{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:54:27Z","timestamp":1791557667824,"version":"4.3.4"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00481","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T01:31:51Z","timestamp":1586914311000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":94,"title":["Impact of TNF-\u03b1 Inhibitors on Body Weight and BMI: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Olivia","family":"Patsalos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethan","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Leppanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A. A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertus","family":"Himmerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"B96","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1177\/0148607111413599","article-title":"Nutrition in Inflammatory Bowel Disease","volume":"35","author":"Alastair","year":"2011","journal-title":"J. Parenter. Enter Nutr."},{"key":"B63","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.2337\/db13-0138","article-title":"Direct effects of TNF-\u03b1 on local fuel metabolism and cytokine levels in the placebo-controlled, bilaterally infused human leg: increased insulin sensitivity, increased net protein breakdown, and increased IL-6 release","volume":"62","author":"Bach","year":"2013","journal-title":"Diabetes"},{"key":"B73","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/clpt.2011.97","article-title":"Mechanisms and Genetics of Antipsychotic-Associated Weight Gain","volume":"90","author":"Balt","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"B101","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1136\/ard.62.5.490","article-title":"Anti-tumour necrosis factor treatment in a patient with anorexia nervosa and juvenile idiopathic arthritis","volume":"62","author":"Barber","year":"2003","journal-title":"Ann. Rheum Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cyto.2011.10.008","article-title":"Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors","volume":"57","author":"Batista","year":"2012","journal-title":"Cytokine"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating Characteristics of a Rank Correlation Test for Publication Bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"B82","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/1043-4666(94)90067-1","article-title":"Characterization of differentiation factor\/leukaemia inhibitory factor effect of lipoprotein lipase activity and mRNA in 3T3-L1 adipocytes","volume":"6","author":"Berg","year":"1994","journal-title":"Cytokine"},{"key":"B65","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0149-7634(95)00046-H","article-title":"Neural: Mediation of food aversions and anorexia induced by tumor necrosis factor and tumors","volume":"20","author":"Bernstein","year":"1996","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nature11824","article-title":"T-helper-1-cell cytokines drive cancer into senescence","volume":"494","author":"Braum\u00fcller","year":"2013","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1385\/ENDO:29:1:109","article-title":"Epidemiology, Trends, and Morbidities of Obesity and the Metabolic Syndrome","volume":"29","author":"Bray","year":"2006","journal-title":"Endocrine"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1136\/ard.2004.028670","article-title":"Body weight, body composition, and bone turnover changes in patients with spondyloarthropathy receiving anti-tumour necrosis factor alpha treatment","volume":"64","author":"Briot","year":"2005","journal-title":"Ann. Rheum Dis."},{"key":"B77","first-page":"855","article-title":"Prospective assessment of body weight, body composition, and bone density changes in patients with spondyloarthropathy receiving anti-tumor necrosis factor-alpha treatment","volume":"35","author":"Briot","year":"2008","journal-title":"J. Rheumatol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s10067-011-1863-6","article-title":"Long-term effects of anti-tumour necrosis factor therapy on weight in patients with rheumatoid arthritis","volume":"31","author":"Brown","year":"2012","journal-title":"Clin. Rheumatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/gut.51.1.37","article-title":"Tumour necrosis factor \u03b1 converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease","volume":"51","author":"Brynskov","year":"2002","journal-title":"Gut"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1016\/0024-3205(94)90144-9","article-title":"Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats","volume":"54","author":"Chance","year":"1994","journal-title":"Life Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1172\/JCI31516","article-title":"AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons","volume":"117","author":"Claret","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B14","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1136\/bmj.j2505","article-title":"Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease","volume":"19","author":"Cohen","year":"2017","journal-title":"BMJ"},{"key":"B31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"key":"B30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/00401706.1977.10489493","article-title":"Detection of Influential Observation in Linear Regression","volume":"19","author":"Cook","year":"1977","journal-title":"Technometrics"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1007\/s10067-019-04663-6","article-title":"Psoriatic arthritis and obesity: the role of anti-IL-12\/IL-23 treatment","volume":"38","author":"Costa","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"49","DOI":"10.15403\/jgld.2014.1121.251.tnf","article-title":"The Effect of anti-TNFalpha Induction Therapy on the Nutritional Status and Dietary Intake in Inflammatory Bowel Disease","volume":"25","author":"Csontos","year":"2016","journal-title":"J. Gastrointestin Liver Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1060028019900660","article-title":"Associations Between Obesity and the Effectiveness of Anti\u2013Tumor Necrosis Factor-\u03b1 Agents in Inflammatory Bowel Disease Patients: A Literature Review and Meta-analysis","volume":"19","author":"Dai","year":"2020","journal-title":"Ann. Pharmacother."},{"key":"B9","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jpsychires.2018.06.002","article-title":"A meta-analysis of cytokine concentrations in eating disorders","volume":"103","author":"Dalton","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1346-8138.2008.00525.x","article-title":"Efficacy of infliximab for severe recalcitrant psoriasis after 6 weeks of treatment","volume":"35","author":"De Oliveira","year":"2008","journal-title":"J. Dermatol."},{"key":"B35","first-page":"880","article-title":"Leptin and adiponectin levels in patients with ankylosing spondylitis. The effect of infliximab treatment","volume":"28","author":"Derdemezis","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1529-8019.2011.01439.x","article-title":"Prospective assessment of body weight and body composition changes in patients with psoriasis receiving anti-TNF-alpha treatment","volume":"24","author":"Di Renzo","year":"2011","journal-title":"Dermatol. Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1590\/1806-9282.63.05.407","article-title":"Impact of biological therapy on body composition of patients with Chron\u2019s disease","volume":"63","author":"Dos Santos","year":"2017","journal-title":"Rev. Assoc. Med. Bras."},{"key":"B11","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A Meta-Analysis of Cytokines in Major Depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B38","first-page":"570","article-title":"Changes in body mass index and lipid profile in psoriatic patients after treatment with standard protocol of infliximab","volume":"54","author":"Ehsani","year":"2016","journal-title":"Acta Med. Iran."},{"key":"B39","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3109\/14397595.2013.843752","article-title":"Effects of infliximab treatment in terms of cardiovascular risk and insulin resistance in ankylosing spondylitis patients","volume":"24","author":"Ersozlu Bozkirli","year":"2014","journal-title":"Mod Rheumatol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/039463200902200124","article-title":"Influence and variation of the body mass index in patients treated with etanercept for plaque-type psoriasis","volume":"22","author":"Esposito","year":"2009","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1055\/s-0031-1287783","article-title":"Systemic blockade of TNF-alpha does not improve insulin resistance in humans","volume":"43","author":"Ferraz-Amaro","year":"2011","journal-title":"Horm. Metab. Res. = Horm. und Stoffwechselforsch = Horm. Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.1210\/jc.2004-1222","article-title":"Impact of infliximab on serum leptin levels in patients with Crohn\u2019s disease","volume":"90","author":"Franchimont","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/S0006-2952(03)00490-8","article-title":"Regulation of proliferation, survival and apoptosis by members of the TNF superfamily","volume":"66","author":"Gaur","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1468-3083.2007.02429.x","article-title":"Anti-tumour necrosis factor-alpha therapy increases body weight in patients with chronic plaque psoriasis: A retrospective cohort study","volume":"22","author":"Gisondi","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"Definition of Metabolic Syndrome","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1126\/science.289.5488.2363","article-title":"NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia","volume":"289","author":"Guttridge","year":"2000","journal-title":"Science"},{"key":"B98","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1007\/s10620-017-4745-1","article-title":"Biologic Agents Are Associated with Excessive Weight Gain in Children with Inflammatory Bowel Disease","volume":"62","author":"Haas","year":"2017","journal-title":"Dig Dis. Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"186","DOI":"10.2174\/092986610790225941","article-title":"TNF-\u03b1 and Ghrelin: Opposite Effects on Immune System, Metabolism and Mental Health","volume":"17","author":"Himmerich","year":"2010","journal-title":"Protein Pept. Lett."},{"key":"B100","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/17512433.2018.1383895","article-title":"Psychopharmacological advances in eating disorders","volume":"11","author":"Himmerich","year":"2018","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1001\/archinte.166.16.1739","article-title":"Plasma levels of tumor necrosis factor alpha and soluble tumor necrosis factor receptors in patients with narcolepsy","volume":"166","author":"Himmerich","year":"2006","journal-title":"Arch. Intern Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"204512531881473","DOI":"10.1177\/2045125318814734","article-title":"Genetic risk factors for eating disorders: an update and insights into pathophysiology","volume":"9","author":"Himmerich","year":"2019","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0306-9877(96)90153-X","article-title":"The role of tumor necrosis factor-\u03b1 in the pathogenesis of anorexia and bulimia nervosa, cancer cachexia and obesity","volume":"47","author":"Holden","year":"1996","journal-title":"Med. Hypotheses."},{"key":"B69","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2174\/1568010023344599","article-title":"The mechanisms of immune-to-brain communication in inflammation as a drug target","volume":"1","author":"Hosoi","year":"2002","journal-title":"Curr. Drug Targets Inflammation Allergy"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.2337\/diab.43.11.1271","article-title":"Tumor Necrosis Factor : A Key Component of the Obesity-Diabetes Link","volume":"43","author":"Hotamisligil","year":"1994","journal-title":"Diabetes"},{"key":"B83","doi-asserted-by":"publisher","first-page":"4854","DOI":"10.1073\/pnas.91.11.4854","article-title":"Tumor necrosis factor \u03b1 inhibits signaling from the insulin receptor","volume":"91","author":"Hotamisligil","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1172\/JCI117495","article-title":"Reduced tyrosine kinase activity of the insulin receptor in obesity- diabetes. Central role of tumor necrosis factor-\u03b1","volume":"94","author":"Hotamisligil","year":"1994","journal-title":"J. Clin. Invest."},{"key":"B71","doi-asserted-by":"publisher","first-page":"4493","DOI":"10.3322\/canjclin.52.272","article-title":"Cancer anorexia-cachexia syndrome: are neuropeptides the key? - PubMed - NCBI","volume":"59","author":"Inui","year":"1999","journal-title":"Cancer Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1007\/s00296-011-2182-6","article-title":"Plasma leptin and neuropeptide Y concentrations in patients with rheumatoid arthritis treated with infliximab, a TNF-alpha antagonist","volume":"32","author":"Kopec-Medrek","year":"2012","journal-title":"Rheumatol Int."},{"key":"B45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/MEG.0b013e328325d42b","article-title":"Effects of tumor necrosis factor alpha inhibition with infliximab on lipid levels and insulin resistance in patients with inflammatory bowel disease","volume":"21","author":"Koutroubakis","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/S1470-2045(03)01247-6","article-title":"Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies","volume":"4","author":"Laviano","year":"2003","journal-title":"Lancet Oncol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1006\/excr.1999.4465","article-title":"Tumor Necrosis Factor-\u03b1 and Basic Fibroblast Growth Factor Differentially Inhibit the Insulin-like Growth Factor-I Induced Expression of Myogenin in C2C12 Myoblasts","volume":"249","author":"Layne","year":"1999","journal-title":"Exp. Cell Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.jacc.2006.07.036","article-title":"A Novel Inhibitory Effect of Naloxone on Macrophage Activation and Atherosclerosis Formation in Mice","volume":"48","author":"Liu","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/acr.22932","article-title":"Impact of Obesity on Remission and Disease Activity in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis","volume":"69","author":"Liu","year":"2017","journal-title":"Arthritis Care Res. (Hoboken)."},{"key":"B79","doi-asserted-by":"publisher","first-page":"E94","DOI":"10.2527\/jas.2007-0462","article-title":"Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes","volume":"86","author":"Lorenzo","year":"2008","journal-title":"J. Anim. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, Obesity, and Depression","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1007\/s00296-011-2262-7","article-title":"Serum ghrelin in female patients with rheumatoid arthritis during treatment with infliximab","volume":"33","author":"Magiera","year":"2013","journal-title":"Rheumatol Int."},{"key":"B47","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/jdv.12066","article-title":"Evaluation of risk factors for body weight increment in psoriatic patients on infliximab: A multicentre, cross-sectional study","volume":"28","author":"Mahe","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1093\/ajcn\/84.6.1463","article-title":"Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis","volume":"84","author":"Marcora","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"B49","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/rheumatology\/kes272","article-title":"No significant changes in arterial stiffness in patients with ankylosing spondylitis after tumour necrosis factor alpha blockade treatment for 6 and 12 months","volume":"52","author":"Mathieu","year":"2013","journal-title":"Rheumatol. (Oxford)."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1093\/rheumatology\/kem291","article-title":"Blockade of tumour necrosis factor-alpha in rheumatoid arthritis: effects on components of rheumatoid cachexia","volume":"46","author":"Metsios","year":"2007","journal-title":"Rheumatol. (Oxford)."},{"key":"B93","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nature02240","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus","volume":"428","author":"Minokoshi","year":"2004","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"6","author":"Moher","year":"2009","journal-title":"PloS Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1177\/014107688107400208","article-title":"Naloxone in the treatment of anorexia nervosa: effect on weight gain and lipolysis","volume":"74","author":"Moore","year":"1981","journal-title":"J. R. Soc. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1348\/000711000159150","article-title":"Distribution of the standardized mean change effect size for meta-analysis on repeated measures","volume":"53","author":"Morris","year":"2000","journal-title":"Br. J. Math Stat. Psychol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.brainres.2004.04.066","article-title":"Effects of lipopolysaccharide on leptin transport across the blood\u2013brain barrier","volume":"1016","author":"Nonaka","year":"2004","journal-title":"Brain Res."},{"key":"B13","article-title":"NRAS - National Rheumatoid Arthritis Society","year":""},{"key":"B16","article-title":"Overview | TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis | Guidance","year":""},{"key":"B51","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/ibd.20931","article-title":"Effects of infliximab therapy on abdominal fat and metabolic profile in patients with Crohn\u2019s disease","volume":"15","author":"Parmentier-Decrucq","year":"2009","journal-title":"Inflammation Bowel Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.lfs.2016.11.033","article-title":"TNF-\u03b1 and cancer cachexia: Molecular insights and clinical implications","volume":"170","author":"Patel","year":"2017","journal-title":"Life Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.humimm.2015.10.008","article-title":"The relationship between body weight and inflammation: Lesson from anti-TNF-alpha antibody therapy","volume":"77","author":"Peluso","year":"2016","journal-title":"Hum. Immunol."},{"key":"B90","first-page":"5","article-title":"[Biological manifestations of the tumor necrosis factor effect and its role in the pathogenesis of various diseases]","volume":"54","author":"Perskidski\u012d","year":"1992","journal-title":"Arkh Patol."},{"key":"B7","first-page":"64","article-title":"Cytokines and anorexia: a brief overview","volume":"25","author":"Plata-Salam\u00e1n","year":"1998","journal-title":"Semin. Oncol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1152\/physiologyonline.1998.13.6.298","article-title":"Cytokines and Feeding","volume":"13","author":"Plata-Salam\u00e1n","year":"1998","journal-title":"News Physiol. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3899\/jrheum.080626","article-title":"Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis","volume":"36","author":"Popa","year":"2009","journal-title":"J. Rheumatol."},{"key":"B26","volume-title":"R: A language and environment for statistical computing","year":"2015"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1002\/art.1780390707","article-title":"Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha","volume":"39","author":"Rall","year":"1996","journal-title":"Arthritis Rheum"},{"key":"B74","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/rr67","article-title":"Tumor necrosis factor-alpha and muscle wasting: a cellular perspective","volume":"2","author":"Reid","year":"2001","journal-title":"Respir. Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.peptides.2007.03.006","article-title":"TNF-\u03b1 acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient-Effects on leptin and insulin signaling pathways","volume":"28","author":"Romanatto","year":"2007","journal-title":"Peptides"},{"key":"B53","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/1471-2474-13-127","article-title":"Anti-TNF\u03b1 therapy transiently improves high density lipoprotein cholesterol levels and microvascular endothelial function in patients with rheumatoid arthritis: a Pilot Study","volume":"13","author":"Sandoo","year":"2012","journal-title":"BMC Musculoskelet Disord."},{"key":"B97","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/jcsm.12320","article-title":"Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta-analysis","volume":"9","author":"Santo","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle."},{"key":"B54","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.phrs.2008.02.006","article-title":"Effect of anti-tumor necrosis factor-alpha therapies on body mass index in patients with psoriasis","volume":"57","author":"Saraceno","year":"2008","journal-title":"Pharmacol. Res."},{"key":"B81","first-page":"245","article-title":"Cytokines in anorexia nervosa\u2013nutritional or neuroimmunal changes","volume":"123","author":"Schattner","year":"1992","journal-title":"Harefuah"},{"key":"B23","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/s41395-018-0104-x","article-title":"Obesity and Response to Infliximab in Patients with Inflammatory Bowel Diseases: Pooled Analysis of Individual Participant Data from Clinical Trials","volume":"113","author":"Singh","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"B25","unstructured":"National Heart, Lung, and Blood Institute (NHLBI)2019"},{"key":"B10","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.biopsych.2010.06.012","article-title":"A Meta-Analysis of Cytokines in Alzheimer\u2019s Disease","volume":"68","author":"Swardfager","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B55","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/ajd.12044","article-title":"Weight gain and tumour necrosis factor-alpha inhibitors in patients with psoriasis","volume":"54","author":"Tan","year":"2013","journal-title":"Australas. J. Dermatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2165\/00063030-200519010-00006","article-title":"TNF alpha Inhibitors in the Treatment of Psoriasis and Psoriatic Arthritis","volume":"19","author":"Tobin","year":"2005","journal-title":"BioDrugs"},{"key":"B56","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00394-013-0599-2","article-title":"TNFalpha blockade for inflammatory rheumatic diseases is associated with a significant gain in android fat mass and has varying effects on adipokines: A 2-year prospective study","volume":"53","author":"Toussirot","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.2337\/db16-0270","article-title":"Tumor necrosis factor-\u03b1 promotes phosphoinositide 3-kinase enhancer A and AMP-activated protein kinase interaction to suppress lipid oxidation in skeletal muscle","volume":"66","author":"Tse","year":"2017","journal-title":"Diabetes"},{"key":"B5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000289203","article-title":"TNF-alpha and Obesity","volume-title":"TNF Pathophysiology","author":"Tzanavari","year":"2010"},{"key":"B8","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/0026-0495(91)90090-J","article-title":"Tumor necrosis factor-alpha and anorexia\u2013cause or effect","volume":"40","author":"Vaisman","year":"1991","journal-title":"Metabolism"},{"key":"B3","first-page":"264","article-title":"TNF-alpha and apoptosis: implications for the pathogenesis and treatment of psoriasis","volume":"1","author":"Victor","year":"2002","journal-title":"J. Drugs Dermatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Softw."},{"key":"B57","first-page":"18","article-title":"A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia","volume":"6","author":"Wiedenmann","year":"2008","journal-title":"J. Support Oncol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"600","DOI":"10.22237\/jmasm\/1257035160","article-title":"Estimation of the Standardized Mean Difference for Repeated Measures Designs","volume":"8","author":"Wolff Smith","year":"2009","journal-title":"J. Mod Appl. Stat. Methods"},{"key":"B88","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/0006-3223(88)90191-6","article-title":"Single-dose naloxone acutely reduces eating in obese humans: Behavioral and biochemical effects","volume":"24","author":"Wolkowitz","year":"1988","journal-title":"Biol. Psychiatry"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1111\/jdv.12296","article-title":"Initiation of TNF inhibitor therapy and change in physiologic measures in psoriasis","volume":"28","author":"Wu","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jaad.2019.07.103","article-title":"Change in body weight and body mass index in psoriasis patients receiving biologics: A systematic review and network meta-analysis","volume":"82","author":"Wu","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.2337\/diabetes.51.6.1876","article-title":"Altered tumor necrosis factor-\u03b1 (TNF-\u03b1) processing in adipocytes and increased expression of transmembrane TNF-\u03b1 in obesity","volume":"51","author":"Xu","year":"2002","journal-title":"Diabetes"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms15143","article-title":"TNF\u03b1 drives mitochondrial stress in POMC neurons in obesity","volume":"8","author":"Yi","year":"2017","journal-title":"Nat. Commun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"549","DOI":"10.14196\/mjiri.32.95","article-title":"Depressive symptoms among metabolically healthy and unhealthy overweight\/obese individuals: a comparative study","volume":"32","author":"Yosaee","year":"2018","journal-title":"Med. J. Islam Repub. Iran."},{"key":"B58","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cyto.2012.11.007","article-title":"Weight change during pharmacological blockade of interleukin-6 or tumor necrosis factor-alpha in patients with inflammatory rheumatic disorders: A 16-week comparative study","volume":"61","author":"Younis","year":"2013","journal-title":"Cytokine"},{"key":"B102","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jpsychires.2015.03.003","article-title":"The incidence of eating disorders in a Danish register study: Associations with suicide risk and mortality","volume":"65","author":"Zerwas","year":"2015","journal-title":"J. Psychiatr. Res."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00481\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T01:32:04Z","timestamp":1586914324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00481\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":104,"alternative-id":["10.3389\/fphar.2020.00481"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00481","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]},"article-number":"481"}}