{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:26:22Z","timestamp":1792689982375,"version":"4.5.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["17JCYBJC42800"],"award-info":[{"award-number":["17JCYBJC42800"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00858","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T04:30:15Z","timestamp":1591677015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":78,"title":["Untargeted Metabolomic Analysis of the Effects and Mechanism of Nuciferine Treatment on Rats With Nonalcoholic Fatty Liver Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Huantian","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaiyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1177\/014572179802400611","article-title":"Liver and biliary ultrasonography in diabetic and non-diabetic obese women","volume":"24","author":"Araujo","year":"1998","journal-title":"Diabetes Metab."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1097\/sla.0b013e3181dbb572","article-title":"Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome p-450 protein content","volume":"251","author":"Bell","year":"2010","journal-title":"Ann. Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/MCG.0b013e31821377e4","article-title":"Hepatic lipid peroxidation and cytochrome P-450 2E1 in pediatric nonalcoholic fatty liver disease and its subtypes","volume":"45","author":"Bell","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1381\/0960892055002347","article-title":"Predictors of nonalcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass","volume":"15","author":"Boza","year":"2005","journal-title":"Obes. Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jnutbio.2016.10.012","article-title":"Antioxidant properties of tea blunt ROS-dependent lipogenesis: beneficial effect on hepatic steatosis in a high fat-high sucrose diet NAFLD obese rat model","volume":"40","author":"Braud","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1139\/apnm-2013-0476","article-title":"Evidence for the use of glomerulomegaly as a surrogate marker of glomerular damage and for alpha-linolenic acid-rich oils in the treatment of early obesity-related glomerulopathy in a diet-induced rodent model of obesity","volume":"39","author":"Caligiuri","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/bs.ircmb.2015.10.001","article-title":"Phosphatidylethanolamine Metabolism in Health and Disease","volume":"321","author":"Calzada","year":"2016","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"B8","first-page":"128","article-title":"Prevalence of nonalcoholic fatty liver disease in subjects with metabolic syndrome","volume":"80","author":"Castro-Martinez","year":"2012","journal-title":"Cir. Cir."},{"key":"B9","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1631\/jzus.B0720016","article-title":"Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease","volume":"9","author":"Chen","year":"2008","journal-title":"J. Zhejiang Univ. Sci. B."},{"key":"B10","doi-asserted-by":"publisher","first-page":"8821","DOI":"10.1007\/s11033-012-1746-1","article-title":"Differential gene expression in pancreatic tissues of streptozocin-induced diabetic rats and genetically-diabetic mice in response to hypoglycemic dipeptide cyclo (his-pro) treatment","volume":"39","author":"Choi","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10616-016-0034-7","article-title":"Icariin-treated human umbilical cord mesenchymal stem cells decrease chronic liver injury in mice","volume":"69","author":"Cui","year":"2017","journal-title":"Cytotechnology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00571","article-title":"Berberine Regulates Treg\/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon","volume":"9","author":"Cui","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ejphar.2015.05.005","article-title":"Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet","volume":"761","author":"Ding","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"295","DOI":"10.12816\/0006468","article-title":"Pharmacological and antioxidant actions of garlic and.or onion in non-alcoholic fatty liver disease (NAFLD) in rats","volume":"44","author":"El-Din","year":"2014","journal-title":"J. Egypt Soc Parasitol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1124\/dmd.109.027466","article-title":"Hepatic cytochrome p450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease","volume":"37","author":"Fisher","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063770","article-title":"Nuciferine Prevents Hepatic Steatosis and Injury Induced by a High-Fat Diet in Hamsters","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1194\/jlr.m700184-jlr200","article-title":"Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes","volume":"49","author":"Han","year":"2008","journal-title":"J. Lipid Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"10180","DOI":"10.3748\/wjg.v22.i46.10180","article-title":"Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat","volume":"22","author":"Jiang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"10038","DOI":"10.1021\/ac9019522","article-title":"FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography\/mass spectrometry","volume":"81","author":"Kind","year":"2009","journal-title":"Anal. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11306-019-1474-9","article-title":"Development of a rapid profiling method for the analysis of polar analytes in urine using HILIC-MS and ion mobility enabled HILIC-MS","volume":"15","author":"King","year":"2019","journal-title":"Metabolomics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2174\/1574887109666141216102231","article-title":"The role of liver biopsy to assess non-alcoholic fatty liver disease","volume":"9","author":"Kobyliak","year":"2014","journal-title":"Rev. Recent Clin. Trials"},{"key":"B22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3350\/cmh.2013.19.3.210","article-title":"Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis","volume":"19","author":"Koo","year":"2013","journal-title":"Clin. Mol. Hepatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.cmet.2006.03.007","article-title":"The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis","volume":"3","author":"Li","year":"2006","journal-title":"Cell Metab."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.12032\/TMR20200201157","article-title":"Hua-Zhuo-Kai-Yu decoction inhibits apoptosis in nonalcoholic fatty liver disease","volume":"1","author":"Li","year":"2020","journal-title":"Tradit. Med. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2002","journal-title":"Methods"},{"key":"B26","doi-asserted-by":"publisher","first-page":"126","DOI":"10.2174\/1574887109666141216111143","article-title":"Non alcoholic fatty liver: epidemiology and natural history","volume":"9","author":"Masarone","year":"2014","journal-title":"Rev. Recent Clin. Trials"},{"key":"B27","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1177\/0192623311432290","article-title":"Phospholipidosis in rats treated with amiodarone: serum biochemistry and whole genome micro-array analysis supporting the lipid traffic jam hypothesis and the subsequent rise of the biomarker BMP","volume":"40","author":"Mesens","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1515\/biol-2019-0079","article-title":"Nuciferine prevents hepatic steatosis by regulating lipid metabolismin diabetic rat model","volume":"14","author":"Ning","year":"2019","journal-title":"Open Life Sci."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109721","article-title":"Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model","volume":"123","author":"Sun","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.mehy.2018.02.010","article-title":"Ammonia: A novel target for the treatment of non-alcoholic steatohepatitis","volume":"113","author":"Thomsen","year":"2018","journal-title":"Med. Hypotheses"},{"key":"B31","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1194\/jlr.M059113","article-title":"Fads2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue","volume":"57","author":"Vaittinen","year":"2015","journal-title":"J. L Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"Van Der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0092-8674(00)80450-X","article-title":"BclxL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria","volume":"91","author":"Vander Heiden","year":"1997","journal-title":"Cell"},{"key":"B34","doi-asserted-by":"publisher","first-page":"7899","DOI":"10.1021\/acs.jafc.6b03031","article-title":"Nuciferine alleviates renal injury by inhibiting inflammatory responses in fructose-fed rats","volume":"64","author":"Wang","year":"2016","journal-title":"J. AGR Food Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1210\/en.2017-00213","article-title":"Rosiglitazone Improves Insulin Resistance Mediated by 10,12 Conjugated Linoleic Acid in a Male Mouse Model of Metabolic Syndrome","volume":"158","author":"Wang","year":"2017","journal-title":"Endocrinology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1556\/OH.2013.29674","article-title":"Nonalcoholic fatty liver disease: diagnosis and management","volume":"88","author":"Wilkins","year":"2013","journal-title":"Am. Fam. Physician"},{"key":"B37","first-page":"1","article-title":"Jian-Gan-Xiao-Zhi decoction ameliorates high-fat high-carbohydrate diet-induced non-alcoholic fatty liver disease and insulin resistance by regulating the AMPK\/JNK pathway","volume-title":"Tradit. Med. Res.","author":"Xie","year":"2019"},{"key":"B38","doi-asserted-by":"publisher","first-page":"E1220","DOI":"10.3390\/ijms20051220","article-title":"Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development","volume":"20","author":"Xu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00902","article-title":"Pharmacokinetics of nuciferine and n-nornuciferine, two major alkaloids from nelumbo nucifera leaves, in rat plasma and the brain","volume":"9","author":"Ye","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8467192","article-title":"Metabonomics Research Progress on Liver Diseases","volume":"2017","author":"Yu","year":"2017","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"701","DOI":"10.4314\/tjpr.v15i4.5","article-title":"Impaired reverse cholesterol transport and hepatic steatosis contribute to pathogenesis of high fat diet-induced hyperlipidemia in murine models","volume":"15","author":"Zeng","year":"2016","journal-title":"Trop. J. Pharm. Res."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00238","article-title":"Nuciferine downregulates Per-Arnt-Sim kinase expression during its alleviation of lipogenesis and inflammatory on oleic acid-induced hepatic steatosis in HepG2 cells","volume":"6","author":"Zhang","year":"2015","journal-title":"Front. Pharmacol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00858\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T04:30:18Z","timestamp":1591677018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00858\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":43,"alternative-id":["10.3389\/fphar.2020.00858"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00858","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"article-number":"858"}}