399000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00208\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":32,"alternative-id":["10.3389\/fphar.2020.00208"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00208","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,10]]},"article-number":"208"}}