{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:48:04Z","timestamp":1778629684248,"version":"3.51.4"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["FONDECYT REGULAR N\u00ba 1170871, FONDECYT N\u00b0 11160877"],"award-info":[{"award-number":["FONDECYT REGULAR N\u00ba 1170871, FONDECYT N\u00b0 11160877"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["CONICYT PAI\/ACADEMIA project N\u00b0 464 79160109."],"award-info":[{"award-number":["CONICYT PAI\/ACADEMIA project N\u00b0 464 79160109."]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00417","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T04:41:50Z","timestamp":1586320910000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Corryocactus brevistylus (K. Schum. ex Vaupel) Britton &amp; Rose (Cactaceae): Antioxidant, Gastroprotective Effects, and Metabolomic Profiling by Ultrahigh-Pressure Liquid Chromatography and Electrospray High Resolution Orbitrap Tandem Mass Spectrometry"],"prefix":"10.3389","volume":"11","author":[{"given":"Carlos","family":"Areche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"Ticona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Simirgiotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Caceres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Borquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Echeverr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Sepulveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.foodchem.2014.06.044","article-title":"Nutritional and phytochemical composition of Annona cherimola Mill. fruits and by-products: Potential health benefits","volume":"193","author":"Albuquerque","year":"2016","journal-title":"Food Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1080\/14786419.2017.1365073","article-title":"Opuntia ficus-indica (L.) Miller as a source of bioactivity compounds for health and nutrition","volume":"32","author":"Aragona","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.lwt.2019.05.028","article-title":"Phenolic compound profile and biological activities of Southern African Opuntia ficus-indica fruit pulp and peels","volume":"111","author":"Aruwa","year":"2019","journal-title":"LWT"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1080\/10408398.2017.1329198","article-title":"Antioxidant and anticancer properties of berries","volume":"58","author":"Baby","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.foodchem.2005.07.042","article-title":"Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses","volume":"99","author":"Balasundram","year":"2006","journal-title":"Food Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12941-014-0054-0","article-title":"Antimicrobial activity of natural products against Helicobacter pylori: A review","volume":"13","author":"Bonif\u00e1cio","year":"2014","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1007\/s12161-015-0337-x","article-title":"Analysis of Ascorbic Acid and Isoascorbic Acid in Orange and Guava Fruit Juices Distributed in Thailand by LC-IT-MS\/MS","volume":"9","author":"Boonpangrak","year":"2016","journal-title":"Food Anal. Methods"},{"key":"B8","doi-asserted-by":"publisher","first-page":"17400","DOI":"10.3390\/molecules191117400","article-title":"HPLC-UV-MS Profiles of Phenolic Compounds and Antioxidant Activity of Fruits from Three Citrus Species Consumed in Northern Chile","volume":"19","author":"Brito","year":"2014","journal-title":"Molecules"},{"key":"B9","first-page":"33","article-title":"Role of prostaglandins in gastroprotection and gastric adaptation","volume":"56","author":"Brzozowski","year":"2005","journal-title":"J. Physiol. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1016\/j.phytochem.2005.07.010","article-title":"Insect growth regulatory effects of some extracts and sterols from Myrtillocactus geometrizans (Cactaceae) against Spodoptera frugiperda and Tenebrio molitor","volume":"66","author":"C\u00e9spedes","year":"2005","journal-title":"Phytochemistry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.foodchem.2009.07.045","article-title":"Phytochemical profile and the antioxidant activity of Chilean wild black-berry fruits, Aristotelia chilensis (Mol) Stuntz (Elaeocarpaceae)","volume":"119","author":"C\u00e9spedes","year":"2010","journal-title":"Food Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.foodchem.2019.05.146","article-title":"New insight into phenolic composition of chayote (Sechium edule (Jacq.) Sw.)","volume":"295","author":"D\u00edaz-de-Cerio","year":"2019","journal-title":"Food Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"979","DOI":"10.3390\/molecules14030979","article-title":"Flavonoids with Gastroprotective Activity","volume":"14","author":"De Lira Mota","year":"2009","journal-title":"Molecules"},{"key":"B14","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1080\/14756366.2018.1563077","article-title":"Chemical composition and enzyme inhibition of Phytolacca dioica L. seeds extracts","volume":"34","author":"Di Petrillo","year":"2019","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.3390\/nu10121833","article-title":"Whole Fruits and Fruit Fiber Emerging Health Effects","volume":"10","author":"Dreher","year":"2018","journal-title":"Nutrients"},{"key":"B16","first-page":"1","article-title":"Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose Cactaceae BT - Ethnobotany of the Andes","volume-title":"Ethnobotany of the Andes","author":"Echeverr\u00eda","year":"2020"},{"key":"B17","doi-asserted-by":"publisher","first-page":"14879","DOI":"10.3390\/molecules190914879","article-title":"Nopal Cactus (Opuntia ficus-indica) as a Source of Bioactive Compounds for Nutrition, Health and Disease","volume":"19","author":"El-Mostafa","year":"2014","journal-title":"Molecules"},{"key":"B18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.5897\/JMPR2015.6031","article-title":"Chemical composition and biological activities of Pouteria campechiana (Kunth) Baehni","volume":"10","author":"Elsayed","year":"2016","journal-title":"J. Med. Plants Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.foodchem.2010.06.032","article-title":"Automated identification of phenolics in plant-derived foods by using library search approach","volume":"124","author":"G\u00f3mez-Romero","year":"2011","journal-title":"Food Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.4297\/najms.2010.2397","article-title":"Evaluation of a gas chromatography method for azelaic acid determination in selected biological samples","volume":"2","author":"Garelnabi","year":"2010","journal-title":"N. Am. J. Med. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.jff.2013.12.025","article-title":"Evaluation of Latin-American fruits rich in phytochemicals with biological effects","volume":"7","author":"Giron\u00e9s-Vilaplana","year":"2014","journal-title":"J. Funct. Foods"},{"key":"B22","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.wasman.2019.03.055","article-title":"Biological activity and chemical characterization of Pouteria lucuma seeds: A possible use of an agricultural waste","volume":"88","author":"Guerrero-Castillo","year":"2019","journal-title":"Waste Manage."},{"key":"B23","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.foodres.2014.03.013","article-title":"Antioxidant activity and characterization of constituents in copao fruits (Eulychnia acida Phil., Cactaceae) by HPLC\u2013DAD\u2013MS\/MSn","volume":"62","author":"Jim\u00e9nez-Aspee","year":"2014","journal-title":"Food Res. Int."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00569","article-title":"Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms","volume":"9","author":"Khan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/0016-5085(90)90464-C","article-title":"Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress-induced gastric lesions","volume":"99","author":"Konturek","year":"1990","journal-title":"Gastroenterology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1159\/000323958","article-title":"Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality","volume":"84","author":"Lau","year":"2011","journal-title":"Digestion"},{"key":"B27","first-page":"201","article-title":"Antiulcer drugs of plant origin","volume-title":"Progress in Medicinal Chemistry","author":"Lewis","year":"1991"},{"key":"B28","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.sajb.2015.12.007","article-title":"Comparative analyses of flavonoid content in Moringa oleifera and Moringa ovalifolia with the aid of UHPLC-qTOF-MS fingerprinting","volume":"105","author":"Makita","year":"2016","journal-title":"South Afr. J. Bot."},{"key":"B29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13065-017-0262-8","article-title":"Highlighting mass spectrometric fragmentation differences and similarities between hydroxycinnamoyl-quinic acids and hydroxycinnamoyl-isocitric acids","volume":"11","author":"Masike","year":"2017","journal-title":"Chem. Cent. J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0960-894X(01)00781-8","article-title":"Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action","volume":"12","author":"Matsuda","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.fct.2017.08.004","article-title":"Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents","volume":"112","author":"Mocan","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1246\/bcsj.36.161","article-title":"The Absolute Configuration of (\u2013)- N , N -Dimethyl-1,2-diphenylethylamine and its Analgesic Activity","volume":"36","author":"Nakazaki","year":"1963","journal-title":"Bull. Chem. Soc Jpn."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7089697","article-title":"Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits","volume":"2017","author":"Nesello","year":"2017","journal-title":"Gastroenterol. Res. Pract."},{"key":"B34","volume-title":"Guide to the care and use of experimental animals","author":"Olfert","year":"1993"},{"key":"B35","volume-title":"Todos los cactus del Per\u00fa","author":"Ostolaza Nano","year":"2014"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1016\/j.bmcl.2015.04.095","article-title":"Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls","volume":"25","author":"Parra","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3390\/nu11051006","article-title":"Are Fruit Juices Healthier Than Sugar-Sweetened Beverages? A Review","volume":"11","author":"Pepin","year":"2019","journal-title":"Nutrients"},{"key":"B38","volume-title":"Applications of time-of-flight and orbitrap mass spectrometry in environmental, food, doping, and forensic analysis","author":"Perez","year":"2016"},{"key":"B39","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1089\/jmf.2008.0113","article-title":"Evaluation of Antihyperglycemia and Antihypertension Potential of Native Peruvian Fruits Using In Vitro Models","volume":"12","author":"Pinto","year":"2009","journal-title":"J. Med. Food"},{"key":"B40","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3390\/molecules19010438","article-title":"Antioxidant Properties and Hyphenated HPLC-PDA-MS Profiling of Chilean Pica Mango Fruits (Mangifera indica L. Cv. pique\u00f1o)","volume":"19","author":"Ramirez","year":"2014","journal-title":"Molecules"},{"key":"B41","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.foodchem.2014.12.039","article-title":"Anthocyanins and antioxidant capacities of six Chilean berries by HPLC\u2013HR-ESI-ToF-MS","volume":"176","author":"Ramirez","year":"2015","journal-title":"Food Chem."},{"key":"B42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4067\/S0718-34292018005002803","article-title":"Evaluation of asexual propagation by two cacti species: Corryocactus brevistylus K. Schum., and Oreocereus leucotrichus (Philippi) Wagenknecht, native species in the foothills of region XV, Arica and Parinacota, Chile","volume":"36","author":"Rispoli","year":"2018","journal-title":"Idesia"},{"key":"B43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2174\/1570193X15666180627120609","article-title":"Maqui (Aristotelia chilensis (Mol.) Stuntz) and murta (Ugni molinae Turcz): Native Chilean sources of polyphenol compounds","volume":"16","author":"Rivera-Tovar","year":"2019","journal-title":"Mini. Rev. Org. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.foodres.2014.04.037","article-title":"In vitro bioaccessibility of health-related compounds as affected by the formulation of fruit juice- and milk-based beverages","volume":"62","author":"Rodr\u00edguez-Roque","year":"2014","journal-title":"Food Res. Int."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s00210-015-1156-8","article-title":"Gastroprotective bio-guiding study of fruits from Mimusops balata","volume":"388","author":"Schlickmann","year":"2015","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S1570-0232(02)00406-3","article-title":"Quantification of 3-hydroxyglutaric acid in urine, plasma, cerebrospinal fluid and amniotic fluid by stable-isotope dilution negative chemical ionization gas chromatography-mass spectrometry","volume":"780","author":"Schor","year":"2002","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.foodchem.2013.01.089","article-title":"Antioxidant capacity, polyphenolic content and tandem HPLC\u2013DAD\u2013ESI\/MS profiling of phenolic compounds from the South American berries Luma apiculata and L. chequ\u00e9n","volume":"139","author":"Simirgiotis","year":"2013","journal-title":"Food Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/molecules21010092","article-title":"Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC\u2013Q\/Orbitrap\/MS\/MS)","volume":"21","author":"Simirgiotis","year":"2016","journal-title":"Molecules"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.3390\/molecules18022061","article-title":"Antioxidant capacity and HPLC-DAD-MS profiling of Chilean Peumo (Cryptocarya alba) fruits and comparison with German Peumo (Crataegus monogyna) from Southern Chile","volume":"18","author":"Simirgiotis","year":"2013","journal-title":"Molecules"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1002\/ptr.6345","article-title":"Opuntia ficus-indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti-angiogenic properties","volume":"33","author":"Smeriglio","year":"2019","journal-title":"Phyther. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.foodcont.2016.01.006","article-title":"Fingerprints of anthocyanins and flavonols of Vaccinium uliginosum berries from different geographical origins in the Greater Khingan Mountains and their antioxidant capacities","volume":"64","author":"Su","year":"2016","journal-title":"Food Control"},{"key":"B52","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/j.1365-2036.2009.03960.x","article-title":"Systematic review: The global incidence and prevalence of peptic ulcer disease","volume":"29","author":"Sung","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B53","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1254\/jjp.78.435","article-title":"Anti-ulcer effects of antioxidants, quercetin, \u03b1-tocopherol, nifedipine and tetracycline in rats","volume":"78","author":"Suzuki","year":"1998","journal-title":"Jpn. J. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.meatsci.2012.06.016","article-title":"The effect of tenderizing acids on linoleic acid oxidation during marination of pork","volume":"92","author":"Toomik","year":"2012","journal-title":"Meat Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1177\/1934578X0800301234","article-title":"Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments","volume":"3","author":"Tundis","year":"2008","journal-title":"Nat. Prod. Commun."},{"key":"B56","volume-title":"Ciencia ind\u00edgena de los Andes del norte de Chile","author":"Villagr\u00e1n","year":"2003"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1177\/153537020122601107","article-title":"Inflammatory Mediators in Gastrointestinal Defense and Injury","volume":"226","author":"Wallace","year":"2001","journal-title":"Exp. Biol. Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1111\/bph.14178","article-title":"Eicosanoids in the gastrointestinal tract","volume":"176","author":"Wallace","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/bph.14527","article-title":"Nitric oxide in the gastrointestinal tract: opportunities for drug development","volume":"176","author":"Wallace","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3390\/molecules21091209","article-title":"Detection of 191 taxifolin metabolites and their distribution in rats using HPLC-ESI-IT-TOF-MSn","volume":"21","author":"Yang","year":"2016","journal-title":"Molecules"},{"key":"B61","first-page":"345","article-title":"Dietary natural products and their potential to influence health and disease including animal model studies *","volume":"36","author":"Yeung","year":"2018","journal-title":"Anim. Sci. Pap. Rep."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00417\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T04:41:54Z","timestamp":1586320914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00417\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":61,"alternative-id":["10.3389\/fphar.2020.00417"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00417","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]},"article-number":"417"}}