{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:18:20Z","timestamp":1768288700545,"version":"3.49.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00473","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T12:32:06Z","timestamp":1586953926000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System"],"prefix":"10.3389","volume":"11","author":[{"given":"Shengnan","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheyong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nrmicro2761","article-title":"The rise of the Enterococcus: beyond vancomycin resistance","volume":"10","author":"Arias","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1586\/14787210.2014.870886","article-title":"Antibiotic resistance in Enterococcus faecium clinical isolates","volume":"12","author":"Cattoir","year":"2014","journal-title":"Expert Rev. Of Anti-Infective Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.jnutbio.2015.06.004","article-title":"Activity of the antiestrogenic cajanin stilbene acid towards breast cancer","volume":"26","author":"Fu","year":"2015","journal-title":"J. Of Nutr. Biochem."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00619","article-title":"Antibacterial Activity and Mechanism of Action of Aspidinol Against Multi-Drug-Resistant Methicillin-Resistant Staphylococcus aureus","volume":"9","author":"Hua","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/ja.2013.30","article-title":"Xanthone derivatives could be potential antibiotics: virtual screening for the inhibitors of enzyme I of bacterial phosphoenolpyruvate-dependent phosphotransferase system","volume":"66","author":"Huang","year":"2013","journal-title":"J. Of Antibiot."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1021\/acs.jafc.6b00227","article-title":"Anti-Inflammatory Effects of Cajaninstilbene Acid and Its Derivatives","volume":"64","author":"Huang","year":"2016","journal-title":"J. Of Agric. And Food Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.foodchem.2009.03.091","article-title":"Ethanol modified supercritical fluid extraction and antioxidant activity of cajaninstilbene acid and pinostrobin from pigeonpea [Cajanus cajan (L.) Millsp.] leaves","volume":"117","author":"Kong","year":"2009","journal-title":"Food Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/1471-2180-10-224","article-title":"Class IIa bacteriocin resistance in Enterococcus faecalis V583: The mannose PTS operon mediates global transcriptional responses","volume":"10","author":"Opsata","year":"2010","journal-title":"BMC Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00281-011-0297-1","article-title":"Targeting the host-pathogen interface for treatment of Staphylococcus aureus infection","volume":"34","author":"Park","year":"2012","journal-title":"Semin. In Immunopathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"14250","DOI":"10.1074\/jbc.M117.795294","article-title":"The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli","volume":"292","author":"Rodionova","year":"2017","journal-title":"J. Of Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.mib.2018.08.004","article-title":"Opportunities for plant natural products in infection control","volume":"45","author":"Salam","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"9162","DOI":"10.1021\/acs.chemrev.6b00184","article-title":"Plant Natural Products Targeting Bacterial Virulence Factors","volume":"116","author":"Silva","year":"2016","journal-title":"Chem. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1128\/AAC.01919-13","article-title":"Nutritional Control of Antibiotic Resistance via an Interface between the Phosphotransferase System and a Two-Component Signaling System","volume":"58","author":"Snyder","year":"2014","journal-title":"Antimicrob. Agents And Chemother."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061578","article-title":"Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery","volume":"19","author":"Thomford","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.tim.2017.01.004","article-title":"Multidrug-Resistant Enterococcal Infections: New Compounds, Novel Antimicrobial Therapies","volume":"25","author":"Van Harten","year":"2017","journal-title":"Trends In Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1021\/jf103970b","article-title":"In Vitro Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Effect of Cajaninstilbene Acid, a Stilbene Compound Derived from Pigeon Pea [Cajanus cajan (L.) Millsp.] Leaves","volume":"59","author":"Wu","year":"2011","journal-title":"J. Of Agric. And Food Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.phymed.2010.04.005","article-title":"Chemical composition of the SFE-CO2 extracts from Cajanus cajan (L.) Huth and their antimicrobial activity in vitro and in vivo","volume":"17","author":"Zu","year":"2010","journal-title":"Phytomedicine"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00473\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:03:21Z","timestamp":1587042201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00473\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":17,"alternative-id":["10.3389\/fphar.2020.00473"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00473","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]},"article-number":"473"}}