{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:33:45Z","timestamp":1771486425242,"version":"3.50.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971190, 81703400, 31801975"],"award-info":[{"award-number":["31971190, 81703400, 31801975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019ZF003, 2019FB040 , 2018ZF001"],"award-info":[{"award-number":["2019ZF003, 2019FB040 , 2018ZF001"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00896","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T04:59:01Z","timestamp":1592283541000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom of Lycosa singoriensis"],"prefix":"10.3389","volume":"11","author":[{"given":"Pengpeng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Er","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Mwangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqiang","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"B1","first-page":"360","article-title":"Epsilon Aminocaproic Acid - an Inhibitor of Plasminogen Activation","volume":"3","author":"Alkjaersig","year":"1959","journal-title":"Thromb. Et Diathesis Haemorrhag."},{"key":"B2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.bbalip.2010.11.005","article-title":"Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: endothelial cell membrane phospholipids as targets for toxicity","volume":"1811","author":"Chaim","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"B3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1365-2141.2009.07605.x","article-title":"Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss","volume":"145","author":"Flight","year":"2009","journal-title":"Br. J. Haematol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.bbrc.2004.11.171","article-title":"Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation","volume":"327","author":"Fry","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1161\/ATVBAHA.107.155952","article-title":"Intrinsic Pathway of Coagulation and Thrombosis","volume":"39","author":"Grover","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1093\/ajcp\/65.3.390","article-title":"Blood recalcification time. A simple and reliable test to monitor heparin therapy","volume":"65","author":"Gulliani","year":"1976","journal-title":"Am. J. Clin. Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s00726-017-2425-2","article-title":"An insecticidal toxin from Nephila clavata spider venom","volume":"49","author":"Jin","year":"2017","journal-title":"Amino Acids"},{"key":"B8","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.foodchem.2009.04.077","article-title":"Isolation and characterisation of an anticoagulant oligopeptide from blue mussel, Mytilus edulis","volume":"117","author":"Jung","year":"2009","journal-title":"Food Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1016\/j.bbamem.2012.07.016","article-title":"Modulation of P2X3 receptors by spider toxins","volume":"1818","author":"Kabanova","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B10","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1097\/MBC.0000000000000336","article-title":"Biochemical characterization of a factor X activator protein purified from Walterinnesia aegyptia venom","volume":"26","author":"Khan","year":"2015","journal-title":"Blood Coagul. Fibrinolysis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1182\/blood-2011-03-339572","article-title":"Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin","volume":"118","author":"Konings","year":"2011","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.annfar.2008.02.009","article-title":"[Haemostasis disorders caused by snake venoms]","volume":"27","author":"Larreche","year":"2008","journal-title":"Ann. Fr. Anesth. Reanim."},{"key":"B13","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.toxicon.2004.02.005","article-title":"An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)]","volume":"43","author":"Liang","year":"2004","journal-title":"Toxicon"},{"key":"B14","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1586\/14789450.5.5.731","article-title":"Proteome and peptidome profiling of spider venoms","volume":"5","author":"Liang","year":"2008","journal-title":"Expert Rev. Proteom."},{"key":"B15","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S1875-5364(16)30071-1","article-title":"Protease inhibitor in scorpion (Mesobuthus eupeus) venom prolongs the biological activities of the crude venom","volume":"14","author":"Ma","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/202498a0","article-title":"An Enzyme Cascade in the Blood Clotting Mechanism, and Its Function as a Biochemical Amplifier","volume":"202","author":"Macfarlane","year":"1964","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1002\/pmic.200401096","article-title":"Proteome analysis of brown spider venom: Identification of loxnecrogin isoforms in Loxosceles gaucho venom","volume":"5","author":"Machado","year":"2005","journal-title":"Proteomics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"pii: E7","DOI":"10.3390\/toxins9010007","article-title":"A Novel Toxin from Haplopelma lividum Selectively Inhibits the NaV1.8 Channel and Possesses Potent Analgesic Efficacy","volume":"9","author":"Meng","year":"2016","journal-title":"Toxins (Basel)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4091278","article-title":"Loxoscelism: Cutaneous and Hematologic Manifestations","volume":"2019","author":"Nguyen","year":"2019","journal-title":"Adv. Hematol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.toxicon.2011.01.006","article-title":"Haemostatically active proteins in snake venoms","volume":"57","author":"Sajevic","year":"2011","journal-title":"Toxicon"},{"key":"B21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/s0014-5793(00)01803-2","article-title":"Interaction of viper venom serine peptidases with thrombin receptors on human platelets","volume":"477","author":"Santos","year":"2000","journal-title":"FEBS Lett."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1182\/blood-2011-04-347849","article-title":"Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets","volume":"118","author":"Schoenwaelder","year":"2011","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/s0304-4165(01)00206-9","article-title":"Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity","volume":"1568","author":"Siigur","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"B24","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1191\/0960327104ht475oa","article-title":"Changes in hematological, hemostatic and biochemical parameters induced experimentally in rabbits by Loxosceles gaucho spider venom","volume":"23","author":"Tavares","year":"2004","journal-title":"Hum. Exp. Toxicol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1177\/0960327110393761","article-title":"Loxosceles gaucho spider venom and its sphingomyelinase fraction trigger the main functions of human and rabbit platelets","volume":"30","author":"Tavares","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1177\/0960327115597983","article-title":"Platelet participation in the pathogenesis of dermonecrosis induced by Loxosceles gaucho venom","volume":"35","author":"Tavares","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1093\/cvr\/cvt276","article-title":"Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence","volume":"101","author":"Tilly","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1111\/j.1538-7836.2007.02382.x","article-title":"Loxosceles spider venom induces the release of thrombomodulin and endothelial protein C receptor: implications for the pathogenesis of intravascular coagulation as observed in loxoscelism","volume":"5","author":"Van Den Berg","year":"2007","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"B29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/s0742-8413(97)00033-9","article-title":"Hemolytic action of anionic surfactants of the diacyl lysine type","volume":"118","author":"Vives","year":"1997","journal-title":"Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.actbio.2009.07.026","article-title":"Rat calvaria osteoblast behavior and antibacterial properties of O(2) and N(2) plasma-implanted biodegradable poly(butylene succinate)","volume":"6","author":"Wang","year":"2010","journal-title":"Acta Biomater."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1213\/ANE.0000000000001485","article-title":"Spine Surgery and Blood Loss: Systematic Review of Clinical Evidence","volume":"123","author":"Willner","year":"2016","journal-title":"Anesth. Analg."},{"key":"B32","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1074\/mcp.M112.018853","article-title":"Chemical punch packed in venoms makes centipedes excellent predators","volume":"11","author":"Yang","year":"2012","journal-title":"Mol. Cell Proteom."},{"key":"B33","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/01.ta.0000152892.24841.54","article-title":"Direct peritoneal resuscitation from hemorrhagic shock: Effect of time delay in therapy initiation","volume":"58","author":"Zakaria","year":"2005","journal-title":"J.\u00a0Trauma."},{"key":"B34","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.zool.2009.04.001","article-title":"Transcriptome analysis of the venom glands of the Chinese wolf spider Lycosa singoriensis","volume":"113","author":"Zhang","year":"2010","journal-title":"Zool. (Jena)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.biochi.2011.10.015","article-title":"Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR","volume":"94","author":"Zhang","year":"2012","journal-title":"Biochimie"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00896\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T04:59:04Z","timestamp":1592283544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00896\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":35,"alternative-id":["10.3389\/fphar.2020.00896"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00896","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"article-number":"896"}}