{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:35:40Z","timestamp":1787510140694,"version":"build-2736575974"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.01164","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T01:53:42Z","timestamp":1596160422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Early Prediction of Clinical Response to Etanercept Treatment in Juvenile Idiopathic Arthritis Using Machine Learning"],"prefix":"10.3389","volume":"11","author":[{"given":"Xiaolan","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chifong","family":"Ieong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huasong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1002\/0470114754","volume-title":"An introduction to categorical data analysis","author":"Agresti","year":"2007"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.5555\/2188385.2343682","article-title":"Analysis of a random forests model","volume":"13","author":"Biau","year":"2012","journal-title":"J. Mach. Learn. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1145\/2939672.2939785","article-title":"XGBoost: a scalable tree boosting system","volume":"2016","author":"Chen","year":"2016","journal-title":"KDD"},{"key":"B4","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/art.24516","article-title":"Development and validation of a composite disease activity score for juvenile idiopathic arthritis","volume":"61","author":"Consolaro","year":"2009","journal-title":"Arthritis Care Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/3-540-45014-9_1","article-title":"Ensemble methods in machine learning","volume":"2000","author":"Dietterich","year":"2000","journal-title":"MCS"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1093\/rheumatology\/ket490","article-title":"Predictors of response to etanercept in polyarticular-course juvenile idiopathic arthritis","volume":"53","author":"Geikowski","year":"2014","journal-title":"Rheumatol. (Oxford)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R","article-title":"Preliminary definition of improvement in juvenile arthritis","volume":"40","author":"Giannini","year":"1997","journal-title":"Arthritis Rheumatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1002\/art.38736","article-title":"Distinct effects of methotrexate and etanercept on the B cell compartment in patients with juvenile idiopathic arthritis","volume":"66","author":"Glaesener","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jtcvs.2006.03.035","article-title":"Randomized controlled trials do not reflect reality: real-world analyses are critical for treatment guidelines","volume":"132","author":"Grapow","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/rheumatology\/ket433","article-title":"Body weight, gender and response to TNF-alpha blockers in axial spondyloarthritis","volume":"53","author":"Gremese","year":"2014","journal-title":"Rheumatol. (Oxford)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1136\/ard.2003.014886","article-title":"The German etanercept registry for treatment of juvenile idiopathic arthritis","volume":"63","author":"Horneff","year":"2004","journal-title":"Ann. Rheum Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.5555\/3294996.3295074","article-title":"LightGBM: a highly efficient gradient boosting decision tree","volume":"2017","author":"Ke","year":"2017","journal-title":"NIPS"},{"key":"B13","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1093\/rheumatology\/kev434","article-title":"Factors associated with improvement in disease activity following initiation of etanercept in children and young people with Juvenile Idiopathic Arthritis: results from the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study","volume":"55","author":"Kearsley-Fleet","year":"2016","journal-title":"Rheumatology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/art.30136","article-title":"Body mass index and clinical response to infliximab in rheumatoid arthritis","volume":"63","author":"Klaasen","year":"2011","journal-title":"Arthritis Rheumatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3390\/jcm7110428","article-title":"Prediction of Acute Kidney Injury after Liver Transplantation: Machine Learning Approaches vs. Logistic Regression Model","volume":"7","author":"Lee","year":"2018","journal-title":"J. Clin. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s10020-019-0093-2","article-title":"IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis","volume":"25","author":"Liu","year":"2019","journal-title":"Mol. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1002\/art.38355","article-title":"Brief Report: Etanercept Inhibits the Tumor Necrosis Factor \u03b1-Driven Shift of Th17 Lymphocytes Toward a Nonclassic Th1 Phenotype in Juvenile Idiopathic Arthritis","volume":"66","author":"Maggi","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3899\/jrheum.180168","article-title":"Toward new classification criteria for juvenile idiopathic arthritis: first steps, pediatric rheumatology international trials organization international consensus","volume":"46","author":"Martini","year":"2019","journal-title":"J. Rheumatol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01155","article-title":"Early and Accurate Prediction of Clinical Response to Methotrexate Treatment in Juvenile Idiopathic Arthritis Using Machine Learning","volume":"10","author":"Mo","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1002\/art.30569","article-title":"Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis","volume":"63","author":"Morbach","year":"2011","journal-title":"Arthritis Rheumatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1093\/eurheartj\/ehw188","article-title":"Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis","volume":"38","author":"Motwani","year":"2017","journal-title":"Eur. Heart J."},{"key":"B22","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nrrheum.2009.232","article-title":"Rheumatoid arthritis: the multifaceted role of adiponectin in inflammatory joint disease","volume":"5","author":"Muller-Ladner","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"B23","first-page":"2116","article-title":"Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis","volume":"23","author":"Murray","year":"1996","journal-title":"J. Rheumatol."},{"key":"B24","first-page":"478","article-title":"Body mass index and response to infliximab in rheumatoid arthritis","volume":"33","author":"Ottaviani","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1001\/jama.2011.1671","article-title":"Factors associated with treatment response to etanercept in juvenile idiopathic arthritis","volume":"306","author":"Otten","year":"2011","journal-title":"JAMA"},{"key":"B26","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J. Rheumatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e1002695","DOI":"10.1371\/journal.pmed.1002695","article-title":"Predicting the risk of emergency admission with machine learning: Development and validation using linked electronic health records","volume":"15","author":"Rahimian","year":"2018","journal-title":"PloS Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1136\/ard.2006.065839","article-title":"Comparison of composite measures of disease activity in an early seropositive rheumatoid arthritis cohort","volume":"66","author":"Ranganath","year":"2007","journal-title":"Ann. Rheum Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1093\/rheumatology\/keq197","article-title":"Patient-reported 28 swollen and tender joint counts accurately represent RA disease activity and can be used to assess therapy responses at the group level","volume":"49","author":"Riazzoli","year":"2010","journal-title":"Rheumatol. (Oxford)"},{"key":"B30","first-page":"7","article-title":"Joint counts in inflammatory arthritis","volume":"32","author":"Scott","year":"2014","journal-title":"Clin. Exp. Rheumatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/art.1780380106","article-title":"Validity and reliability of the twenty-eight-joint count for the assessment of rheumatoid arthritis activity","volume":"38","author":"Smolen","year":"1995","journal-title":"Arthritis Rheumatol."},{"key":"B32","first-page":"1684","article-title":"Inhibited apoptosis of synovial fluid lymphocytes in children with juvenile idiopathic arthritis is associated with increased expression of myeloid cell leukemia 1 and XIAP proteins","volume":"33","author":"Smolewska","year":"2006","journal-title":"J. Rheumatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3899\/jrheum.120842","article-title":"Factors associated with achievement of inactive disease in children with juvenile idiopathic arthritis treated with etanercept","volume":"40","author":"Solari","year":"2013","journal-title":"J. Rheumatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.jid.2019.09.023","article-title":"Early Quantification of Systemic Inflammatory Proteins Predicts Long-Term Treatment Response to Tofacitinib and Etanercept","volume":"140","author":"Tomalin","year":"2019","journal-title":"J. Invest. Dermatol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1136\/ard.2010.143347","article-title":"Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE\u2013JIA): a multicentre randomised open-label clinical trial","volume":"70","author":"Tynj\u00e4l\u00e4","year":"2011","journal-title":"Ann. Rheum Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1136\/annrheumdis-2018-214354","article-title":"Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes","volume":"78","author":"Van Nieuwenhove","year":"2019","journal-title":"Ann. Rheum Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1002\/art.34343","article-title":"Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis","volume":"64","author":"Wallace","year":"2012","journal-title":"Arthritis Rheumatol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01164\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T01:53:50Z","timestamp":1596160430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01164\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":38,"alternative-id":["10.3389\/fphar.2020.01164"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.01164","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"article-number":"1164"}}