{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:05:56Z","timestamp":1781139956098,"version":"3.54.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.00917","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T06:27:47Z","timestamp":1594189667000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Phytotherapy for Cachexia: Where Do We Stand?"],"prefix":"10.3389","volume":"11","author":[{"given":"Kenny","family":"Kuchta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"B1","unstructured":"Merriam-Webster.com Dictionary"},{"key":"B2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/j.1600-079X.2006.00337.x","article-title":"Melatonin in Glycyrrhiza uralensis: response of plant roots to spectral quality of light and UV-B radiation","volume":"41","author":"Afreen","year":"2006","journal-title":"J. Pineal Res."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00150","article-title":"The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo","volume":"6","author":"Amitani","year":"2015","journal-title":"Front. Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/01.mco.0000198060.10991.50","article-title":"Nutrition and cardiac cachexia","volume":"9","author":"Azhar","year":"2006","journal-title":"Curr. Opin. Nutr. Metab. Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/jcsm.12054","article-title":"Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling","volume":"7","author":"Chen","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"B6","doi-asserted-by":"publisher","first-page":"736563","DOI":"10.1155\/2014\/736563","article-title":"Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 tumor-bearing mice","author":"Choi","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B7","first-page":"1182","article-title":"Effect of total saponins from Panax notoginseng on expession of melatonin receptor mRNA in gastric mucosa of stress rats","volume":"31","author":"Deng","year":"2008","journal-title":"Zhong Yao Cai"},{"key":"B8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.phrs.2019.04.010","article-title":"Saponins regulate intestinal inflammation in colon cancer and IBD","volume":"144","author":"Dong","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1038\/tp.2011.25","article-title":"Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival","volume":"1","author":"Fujitsuka","year":"2011","journal-title":"Trans. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1038\/mp.2015.220","article-title":"Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1","volume":"21","author":"Fujitsuka","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B11","first-page":"4493","article-title":"Cancer anorexia-cachexia syndrome: are neuropeptides the key","volume":"59","author":"Inui","year":"1999","journal-title":"Cancer Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"16340","DOI":"10.1002\/jcb.29151","article-title":"The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review","volume":"120","author":"Jafari-Vayghan","year":"2019","journal-title":"J. Cell Biochem."},{"key":"B13","unstructured":"2017"},{"key":"B14","unstructured":"2017"},{"key":"B15","unstructured":"2017"},{"key":"B16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/1534735410383170","article-title":"Bojungikki-tang for cancer-related fatigue: a pilot randomized clinical trial","volume":"9","author":"Jeong","year":"2010","journal-title":"Integr. Cancer Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1089\/acm.2000.6.557","article-title":"The effect of a traditional Chinese prescription for a case of lung carcinoma","volume":"6","author":"Kamei","year":"2000","journal-title":"J. Altern. Complement Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neulet.2003.08.070","article-title":"The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice","volume":"353","author":"Kim","year":"2003","journal-title":"Neurosci. Lett."},{"key":"B19","first-page":"1837","article-title":"Effect of Kampo Medicine, \u201cHochu-ekki-to,\u201d on chronic fatigue syndrome","volume":"74","author":"Kuratsune","year":"1997","journal-title":"Clin. Res."},{"key":"B20","first-page":"173","article-title":"The clinical evaluation of hochuekkito for symptoms of malignant neoplasm patients","volume":"31","author":"Kuroda","year":"1985","journal-title":"Hinyokika Kiyo"},{"key":"B21","first-page":"16","article-title":"State of nonspecific resistance","volume":"3","author":"Lazarev","year":"1959","journal-title":"Patol. Fiziol ExperimTer."},{"key":"B22","first-page":"81","article-title":"General and specific in action of pharmacological agents","volume":"21","author":"Lazarev","year":"1958","journal-title":"Farmacol. Toxicol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/514049","article-title":"Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea","volume":"514049","author":"Lee","year":"2013","journal-title":"Evid. Based. Complement Alternat. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e0216759","DOI":"10.1371\/journal.pone.0216759","article-title":"The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K\/Akt\/mTOR pathway","volume":"14","author":"Liu","year":"2019","journal-title":"PloS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jpba.2014.11.036","article-title":"An UPLC-MS-based metabolomics investigation on the anti-fatigue effect of salidroside in mice","volume":"105","author":"Ma","year":"2015","journal-title":"J. Pharm. BioMed. Anal."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00005","article-title":"Japanese Herbal Medicine Ninjinyoeito Mediates Its Orexigenic Properties Partially by Activating Orexin 1 Receptors","volume":"7","author":"Miyano","year":"2020","journal-title":"Front. Nutr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/SPC.0000000000000091","article-title":"Role of interleukin-6 in cachexia: therapeutic implications","volume":"8","author":"Narsale","year":"2014","journal-title":"Curr. Opin. Supp. Palliat Care"},{"key":"B28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1751-0759-8-6","article-title":"Kampo medicine for palliative care in Japan","volume":"8","author":"Okumi","year":"2014","journal-title":"Biopsychosoc. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.phymed.2018.09.204","article-title":"Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology","volume":"50","author":"Panossian","year":"2018","journal-title":"Phytomedicine"},{"key":"B30","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s13539-011-0047-1","article-title":"The effect of exercise on il-6-induced cachexia in the apc (min\/+) mouse","volume":"3","author":"Puppa","year":"2012","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"B31","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1096\/fj.13-240580","article-title":"Skeletal muscle glycoprotein 130\u2019s role in lewis lung carcinoma-induced cachexia","volume":"28","author":"Puppa","year":"2014","journal-title":"FASEB J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.phymed.2004.06.014","article-title":"A randomized double blind placebo-controlled clinical trial of Hochuekkito, a traditional herbal medicine, in the treatment of elderly patients with weakness N of one and responder restricted design","volume":"12","author":"Satoh","year":"2005","journal-title":"Phytomedicine"},{"key":"B33","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1081\/IPH-120026435","article-title":"Effect of bojungikki-tang on lipopolysaccharide-induced cytokine production from peripheral blood mononuclear cells of chronic fatigue syndrome patients","volume":"25","author":"Shin","year":"2003","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"B34","unstructured":"Suppl II JPX. V. I.\n          2014"},{"key":"B35","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1532-5415.2009.02034.x","article-title":"Hochuekkito improves systemic inflammation and nutritional status in elderly patients with chronic obstructive pulmonary disease","volume":"57","author":"Tatsumi","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"B36","doi-asserted-by":"publisher","first-page":"E373","DOI":"10.1152\/ajpendo.00116.2013","article-title":"New cancer cachexia rat model generated by implantation of a peritoneal disseminationderived human stomach cancer cell line","volume":"306","author":"Terawaki","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e0173113","DOI":"10.1371\/journal.pone.0173113","article-title":"Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the kampo medicine rikkunshito on the model","volume":"12","author":"Terawaki","year":"2017","journal-title":"PloS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"34748","DOI":"10.18632\/oncotarget.26190","article-title":"Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats","volume":"9","author":"Terawaki","year":"2018","journal-title":"Oncotarget"},{"key":"B39","first-page":"1129","article-title":"Successful antiemetic treatment of Tsumura rikkunshi-to extract granules for ethical use in addition to other antiemetic agents in neoadjuvant chemotherapy for an advanced breast cancer patient","volume":"33","author":"Tomono","year":"2006","journal-title":"Jpn. J. Cancer Chemother."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1002\/ijc.23828","article-title":"Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress","volume":"123","author":"Tsuchiya","year":"2008","journal-title":"Int. J. Cancer"},{"key":"B41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1479-8301.2010.00347.x","article-title":"Effect of Rikkunshi-to on appetite loss found in elderly dementia patients: a preliminary study","volume":"11","author":"Utumi","year":"2011","journal-title":"Psychogeriatrics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1517\/13543784.14.2.163","article-title":"Future prospects of anticytokine therapy in chronic heart failure","volume":"14","author":"von Haehling","year":"2005","journal-title":"Expert Opin. Invest. Drugs"},{"key":"B43","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.pharmthera.2008.09.009","article-title":"Cardiac cachexia: a systematic overview","volume":"121","author":"von Haehling","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"B44","volume-title":"Kachexie bei Tumorerkrankungen: Erkennen und multimodal behandeln","author":"von Haehling","year":"2017"},{"key":"B45","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.phymed.2006.03.021","article-title":"Multitarget therapy - the future of treatment for more than just functional dyspepsia","author":"Wagner","year":"2006","journal-title":"Phytomedicine"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e24650","DOI":"10.1371\/journal.pone.0024650","article-title":"The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the apc(min\/+) mouse","volume":"6","author":"White","year":"2011","journal-title":"PloS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"E1042","DOI":"10.1152\/ajpendo.00410.2012","article-title":"Muscle mtorc1 suppression by il-6 during cancer cachexia: A role for ampk","volume":"304","author":"White","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B48","doi-asserted-by":"publisher","first-page":"976926","DOI":"10.1155\/2012\/976926","article-title":"Hochuekkito (TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice","author":"Yae","year":"2012","journal-title":"Evid. Based. Complement Alternat. Med."},{"key":"B49","first-page":"85","article-title":"Acupuncture and Integrative Medicine","volume":"1","author":"Yasui","year":"2005","journal-title":"J. Kampo"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00788","article-title":"Mtor as a key regulator in maintaining skeletal muscle mass","volume":"8","author":"Yoon","year":"2017","journal-title":"Front. Physiol."},{"key":"B51","first-page":"915","article-title":"Effect of ginsenoside on IL-1\u03b2 and IL-6 mRNA expression in hippocampal neurons of chronic inflammation model of aged rats","volume":"21","author":"Yu","year":"2000","journal-title":"Acta Pharmacolog. Sin."},{"key":"B52","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.taap.2014.07.001","article-title":"Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6","volume":"279","author":"Zhao","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12906-019-2536-2","article-title":"Panax notoginseng saponins promote liver regeneration through activation of the PI3K\/AKT\/mTOR cell proliferation pathway and upregulation of the AKT\/Bad cell survival pathway in mice","volume":"19","author":"Zhong","year":"2019","journal-title":"BMC Complement Altern. Med."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00917\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T06:27:53Z","timestamp":1594189673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.00917\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,8]]},"references-count":53,"alternative-id":["10.3389\/fphar.2020.00917"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.00917","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,8]]},"article-number":"917"}}