{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:14:26Z","timestamp":1776770066305,"version":"3.51.2"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.01150","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T05:56:57Z","timestamp":1596175017000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6\/AMPK Autophagy"],"prefix":"10.3389","volume":"11","author":[{"given":"Yaling","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100492","article-title":"Length-independent telomere damage drives post-mitotic cardiomyocyte senescence","volume":"38","author":"Anderson","year":"2019","journal-title":"EMBO J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/s0047-6374(97)00165-6","article-title":"Age-dependent expression of fibrosis-related genes and collagen deposition in the rat myocardium","volume":"101","author":"Annoni","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cell.2018.03.011","article-title":"H2S to Mitigate Vascular Aging: A SIRT1 Connection","volume":"173","author":"Arumugam","year":"2018","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.biopha.2018.02.084","article-title":"Investigation of insulin resistance in the popularly used four rat models of type-2 diabetes","volume":"101","author":"Chao","year":"2018","journal-title":"BioMed. Pharmacother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41419-017-0085-5","article-title":"Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"9620","DOI":"10.1002\/anie.201603328","article-title":"Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution","volume":"55","author":"Doura","year":"2016","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"B7","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.celrep.2013.08.006","article-title":"Multiple regulatory layers of SREBP1\/2 by SIRT6","volume":"4","author":"Elhanati","year":"2013","journal-title":"Cell Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s10741-011-9257-z","article-title":"Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment","volume":"17","author":"Falcao-Pires","year":"2012","journal-title":"Heart Fail Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"701","DOI":"10.7150\/ijbs.29323","article-title":"Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation","volume":"15","author":"Fan","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s10522-013-9478-8","article-title":"SIRT6, a protein with many faces","volume":"14","author":"Gertler","year":"2013","journal-title":"Biogerontology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1377\/hlthaff.2013.1359","article-title":"Rates of major obstetrical complications vary almost fivefold among US hospitals","volume":"33","author":"Glance","year":"2014","journal-title":"Health Aff. (Millwood)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.bbadis.2017.09.029","article-title":"Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-kappaB-mediated inflammation both in vitro and in vivo","volume":"1864","author":"Guo","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/cphy.c160021","article-title":"Pathophysiological Fundamentals of Diabetic Cardiomyopathy","volume":"7","author":"Hu","year":"2017","journal-title":"Compr. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/acel.12276","article-title":"Cathepsin K knockout alleviates aging-induced cardiac dysfunction","volume":"14","author":"Hua","year":"2015","journal-title":"Aging Cell"},{"key":"B15","doi-asserted-by":"publisher","first-page":"10872","DOI":"10.1096\/fj.201900767R","article-title":"The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other\u2019s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy","volume":"33","author":"Kanwal","year":"2019","journal-title":"FASEB J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.bbrc.2018.07.057","article-title":"Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells","volume":"503","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1370\/afm.214","article-title":"Changes in age at diagnosis of type 2 diabetes mellitus in the United States, 1988 to 2000","volume":"3","author":"Koopman","year":"2005","journal-title":"Ann. Fam Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/gerona\/glu090","article-title":"MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart","volume":"70","author":"Kwak","year":"2015","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1161\/01.cir.0000048892.83521.58","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a \u201cset up\u201d for vascular disease","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"18829","DOI":"10.18632\/oncotarget.4774","article-title":"Inhibition of microRNA-497 ameliorates anoxia\/reoxygenation injury in cardiomyocytes by suppressing cell apoptosis and enhancing autophagy","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"B21","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1507\/endocrj.EJ17-0445","article-title":"Hydrogen sulfide ameliorates rat myocardial fibrosis induced by thyroxine through PI3K\/AKT signaling pathway","volume":"65","author":"Liu","year":"2018","journal-title":"Endocr. J."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.3892\/ijmm.2018.3419","article-title":"Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK\/STAT signaling pathway","volume":"41","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/eurheartj\/ehq253","article-title":"Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia\/reperfusion injury: role of autophagy paradox and toxic aldehyde","volume":"32","author":"Ma","year":"2011","journal-title":"Eur. Heart J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"18545","DOI":"10.1038\/s41598-019-53867-y","article-title":"Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling","volume":"9","author":"Martin","year":"2019","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.mad.2013.11.006","article-title":"Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage","volume":"134","author":"Ning","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s10741-018-9749-1","article-title":"Diabetic cardiomyopathy: molecular mechanisms, detrimental effects of conventional treatment, and beneficial effects of natural therapy","volume":"24","author":"Parim","year":"2019","journal-title":"Heart Fail Rev."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00121","article-title":"Corrigendum: Cystathionine beta-Synthase Is Necessary for Axis Development in vivo","volume":"6","author":"Prabhudesai","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1042\/CS20160916","article-title":"Down-regulation of miR-15a\/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart","volume":"131","author":"Rawal","year":"2017","journal-title":"Clin. Sci. (Lond)"},{"key":"B30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1161\/01.RES.0000231289.63468.08","article-title":"Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene","volume":"99","author":"Rota","year":"2006","journal-title":"Circ. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1161\/CIRCRESAHA.116.307474","article-title":"Aging and Autophagy in the Heart","volume":"118","author":"Shirakabe","year":"2016","journal-title":"Circ. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00395-016-0531-z","article-title":"SIRT6 protects cardiomyocytes against ischemia\/reperfusion injury by augmenting FoxO3alpha-dependent antioxidant defense mechanisms","volume":"111","author":"Wang","year":"2016","journal-title":"Basic Res. Cardiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5744","DOI":"10.1158\/1078-0432.CCR-18-1489","article-title":"Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer","volume":"24","author":"Wang","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190317","article-title":"Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM","volume":"39","author":"Wang","year":"2019","journal-title":"Biosci. Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3892\/ijmm.2014.2007","article-title":"Exogenous H2S protects H9c2 cardiac cells against high glucose-induced injury and inflammation by inhibiting the activation of the NF-kappaB and IL-1beta pathways","volume":"35","author":"Xu","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"13994","DOI":"10.1002\/jcb.28674","article-title":"Loss of p27(kip1) suppresses the myocardial senescence caused by estrogen deficiency","volume":"120","author":"Yan","year":"2019","journal-title":"J. Cell Biochem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.3390\/ijms20112833","article-title":"Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy","volume":"20","author":"Zamora","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s12011-018-1292-3","article-title":"Endogenous Hydrogen Sulfide Promotes Apoptosis via Mitochondrial Pathways in the Livers of Broilers with Selenium Deficiency Exudative Diathesis Disease","volume":"186","author":"Zheng","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.7150\/ijbs.35736","article-title":"Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition","volume":"15","author":"Zheng","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5132","DOI":"10.3892\/mmr.2018.8504","article-title":"Evaluation of type 2 diabetic mellitus animal models via interactions between insulin and mitogenactivated protein kinase signaling pathways induced by a high fat and sugar diet and streptozotocin","volume":"17","author":"Zhuo","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01150\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T05:56:58Z","timestamp":1596175018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01150\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":41,"alternative-id":["10.3389\/fphar.2020.01150"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.01150","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"article-number":"1150"}}