{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:16:33Z","timestamp":1791771393948,"version":"4.3.4"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2020.01301","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T12:04:46Z","timestamp":1598011486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Antioxidant Phytoconstituents From Onosma bracteata Wall. (Boraginaceae) Ameliorate the CCl4 Induced Hepatic Damage: In Vivo Study in Male Wistar Rats"],"prefix":"10.3389","volume":"11","author":[{"given":"Ajay","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritika","family":"Pandit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep Singh","family":"Tuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Sak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subheet Kumar","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satwinderjeet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"In Methods Enzymology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1248\/cpb.53.907","article-title":"Isolation of onosmins A and B, lipoxygenase inhibitors from Onosma hispida","volume":"53","author":"Ahmad","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"B3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.5567\/pharmacologia.2013.525.528","article-title":"Antibacterial and antifungal studies of the crude extract and solvent fractions of Onosma khyberianum","volume":"4","author":"Ahmad","year":"2013","journal-title":"Pharmacologica"},{"key":"B4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.15406\/mojbb.2018.05.00122","article-title":"The Effect of Onosma bracteatum in cancer cells","volume":"5","author":"Albaqami","year":"2018","journal-title":"MOJ Bioequiv. Availab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41389-017-0025-3","article-title":"Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases","volume":"7","author":"Allocati","year":"2018","journal-title":"Oncogenesis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3390\/medicina55090526","article-title":"Hepatocellular carcinoma: Molecular mechanisms and targeted therapies","volume":"55","author":"Alqahtani","year":"2019","journal-title":"Medicina"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/9895485","article-title":"Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats","volume":"2019","author":"Aly","year":"2019","journal-title":"Anal. Cell. Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","article-title":"Determination of glutathione and glutathione disulfide in biological samples","volume":"113","author":"Anderson","year":"1985","journal-title":"Methods Enzymology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1002\/hep.22580","article-title":"Molecular mechanisms of hepatocellular carcinoma","volume":"48","author":"Aravalli","year":"2008","journal-title":"Hepatology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1559325819891262","article-title":"Dose-dependent, antidepressant, and anxiolytic effects of a traditional medicinal plant for the management of behavioral dysfunctions in animal models","volume":"17","author":"Asif","year":"2019","journal-title":"Dose-Response"},{"key":"B11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1023\/a:1019963222510","article-title":"Inhibition of TNF\u03b1-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-\u03baB activation in A549 cells","volume":"238","author":"Banerjee","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4314\/ajtcam.v11i2.2","article-title":"Hepatoprotective properties of aqueous leaf extract of Persea americana, mill (lauraceae)\u2019avocado\u2019against CCl 4-induced damage in rats","volume":"11","author":"Brai","year":"2014","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1051\/fopen\/2019010","article-title":"NF-\u03baB signaling and crosstalk during carcinogenesis","volume":"2","author":"Br\u00fccher","year":"2019","journal-title":"4open"},{"key":"B15","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.ccell.2017.11.004","article-title":"Myeloid cell-derived reactive oxygen species induce epithelial mutagenesis","volume":"32","author":"Canli","year":"2017","journal-title":"Cancer Cell"},{"key":"B16","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","article-title":"Purification and characterization of the flavoenzyme glutathione reductase from rat liver","volume":"250","author":"Carlberg","year":"1975","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bpg.2004.11.005","article-title":"Molecular mechanisms in hepatocellular carcinoma development","volume":"19","author":"Cha","year":"2005","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/antiox8080251","article-title":"Antioxidant Activity of Graptopetalum paraguayense E. Walther Leaf Extract Counteracts Oxidative Stress Induced by Ethanol and Carbon Tetrachloride Co-Induced Hepatotoxicity in Rats","volume":"8","author":"Chao","year":"2019","journal-title":"Antioxidants"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms20040830","article-title":"Plant natural products for human health","volume":"20","author":"Che","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1128\/MCB.00630-10","article-title":"Cyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7","volume":"31","author":"Chibazakura","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.5483\/BMBRep.2003.36.3.332","article-title":"Microplate assay measurement of cytochrome P450-carbon monoxide complexes","volume":"36","author":"Choi","year":"2003","journal-title":"BMB Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/5615647","article-title":"Green tea extracts epigallocatechin-3-gallate for different treatments","volume":"2017","author":"Chu","year":"2017","journal-title":"BioMed Res. Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1385\/1-59259-173-6:147","article-title":"Oxidation of cellular DNA measured with the comet assay","volume":"186","author":"Collins","year":"2002","journal-title":"Oxidative stress biomarkers and antioxidant protocols."},{"key":"B24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0005-2760(83)90207-2","article-title":"Differences in lipid peroxidation of rat liver rough and smooth microsomes","volume":"750","author":"Devasagayam","year":"1983","journal-title":"Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"8865","DOI":"10.5897\/AJB10.782","article-title":"In vitro antioxidant and free radical scavenging activity of Leonurus cardiaca subsp. Persicus, Grammosciadium platycarpum and Onosma demawendicum","volume":"9","author":"Ebrahimzadeh","year":"2010","journal-title":"Afr. J. Biotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3892\/etm.2019.8353","article-title":"Antioxidant, anti-inflammatory and anti-fibrotic effects of Boswellia serrate gum resin in CCl4-induced hepatotoxicity","volume":"19","author":"Eltahir","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"B27","first-page":"1356","article-title":"Psychoimmunomodulatory Effects of Onosma bracteatum Wall. (Gaozaban) on Stress Model in Sprague Dawley Rats","volume":"6","author":"Fareed","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.3390\/molecules24071428","article-title":"Novel Anti-Aging Benzoquinone Derivatives from Onosma bracteatum Wall","volume":"24","author":"Farooq","year":"2019","journal-title":"Molecules"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3109\/13880209.2014.967782","article-title":"Ameliorative effect of methanol extract of Rumex vesicarius on CCl4-induced liver damage in Wistar albino rats","volume":"53","author":"Ganaie","year":"2015","journal-title":"Pharm. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3892\/etm.2015.2931","article-title":"Hepatic injury is associated with cell cycle arrest and apoptosis with alteration of cyclin A and D1 in ammonium chloride-induced hyperammonemic rats","volume":"11","author":"Gao","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"B31","first-page":"2058","article-title":"Liver microsomal metabolism of aflatoxin B1 to a reactive derivative toxic to Salmonella typhimurium TA 1530","volume":"32","author":"Garner","year":"1972","journal-title":"Cancer Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1172\/JCI106340","article-title":"Catalase-dependent peroxidative metabolism in the alveolar macrophage during phagocytosis","volume":"49","author":"Gee","year":"1970","journal-title":"J. Clin. Invest."},{"key":"B33","unstructured":"2018"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1462399411002110","article-title":"Molecular mechanisms underlying chemical liver injury","volume":"14","author":"Gu","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"key":"B35","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferase\u2014the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40659-015-0022-y","article-title":"Hepato-protective effect of rutin via IL-6\/STAT3 pathway in CCl4-induced hepatotoxicity in rats","volume":"48","author":"Hafez","year":"2015","journal-title":"Biol. Res."},{"key":"B37","volume-title":"Free radicals in biology and medicine","author":"Halliwell","year":"1989"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101117","article-title":"(-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury","volume":"22","author":"Huang","year":"2019","journal-title":"Redox Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3329\/bjms.v17i1.35276","article-title":"Onosma bracteatum wall: A Potent analgesic agent","volume":"17","author":"Imran","year":"2018","journal-title":"Bangladesh J. Med. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/0003-2697(92)90122-N","article-title":"Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein","volume":"202","author":"Jiang","year":"1992","journal-title":"Anal. Biochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1002\/nbm.3431","article-title":"Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1-13C] pyruvate","volume":"28","author":"Josan","year":"2015","journal-title":"NMR Biomed."},{"key":"B42","first-page":"265","article-title":"The Flora of \u00dcz\u00fcml\u00fc-Sakaltutan (Erzincan-G\u00fcm\u00fc\u015fhane)","volume":"32","author":"Kandemir","year":"2008","journal-title":"Turkish J. Bot."},{"key":"B43","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jhazmat.2011.08.027","article-title":"Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4)","volume":"195","author":"Karakus","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/s0278-6915(00)00104-6","article-title":"Modulatory effects of a tannin fraction isolated from Terminalia arjuna on the genotoxicity of mutagens in Salmonella typhimurium","volume":"38","author":"Kaur","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/JEnvironPatholToxicolOncol.v20.i1.20","article-title":"Antimutagenic potential of extracts isolated from Terminalia arjuna","volume":"20","author":"Kaur","year":"2001","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.fct.2016.10.027","article-title":"Modulatory effects of Cassia fistula fruits against free radicals and genotoxicity of mutagens","volume":"98","author":"Kaur","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.biopha.2017.01.165","article-title":"Hepatoprotective activity of Butea monosperma bark against thioacetamide-induced liver injury in rats","volume":"89","author":"Kaur","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B48","doi-asserted-by":"publisher","first-page":"29930","DOI":"10.1007\/s11356-019-06158-y","article-title":"Amelioration of hepatic function, oxidative stress, and histopathologic damages by Cassia fistula L. fraction in thioacetamide-induced liver toxicity","volume":"26","author":"Kaur","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12906-019-2432-9","article-title":"Development of aqueous-based multi-herbal combination using principal component analysis and its functional significance in HepG2 cells","volume":"19","author":"Kaur","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/1472-6882-12-178","article-title":"CCl 4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat","volume":"12","author":"Khan","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"140","DOI":"10.4103\/0973-7847.120513","article-title":"Onosma L.: A review of phytochemistry and ethnopharmacology","volume":"7","author":"Kumar","year":"2013","journal-title":"Pharmacognosy Rev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.apjtm.2017.03.005","article-title":"Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl4 induced hepatic damage in rats","volume":"10","author":"Laouar","year":"2017","journal-title":"Asian Pac. J. Trop. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"6490","DOI":"10.1021\/jf020388c","article-title":"Antioxidant property of an ethanol extract of the stem of Opuntia ficus-indica var. saboten","volume":"50","author":"Lee","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"117","DOI":"10.7324\/JAPS.2019.90415","article-title":"Combined effects of celecoxib and cepharanthine on human colorectal cancer cells in vitro","volume":"9","author":"Lerdwanangkun","year":"2019","journal-title":"J. Appl. Pharm. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.ijbiomac.2014.09.066","article-title":"Antioxidant and protective effect of inulin and catechin grafted inulin against CCl4-induced liver injury","volume":"72","author":"Liu","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00477","article-title":"Role of ROS and nutritional antioxidants in human diseases","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0165-1161(83)90010-9","article-title":"Revised methods for the Salmonella mutagenicity test","volume":"113","author":"Maron","year":"1983","journal-title":"Mutat. Research\/Environmental Mutagenesis Relat. Subj."},{"key":"B58","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s11095-010-0085-y","article-title":"Cancer chemoprevention by natural products: how far have we come","volume":"27","author":"Mehta","year":"2010","journal-title":"Pharm. Res."},{"key":"B59","first-page":"16","article-title":"Free radical scavenging capacity and antioxidant activity of Onosma bracteatum","volume":"4","author":"Menghani","year":"2011","journal-title":"Int. J. Pharm. Res. Dev."},{"key":"B60","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/oxfordjournals.jbchem.a129819","article-title":"Partial purification of NADH-cytochrome b5 reductase from rabbit liver microsomes with detergents and its properties","volume":"71","author":"Mihara","year":"1972","journal-title":"J. Biochem."},{"key":"B61","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.micres.2005.05.001","article-title":"Antibacterial activity directed isolation of compounds from Onosma hispidum","volume":"161","author":"Naz","year":"2006","journal-title":"Microbiol. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B64","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature","volume":"239","author":"Omura","year":"1964","journal-title":"J. Biol. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.indcrop.2017.10.026","article-title":"Onosma heterophyllum: Phenolic composition, enzyme inhibitory and antioxidant activities","volume":"111","author":"Ozer","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3390\/nu10091280","article-title":"Polyphenols in Liubao tea can prevent CCl4-induced hepatic damage in mice through its antioxidant capacities","volume":"10","author":"Pan","year":"2018","journal-title":"Nutrients"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"B68","first-page":"1","article-title":"Oxidative stress, prooxidants, and antioxidants: the interplay","volume-title":"BioMed. Res. Int.","author":"Rahal","year":"2014"},{"key":"B69","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1017\/S0960428605000211","article-title":"A new species of Onosma (Boraginaceae\u2013Lithospermeae) from southern Turkey","volume":"61","author":"Riedl","year":"2004","journal-title":"Edinburgh J. Bot."},{"key":"B70","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.toxrep.2015.05.012","article-title":"A single acute hepatotoxic dose of CCl4 causes oxidative stress in the rat brain","volume":"2","author":"Ritesh","year":"2015","journal-title":"Toxicol. Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.indcrop.2015.05.038","article-title":"Inhibition of DNA oxidative damage and antimutagenic activity by dichloromethane extract of Brassica rapa var. rapa L. seeds","volume":"74","author":"Robin","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"B72","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/antiox8050137","article-title":"Dietary flavonoids as cancer chemopreventive agents: an updated review of human studies","volume":"8","author":"Rodr\u00edguez-Garc\u00eda","year":"2019","journal-title":"Antioxidants"},{"key":"B73","first-page":"1551","article-title":"Hepatoprotective activity and phenolic profile of Zanthoxylum alatum Roxb. fruit extract","volume":"30","author":"Sabir","year":"2017","journal-title":"Pakistan J. Pharm. Sci."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111878","article-title":"A comparative study on the phenolic composition, antioxidant and enzyme inhibition activities of two endemic Onosma species","volume":"142","author":"Saravanakumar","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"B75","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1756-9966-28-80","article-title":"Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant\/antioxidant activity: molecular and histological evidences","volume":"28","author":"Seufi","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3109\/13880209.2014.909502","article-title":"Antioxidative and chemopreventive effects of Nephrolepis biserrata against carbon tetrachloride (CCl4)-induced oxidative stress and hepatic dysfunction in rats","volume":"53","author":"Shah","year":"2015","journal-title":"Pharm. Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"842","DOI":"10.3109\/10715762.2012.684245","article-title":"Epicatechin ameliorates ionising radiation-induced oxidative stress in mouse liver","volume":"46","author":"Sinha","year":"2012","journal-title":"Free Radical Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/6175804","article-title":"ROS Generation and antioxidant defense systems in normal and malignant cells","volume":"2019","author":"Snezhkina","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B79","doi-asserted-by":"publisher","first-page":"6228","DOI":"10.1038\/onc.2008.300","article-title":"NF-\u03baB signaling, liver disease and hepatoprotective agents","volume":"27","author":"Sun","year":"2008","journal-title":"Oncogene"},{"key":"B80","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"B81","first-page":"1475","article-title":"(envis. frlht. org\/frlhtenvis. nic. in)","author":"Ved","year":"2016"},{"key":"B82","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.jfda.2014.10.002","article-title":"Hepatoprotective effects of kaempferol 3-O-rutinoside and kaempferol 3-O-glucoside from Carthamus tinctorius L. @ on CCl4-induced oxidative liver injury in mice","volume":"23","author":"Wang","year":"2015","journal-title":"J. Food Drug Anal."},{"key":"B83","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jfda.2016.10.019","article-title":"Chemopreventive effect of natural dietary compounds on xenobiotic-induced toxicity","volume":"25","author":"Wu","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"B84","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1158\/1078-0432.CCR-07-1644","article-title":"WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt\/\u03b2-catenin signaling, and is frequently methylated in colorectal cancer","volume":"14","author":"Ying","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"B85","first-page":"1475","article-title":"Ameliorating role of methanolic leaves extract of Fraxinus xanthoxyloides against CCl4-challanged nephrotoxicity in rats","volume":"31","author":"Younis","year":"2018","journal-title":"Pakistan J. Pharm. Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5947234","article-title":"Amelioration of CCl4-Induced Hepatotoxicity in Rabbits by Lepidium sativum Seeds","volume":"2019","author":"Zamzami","year":"2019","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1007\/s13197-018-3385-6","article-title":"Protective effects of dietary kaempferol glycoside components from unripe soybean (Edamame, Glycine max L. Merrill.\u2019Jindai\u2019) leaves and their serous metabolite on carbon tetrachloride-induced liver injury mice","volume":"55","author":"Zang","year":"2018","journal-title":"J. Food Sci. Technol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01301\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:24:42Z","timestamp":1616977482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2020.01301\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":87,"alternative-id":["10.3389\/fphar.2020.01301"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2020.01301","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,21]]},"article-number":"1301"}}