{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:15:45Z","timestamp":1791818145008,"version":"4.3.4"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.01210","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T08:00:38Z","timestamp":1598947238000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":78,"title":["Synergistic Effect of Berberine-Based Chinese Medicine Assembled Nanostructures on Diarrhea-Predominant Irritable Bowel Syndrome In Vivo"],"prefix":"10.3389","volume":"11","author":[{"given":"Lei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchai","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunnong","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhao","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penglong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongri","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1039\/b918763b","article-title":"Green chemistry: principles and practice","volume":"39","author":"Anastas","year":"2010","journal-title":"Chem. Soc Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"5163","DOI":"10.2174\/1381612823666170822101606","article-title":"The efficacy and potential mechanisms of Chinese herbal medicine on irritable bowel syndrome","volume":"23","author":"Bi","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"B3","doi-asserted-by":"publisher","first-page":"0188563-0188579","DOI":"10.1371\/journal.pone.0188563","article-title":"Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS","volume":"12","author":"Brun","year":"2017","journal-title":"PloS One"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145556","article-title":"Berberine improves intestinal motility and visceral pain in the mouse models mimicking diarrheapredominant Irritable Bowel Syndrome (IBS-D) symptoms in an opioid-receptor dependent manner","volume":"10","author":"Chen","year":"2015","journal-title":"PloS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1001\/jama.2015.0954","article-title":"Irritable bowel syndrome: a clinical review","volume":"313","author":"Chey","year":"2015","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jtcms.2020.01.004","article-title":"Adding Chinese herbal medicine to probiotics for irritable bowel syndrome-diarrhea: a systematic review and meta-analysis of randomized controlled trials","volume":"7","author":"Fan","year":"2020","journal-title":"J. Trad. Chin. Med. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.biopha.2018.01.071","article-title":"Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin","volume":"99","author":"Feng","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/978-1-49390897-49","article-title":"Neuropeptides and the microbiotagut-brain axis","volume":"817","author":"Holzer","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"109206","DOI":"10.1016\/j.biopha.2019.109206","article-title":"Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice","volume":"118","author":"Hou","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1021\/acsami.9b17722","article-title":"Staphylococcus aureusSelf-Assemblies Based on Traditional Medicine Berberine and Cinnamic Acid for Adhesion-Induced Inhibition Multidrug-Resistant","volume":"12","author":"Huang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"B12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/healthcare5020021","article-title":"Irritable bowel syndrome: clinical manifestations, dietary in\ufb02uences, and management","volume":"5","author":"Ikechi","year":"2017","journal-title":"Healthcare (Basel)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087810","article-title":"Ginsenoside Metabolite Compound K promotes recovery of Dextran Sulfate Sodium-induced Colitis and inhibits inflammatory responses by suppressing NF-\u03baB activation","volume":"9","author":"Juan","year":"2014","journal-title":"PloS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3349\/ymj.2016.57.1.146","article-title":"Irritable bowel syndrome may be associated with elevated alanine aminotransferase and metabolic syndrome","volume":"57","author":"Lee","year":"2016","journal-title":"Yonsei Med. J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"6770","DOI":"10.1021\/acsnano.9b01346","article-title":"Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01466","article-title":"The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat","volume":"10","author":"Liang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jep.2017.02.045","article-title":"Chemical profiles and pharmacological activities of Chang-Kang-Fang, a multi-herb Chinese medicinal formula, for treating irritable bowel syndrome","volume":"201","author":"Mao","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"B18","article-title":"Guide for the care and use of laboratory animals","year":"1996"},{"key":"B19","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3389\/fphar.2018.00557","article-title":"Berberine: Botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders","volume":"9","author":"Neag","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.advms.2016.11.001","article-title":"New insights into the pathogenesis and treatment of irritable bowel syndrome","volume":"62","author":"O\u015bwi\u0119cimska","year":"2017","journal-title":"Adv. Med. Sci."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4530203","article-title":"Fecal microbiota of diarrhea-predominant irritable bowel syndrome patients causes hepatic inflammation of germ-free rats and Berberine reverses it partially","author":"Qiong","year":"2019","journal-title":"BioMed. Res. Int."},{"key":"B22","doi-asserted-by":"publisher","first-page":"G529","DOI":"10.1152\/ajpgi.00207.2012","article-title":"Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome","volume":"305","author":"Ringel","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/152165401317291183","article-title":"Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane","volume":"52","author":"Severina","year":"2001","journal-title":"IUBMB Life"},{"key":"B24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s13318-013-0161-x","article-title":"Pharmacokinetic\u2013 pharmacodynamic evaluation of the major component astragaloside IV on the immunomodulatory e\ufb00ects of Yu-ping-feng prescription","volume":"39","author":"Song","year":"2013","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1007\/s00535-012-0627-7","article-title":"Alterd neuro-endocrine-immune pathways in the irritable bowel syndrome: the top-down and the bottom-up mode","volume":"47","author":"Stasi","year":"2012","journal-title":"J. Gastroenterol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s12906-015-0863-5","article-title":"Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome (D-IBS)","volume":"15","author":"Sun","year":"2015","journal-title":"BMC Complement Altern. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"754761","DOI":"10.1016\/j.jep.2011.04.007","article-title":"Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome","volume":"135","author":"Tjong","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.3390\/molecules22091456","article-title":"Origin and formation mechanism investigation of compound precipitation from the traditional Chinese Prescription Huang-Lian-Jie-Du-Tang by Isothermal Titration Calorimetry","volume":"22","author":"Wang","year":"2017","journal-title":"Molecules"},{"key":"B29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/17474124.2017.1292130","article-title":"Irritable bowel syndrome: what do the new Rome IV diagnostic guidelines mean for patient management","volume":"11","author":"Whitehead","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1248\/bpb.35.355","article-title":"Huanglian-jie-du-tang extract protects against chronic brain injury after focal cerebral ischemia via hypoxia-inducible-factor-1\u03b1-regulated vascular endothelial growth factor signaling in mice","volume":"35","author":"Ye","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00694","article-title":"System Pharmacology-Based Dissection of the Synergistic Mechanism of Huangqi and Huanglian for Diabetes Mellitus","volume":"8","author":"Yue","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.3390\/molecules21081094","article-title":"Compositions, formation mechanism, and neuroprotective effect of compound precipitation from the traditional chinese prescription huang-lian-jie-du-tang","volume":"21","author":"Zhang","year":"2016","journal-title":"Molecules"},{"key":"B33","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.intimp.2018.09.001","article-title":"Baicalin exerts neuroprotective effects via inhibiting activation of GSK3\u03b2\/NF-\u03baB\/NLRP3 signal pathway in a rat model of depression","volume":"64","author":"Zhang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jep.2019.03.045","article-title":"Effect of water extract from Berberis heteropoda Schrenk roots on diarrhea-predominant irritable bowel syndrome by adjusting intestinal flora","volume":"237","author":"Zhu","year":"2019","journal-title":"J. Ethnopharmacol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01210\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T08:00:40Z","timestamp":1598947240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01210\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":34,"alternative-id":["10.3389\/fphar.2020.01210"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.01210","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]},"article-number":"1210"}}