{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:23:29Z","timestamp":1780410209649,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00268","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T04:31:54Z","timestamp":1584073914000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Rosiglitazone Protects Endothelial Cells From Irradiation-Induced Mitochondrial Dysfunction"],"prefix":"10.3389","volume":"11","author":[{"given":"Bjorn","family":"Baselet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Driesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Coninx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Belmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Sieprath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Lambrichts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnok H.","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Baatout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sonveaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Aerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.213","article-title":"Computational classification of mitochondrial shapes reflects stress and redox state.","volume":"4","author":"Ahmad","year":"2013","journal-title":"Cell Death Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1590\/1414-431x20132856","article-title":"Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats.","volume":"46","author":"Bakkal","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1016\/j.febslet.2009.10.013","article-title":"Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase.","volume":"583","author":"Belikova","year":"2009","journal-title":"FEBS Lett."},{"key":"B4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.semcdb.2016.01.045","article-title":"Ionizing radiation and heart risks.","volume":"58","author":"Bhattacharya","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/mutage\/14.1.77","article-title":"Detection of the \u20184977 bp\u2019 mitochondrial DNA deletion in human atherosclerotic lesions.","volume":"14","author":"Bogliolo","year":"1999","journal-title":"Mutagenesis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.mrfmmm.2004.10.003","article-title":"Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease.","volume":"570","author":"Botto","year":"2005","journal-title":"Mutat. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0921-8734(92)90021-g","article-title":"Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease.","volume":"275","author":"Corral-Debrinski","year":"1992","journal-title":"Mutat. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer.","volume":"368","author":"Darby","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1667\/RR1617.1","article-title":"Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation.","volume":"172","author":"Dayal","year":"2009","journal-title":"Radiat. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","article-title":"Role of PFKFB3-driven glycolysis in vessel sprouting.","volume":"154","author":"De Bock","year":"2013","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bbrc.2008.11.141","article-title":"TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis.","volume":"379","author":"Fujisawa","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B12","year":"1996","journal-title":"Medical Use Program. and Institute of Medicine (U.S.). Committee for Review and Evaluation of the Medical Use Program of the Nuclear Regulatory Commission.: Radiation in medicine: a Need For Regulatory Reform."},{"key":"B13","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1161\/01.RES.0000179773.18195.12","article-title":"Mitochondria and reactive oxygen species: an evolution in function.","volume":"97","author":"Gutterman","year":"2005","journal-title":"Circ. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.mrfmmm.2010.01.007","article-title":"Non-cancer diseases and non-targeted effects.","volume":"687","author":"Hildebrandt","year":"2010","journal-title":"Mutat. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1080\/09553002.2017.1286048","article-title":"New insight into mitochondrial changes in vascular endothelial cells irradiated by gamma ray.","volume":"93","author":"Hu","year":"2017","journal-title":"Int. J. Radiat. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0020-0190(89)90010-0","article-title":"Termination detection by using distributed snapshots.","volume":"32","author":"Huang","year":"1989","journal-title":"Inform. Process. Lett."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.redox.2017.08.010","article-title":"A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration.","volume":"14","author":"Hung","year":"2018","journal-title":"Redox Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1242\/bio.029009","article-title":"Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes.","volume":"6","author":"Jang","year":"2017","journal-title":"Biol. Open"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1039\/c6ib00192k","article-title":"Mitochondrial respiration is sensitive to cytoarchitectural breakdown.","volume":"8","author":"Kandel","year":"2016","journal-title":"Integr. Biol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep24108","article-title":"Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis.","volume":"6","author":"Karnewar","year":"2016","journal-title":"Sci. Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1126\/science.2814477","article-title":"Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/s0014-5793(97)01159-9","article-title":"High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria.","volume":"416","author":"Korshunov","year":"1997","journal-title":"FEBS Lett."},{"key":"B23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/onc.2012.583","article-title":"Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi anemia cells.","volume":"33","author":"Kumari","year":"2014","journal-title":"Oncogene"},{"key":"B24","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.freeradbiomed.2017.04.019","article-title":"Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation.","volume":"108","author":"Lafargue","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1667\/RR1070.1","article-title":"A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms.","volume":"169","author":"Little","year":"2008","journal-title":"Radiat. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1177\/2050640616640443","article-title":"A PPAR-gamma agonist protects from radiation-induced intestinal toxicity.","volume":"5","author":"Mangoni","year":"2017","journal-title":"U. Eur. Gastroenterol. J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1667\/RR0769.1","article-title":"Increased mitochondrial mass in cells with functionally compromised mitochondria after exposure to both direct gamma radiation and bystander factors.","volume":"168","author":"Nugent","year":"2007","journal-title":"Radiat. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1089\/ars.2006.8.1253","article-title":"Normal human fibroblasts exposed to high- or low-dose ionizing radiation: differential effects on mitochondrial protein import and membrane potential.","volume":"8","author":"Pandey","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026989","article-title":"Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor gamma coactivator-1alpha.","volume":"6","author":"Pardo","year":"2011","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S1567-7249(03)00033-3","article-title":"Quantification of total mitochondrial DNA and the 4977-bp common deletion in Pearson\u2019s syndrome lymphoblasts using a fluorogenic 5\u2019-nuclease (TaqMan) real-time polymerase chain reaction assay and plasmid external calibration standards.","volume":"2","author":"Pogozelski","year":"2003","journal-title":"Mitochondrion"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5349","article-title":"Radiation exposure and circulatory disease risk: hiroshima and Nagasaki atomic bomb survivor data, 1950-2003.","volume":"340","author":"Shimizu","year":"2010","journal-title":"BMJ"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e55449","DOI":"10.3791\/55449","article-title":"Cellular redox profiling using high-content microscopy.","volume":"123","author":"Sieprath","year":"2017","journal-title":"J. Vis. Exp."},{"key":"B33","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1080\/2015.1050568","article-title":"Sustained accumulation of prelamin A and depletion of lamin A\/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.","volume":"6","author":"Sieprath","year":"2015","journal-title":"Nucleus"},{"key":"B34","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-3-319-28549-8_6","article-title":"Integrated High-Content quantification of intracellular ROS levels and mitochondrial morphofunction.","volume":"219","author":"Sieprath","year":"2016","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3930","DOI":"10.1172\/JCI36843","article-title":"Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.","volume":"118","author":"Sonveaux","year":"2008","journal-title":"J. Clin. Invest."},{"key":"B36","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species.","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1161\/01.cir.0000028581.07992.56","article-title":"Endothelial function: a barometer for cardiovascular risk?","volume":"106","author":"Vita","year":"2002","journal-title":"Circulation"},{"key":"B38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.5339\/gcsp.2014.43","article-title":"Endothelial dysfunction and cardiovascular disease.","volume":"2014","author":"Widmer","year":"2014","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"B39","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1074\/jbc.RA118.005913","article-title":"Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate-evoked calcium signaling.","volume":"294","author":"Wilson","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1128\/mcb.23.3.1085-1094.2003","article-title":"Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.","volume":"23","author":"Wilson-Fritch","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1161\/CIRCULATIONAHA.113.002271","article-title":"Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans.","volume":"128","author":"Yu","year":"2013","journal-title":"Circulation"},{"key":"B42","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1093\/cvr\/cvs111","article-title":"Mitochondria in vascular disease.","volume":"95","author":"Yu","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4490","DOI":"10.3892\/mmr.2018.8433","article-title":"PGC-1alpha ameliorates kidney fibrosis in mice with diabetic kidney disease through an antioxidative mechanism.","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00268\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T04:31:57Z","timestamp":1584073917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00268\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,13]]},"references-count":43,"alternative-id":["10.3389\/fphar.2020.00268"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00268","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,13]]},"article-number":"268"}}