{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:16:43Z","timestamp":1784254603887,"version":"3.55.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600726"],"award-info":[{"award-number":["81600726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870653"],"award-info":[{"award-number":["81870653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016HB53"],"award-info":[{"award-number":["ZR2016HB53"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00302","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T06:06:46Z","timestamp":1584425206000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Rho-Associated Protein Kinase Inhibitor Treatment Promotes Proliferation and Phagocytosis in Trabecular Meshwork Cells"],"prefix":"10.3389","volume":"11","author":[{"given":"Wenshi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/s0161-6420(84)34248-8","article-title":"Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals.","volume":"91","author":"Alvarado","year":"1984","journal-title":"Ophthalmology."},{"key":"B2","first-page":"714","article-title":"Age-related changes in trabecular meshwork cellularity.","volume":"21","author":"Alvarado","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B3","first-page":"2156","article-title":"Human trabecular meshwork phagocytosis. Observations in an organ culture system.","volume":"31","author":"Buller","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1152\/physrev.00003.2012","article-title":"Regulation of small GTPases by GEFs, GAPs, and GDIs.","volume":"93","author":"Cherfils","year":"2013","journal-title":"Physiol. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00417-018-4175-6","article-title":"RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis.","volume":"257","author":"Dang","year":"2019","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1080\/14656566.2017.1328498","article-title":"Topical treatment of glaucoma: established and emerging pharmacology.","volume":"18","author":"Dikopf","year":"2017","journal-title":"Expert Opin. Pharmacother."},{"key":"B7","doi-asserted-by":"publisher","first-page":"5000","DOI":"10.1167\/iovs.13-12084","article-title":"Activated alphavbeta3 integrin regulates alphavbeta5 integrin-mediated phagocytosis in trabecular meshwork cells.","volume":"54","author":"Gagen","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1007\/s40265-014-0333-2","article-title":"Ripasudil: first global approval.","volume":"74","author":"Garnock-Jones","year":"2014","journal-title":"Drugs"},{"key":"B9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1089\/jop.2013.0192","article-title":"Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632.","volume":"30","author":"Gong","year":"2014","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10384-018-0566-9","article-title":"Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma.","volume":"62","author":"Honjo","year":"2018","journal-title":"Jpn. J. Ophthalmol."},{"key":"B11","first-page":"137","article-title":"Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.","volume":"42","author":"Honjo","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"5549","DOI":"10.1167\/iovs.07-0878","article-title":"Potential role of Rho-associated protein kinase inhibitor Y-27632 in glaucoma filtration surgery.","volume":"48","author":"Honjo","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.05.002","article-title":"Rho-associated kinase inhibitors: a novel glaucoma therapy.","volume":"37","author":"Inoue","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1089\/jop.2016.0028","article-title":"Ocular penetration and pharmacokinetics of ripasudil following topical administration to rabbits.","volume":"32","author":"Isobe","year":"2016","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma.","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ejphar.2016.04.002","article-title":"Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes.","volume":"787","author":"Li","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1167\/iovs.10-6069","article-title":"Assessment of aqueous humor dynamics in the mouse by a novel method of constant-flow infusion.","volume":"52","author":"Millar","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1167\/iovs.13-12225","article-title":"Involvement of cyclin D and p27 in cell proliferation mediated by ROCK inhibitors Y-27632 and Y-39983 during corneal endothelium wound healing.","volume":"55","author":"Okumura","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jcp.24524","article-title":"Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling.","volume":"229","author":"Pattabiraman","year":"2014","journal-title":"J. Cell Physiol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.7.6.6","article-title":"Rho-kinase inhibition reduces myofibroblast differentiation and proliferation of scleral fibroblasts induced by transforming growth factor beta and experimental Glaucoma.","volume":"7","author":"Pitha","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma.","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"B22","first-page":"1029","article-title":"Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.","volume":"42","author":"Rao","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.exer.2016.08.023","article-title":"Role of the Rho GTPase\/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: bench to bedside research.","volume":"158","author":"Rao","year":"2017","journal-title":"Exp. Eye Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nrm1128","article-title":"Rocks: multifunctional kinases in cell behaviour.","volume":"4","author":"Riento","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1074\/jbc.M708250200","article-title":"Rho GTPase and cAMP\/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells.","volume":"283","author":"Shen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.preteyeres.2014.08.002","article-title":"Biomechanics of Schlemm\u2019s canal endothelium and intraocular pressure reduction.","volume":"44","author":"Stamer","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.exer.2016.07.009","article-title":"The many faces of the trabecular meshwork cell.","volume":"158","author":"Stamer","year":"2017","journal-title":"Exp. Eye Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1016\/j.bmcl.2016.03.104","article-title":"Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma.","volume":"26","author":"Sturdivant","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1167\/iovs.10-5265","article-title":"Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.","volume":"52","author":"Sugiyama","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1111\/aos.12829","article-title":"One-year clinical evaluation of 0.4% ripasudil (K-115) in patients with open-angle glaucoma and ocular hypertension.","volume":"94","author":"Tanihara","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/j.ophtha.2018.04.040","article-title":"Rho kinase inhibitors as a novel treatment for glaucoma and ocular hypertension.","volume":"125","author":"Tanna","year":"2018","journal-title":"Ophthalmology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1167\/iovs.12-9472","article-title":"Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells.","volume":"53","author":"Tian","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"7126","DOI":"10.1167\/iovs.13-13842","article-title":"The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma.","volume":"55","author":"Yamamoto","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"E3492","DOI":"10.1073\/pnas.1604153113","article-title":"Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.","volume":"113","author":"Zhu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.1172\/JCI58183","article-title":"Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.","volume":"121","author":"Zode","year":"2011","journal-title":"J. Clin. Invest."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00302\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T06:06:49Z","timestamp":1584425209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00302\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,17]]},"references-count":35,"alternative-id":["10.3389\/fphar.2020.00302"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00302","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,17]]},"article-number":"302"}}