{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:08:29Z","timestamp":1792451309083,"version":"4.5.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.01053","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T15:06:10Z","timestamp":1595603170000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis"],"prefix":"10.3389","volume":"11","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fucun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijian","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/s0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"key":"B2","first-page":"139","article-title":"The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review","volume":"26","author":"Bondeson","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/15563650902904407","article-title":"Aconite poisoning","volume":"47","author":"Chan","year":"2009","journal-title":"Clin. Toxicol. (Phila)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.3390\/ijerph16162897","article-title":"The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate","volume":"16","author":"Chin","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B5","first-page":"191","volume-title":"Pharmacopeia of the People\u2019s Republic of China (The First Division)","year":"2015"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.13863\/j.issn1001-4454.2008.07.007","article-title":"Clinical research on Gancao Fuzi decoction in treating osteoarthritis of knee joint","volume":"31","author":"Deng","year":"2008","journal-title":"J. Chin. Med. Mater."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1002\/jor.20137","article-title":"Chondrocyte gene expression in osteoarthritis: Correlation with disease severity","volume":"24","author":"Eid","year":"2006","journal-title":"J. Orthop. Res."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/srep32001","article-title":"Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5","volume":"6","author":"Feng","year":"2016","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","article-title":"Osteoarthritis as a disease of the cartilage pericellular matrix","author":"Guilak","year":"2018","journal-title":"Matrix Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"13023","DOI":"10.1038\/s41598-017-13499-6","article-title":"Simultaneous quantification of nine aconitum alkaloids in Aconiti Lateralis Radix Praeparata and related products using UHPLC-QQQ-MS\/MS","volume":"7","author":"He","year":"2017","journal-title":"Sci. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.joca.2019.01.001","article-title":"Potential diagnostic value of a type X collagen neo-epitope biomarker for knee osteoarthritis","volume":"27","author":"He","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1080\/21691401.2019.1647223","article-title":"Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis","volume":"47","author":"Hu","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"B13","first-page":"38","article-title":"Shanghan Zabing Lun","volume":"2","author":"Huang","year":"2013","journal-title":"Clin. J. Tradit. Chin. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.berh.2014.01.004","article-title":"The epidemiology of osteoarthritis","volume":"28","author":"Johnson","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00590-013-1205-2","article-title":"Useful animal models for the research of osteoarthritis","volume":"24","author":"Lampropoulou-Adamidou","year":"2014","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"B16","first-page":"10","article-title":"Clinical study on Fuzi Tang for treatment of mild-to-moderate knee osteoarthritis with Cold-dampness stagnation syndrome","volume":"28","author":"Liu","year":"2016","journal-title":"J. Tradit. Chin. Orthoped. Traumatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bcp.2019.02.033","article-title":"Inhibition of MMPs and ADAM\/ADAMTS","volume":"165","author":"Malemud","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.joca.2018.11.001","article-title":"Osteoarthritis year in review 2018: clinical","volume":"27","author":"Mandl","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116786","article-title":"The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review","volume":"234","author":"Mehana","year":"2019","journal-title":"Life Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.berh.2018.10.007","article-title":"Update on the epidemiology, risk factors and disease outcomes of osteoarthritis","volume":"32","author":"O\u2019Neill","year":"2018","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/j.1532-2149.2012.00223.x","article-title":"Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl\/6 mice","volume":"17","author":"Ogbonna","year":"2013","journal-title":"Eur. J. Pain"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111556","article-title":"Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1","volume":"383","author":"Ohtsuki","year":"2019","journal-title":"Exp. Cell Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1097\/j.pain.0000000000001052","article-title":"Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis","volume":"158","author":"Philpott","year":"2017","journal-title":"Pain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"53746","DOI":"10.3791\/53746","article-title":"The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse","author":"Pitcher","year":"2016","journal-title":"J. Vis. Exp."},{"key":"B26","first-page":"43","article-title":"DPS data processing system experimental design, statistical analysis and data mining","author":"Tang","year":"2007","journal-title":"Beijing Sci. Press"},{"key":"B27","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jep.2013.01.025","article-title":"Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy","volume":"146","author":"Tong","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s12011-013-9640-9","article-title":"Effects of strontium on collagen content and expression of related genes in rat chondrocytes cultured in vitro","volume":"153","author":"Wang","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3390\/toxins10100391","article-title":"Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids","volume":"10","author":"Yang","year":"2018","journal-title":"Toxins (Basel)"},{"key":"B30","doi-asserted-by":"publisher","first-page":"14811","DOI":"10.4238\/2015.November.18.46","article-title":"High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis","volume":"14","author":"Zeng","year":"2015","journal-title":"Genet. Mol. Res."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01053\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T15:06:17Z","timestamp":1595603177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01053\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":30,"alternative-id":["10.3389\/fphar.2020.01053"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.01053","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]},"article-number":"1053"}}